Pannexin channels: The emerging therapeutic targets

Current Drug Targets

Volumn 15, Issue 3, 2014, Pages 272-280

  Mohammad, Misbahuddin ^a   Habib, Hamed Said ^a  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Calcium; Cellular communication; Channels; Hypertension; Purine

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADRENERGIC RECEPTOR; CALCIUM; GAP JUNCTION PROTEIN; INNEXIN; PANNEXIN; PROTEIN; PURINERGIC RECEPTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CARCINOGENESIS; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CELL MEMBRANE POTENTIAL; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; CHEMICAL STRUCTURE; EPILEPSY; GLYCOSYLATION; HUMAN; HUMAN CELL; HYPERTENSION; IMMUNE RESPONSE; INFLAMMATION; INTERNALIZATION; ISCHEMIA; PATHOPHYSIOLOGY; SEIZURE; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CELL COMMUNICATION; CONNEXINS; HUMANS; MOLECULAR TARGETED THERAPY; NERVE TISSUE PROTEINS;

EID: 84896691333     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/13894501113146660217     Document Type: Article

References (70)

1. Bruzzone R, White TW, Paul DL. Connections with connexins: the molecular basis of direct intercellular signaling. Eur J Biochem 1996; 238: 1-27.
2. White TW, Paul DL. Genetic diseases and gene knockouts reveal diverse connexins functions. Annual Rev Physiol 1999; 61: 283-310.
3. Phelan P, Bacon JP, Davies JA, et al. Innexins: a family of invertebrate gap-junction proteins. Trends Genet 1998; 14: 348-9.
4. Barnes TM. OPUS: a growing family of gap junction proteins?. Trends Genet 1994; 10: 303-5.
5. Starich TA, Lee RY, Panzarella C, Avery L, Shaw JE. eat-5 and unc-7 represent a multigene family in Caenorhabditis elegans involved in cell-cell coupling. J Cell Biol 1996; 134: 537-47.
6. Landesman Y, White TW, Starich TA, Shaw JE, Goodenough DA, Paul DL. Innexin-3 forms connexin-like intercellular channels. J Cell Sci 1999; 112: 2391-96.
7. Panchina Y, Kelmanson I, Matz M, et al. A ubiquitous family of putative gap junction molecules. Curr Biol 2000; 10: 13.
8. Ransford GA, Dahl G, Fregien N, Conner GE, Salathe M. Pannexin 1 expression in airway epithelia. Am J Resp Crit Care Med. 2007; 175: A887.
9. Zoidl G, Petrasch-Parwez E, Ray A, et al. Localization of the pannexin1 protein at postsynaptic sites in the cerebral cortex and hippocampus. Neuroscience. 2007; 146: 9-16.
10. Penuela S, Bhalla R, Gong XQ, et al. Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins. J Cell Sci 2007; 120: 3772-83.
11. Dahl G, Harris AL. In: Connexins: A Guide; Andrew Harris, Ed. New York: Humana Press, a part of Springer Science+Business Media, LLC 2009: pp 287-301.
12. Huang Y, Grinspan JB, Abrams CK, Scherer SS. Pannexin1 is expressed by neurons and glia but does not form functional gap junctions. Glia. 2007; 55: 46-56.
13. Baranova D, Ivanov N, Petrash A, et al. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Genomics 2004; 83: 706-16.
14. Yen MR, Saier MH Jr. Gap junctional proteins of animals: the innexin/pannexin superfamily. Prog. Biophys. Mol. Biol 2007; 94: 5-14.
15. Bruzzone R, Hormuzdi SG, Barbe MT, Herb A, Monyer H. Pannexins, a family of gap junction proteins expressed in brain. Proc Natl Acad Sci USA 2003; 100: 13644-49.
16. Penuela S, Gehi R, Laird DW. The biochemistry and function of Pannexin channels. Biochem Biophys Acta 2013; 1828 (1): 15-22.
17. Scemes E, Suadicani SO, Dahl G, Spray DC. Connexin and pannexin mediated cell-cell communication. Neuron Glia Biol 2007; 3: 199-208.
18. Penuela S, Bhalla R, Nag K, Laird DW. Glycosylation regulates pannexin intermixing and cellular localization. Mol Biol Cell 2009; 20: 4313-23.
19. Ambrosi C, Gassmann O, Pranskevich JN, et al. Pannexin 1 and Pannexin 2 channels show quaternary similarities to connexons and different oligomerization numbers from each other. J Biol Chem 2010; 285 (32): 24420-31.
20. Sosinsky GE, Boassa D, Dermietzel R, et al. Pannexin channels are not gap junction hemichannels. Channels (Austin) 2011; 5: 193-7.
21. Ray G, Zoidl P, Wahle R. Pannexin expression in the cerebellum Cerebellum 2006; 5: 189-92.
22. Sohl G, Maxeiner S, Willecke K. Expression and functions of neuronal gap junctions. Nat Rev Neurosci 2005; 6: 191-200.
23. Zappala A, Cicero D, Serapide MF, et al. Expression of pannexin1 in the CNS of adult mouse: cellular localization and effect of 4-aminopyridine-induced seizures. Neuroscience 2006; 141: 167-78.
24. Vogt SG, Hormuzdi H. Pannexin1 and pannexin2 expression in the developing and mature rat brain. Mol Brain Res 2005; 141: 113-20.
25. Pelegrin P, Surprenant A. The P2X(7) receptor-pannexin connection to dye uptake and IL-1beta release. Purinergic Signal 2009; 5: 129-37.
26. Bao L, Locovei S, Dahl G. Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett 2004; 572: 65-8.
27. Dahl G, Locovei S. Pannexin: to gap or not to gap, is that a question? IUBMB Life. 2006; 58: 409-19.
28. Locovei S, Wang J, Dahl G. Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett 2006; 580: 239-44.
29. Sanderson MJ, Charles AC, Dirksen ER. Mechanical stimulation and intercellular communication increases intracellular Ca2+ in epithelial cells. Cell Regul 1990; 1: 585-96.
30. Osipchuk Y, Cahalan M. Cell-to-cell spread of calcium signals mediated by ATP receptors in mast cells. Nature 1992; 359: 241-44.
31. Hassinger TD, Guthrie PB, Atkinson PB, Bennett MVL, Kater SB. An extracellular signaling component in propagation of astrocytic calcium waves. Proc Natl Acad Sci USA 1996; 93: 13268-73.
32. Barbe MT, Monyer, Bruzzone HR. Cell-cell communication beyond connexins: the pannexin channels. Physiol 2006; 21: 103-14.
33. Scemes E, Spray DC, Meda P. Connexins, pannexins, innexins: novel roles of "hemi-channels". Pflugers Arch 2009; 457: 1207-26.
34. Pelegrin P, Surprenant A. Pannexin-1 mediates large pore formation and interleukin-1b release by the ATP-gated P2X7 receptor. EMBO J 2006; 25: 5071-82.
35. Bergfeld GR, Forrester T. Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia. Cardiovasc Res 1992; 26: 40-47.
36. Locovei S, Scemes E, Qiu F, Spray DC, Dahl G. Pannexin1 is part of the pore forming unit of the P2X7 receptor death complex. FEBS Lett 2007; 581: 483-88.
37. Qiu F, Wang J, David C, Eliana S, Scemes E, Gerhard Dahl. Two non-vesicular ATP release pathways in the mouse erythrocyte membrane. FEBS Lett 2013; 587 (21): 3430-5.
38. Wang J, Ma M, Locovei S, Keane R, Dahl GP. Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am J Physiol Cell Physiol 2007; 293: C1112-9.
39. Fabien AV, Bidaux G, Gordienko D, et al. Functional implications of calcium permeability of the channel formed by pannexin 1. J Cell Biol 2006; 174(4): 535-46.
40. Newman EA. Propagation of intercellular calcium waves in retinal astrocytes and Müller cells. J Neurosci 2001; 21: 2215-23.
41. Charles A. Reaching Out Beyond the Synapse: Glial Intercellular Waves Coordinate Metabolism. Sci. STKE 2005; 270: pe6.
42. Sigurdson WJ, Sachs F, Diamond SL. Mechanical perturbation of cultured human endothelial cells causes rapid increases of intracellular calcium. Am J Physiol 1993; 264(6 Pt 2): H1745-52.
43. Jorgensen NR, Geist ST, Civitelli R, Steinberg TH. ATP-and gap junction-dependent intercellular calcium signaling in osteoblastic cells. J Cell Biol 1997; 139(2): 497-506.
44. Bodin P, Burnstock G. Synergistic effect of acute hypoxia on flowinduced release of ATP from cultured endothelial cells. Experientia 1995; 51(3): 256-9.
45. Billaud M, Lohman AW, Straub AC, et al. Pannexin1 regulates alpha1-adrenergic receptor-mediated vasoconstriction. Circ Res 2011; 109: 80-5.
46. Kauffenstein G, Hechler B, Cazenave JP, Gachet C. Adenine triphosphate nucleotides are antagonists at the P2Y receptor. J Thromb Haemost 2004; 2(11): 1980-8.
47. Sridharan M, Adderley SP, Bowles EA, et al. Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes. Am J Physiol Heart Circ Physiol 2010; 299(4): H1146-52.
48. Dando R, Roper SD. Cell-to-cell communication in intact taste buds through ATP signalling from pannexin 1 gap junction hemichannels. J Physiol 2009; 587: 5899-906.
49. Huang YJ, Maruyama Y, Dvoryanchikov G, Pereira E, Chaudhari N, Roper SD. The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds. Proc Natl Acad Sci USA 2007; 104: 6436-41.
50. Seror MT, Melki F, Subra SQ, Raza M, Bras H, Saidi R. Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection. J Exp Med 2011; 208: 1823-34.
51. Lai CPK, Bechberger JF, Thompson RJ, MacVicar BA, Bruzzone R, Naus CC. Tumor-suppressive effects of pannexin 1 in C6 glioma cells. Cancer Res 2007; 67: 1545-54.
52. Thompson RJ, Zhou N, MacVicar BA. Ischemia opens neuronal gap junction hemichannels. Science 2006; 312: 924-27.
53. Thompson RJ, Jackson MF, Olah ME, et al. Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science 2008; 322: 1555-59.
54. Iwabuchi S, Kawahara K. Functional significance of the negativefeedback regulation of ATP release via pannexin-1 hemichannels under ischemic stress in astrocytes. Neurochem Int 2011; 58: 376-84.
55. Chekeni FB, Elliott MR, Sandilos JK, et al. Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature 2010; 467: 863-67.
56. Qu Y, Newton SK, Gilmour LL, et al. Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation. J Immunol 2011; 186: 6553-61.
57. Celetti SJ, Cowan KN, Penuela S, Shao SQ, Churko J, Laird DW. Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation. J Cell Sci 2010; 123: 1363-72.
58. Iwamoto T, Nakamura T, Doyle Ishikawa AM, de Vega S, Fukumoto S, Yamada Y. Pannexin 3 regulates intracellular ATP / cAMP levels and promotes chondrocyte differentiation. J Biol Chem 2010; 285: 18948-58.
59. Turmel P, Dufresne J, Hermo L, et al. Characterization of pannexin1 and pannexin3 and their regulation by androgens in the male reproductive tract of the adult rat. Mol Reprod Dev 2011; 78: 124-38.
60. Swayne LA, Sorbara CD, Bennett SA. Pannexin 2 is expressed by postnatal hippocampal neural progenitors and modulates neuronal commitment. J Biol Chem 2010; 285: 24977-86.
61. Lai CP, Bechberger JF, Naus CC. Pannexin2 as a novel growth regulator in C6 glioma cells. Oncogene 2009; 28: 4402-08.
62. Bhalla-Gehi R, Penuela S, Churko JM, Shao Q, Laird DW. Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions. J Biol Chem 2010; 285: 9147-60.
63. Boassa D, Ambrosi C, Qiu F, Dahl G, Gaietta G, Sosinsky G. Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane. J Biol Chem 2007; 282: 31733-43.
64. Gehi R, Shao Q, Laird DW. Pathways regulating the trafficking and turnover of pannexin1 protein and the role of the C-terminal domain. J Biol Chem 2011; 286: 27639-53.
65. Ransford GA, Fregien N, Qiu F, Dahl G, Conner GE, Salathe M. Pannexin 1 Contributes to ATP Release in Airway EpitheliaAm J Respir Cell Mol Biol 2009; 41: 525-34.
66. Cyr DG. Connexins and pannexins: Coordinating cellular communication in the testis and epididymis. Spermatogenesis 2011; 1(4): 325-38.
67. Siverman W, Locovei S, Dahl G. Probenecid, a gout remedy, inhibhits Pannexin1 channels. Am J Physiol Cell Physiol 2008; 295 (3): C761-7.
68. McKuen MJ, Dahl G, Fields KA. Assessing a Potential Role of Host Pannexin 1 during Chlamydia trachomatis Infection. PLoS ONE 2013; 8(5): e63732
69. Bruzzone R, Barbe MT, Jakob NJ, Monyer H. Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes. J Neurochem 2005; 92(5): 1033-43
70. Qiu F, Dahl G. A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP. Am J Physiol Cell Physiol 2009; 296(2): C250-55.