Towards the bioequivalence of pressurised metered dose inhalers 1: Design and characterisation of aerodynamically equivalent beclomethasone dipropionate inhalers with and without glycerol as a non-volatile excipient

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 86, Issue 1, 2014, Pages 31-37

  Lewis, D A ^a   Young, P M ^b,c   Buttini, F ^d   Church, T ^a   Colombo, P ^d   Forbes, B ^e   Haghi, M ^b,c   Johnson, R ^a   O'Shea, H ^a   Salama, R ^b,c   Traini, D ^b,c  

^a CHIESI FARMACEUTICI S P A   (Italy)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF PARMA   (Italy)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Aerosol Performance; Beclomethasone dipropionate; Bioequivalence; Glycerol; Non volatile excipients; pMDI

Indexed keywords

BECLOMETASONE DIPROPIONATE; FLUORINATED HYDROCARBON; GLYCEROL; PROPELLANT;

AERODYNAMIC; AEROSOL; ARTICLE; BIOEQUIVALENCE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG SOLUBILITY; DYNAMICS; METERED DOSE INHALER; PHYSICAL CHEMISTRY; SCANNING ELECTRON MICROSCOPY; THERMOGRAVIMETRY;

AEROSOL PERFORMANCE; BECLOMETHASONE DIPROPIONATE; BIOEQUIVALENCE; GLYCEROL; NON-VOLATILE EXCIPIENTS; PMDI;

ADMINISTRATION, INHALATION; AEROSOLS; BECLOMETHASONE; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; EXCIPIENTS; GLYCEROL; METERED DOSE INHALERS; MICROSCOPY, ELECTRON, SCANNING; MODELS, BIOLOGICAL; MODELS, CHEMICAL; PARTICLE SIZE; POROSITY; SOLUBILITY; SURFACE PROPERTIES; THERAPEUTIC EQUIVALENCY; VOLATILIZATION;

EID: 84896690141     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.02.014     Document Type: Article

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