A molecular mechanism for adrenergic-induced long QT syndrome

Journal of the American College of Cardiology

Volumn 63, Issue 8, 2014, Pages 819-827

  Wu, Jie ^a,b   Naiki, Nobu ^b   Ding, Wei Guang ^b   Ohno, Seiko ^b   Kato, Koichi ^b   Zang, Wei Jin ^a   Delisle, Brian P ^c   Matsuura, Hiroshi ^b   Horie, Minoru ^b  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

heterologous expression; KCNQ1 mutation; long QT syndrome; protein kinase A stimulation

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; DELAYED RECTIFIER POTASSIUM CHANNEL; ISOPRENALINE; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNQ1;

ADRENERGIC STIMULATION; ADULT; ALPHA CHAIN; ARTICLE; ASYMPTOMATIC DISEASE; CASE REPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME PHOSPHORYLATION; EXERCISE; FEMALE; GENE EXPRESSION; GENE MUTATION; GENETIC ASSOCIATION; HETEROZYGOSITY; HUMAN; KCNE1 CELL; KCNQ1 GENE; LONG QT SYNDROME; MALE; MAMMAL CELL; PATCH CLAMP TECHNIQUE; PHOSPHOMIMETIC SUBSTITUTION; PRIORITY JOURNAL; QT INTERVAL; SUBSTITUTION REACTION; WILD TYPE;

HETEROLOGOUS EXPRESSION; KCNQ1 MUTATION; LONG QT SYNDROME; PROTEIN KINASE A STIMULATION;

ADOLESCENT; ADRENERGIC BETA-AGONISTS; ANIMALS; CHILD; CHO CELLS; CRICETINAE; CRICETULUS; EXERCISE TEST; FEMALE; HEK293 CELLS; HUMANS; KCNQ1 POTASSIUM CHANNEL; LONG QT SYNDROME; MALE; MUTATION; PEDIGREE; POTASSIUM CHANNELS, INWARDLY RECTIFYING; YOUNG ADULT;

EID: 84896690741     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.08.1648     Document Type: Article

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