Computational models of ventricular-and atrial-like human induced pluripotent stem cell derived cardiomyocytes

Annals of Biomedical Engineering

Volumn 41, Issue 11, 2013, Pages 2334-2348

  Paci, Michelangelo ^a,b,d   Hyttinen, Jari ^b,d   Aalto Setälä, Katriina ^b,c,d   Severi, Stefano ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

^d TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

Action potential; Computer simulation; Current blocker; Pharmacology

Indexed keywords

COMPUTATION THEORY; COMPUTATIONAL METHODS; COMPUTER SIMULATION; ELECTROPHYSIOLOGY; SODIUM COMPOUNDS;

ACTION POTENTIALS; COMPUTATIONAL APPROACH; COMPUTATIONAL MODEL; DIFFERENTIATION PROCESS; HUMAN-INDUCED PLURIPOTENT STEM CELLS; IN-VITRO MODELS; IONIC MECHANISMS; PHARMACOLOGY;

STEM CELLS;

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); NIFEDIPINE; SODIUM CALCIUM EXCHANGE PROTEIN; TETRODOTOXIN;

ANALYTIC METHOD; ARTICLE; CALCIUM CURRENT; CELL DIFFERENTIATION; COMPARATIVE STUDY; COMPUTER MODEL; COMPUTER SIMULATION; CONTROLLED STUDY; CYTOSOL; HEART ATRIUM; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART VENTRICLE; HUMAN; HUMAN CELL; HUMAN INDUCED PLURIPOTENT STEM CELL DERIVED CARDIOMYOCYTE; IN VITRO STUDY; ION CURRENT; MEMBRANE CURRENT; PHENOTYPE; PLURIPOTENT STEM CELL; POTASSIUM CURRENT; SARCOPLASMIC RETICULUM; SODIUM CURRENT; STEADY STATE;

ACTION POTENTIALS; COMPUTER SIMULATION; HEART ATRIA; HEART VENTRICLES; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MODELS, CARDIOVASCULAR; MYOCARDIUM; MYOCYTES, CARDIAC;

EID: 84896689737     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-013-0833-3     Document Type: Article

References (35)

1. Accili, E. A., C. Proenza, M. Baruscotti, and D. DiFrancesco. From funny current to HCN channels: 20 years of excitation. News Physiol. Sci. 17:32-37, 2002.
2. Amos, G. J., E. Wettwer, F. Metzger, Q. Li, H. M. Himmel, and U. Ravens. Differences between outward currents of human atrial and subepicardial ventricular myocytes. J. Physiol. (Lond.) 491(Pt 1):31-50, 1996.
3. Beaumont, J., F. A. Roberge, and D. R. Lemieux. Estimation of the steady-state characteristics of the Hodgkin-Huxley model from voltage-clamp data. Math. Biosci. 115:145-186, 1993.
4. Camara, A. K., Z. Begic, W. M. Kwok, and Z. J. Bosnjak. Differential modulation of the cardiac L-and T-type calcium channel currents by isoflurane. Anesthesiology 95:515-524, 2001.
5. Carro, J., J. Rodriguez, P. Laguna, and E. Pueyo. A human ventricular cell model for investigation of cardiac arrhythmias under hyperkalaemic conditions. Philos. Trans. A: Math. Phys. Eng. Sci. 369:4205-4232, 2011.
6. +]i overloaded cardiac myocytes: a simulation study. Biophys. J. 78:2392-2404, 2008.
7. Gerlach, A. C., S. J. Stoehr, and N. A. Castle. Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N-(4-phenoxyphenyl) benzamide (ICA-105574). Mol. Pharmacol. 77:58-68, 2010.
8. 2+ model: sinus rhythm and chronic atrial fibrillation. Circ. Res. 109:1055-1066, 2011.
9. Grandi, E., F. S. Pasqualini, and D. M. Bers. A novel computational model of the human ventricular action potential and Ca transient. J. Mol. Cell. Cardiol. 48:112-121, 2010.
10. 2+ in human cardiomyocytes. J Mol Cell Cardiol 46:332-342, 2009.
11. 2+ channel of the atrium and ventricle of rat hearts. Circ. J. 70:610-614, 2006.
12. Hund, T. J., and Y. Rudy. Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model. Circulation 110:3168-3174, 2004.
13. Kehat, I., A. Gepstein, A. Spira, J. Itskovitz-Eldor, and L. Gepstein. High-resolution electrophysiological assessment of human embryonic stem cell-derived cardiomyocytes: a novel in vitro model for the study of conduction. Circ. Res. 91:659-661, 2002.
14. Lahti, A. L., V. J. Kujala, H. Chapman, A.-P. Koivisto, M. Pekkanen-Mattila, E. Kerkela, J. Hyttinen, K. Kontula, H. Swan, B. R. Conklin, S. Yamanaka, O. Silvennoinen, and K. Aalto-Setala. Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture. Dis. Model. Mech. 5:220-230, 2011.
15. Li, G., C. Lau, and A. Shrier. Heterogeneity of sodium current in atrial vs epicardial ventricular myocytes of adult guinea pig hearts. J. Mol. Cell. Cardiol. 34:1185-1194, 2002.
16. Ma, J., L. Guo, S. Fiene, B. Anson, J. Thomson, T. Kamp, K. Kolaja, B. Swanson, and C. January. High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. Am. J. Physiol. Heart Circ. Physiol. 301:H2006-H2017, 2011.
17. 2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model. Am. J. Physiol. Heart Circ. Physiol. 296:H594-H615, 2009.
18. Matsa, E., D. Rajamohan, E. Dick, L. Young, I. Mellor, A. Staniforth, and C. Denning. Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. Eur. Heart J. 32:952-962, 2011.
19. Moretti, A., M. Bellin, A. Welling, C. B. Jung, J. T. Lam, L. Bott-Flügel, T. Dorn, A. Goedel, C. Höhnke, F. Hofmann, M. Seyfarth, D. Sinnecker, A. Schömig, and K.-L. Laugwitz. Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N. Engl. J. Med. 363:1397-1409, 2010.
20. O'hara, T., L. Virág, A. Varró, and Y. Rudy. Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation. PLoS Comput. Biol. 7:e1002061, 2011.
21. Paci, M., L. Sartiani, M. Lungo, M. Jaconi, A. Mugelli, E. Cerbai, and S. Severi. Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes. Biomed. Eng. Online 11:61, 2012.
22. + current. Differential sensitivity to block by class III antiarrhythmic agents. J. Gen. Physiol. 96:195-215, 1990.
23. Sartiani, L., E. Bettiol, F. Stillitano, A. Mugelli, E. Cerbai, and M. E. Jaconi. Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach. Stem Cells 25:1136-1144, 2007.
24. Satoh, H., L. M. D. Delbridge, L. A. Blatter, and D. M. Bers. Surface:volume relationship in cardiac myocytes studied with confocal microscopy and membrane capacitance measurements: species-dependence and developmental effects. Biophys. J. 70:1494-1504, 1996.
25. Schram, G., M. Pourrier, P. Melnyk, and S. Nattel. Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function. Circ. Res. 90:939-950, 2002.
26. Shannon, T., F. Wang, J. Puglisi, C. Weber, and D. M. Bers. A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys. J. 87:3351-3371, 2004.
27. Takahashi, K., K. Tanabe, M. Ohnuki, M. Narita, T. Ichisaka, K. Tomoda, and S. Yamanaka. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-872, 2007.
28. Ten Tusscher, K. H. W. J., D. Noble, P. J. Noble, and A. V. Panfilov. A model for human ventricular tissue. Am. J. Physiol. Heart Circ. Physiol. 286:H1573-H1589, 2004.
29. Ten Tusscher, K. H. W. J., and A. V. Panfilov. Alternans and spiral breakup in a human ventricular tissue model. Am. J. Physiol. Heart Circ. Physiol. 291:H1088-H1100, 2006.
30. 2+ exchanger in the human heart. J. Clin. Invest. 98:1650-1658, 1996.
31. Yazawa, M., B. Hsueh, X. Jia, A. M. Pasca, J. A. Bernstein, J. Hallmayer, and R. E. Dolmetsch. Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. Nature 471:230-234, 2011.
32. Yokoo, N., S. Baba, S. Kaichi, A. Niwa, T. Mima, H. Doi, S. Yamanaka, T. Nakahata, and T. Heike. The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells. Biochem. Biophys. Res. Commun. 387:482-488, 2009.
33. Yu, J., M. A. Vodyanik, K. Smuga-Otto, J. Antosiewicz-Bourget, J. L. Frane, S. Tian, J. Nie, G. A. Jonsdottir, V. Ruotti, R. Stewart, I. I. Slukvin, and J. A. Thomson. Induced pluripotent stem cell lines derived from human somatic cells. Science 318:1917-1920, 2007.
34. Zhang, H., B. Zou, H. Yu, A. Moretti, X. Wang, W. Yan, J. J. Babcock, M. Bellin, O. B. McManus, G. Tomaselli, F. Nan, K. L. Lauqwitz, and M. Li. Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel. Proc. Natl. Acad. Sci. U.S.A. 109:11866-11871, 2012.
35. Zhang, J., G. F. Wilson, A. G. Soerens, C. H. Koonce, J. Yu, S. P. Palecek, J. A. Thomson, and T. J. Kamp. Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ. Res. 104:e30-e41, 2009.