메뉴 건너뛰기




Volumn 14, Issue 5, 2014, Pages

Cardiovascular actions of GLP-1 and incretin-based pharmacotherapy

Author keywords

Cardiovascular disease; Diabetes; Dipeptidyl peptidase 4 inhibitor; GLP 1 receptor antagonist; Incretin based pharmacotherapy; Treatment

Indexed keywords

ALOGLIPTIN; APOLIPOPROTEIN B48; C REACTIVE PROTEIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; FATTY ACID; GELATINASE B; GLIMEPIRIDE; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE RECEPTOR AGONIST; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN GLARGINE; INTERLEUKIN 1BETA; LIPID; LIRAGLUTIDE; METFORMIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PIOGLITAZONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SAXAGLIPTIN; SITAGLIPTIN; TRIACYLGLYCEROL; VILDAGLIPTIN; ANTIDIABETIC AGENT; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; GLUCOSE BLOOD LEVEL; INCRETIN;

EID: 84896587066     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-014-0483-3     Document Type: Review
Times cited : (27)

References (103)
  • 1
    • 33845902544 scopus 로고    scopus 로고
    • The cardiovascular disease continuum validated: Clinical evidence of improved patient outcomes: Part I: Pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease)
    • DOI 10.1161/CIRCULATIONAHA.106.655688, PII 0000301720061219000016
    • Dzau VJ, Antman EM, Black HR, Hayes DL, Manson JE, Plutzky J, et al. The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part I: pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease). Circulation. 2006;114:2850-70. (Pubitemid 46018288)
    • (2006) Circulation , vol.114 , Issue.25 , pp. 2850-2870
    • Dzau, V.J.1    Antman, E.M.2    Black, H.R.3    Hayes, D.L.4    Manson, J.E.5    Plutzky, J.6    Popma, J.J.7    Stevenson, W.8
  • 2
    • 56949103019 scopus 로고    scopus 로고
    • Endothelial dysfunction: Causes and consequences in patients with diabetes mellitus
    • Avogaro A, de Kreutzenberg SV, Fadini G. Endothelial dysfunction: causes and consequences in patients with diabetes mellitus. Diabetes Res Clin Pract. 2008;82 Suppl 2:S94-101.
    • (2008) Diabetes Res Clin Pract , vol.82 , Issue.SUPPL. 2
    • Avogaro, A.1    De Kreutzenberg, S.V.2    Fadini, G.3
  • 3
    • 58549094758 scopus 로고    scopus 로고
    • The pathologic continuum of diabetic vascular disease
    • Orasanu G, Plutzky J. The pathologic continuum of diabetic vascular disease. J Am Coll Cardiol. 2009;53(5 Suppl):S35-42.
    • (2009) J Am Coll Cardiol , vol.53 , Issue.5 SUPPL.
    • Orasanu, G.1    Plutzky, J.2
  • 6
    • 84883419226 scopus 로고    scopus 로고
    • Implications of DPP4 modification of proteins that regulate stem/progenitor andmore mature cell types
    • Extensive review on the role of DPP4 inhibition on different proteins other than GLP-1
    • • Ou X, O'Leary HA, Broxmeyer HE. Implications of DPP4 modification of proteins that regulate stem/progenitor andmore mature cell types. Blood. 2013;122:161-9. Extensive review on the role of DPP4 inhibition on different proteins other than GLP-1.
    • (2013) Blood , vol.122 , pp. 161-169
    • Ou, X.1    O'Leary, H.A.2    Broxmeyer, H.E.3
  • 7
    • 0027425034 scopus 로고
    • Cloning and functional expression of the human islet GLP-1 receptor: Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor
    • Thorens B, Porret A, Buhler L, Deng SP, Morel P, Widmann C. Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes. 1993;42:1678-82. (Pubitemid 23318127)
    • (1993) Diabetes , vol.42 , Issue.11 , pp. 1678-1682
    • Thorens, B.1    Porret, A.2    Buhler, L.3    Deng, S.-P.4    Morel, P.5    Widmann, C.6
  • 8
    • 0030013475 scopus 로고    scopus 로고
    • Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor
    • DOI 10.1210/en.137.7.2968
    • Bullock BP, Heller RS, Habener JF. Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology. 1996;137:2968-78. (Pubitemid 26192194)
    • (1996) Endocrinology , vol.137 , Issue.7 , pp. 2968-2978
    • Bullock, B.P.1    Heller, R.S.2    Habener, J.F.3
  • 9
    • 84878936553 scopus 로고    scopus 로고
    • Extra-pancreatic effects of incretin-based therapies: Potential benefit for cardiovascular-risk management in type 2 diabetes
    • van Genugten RE, Moller-Goede DL, van Raalte DH, Diamant M. Extra-pancreatic effects of incretin-based therapies: potential benefit for cardiovascular-risk management in type 2 diabetes. Diabetes Obes Metab. 2013;15:593-606.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 593-606
    • Van Genugten, R.E.1    Moller-Goede, D.L.2    Van Raalte, D.H.3    Diamant, M.4
  • 10
    • 77956230708 scopus 로고    scopus 로고
    • Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus
    • Schwartz EA, Koska J, Mullin MP, Syoufi I, Schwenke DC, Reaven PD. Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus. Atherosclerosis. 2010;212:217-22.
    • (2010) Atherosclerosis , vol.212 , pp. 217-222
    • Schwartz, E.A.1    Koska, J.2    Mullin, M.P.3    Syoufi, I.4    Schwenke, D.C.5    Reaven, P.D.6
  • 11
    • 77956231970 scopus 로고    scopus 로고
    • One-year treatment with exenatide vs insulin glargine: Effects on postprandial glycemia, lipid profiles, and oxidative stress
    • Bunck MC, Corner A, Eliasson B, Heine RJ, Shaginian RM, Wu Y, et al. One-year treatment with exenatide vs insulin glargine: effects on postprandial glycemia, lipid profiles, and oxidative stress. Atherosclerosis. 2010;212:223-9.
    • (2010) Atherosclerosis , vol.212 , pp. 223-229
    • Bunck, M.C.1    Corner, A.2    Eliasson, B.3    Heine, R.J.4    Shaginian, R.M.5    Wu, Y.6
  • 12
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
    • Zinman B, Gerich J, Buse JB, Lewin A, Schwartz S, Raskin P, et al. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care. 2009;32:1224-30.
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3    Lewin, A.4    Schwartz, S.5    Raskin, P.6
  • 13
    • 84857903646 scopus 로고    scopus 로고
    • DPP-4 inhibitors and lipids: Systematic review and meta-analysis
    • Monami M, Lamanna C, Desideri CM, Mannucci E. DPP-4 inhibitors and lipids: systematic review and meta-analysis. Adv Ther. 2012;29:14-25.
    • (2012) Adv Ther , vol.29 , pp. 14-25
    • Monami, M.1    Lamanna, C.2    Desideri, C.M.3    Mannucci, E.4
  • 14
    • 84859463659 scopus 로고    scopus 로고
    • Lowering of postprandial lipids in individuals with type 2 diabetes treated with alogliptin and/or pioglitazone: A randomized double-blind placebo-controlled study
    • Eliasson B, Moller-Goede D, Eeg-Olofsson K, Wilson C, Cederholm J, Fleck P, et al. Lowering of postprandial lipids in individuals with type 2 diabetes treated with alogliptin and/or pioglitazone: a randomized double-blind placebo-controlled study. Diabetologia. 2012;55:915-25.
    • (2012) Diabetologia , vol.55 , pp. 915-925
    • Eliasson, B.1    Moller-Goede, D.2    Eeg-Olofsson, K.3    Wilson, C.4    Cederholm, J.5    Fleck, P.6
  • 15
    • 84861528676 scopus 로고    scopus 로고
    • Exenatide, a glucagon-like peptide-1 receptor agonist, acutely inhibits intestinal lipoprotein production in healthy humans
    • Xiao C, Bandsma RH, Dash S, Szeto L, Lewis GF. Exenatide, a glucagon-like peptide-1 receptor agonist, acutely inhibits intestinal lipoprotein production in healthy humans. Arterioscler Thromb Vasc Biol. 2012;32:1513-9.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 1513-1519
    • Xiao, C.1    Bandsma, R.H.2    Dash, S.3    Szeto, L.4    Lewis, G.F.5
  • 16
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide vs glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomized, 52-week, phase III, double-blind, parallel-treatment trial
    • Garber A, Henry R, Ratner R, Garcia-Hernandez PA, Rodriguez-Pattzi H, Olvera-Alvarez I, et al. Liraglutide vs glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomized, 52-week, phase III, double-blind, parallel-treatment trial. Lancet. 2009;373:473-81.
    • (2009) Lancet , vol.373 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3    Garcia-Hernandez, P.A.4    Rodriguez-Pattzi, H.5    Olvera-Alvarez, I.6
  • 17
    • 76749161358 scopus 로고    scopus 로고
    • Effects of exenatide on systolic blood pressure in subjects with type 2 diabetes
    • Okerson T, Yan P, Stonehouse A, Brodows R. Effects of exenatide on systolic blood pressure in subjects with type 2 diabetes. Am J Hypertens. 2010;23:334-9.
    • (2010) Am J Hypertens , vol.23 , pp. 334-339
    • Okerson, T.1    Yan, P.2    Stonehouse, A.3    Brodows, R.4
  • 18
    • 84879800350 scopus 로고    scopus 로고
    • Blood pressure-lowering effects of GLP-1 receptor agonists exenatide and liraglutide: A meta-analysis of clinical trials
    • Wang B, Zhong J, Lin H, Zhao Z, Yan Z, He H, et al. Blood pressure-lowering effects of GLP-1 receptor agonists exenatide and liraglutide: a meta-analysis of clinical trials. Diabetes Obes Metab. 2013;15:737-49.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 737-749
    • Wang, B.1    Zhong, J.2    Lin, H.3    Zhao, Z.4    Yan, Z.5    He, H.6
  • 21
    • 43249089631 scopus 로고    scopus 로고
    • Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways
    • DOI 10.1161/CIRCULATIONAHA.107.739938, PII 0000301720080506000007
    • Ban K, Noyan-Ashraf MH, Hoefer J, Bolz SS, Drucker DJ, Husain M. Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation. 2008;117:2340-50. (Pubitemid 351653542)
    • (2008) Circulation , vol.117 , Issue.18 , pp. 2340-2350
    • Ban, K.1    Noyan-Ashraf, M.H.2    Hoefer, J.3    Bolz, S.-S.4    Drucker, D.J.5    Husain, M.6
  • 22
    • 84877317750 scopus 로고    scopus 로고
    • GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
    • A molecular clarification of the natriuretic effect of GLP-1RA is provided for the first time
    • •• Kim M, Platt MJ, Shibasaki T, Quaggin SE, Backx PH, Seino S, et al. GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nat Med. 2013;19:567-75. A molecular clarification of the natriuretic effect of GLP-1RA is provided for the first time.
    • (2013) Nat Med , vol.19 , pp. 567-575
    • Kim, M.1    Platt, M.J.2    Shibasaki, T.3    Quaggin, S.E.4    Backx, P.H.5    Seino, S.6
  • 23
    • 45849115827 scopus 로고    scopus 로고
    • Sitagliptin augments sympathetic enhancement of the renovascular effects of angiotensin II in genetic hypertension
    • Jackson EK, Mi Z. Sitagliptin augments sympathetic enhancement of the renovascular effects of angiotensin II in genetic hypertension. Hypertension. 2008;51:1637-42.
    • (2008) Hypertension , vol.51 , pp. 1637-1642
    • Jackson, E.K.1    Mi, Z.2
  • 24
    • 77957231074 scopus 로고    scopus 로고
    • Interactive hemodynamic effects of dipeptidyl peptidase-IV inhibition and angiotensin-converting enzyme inhibition in humans
    • Marney A, Kunchakarra S, Byrne L, Brown NJ. Interactive hemodynamic effects of dipeptidyl peptidase-IV inhibition and angiotensin-converting enzyme inhibition in humans. Hypertension. 2010;56:728-33.
    • (2010) Hypertension , vol.56 , pp. 728-733
    • Marney, A.1    Kunchakarra, S.2    Byrne, L.3    Brown, N.J.4
  • 25
    • 84865492970 scopus 로고    scopus 로고
    • Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism
    • Liu L, Liu J, Wong WT, Tian XY, Lau CW, Wang YX, et al. Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism. Hypertension. 2012;60:833-41.
    • (2012) Hypertension , vol.60 , pp. 833-841
    • Liu, L.1    Liu, J.2    Wong, W.T.3    Tian, X.Y.4    Lau, C.W.5    Wang, Y.X.6
  • 26
    • 67449155340 scopus 로고    scopus 로고
    • Interrelationship of dipeptidyl peptidase IV (DPP4) with the development of diabetes, dyslipidemia and nephropathy: A streptozotocin-induced model using wild-type and DPP4-deficient rats
    • Kirino Y, Sato Y, Kamimoto T, Kawazoe K, Minakuchi K, Nakahori Y. Interrelationship of dipeptidyl peptidase IV (DPP4) with the development of diabetes, dyslipidemia and nephropathy: a streptozotocin-induced model using wild-type and DPP4-deficient rats. J Endocrinol. 2009;200:53-61.
    • (2009) J Endocrinol , vol.200 , pp. 53-61
    • Kirino, Y.1    Sato, Y.2    Kamimoto, T.3    Kawazoe, K.4    Minakuchi, K.5    Nakahori, Y.6
  • 28
    • 80051786501 scopus 로고    scopus 로고
    • The role of incretins in salt-sensitive hypertension: The potential use of dipeptidyl peptidase-IV inhibitors
    • Tanaka T, Nangaku M, Nishiyama A. The role of incretins in salt-sensitive hypertension: the potential use of dipeptidyl peptidase-IV inhibitors. Curr Opin Nephrol Hypertens. 2011;20:476-81.
    • (2011) Curr Opin Nephrol Hypertens , vol.20 , pp. 476-481
    • Tanaka, T.1    Nangaku, M.2    Nishiyama, A.3
  • 29
    • 79951677095 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition attenuates blood pressure rising in young spontaneously hypertensive rats
    • Pacheco BP, Crajoinas RO, Couto GK, Davel AP, Lessa LM, Rossoni LV, et al. Dipeptidyl peptidase IV inhibition attenuates blood pressure rising in young spontaneously hypertensive rats. J Hypertens. 2011;29:520-8.
    • (2011) J Hypertens , vol.29 , pp. 520-528
    • Pacheco, B.P.1    Crajoinas, R.O.2    Couto, G.K.3    Davel, A.P.4    Lessa, L.M.5    Rossoni, L.V.6
  • 31
    • 41849099939 scopus 로고    scopus 로고
    • Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood pressure in nondiabetic patients with mild to moderate hypertension
    • DOI 10.1177/0091270008316885
    • Mistry GC, Maes AL, Lasseter KC, Davies MJ, Gottesdiener KM, Wagner JA, et al. Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood pressure in nondiabetic patients with mild to moderate hypertension. J Clin Pharmacol. 2008;48:592-8. (Pubitemid 351503521)
    • (2008) Journal of Clinical Pharmacology , vol.48 , Issue.5 , pp. 592-598
    • Mistry, G.C.1    Maes, A.L.2    Lasseter, K.C.3    Davies, M.J.4    Gottesdiener, K.M.5    Wagner, J.A.6    Herman, G.A.7
  • 32
    • 77955573674 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly vs sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): A randomized trial
    • Bergenstal RM, Wysham C, Macconell L, Malloy J, Walsh B, Yan P, et al. Efficacy and safety of exenatide once weekly vs sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomized trial. Lancet. 2010;376:431-9.
    • (2010) Lancet , vol.376 , pp. 431-439
    • Bergenstal, R.M.1    Wysham, C.2    Macconell, L.3    Malloy, J.4    Walsh, B.5    Yan, P.6
  • 33
    • 77956654077 scopus 로고    scopus 로고
    • Weight loss, glycemic control, and changes in cardiovascular biomarkers in patients with type 2 diabetes receiving incretin therapies or insulin in a large cohort database
    • Horton ES, Silberman C, Davis KL, Berria R. Weight loss, glycemic control, and changes in cardiovascular biomarkers in patients with type 2 diabetes receiving incretin therapies or insulin in a large cohort database. Diabetes Care. 2010;33:1759-65.
    • (2010) Diabetes Care , vol.33 , pp. 1759-1765
    • Horton, E.S.1    Silberman, C.2    Davis, K.L.3    Berria, R.4
  • 34
    • 84863791439 scopus 로고    scopus 로고
    • The effect of sitagliptin vs glibenclamide on arterial stiffness, blood pressure, lipids, and inflammation in type 2 diabetes mellitus patients
    • Koren S, Shemesh-Bar L, Tirosh A, Peleg RK, Berman S, Hamad RA, et al. The effect of sitagliptin vs glibenclamide on arterial stiffness, blood pressure, lipids, and inflammation in type 2 diabetes mellitus patients. Diabetes Technol Ther. 2012;14:561-7.
    • (2012) Diabetes Technol Ther , vol.14 , pp. 561-567
    • Koren, S.1    Shemesh-Bar, L.2    Tirosh, A.3    Peleg, R.K.4    Berman, S.5    Hamad, R.A.6
  • 35
    • 84855770694 scopus 로고    scopus 로고
    • Saxagliptin for the treatment of type 2 diabetes mellitus: Assessing cardiovascular data
    • Cobble ME, Frederich R. Saxagliptin for the treatment of type 2 diabetes mellitus: assessing cardiovascular data. Cardiovasc Diabetol. 2012;11:6.
    • (2012) Cardiovasc Diabetol , vol.11 , pp. 6
    • Cobble, M.E.1    Frederich, R.2
  • 36
    • 79960347241 scopus 로고    scopus 로고
    • Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor linagliptin: A 4-week multicenter, randomized, double-blind, placebo-controlled phase IIa study in Japanese type 2 diabetes patients
    • Horie Y, Kanada S, Watada H, Sarashina A, Taniguchi A, Hayashi N, et al. Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor linagliptin: a 4-week multicenter, randomized, double-blind, placebo-controlled phase IIa study in Japanese type 2 diabetes patients. Clin Ther. 2011;33:973-89.
    • (2011) Clin Ther , vol.33 , pp. 973-989
    • Horie, Y.1    Kanada, S.2    Watada, H.3    Sarashina, A.4    Taniguchi, A.5    Hayashi, N.6
  • 37
    • 44549085494 scopus 로고    scopus 로고
    • Revisiting an old acquaintance: CD26 and its molecular mechanisms in T cell function
    • Ohnuma K, Dang NH, Morimoto C. Revisiting an old acquaintance: CD26 and its molecular mechanisms in T cell function. Trends Immunol. 2008;29:295-301.
    • (2008) Trends Immunol , vol.29 , pp. 295-301
    • Ohnuma, K.1    Dang, N.H.2    Morimoto, C.3
  • 38
    • 84872041568 scopus 로고    scopus 로고
    • A potential role for dendritic cell/macrophage-expressing DPP4 in obesity-induced visceral inflammation
    • Zhong J, Rao X, Deiuliis J, Braunstein Z, Narula V, Hazey J, et al. A potential role for dendritic cell/macrophage-expressing DPP4 in obesity-induced visceral inflammation. Diabetes. 2013;62:149-57.
    • (2013) Diabetes , vol.62 , pp. 149-157
    • Zhong, J.1    Rao, X.2    Deiuliis, J.3    Braunstein, Z.4    Narula, V.5    Hazey, J.6
  • 39
    • 80052096595 scopus 로고    scopus 로고
    • Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome
    • The first demonstration that DPP4 is an actively secreted adipokine by visceral adipose tissues
    • •• Lamers D, Famulla S, Wronkowitz N, Hartwig S, Lehr S, Ouwens DM, et al. Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome. Diabetes. 2011;60:1917-25. The first demonstration that DPP4 is an actively secreted adipokine by visceral adipose tissues.
    • (2011) Diabetes , vol.60 , pp. 1917-1925
    • Lamers, D.1    Famulla, S.2    Wronkowitz, N.3    Hartwig, S.4    Lehr, S.5    Ouwens, D.M.6
  • 40
    • 77955406467 scopus 로고    scopus 로고
    • Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat)
    • Ferreira L, Teixeira-de-Lemos E, Pinto F, Parada B, Mega C, Vala H, et al. Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat). Mediat Inflamm. 2010;2010:592760.
    • (2010) Mediat Inflamm , vol.2010 , pp. 592760
    • Ferreira, L.1    Teixeira-de-Lemos, E.2    Pinto, F.3    Parada, B.4    Mega, C.5    Vala, H.6
  • 41
    • 79251541159 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitor sitagliptin reduces local inflammation in adipose tissue and in pancreatic islets of obesemice
    • Dobrian AD, Ma Q, Lindsay JW, Leone KA, Ma K, Coben J, et al. Dipeptidyl peptidase IV inhibitor sitagliptin reduces local inflammation in adipose tissue and in pancreatic islets of obesemice.Am J Physiol Endocrinol Metab. 2011;300:E410-21.
    • (2011) Am J Physiol Endocrinol Metab , vol.300
    • Dobrian, A.D.1    Ma, Q.2    Lindsay, J.W.3    Leone, K.A.4    Ma, K.5    Coben, J.6
  • 42
    • 80051785333 scopus 로고    scopus 로고
    • DPP-4 (CD26) inhibitor alogliptin inhibits atherosclerosis in diabetic apolipoprotein E-deficient mice
    • Ta NN, Schuyler CA, Li Y, Lopes-Virella MF, Huang Y. DPP-4 (CD26) inhibitor alogliptin inhibits atherosclerosis in diabetic apolipoprotein E-deficient mice. J Cardiovasc Pharmacol. 2011;58:157-66.
    • (2011) J Cardiovasc Pharmacol , vol.58 , pp. 157-166
    • Ta, N.N.1    Schuyler, C.A.2    Li, Y.3    Lopes-Virella, M.F.4    Huang, Y.5
  • 43
    • 81855222104 scopus 로고    scopus 로고
    • Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis
    • Shah Z, Kampfrath T, Deiuliis JA, Zhong J, Pineda C, Ying Z, et al. Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis. Circulation. 2011;124:2338-49.
    • (2011) Circulation , vol.124 , pp. 2338-2349
    • Shah, Z.1    Kampfrath, T.2    Deiuliis, J.A.3    Zhong, J.4    Pineda, C.5    Ying, Z.6
  • 44
    • 84866356839 scopus 로고    scopus 로고
    • Sitagliptin reduces plaque macrophage content and stabilizes arteriosclerotic lesions in Apoe (-/-) mice
    • Vittone F, Liberman A, Vasic D, Ostertag R, Esser M, Walcher D, et al. Sitagliptin reduces plaque macrophage content and stabilizes arteriosclerotic lesions in Apoe (-/-) mice. Diabetologia. 2012;55:2267-75.
    • (2012) Diabetologia , vol.55 , pp. 2267-2275
    • Vittone, F.1    Liberman, A.2    Vasic, D.3    Ostertag, R.4    Esser, M.5    Walcher, D.6
  • 45
    • 84866644965 scopus 로고    scopus 로고
    • Glucose-independent improvement of vascular dysfunction in experimental sepsis by dipeptidyl-peptidase 4 inhibition
    • Kroller-Schon S, Knorr M, Hausding M, Oelze M, Schuff A, Schell R, et al. Glucose-independent improvement of vascular dysfunction in experimental sepsis by dipeptidyl-peptidase 4 inhibition. Cardiovasc Res. 2012;96:140-9.
    • (2012) Cardiovasc Res , vol.96 , pp. 140-149
    • Kroller-Schon, S.1    Knorr, M.2    Hausding, M.3    Oelze, M.4    Schuff, A.5    Schell, R.6
  • 46
    • 84876284612 scopus 로고    scopus 로고
    • Dipeptidyl peptidases in atherosclerosis: Expression and role inmacrophage differentiation, activation and apoptosis
    • Matheeussen V, Waumans Y, Martinet W, Van Goethem S, Van der Veken P, Scharpe S, et al. Dipeptidyl peptidases in atherosclerosis: expression and role inmacrophage differentiation, activation and apoptosis. Basic Res Cardiol. 2013;108:350.
    • (2013) Basic Res Cardiol , vol.108 , pp. 350
    • Matheeussen, V.1    Waumans, Y.2    Martinet, W.3    Van Goethem, S.4    Van Der Veken, P.5    Scharpe, S.6
  • 47
    • 84866645242 scopus 로고    scopus 로고
    • Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: Role of dipeptidyl peptidase-IV inhibition
    • Rizzo MR, Barbieri M, Marfella R, Paolisso G. Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: role of dipeptidyl peptidase-IV inhibition. Diabetes Care. 2012;35:2076-82.
    • (2012) Diabetes Care , vol.35 , pp. 2076-2082
    • Rizzo, M.R.1    Barbieri, M.2    Marfella, R.3    Paolisso, G.4
  • 48
    • 84875054251 scopus 로고    scopus 로고
    • Decreased carotid atherosclerotic process by control of daily acute glucose fluctuations in diabetic patients treated by DPP-IV inhibitors
    • Barbieri M, Rizzo MR, Marfella R, Boccardi V, Esposito A, Pansini A, et al. Decreased carotid atherosclerotic process by control of daily acute glucose fluctuations in diabetic patients treated by DPP-IV inhibitors. Atherosclerosis. 2013;227:349-54.
    • (2013) Atherosclerosis , vol.227 , pp. 349-354
    • Barbieri, M.1    Rizzo, M.R.2    Marfella, R.3    Boccardi, V.4    Esposito, A.5    Pansini, A.6
  • 50
    • 84874111992 scopus 로고    scopus 로고
    • A dipeptidyl peptidase-4 inhibitor, sitagliptin, exerts anti-inflammatory effects in type 2 diabetic patients
    • Satoh-Asahara N, Sasaki Y, Wada H, Tochiya M, Iguchi A, Nakagawachi R, et al. A dipeptidyl peptidase-4 inhibitor, sitagliptin, exerts anti-inflammatory effects in type 2 diabetic patients. Metabolism. 2013;62:347-51.
    • (2013) Metabolism , vol.62 , pp. 347-351
    • Satoh-Asahara, N.1    Sasaki, Y.2    Wada, H.3    Tochiya, M.4    Iguchi, A.5    Nakagawachi, R.6
  • 51
    • 84858707110 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 analog liraglutide reduces TNF-alpha-induced oxidative stress and inflammation in endothelial cells
    • Shiraki A, Oyama J, Komoda H, Asaka M, Komatsu A, Sakuma M, et al. The glucagon-like peptide 1 analog liraglutide reduces TNF-alpha-induced oxidative stress and inflammation in endothelial cells. Atherosclerosis. 2012;221:375-82.
    • (2012) Atherosclerosis , vol.221 , pp. 375-382
    • Shiraki, A.1    Oyama, J.2    Komoda, H.3    Asaka, M.4    Komatsu, A.5    Sakuma, M.6
  • 52
    • 79551607371 scopus 로고    scopus 로고
    • Effect of exenatide on inflammatory and oxidative stressmarkers in patients with type 2 diabetes mellitus
    • Wu JD, Xu XH, Zhu J, Ding B, Du TX, Gao G, et al. Effect of exenatide on inflammatory and oxidative stressmarkers in patients with type 2 diabetes mellitus. Diabetes Technol Ther. 2011;13:143-8.
    • (2011) Diabetes Technol Ther , vol.13 , pp. 143-148
    • Wu, J.D.1    Xu, X.H.2    Zhu, J.3    Ding, B.4    Du, T.X.5    Gao, G.6
  • 53
    • 84875385071 scopus 로고    scopus 로고
    • Treatment with exenatide once weekly or twice daily for 30 weeks is associated with changes in several cardiovascular risk markers
    • Chiquette E, Toth PP, Ramirez G, Cobble M, Chilton R. Treatment with exenatide once weekly or twice daily for 30 weeks is associated with changes in several cardiovascular risk markers. Vasc Health Risk Manag. 2012;8:621-9.
    • (2012) Vasc Health Risk Manag , vol.8 , pp. 621-629
    • Chiquette, E.1    Toth, P.P.2    Ramirez, G.3    Cobble, M.4    Chilton, R.5
  • 54
    • 84874187571 scopus 로고    scopus 로고
    • Cardiovascular effects of GLP-1 and GLP-1-based therapies: Implications for the cardiovascular continuum in diabetes?
    • Burgmaier M, Heinrich C, Marx N. Cardiovascular effects of GLP-1 and GLP-1-based therapies: implications for the cardiovascular continuum in diabetes? Diabet Med. 2013;30:289-99.
    • (2013) Diabet Med , vol.30 , pp. 289-299
    • Burgmaier, M.1    Heinrich, C.2    Marx, N.3
  • 55
    • 84860204551 scopus 로고    scopus 로고
    • Cardiovascular biology of the incretin system
    • Extensive review on the cardiovascular effect of incretins
    • • Ussher JR, Drucker DJ. Cardiovascular biology of the incretin system. Endocr Rev. 2012;33:187-215. Extensive review on the cardiovascular effect of incretins.
    • (2012) Endocr Rev , vol.33 , pp. 187-215
    • Ussher, J.R.1    Drucker, D.J.2
  • 56
    • 79953173175 scopus 로고    scopus 로고
    • GLP-1-derived nonapeptide GLP-1(28-36) amide targets to mitochondria and suppresses glucose production and oxidative stress in isolated mouse hepatocytes
    • Tomas E, Stanojevic V, Habener JF. GLP-1-derived nonapeptide GLP-1(28-36) amide targets to mitochondria and suppresses glucose production and oxidative stress in isolated mouse hepatocytes. Regul Pept. 2011;167:177-84.
    • (2011) Regul Pept , vol.167 , pp. 177-184
    • Tomas, E.1    Stanojevic, V.2    Habener, J.F.3
  • 57
    • 4043117769 scopus 로고    scopus 로고
    • Modulation of hematopoietic stem cell homing and engraftment by CD26
    • DOI 10.1126/science.1097071
    • Christopherson II KW, Hangoc G, Mantel CR, Broxmeyer HE. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science. 2004;305:1000-3. (Pubitemid 39071774)
    • (2004) Science , vol.305 , Issue.5686 , pp. 1000-1003
    • Christopherson II, K.W.1    Hangoc, G.2    Mantel, C.R.3    Broxmeyer, H.E.4
  • 58
    • 84855412101 scopus 로고    scopus 로고
    • Diabetic stem-cell "mobilopathy"
    • DiPersio JF. Diabetic stem-cell "mobilopathy". N Engl J Med. 2011;365:2536-8.
    • (2011) N Engl J Med , vol.365 , pp. 2536-2538
    • DiPersio, J.F.1
  • 59
    • 62949195390 scopus 로고    scopus 로고
    • Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction
    • Zaruba MM, Theiss HD, Vallaster M, Mehl U, Brunner S, David R, et al. Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction. Cell Stem Cell. 2009;4:313-23.
    • (2009) Cell Stem Cell , vol.4 , pp. 313-323
    • Zaruba, M.M.1    Theiss, H.D.2    Vallaster, M.3    Mehl, U.4    Brunner, S.5    David, R.6
  • 60
    • 77958195997 scopus 로고    scopus 로고
    • The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: Possible role of stromal-derived factor-1alpha
    • The first report of an effect of DPP4-I on endothelial progenitor cells in vivo, in diabetic patients
    • • Fadini GP, Boscaro E, Albiero M, Menegazzo L, Frison V, de Kreutzenberg, et al. The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha. Diabetes Care. 2010;33:1607-9. The first report of an effect of DPP4-I on endothelial progenitor cells in vivo, in diabetic patients.
    • (2010) Diabetes Care , vol.33 , pp. 1607-1609
    • Fadini, G.P.1    Boscaro, E.2    Albiero, M.3    Menegazzo, L.4    Frison, V.5    De Kreutzenberg6
  • 61
    • 84867254999 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 modulates left ventricular dysfunction in chronic heart failure via angiogenesis-dependent and - independent actions
    • Shigeta T, Aoyama M, Bando YK, Monji A, Mitsui T, Takatsu M, et al. Dipeptidyl peptidase-4 modulates left ventricular dysfunction in chronic heart failure via angiogenesis-dependent and - independent actions. Circulation. 2012;126:1838-51.
    • (2012) Circulation , vol.126 , pp. 1838-1851
    • Shigeta, T.1    Aoyama, M.2    Bando, Y.K.3    Monji, A.4    Mitsui, T.5    Takatsu, M.6
  • 62
    • 84869876137 scopus 로고    scopus 로고
    • Stem cell compartmentalization in diabetes and high cardiovascular risk reveals the role of DPP-4 in diabetic stem cell mobilopathy
    • Fadini GP, Albiero M, Seeger F, Poncina N, Menegazzo L, Angelini A, et al. Stem cell compartmentalization in diabetes and high cardiovascular risk reveals the role of DPP-4 in diabetic stem cell mobilopathy. Basic Res Cardiol. 2013;108:313.
    • (2013) Basic Res Cardiol , vol.108 , pp. 313
    • Fadini, G.P.1    Albiero, M.2    Seeger, F.3    Poncina, N.4    Menegazzo, L.5    Angelini, A.6
  • 64
    • 80053358548 scopus 로고    scopus 로고
    • Early and late effects of the DPP-4 inhibitor vildagliptin in a ratmodel of postmyocardial infarction heart failure
    • Yin M, Sillje HH, Meissner M, van Gilst WH, de Boer RA. Early and late effects of the DPP-4 inhibitor vildagliptin in a ratmodel of postmyocardial infarction heart failure. Cardiovasc Diabetol. 2011;10:85.
    • (2011) Cardiovasc Diabetol , vol.10 , pp. 85
    • Yin, M.1    Sillje, H.H.2    Meissner, M.3    Van Gilst, W.H.4    De Boer, R.A.5
  • 66
    • 84878895774 scopus 로고    scopus 로고
    • Different modulation of dipeptidyl peptidase-4 activity between microvascular and macrovascular human endothelial cells
    • Pala L, Pezzatini A, Dicembrini I, Ciani S, Gelmini S, Vannelli BG, et al. Different modulation of dipeptidyl peptidase-4 activity between microvascular and macrovascular human endothelial cells. Acta Diabetol. 2012;49 Suppl 1:S59-63.
    • (2012) Acta Diabetol , vol.49 , Issue.SUPPL. 1
    • Pala, L.1    Pezzatini, A.2    Dicembrini, I.3    Ciani, S.4    Gelmini, S.5    Vannelli, B.G.6
  • 67
    • 84862908699 scopus 로고    scopus 로고
    • A dipeptidyl peptidase-4 inhibitor, des-fluorositagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice
    • Matsubara J, Sugiyama S, Sugamura K, Nakamura T, Fujiwara Y, Akiyama E, et al. A dipeptidyl peptidase-4 inhibitor, des-fluorositagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice. J Am Coll Cardiol. 2012;59:265-76.
    • (2012) J Am Coll Cardiol , vol.59 , pp. 265-276
    • Matsubara, J.1    Sugiyama, S.2    Sugamura, K.3    Nakamura, T.4    Fujiwara, Y.5    Akiyama, E.6
  • 70
    • 84865130603 scopus 로고    scopus 로고
    • Addition of liraglutide in patients with Type 2 diabetes well controlled on metformin monotherapy improves several markers of vascular function
    • Forst T, Michelson G, Ratter F, Weber MM, Anders S, Mitry M, et al. Addition of liraglutide in patients with Type 2 diabetes well controlled on metformin monotherapy improves several markers of vascular function. Diabet Med. 2012;29:1115-8.
    • (2012) Diabet Med , vol.29 , pp. 1115-1118
    • Forst, T.1    Michelson, G.2    Ratter, F.3    Weber, M.M.4    Anders, S.5    Mitry, M.6
  • 71
    • 79956119675 scopus 로고    scopus 로고
    • The possible protective role of glucagon-like peptide 1 on endothelium during the meal and evidence for an "endothelial resistance" to glucagon-like peptide 1 in diabetes
    • Ceriello A, Esposito K, Testa R, Bonfigli AR, Marra M, Giugliano D. The possible protective role of glucagon-like peptide 1 on endothelium during the meal and evidence for an "endothelial resistance" to glucagon-like peptide 1 in diabetes. Diabetes Care. 2011;34:697-702.
    • (2011) Diabetes Care , vol.34 , pp. 697-702
    • Ceriello, A.1    Esposito, K.2    Testa, R.3    Bonfigli, A.R.4    Marra, M.5    Giugliano, D.6
  • 72
    • 84879783953 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 reduces endothelial dysfunction, inflammation, and oxidative stress induced by both hyperglycemia and hypoglycemia in type 1 diabetes
    • Ceriello A, Novials A, Ortega E, Canivell S, La Sala L, Pujadas G, et al. Glucagon-like peptide 1 reduces endothelial dysfunction, inflammation, and oxidative stress induced by both hyperglycemia and hypoglycemia in type 1 diabetes. Diabetes Care. 2013;36:2346-50.
    • (2013) Diabetes Care , vol.36 , pp. 2346-2350
    • Ceriello, A.1    Novials, A.2    Ortega, E.3    Canivell, S.4    La Sala, L.5    Pujadas, G.6
  • 73
    • 84872020915 scopus 로고    scopus 로고
    • Alogliptin ameliorates postprandial lipemia and postprandial endothelial dysfunction in nondiabetic subjects: A preliminary report
    • Noda Y, Miyoshi T, Oe H, Ohno Y, Nakamura K, Toh N, et al. Alogliptin ameliorates postprandial lipemia and postprandial endothelial dysfunction in nondiabetic subjects: a preliminary report. Cardiovasc Diabetol. 2013;12:8.
    • (2013) Cardiovasc Diabetol , vol.12 , pp. 8
    • Noda, Y.1    Miyoshi, T.2    Oe, H.3    Ohno, Y.4    Nakamura, K.5    Toh, N.6
  • 74
    • 84874442329 scopus 로고    scopus 로고
    • Effects of GLP-1 on forearm vasodilator function and glucose disposal during hyperinsulinemia in the metabolic syndrome
    • Tesauro M, Schinzari F, Adamo A, Rovella V, Martini F, Mores N, et al. Effects of GLP-1 on forearm vasodilator function and glucose disposal during hyperinsulinemia in the metabolic syndrome. Diabetes Care. 2013;36:683-9.
    • (2013) Diabetes Care , vol.36 , pp. 683-689
    • Tesauro, M.1    Schinzari, F.2    Adamo, A.3    Rovella, V.4    Martini, F.5    Mores, N.6
  • 75
    • 84861944029 scopus 로고    scopus 로고
    • Effects of exenatide vs metformin on endothelial function in obese patients with prediabetes: A randomized trial
    • Kelly AS, Bergenstal RM, Gonzalez-Campoy JM, Katz H, Bank AJ. Effects of exenatide vs metformin on endothelial function in obese patients with prediabetes: a randomized trial. Cardiovasc Diabetol. 2012;11:64.
    • (2012) Cardiovasc Diabetol , vol.11 , pp. 64
    • Kelly, A.S.1    Bergenstal, R.M.2    Gonzalez-Campoy, J.M.3    Katz, H.4    Bank, A.J.5
  • 76
    • 79955480528 scopus 로고    scopus 로고
    • Vildagliptin blocks vascular injury in thoracic aorta of diabetic rats by suppressing advanced glycation end product-receptor axis
    • Matsui T, Nishino Y, Takeuchi M, Yamagishi S. Vildagliptin blocks vascular injury in thoracic aorta of diabetic rats by suppressing advanced glycation end product-receptor axis. Pharmacol Res. 2011;63:383-8.
    • (2011) Pharmacol Res , vol.63 , pp. 383-388
    • Matsui, T.1    Nishino, Y.2    Takeuchi, M.3    Yamagishi, S.4
  • 77
    • 80052963329 scopus 로고    scopus 로고
    • Sitagliptin augments protective effects of GLP-1 against advanced glycation end product receptor axis in endothelial cells
    • Ishibashi Y, Matsui T, Takeuchi M, Yamagishi S. Sitagliptin augments protective effects of GLP-1 against advanced glycation end product receptor axis in endothelial cells. Horm Metab Res. 2011;43:731-4.
    • (2011) Horm Metab Res , vol.43 , pp. 731-734
    • Ishibashi, Y.1    Matsui, T.2    Takeuchi, M.3    Yamagishi, S.4
  • 78
    • 84862027177 scopus 로고    scopus 로고
    • Vildagliptin inhibits oxidative stress and vascular damage in streptozotocin-induced diabetic rats
    • Maeda S, Matsui T, Yamagishi S. Vildagliptin inhibits oxidative stress and vascular damage in streptozotocin-induced diabetic rats. Int J Cardiol. 2012;158:171-3.
    • (2012) Int J Cardiol , vol.158 , pp. 171-173
    • Maeda, S.1    Matsui, T.2    Yamagishi, S.3
  • 79
    • 84871309097 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression
    • Ojima A, Ishibashi Y, Matsui T, Maeda S, Nishino Y, Takeuchi M, et al. Glucagon-like peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression. Am J Pathol. 2013;182:132-41.
    • (2013) Am J Pathol , vol.182 , pp. 132-141
    • Ojima, A.1    Ishibashi, Y.2    Matsui, T.3    Maeda, S.4    Nishino, Y.5    Takeuchi, M.6
  • 80
    • 84856485110 scopus 로고    scopus 로고
    • GLP-1 analogue, Liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stress
    • Schisano B, Harte AL, Lois K, Saravanan P, Al-Daghri N, Al-Attas O, et al. GLP-1 analogue, Liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stress. Regul Pept. 2012;174:46-52.
    • (2012) Regul Pept , vol.174 , pp. 46-52
    • Schisano, B.1    Harte, A.L.2    Lois, K.3    Saravanan, P.4    Al-Daghri, N.5    Al-Attas, O.6
  • 81
    • 77951168113 scopus 로고    scopus 로고
    • Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice
    • The first molecular evidence on the effect of DPP4 deletion in the heart
    • • Sauve M, Ban K, Momen MA, Zhou YQ, Henkelman RM, Husain M, et al. Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice. Diabetes. 2010;59:1063-73. The first molecular evidence on the effect of DPP4 deletion in the heart.
    • (2010) Diabetes , vol.59 , pp. 1063-1073
    • Sauve, M.1    Ban, K.2    Momen, M.A.3    Zhou, Y.Q.4    Henkelman, R.M.5    Husain, M.6
  • 83
    • 77954948794 scopus 로고    scopus 로고
    • Improvement of postprandial endothelial function after a single dose of exenatide in individuals with impaired glucose tolerance and recent-onset type 2 diabetes
    • Koska J, Schwartz EA, Mullin MP, Schwenke DC, Reaven PD. Improvement of postprandial endothelial function after a single dose of exenatide in individuals with impaired glucose tolerance and recent-onset type 2 diabetes. Diabetes Care. 2010;33:1028-30.
    • (2010) Diabetes Care , vol.33 , pp. 1028-1030
    • Koska, J.1    Schwartz, E.A.2    Mullin, M.P.3    Schwenke, D.C.4    Reaven, P.D.5
  • 84
    • 84865492997 scopus 로고    scopus 로고
    • Meta-analysis of effect of dipeptidyl peptidase-4 inhibitors on cardiovascular risk in type 2 diabetes mellitus
    • Patil HR, Al Badarin FJ, Al Shami HA, Bhatti SK, Lavie CJ, Bell DS, et al. Meta-analysis of effect of dipeptidyl peptidase-4 inhibitors on cardiovascular risk in type 2 diabetes mellitus. Am J Cardiol. 2012;110:826-33.
    • (2012) Am J Cardiol , vol.110 , pp. 826-833
    • Patil, H.R.1    Al Badarin, F.J.2    Al Shami, H.A.3    Bhatti, S.K.4    Lavie, C.J.5    Bell, D.S.6
  • 85
    • 84871936025 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and cardiovascular risk: A meta-analysis of randomized clinical trials
    • Monami M, Ahren B, Dicembrini I, Mannucci E. Dipeptidyl peptidase-4 inhibitors and cardiovascular risk: a meta-analysis of randomized clinical trials. Diabetes Obes Metab. 2013;15:112-20.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 112-120
    • Monami, M.1    Ahren, B.2    Dicembrini, I.3    Mannucci, E.4
  • 86
    • 79951702236 scopus 로고    scopus 로고
    • Risk of cardiovascular disease events in patients with type 2 diabetes prescribed the glucagon-like peptide 1 (GLP-1) receptor agonist exenatide twice daily or other glucose-lowering therapies: A retrospective analysis of the LifeLink database
    • Best JH, Hoogwerf BJ, Herman WH, Pelletier EM, Smith DB, Wenten M, et al. Risk of cardiovascular disease events in patients with type 2 diabetes prescribed the glucagon-like peptide 1 (GLP-1) receptor agonist exenatide twice daily or other glucose-lowering therapies: a retrospective analysis of the LifeLink database. Diabetes Care. 2011;34:90-5.
    • (2011) Diabetes Care , vol.34 , pp. 90-95
    • Best, J.H.1    Hoogwerf, B.J.2    Herman, W.H.3    Pelletier, E.M.4    Smith, D.B.5    Wenten, M.6
  • 87
    • 84873554686 scopus 로고    scopus 로고
    • Effects of exenatide and liraglutide on heart rate, blood pressure and body weight: Systematic review and meta-analysis
    • Robinson LE, Holt TA, Rees K, Randeva HS, O'Hare JP. Effects of exenatide and liraglutide on heart rate, blood pressure and body weight: systematic review and meta-analysis. BMJ Open. 2013;3:E001986.
    • (2013) BMJ Open , vol.3
    • Robinson, L.E.1    Holt, T.A.2    Rees, K.3    Randeva, H.S.4    O'Hare, J.P.5
  • 88
    • 77949287808 scopus 로고    scopus 로고
    • Reduced plasma levels of glucagon-like peptide-1 in elderly men are associated with impaired glucose tolerance but not with coronary heart disease
    • Nathanson D, Zethelius B, Berne C, Holst JJ, Sjoholm A, Nystrom T. Reduced plasma levels of glucagon-like peptide-1 in elderly men are associated with impaired glucose tolerance but not with coronary heart disease. Diabetologia. 2010;53:277-80.
    • (2010) Diabetologia , vol.53 , pp. 277-280
    • Nathanson, D.1    Zethelius, B.2    Berne, C.3    Holst, J.J.4    Sjoholm, A.5    Nystrom, T.6
  • 89
    • 79851489434 scopus 로고    scopus 로고
    • Plasma levels of glucagon like peptide-1 associate with diastolic function in elderly men
    • Nathanson D, Zethelius B, Berne C, Lind L, Andren B, Ingelsson E, et al. Plasma levels of glucagon like peptide-1 associate with diastolic function in elderly men. Diabet Med. 2011;28:301-5.
    • (2011) Diabet Med , vol.28 , pp. 301-305
    • Nathanson, D.1    Zethelius, B.2    Berne, C.3    Lind, L.4    Andren, B.5    Ingelsson, E.6
  • 90
    • 1442311383 scopus 로고    scopus 로고
    • Effects of Glucagon-Like Peptide-1 in Patients with Acute Myocardial Infarction and Left Ventricular Dysfunction after Successful Reperfusion
    • DOI 10.1161/01.CIR.0000120505.91348.58
    • Nikolaidis LA, Mankad S, Sokos GG, Miske G, Shah A, Elahi D, et al. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation. 2004;109:962-5. (Pubitemid 38282847)
    • (2004) Circulation , vol.109 , Issue.8 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3    Miske, G.4    Shah, A.5    Elahi, D.6    Shannon, R.P.7
  • 91
    • 84857111888 scopus 로고    scopus 로고
    • Cardioprotection against ischaemia induced by dobutamine stress using glucagon-like peptide-1 in patients with coronary artery disease
    • Read PA, Khan FZ, Dutka DP. Cardioprotection against ischaemia induced by dobutamine stress using glucagon-like peptide-1 in patients with coronary artery disease. Heart. 2012;98:408-13.
    • (2012) Heart , vol.98 , pp. 408-413
    • Read, P.A.1    Khan, F.Z.2    Dutka, D.P.3
  • 92
    • 33644682164 scopus 로고    scopus 로고
    • Initial experience with GLP-1 treatment on metabolic control and myocardial function in patients with type 2 diabetes mellitus and heart failure
    • Thrainsdottir I, Malmberg K, Olsson A, Gutniak M, Ryden L. Initial experience with GLP-1 treatment on metabolic control and myocardial function in patients with type 2 diabetes mellitus and heart failure. Diab Vasc Dis Res. 2004;1:40-3.
    • (2004) Diab Vasc Dis Res , vol.1 , pp. 40-43
    • Thrainsdottir, I.1    Malmberg, K.2    Olsson, A.3    Gutniak, M.4    Ryden, L.5
  • 93
    • 33845293219 scopus 로고    scopus 로고
    • Glucagon-Like Peptide-1 Infusion Improves Left Ventricular Ejection Fraction and Functional Status in Patients With Chronic Heart Failure
    • DOI 10.1016/j.cardfail.2006.08.211, PII S1071916406011092
    • Sokos GG, Nikolaidis LA, Mankad S, Elahi D, Shannon RP. Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure. J Card Fail. 2006;12:694-9. (Pubitemid 44881367)
    • (2006) Journal of Cardiac Failure , vol.12 , Issue.9 , pp. 694-699
    • Sokos, G.G.1    Nikolaidis, L.A.2    Mankad, S.3    Elahi, D.4    Shannon, R.P.5
  • 95
    • 84879194479 scopus 로고    scopus 로고
    • A meta-analysis of the therapeutic effects of glucagon-like Peptide-1 agonist in heart failure
    • Munaf M, Pellicori P, Allgar V, Wong K. A meta-analysis of the therapeutic effects of glucagon-like Peptide-1 agonist in heart failure. Int J Pept. 2012;2012:249827.
    • (2012) Int J Pept , vol.2012 , pp. 249827
    • Munaf, M.1    Pellicori, P.2    Allgar, V.3    Wong, K.4
  • 96
    • 77749273703 scopus 로고    scopus 로고
    • Cardiovascular and metabolic effects of 48-h glucagon-like peptide-1 infusion in compensated chronic patients with heart failure
    • Halbirk M, Norrelund H, Moller N, Holst JJ, Schmitz O, Nielsen R, et al. Cardiovascular and metabolic effects of 48-h glucagon-like peptide-1 infusion in compensated chronic patients with heart failure. Am J Physiol Heart Circ Physiol. 2010;298:H1096-102.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298
    • Halbirk, M.1    Norrelund, H.2    Moller, N.3    Holst, J.J.4    Schmitz, O.5    Nielsen, R.6
  • 97
    • 84863560602 scopus 로고    scopus 로고
    • Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction
    • Lonborg J, Vejlstrup N, Kelbaek H, Botker HE, Kim WY, Mathiasen AB, et al. Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction. Eur Heart J. 2012;33:1491-9.
    • (2012) Eur Heart J , vol.33 , pp. 1491-1499
    • Lonborg, J.1    Vejlstrup, N.2    Kelbaek, H.3    Botker, H.E.4    Kim, W.Y.5    Mathiasen, A.B.6
  • 98
    • 84860807487 scopus 로고    scopus 로고
    • Exenatide reduces final infarct size in patients with ST-segment-elevation myocardial infarction and short-duration of ischemia
    • Lonborg J, Kelbaek H, Vejlstrup N, Botker HE, Kim WY, Holmvang L, et al. Exenatide reduces final infarct size in patients with ST-segment-elevation myocardial infarction and short-duration of ischemia. Circ Cardiovasc Interv. 2012;5:288-95.
    • (2012) Circ Cardiovasc Interv , vol.5 , pp. 288-295
    • Lonborg, J.1    Kelbaek, H.2    Vejlstrup, N.3    Botker, H.E.4    Kim, W.Y.5    Holmvang, L.6
  • 99
    • 77951934948 scopus 로고    scopus 로고
    • DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease
    • Read PA, Khan FZ, Heck PM, Hoole SP, Dutka DP. DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease. Circ Cardiovasc Imaging. 2010;3:195-201.
    • (2010) Circ Cardiovasc Imaging , vol.3 , pp. 195-201
    • Read, P.A.1    Khan, F.Z.2    Heck, P.M.3    Hoole, S.P.4    Dutka, D.P.5
  • 100
    • 80053650554 scopus 로고    scopus 로고
    • EXamination of cArdiovascular outcoMes with alogliptIN vs standard of carE in patients with type 2 diabetes mellitus and acute coronary syndrome (EXAMINE): A cardiovascular safety study of the dipeptidyl peptidase 4 inhibitor alogliptin in patients with type 2 diabeteswith acute coronary syndrome
    • White WB, Bakris GL, Bergenstal RM, Cannon CP, Cushman WC, Fleck P, et al. EXamination of cArdiovascular outcoMes with alogliptIN vs standard of carE in patients with type 2 diabetes mellitus and acute coronary syndrome (EXAMINE): a cardiovascular safety study of the dipeptidyl peptidase 4 inhibitor alogliptin in patients with type 2 diabeteswith acute coronary syndrome.Am Heart J. 2011;162:620-6. e621.
    • (2011) Am Heart J , vol.162
    • White, W.B.1    Bakris, G.L.2    Bergenstal, R.M.3    Cannon, C.P.4    Cushman, W.C.5    Fleck, P.6
  • 101
    • 81255201441 scopus 로고    scopus 로고
    • The design and rationale of the saxagliptin assessment of vascular outcomes recorded in patients with diabetes mellitus-thrombolysis in myocardial infarction (SAVOR-TIMI) 53 study
    • Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, et al. The design and rationale of the saxagliptin assessment of vascular outcomes recorded in patients with diabetes mellitus-thrombolysis in myocardial infarction (SAVOR-TIMI) 53 study. Am Heart J. 2011;162:818-25. e816.
    • (2011) Am Heart J , vol.162
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3    Steg, P.G.4    Davidson, J.5    Hirshberg, B.6
  • 102
    • 84883745765 scopus 로고    scopus 로고
    • Alogliptin after acute coronary syndrome in patients with type 2 diabetes
    • The first randomized controlled trial reporting safety for alogliptin in post-AMI T2DM patients
    • •• White WB, Cannon CP, Heller SR, Nissen SE, Bergenstal RM, Bakris GL, et al. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med. 2013;369:1327-35. The first randomized controlled trial reporting safety for alogliptin in post-AMI T2DM patients.
    • (2013) N Engl J Med , vol.369 , pp. 1327-1335
    • White, W.B.1    Cannon, C.P.2    Heller, S.R.3    Nissen, S.E.4    Bergenstal, R.M.5    Bakris, G.L.6
  • 103
    • 84883765959 scopus 로고    scopus 로고
    • Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • The first randomized controlled trial reporting safety for saxagliptin in high risk T2DM patients
    • •• Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, et al. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med. 2013;369:1317-26. The first randomized controlled trial reporting safety for saxagliptin in high risk T2DM patients.
    • (2013) N Engl J Med , vol.369 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3    Steg, P.G.4    Davidson, J.5    Hirshberg, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.