Gene expression signatures of primary and metastatic uterine leiomyosarcoma

Human Pathology

Volumn 45, Issue 4, 2014, Pages 691-700

  Davidson, Ben ^a,b   Abeler, Vera Maria ^a   Førsund, Mette ^a   Holth, Arild ^a   Yang, Yanqin ^c   Kobayashi, Yusuke ^d   Chen, Lily ^d   Kristensen, Gunnar B ^a   Shih, Ie Ming ^d   Wang, Tian Li ^d  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^d DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Gene expression array; Metastasis; Uterine leiomyosarcoma

Indexed keywords

AGT PROTEIN; ASS1 PROTEIN; CRYM PROTEIN; EARLY GROWTH RESPONSE FACTOR 2; FOLR3 PROTEIN; GJA1 PROTEIN; HRASLS PROTEIN; MASP1 PROTEIN; NEUROLIGIN 1; NLGN4X PROTEIN; OSTN PROTEIN; PROTEIN; RETINOID RELATED ORPHAN RECEPTOR BETA; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SHMT1 PROTEIN; SLITRK4 PROTEIN; TDO2 PROTEIN; THBS1 PROTEIN; TNNT1 PROTEIN; TSPAN10 PROTEIN; TSPAN7 PROTEIN; UNCLASSIFIED DRUG; XRN2 PROTEIN; ARGININOSUCCINATE SYNTHASE; CONNEXIN 43; CRYSTALLIN; CRYSTALLIN MU; EXORIBONUCLEASE; GLYCINE HYDROXYMETHYLTRANSFERASE; MEMBRANE PROTEIN; NEUROLIGIN 4X; OSTEOCRIN; TRYPTOPHAN 2,3 DIOXYGENASE;

ARTICLE; CANCER GROWTH; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; IMMUNOHISTOCHEMISTRY; METASTASIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; UTERUS SARCOMA; CANCER PROGNOSIS; CANCER SURVIVAL; DISTANT METASTASIS; HUMAN TISSUE; LUNG METASTASIS; PRIMARY TUMOR;

GENE EXPRESSION ARRAY; METASTASIS; UTERINE LEIOMYOSARCOMA;

CLUSTER ANALYSIS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LEIOMYOSARCOMA; NEOPLASM METASTASIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; TRANSCRIPTOME; UTERINE NEOPLASMS;

EID: 84896548189     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2013.11.003     Document Type: Article

References (35)

1. J.R. Toro, L.B. Travis, and H.J. Wu et al. Incidence patterns of soft tissue sarcomas, regardless of primary site, in the surveillance, epidemiology and end results program, 1978-2001: an analysis of 26,758 cases Int J Cancer 119 2006 2922 2930 (Pubitemid 44846246)
2. E. D'Angelo, and J. Prat Uterine sarcomas: a review Gynecol Oncol 116 2010 131 139
3. V.M. Abeler, O. Røyne, and S. Thoresen et al. Uterine sarcomas in Norway. A histopathological and prognostic survey of a total population from 1970 to 2000 including 419 patients Histopathology 54 2009 355 364
4. F. Amant, A. Coosemans, and M. Debiec-Rychter et al. Clinical management of uterine sarcomas Lancet Oncol 10 2009 1188 1198
5. B. Edris, I. Espinosa, and T. Mühlenberg et al. ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour J Pathol 227 2012 223 233
6. L. Gibault, G. Pérot, and F. Chibon et al. New insights in sarcoma oncogenesis: a comprehensive analysis of a large series of 160 soft tissue sarcomas with complex genomics J Pathol 223 2011 64 71
7. A.M. Mills, A.H. Beck, and K.D. Montgomery et al. Expression of subtype-specific group 1 leiomyosarcoma markers in a wide variety of sarcomas by gene expression analysis and immunohistochemistry Am J Surg Pathol 35 2011 583 589
8. A.H. Beck, C.H. Lee, and D.M. Witten et al. Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling Oncogene 29 2010 845 854
9. Y.F. Lee, M. John, and A. Falconer et al. A gene expression signature associated with metastatic outcome in human leiomyosarcomas Cancer Res 64 2004 7201 7204 (Pubitemid 39372051)
10. B.J. Quade, T.Y. Wang, and K. Sornberger et al. Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling Genes Chromosomes Cancer 40 2004 97 108 (Pubitemid 38579878)
11. K.M. Skubitz, and A.P. Skubitz Differential gene expression in leiomyosarcoma Cancer 98 2003 1029 1038 (Pubitemid 37022105)
12. N. Matsumura, M. Mandai, and M. Miyanishi et al. Oncogenic property of acrogranin in human uterine leiomyosarcoma: direct evidence of genetic contribution in in vivo tumorigenesis Clin Cancer Res 12 2006 1402 1411
13. M. Raish, M. Khurshid, and M.A. Ansari et al. Analysis of molecular cytogenetic alterations in uterine leiomyosarcoma by array-based comparative genomic hybridization J Cancer Res Clin Oncol 138 2012 1173 1186
14. Y.L. Cho, S. Bae, and M.S. Koo et al. Array comparative genomic hybridization analysis of uterine leiomyosarcoma Gynecol Oncol 99 2005 545 551 (Pubitemid 41686534)
15. V.M. Abeler, and M. Nenodovic Diagnostic immunohistochemistry in uterine sarcomas: a study of 397 cases Int J Gynecol Pathol 30 2011 236 243
16. Morrison TB, Weis JJ, Wittwer CT. Quantification of low-copy transcripts by continuous SYBR Green I monitoring during amplification. Biotechniques 1998;24:954-8, 960, 962.
17. B. Davidson, V.M. Abeler, and E. Hellesylt et al. Gene expression signatures differentiate uterine endometrial stromal sarcoma from leiomyosarcoma Gynecol Oncol 128 2013 349 355
18. P. Moffatt, and G.P. Thomas Osteocrin - beyond just another bone protein? Cell Mol Life Sci 66 2009 1135 1139
19. A. Bottos, A. Rissone, and F. Bussolino et al. Neurexins and neuroligins: synapses look out of the nervous system Cell Mol Life Sci 68 2011 2655 2666
20. J. Aruga, N. Yokota, and K. Mikoshiba Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. Gene 315 2003 87 94 (Pubitemid 37214900)
21. A. Bell, D. Bell, and R.S. Weber et al. CpG island methylation profiling in human salivary gland adenoid cystic carcinoma Cancer 117 2011 2898 2909
22. M.E. Hemler Targeting of tetraspanin proteins - potential benefits and strategies Nat Rev Drug Discov 7 2008 747 758
23. J. Briese, H.M. Schulte, and M. Sajin et al. Correlations between reduced expression of the metastasis suppressor gene KAI-1 and accumulation of p53 in uterine carcinomas and sarcomas Virchows Arch 453 2008 89 96
24. Y. Yuan, D.A. Nymoen, and H.P. Dong et al. Expression of the folate receptor genes FOLR1 and FOLR3 differentiates ovarian carcinoma from breast carcinoma and malignant mesothelioma in serous effusions Hum Pathol 40 2009 1453 1460
25. I.J. Koppen, F.J. Hermans, and G.J. Kaspers Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia Br J Haematol 148 2010 3 14
26. J. Both, T. Wu, and J. Bras et al. Identification of novel candidate oncogenes in chromosome region 17p11.2-p12 in human osteosarcoma PLoS One 7 2012 e30907
27. S.M. Bakmiwewa, A.A. Fatokun, and A. Tran et al. Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2 Bioorg Med Chem Lett 22 2012 7641 7646
28. H. Urakawa, Y. Nishida, and H. Nakashima et al. Prognostic value of indoleamine 2,3-dioxygenase expression in high grade osteosarcoma Clin Exp Metastasis 26 2009 1005 1012
29. J. Ochala Thin filament proteins mutations associated with skeletal myopathies: defective regulation of muscle contraction J Mol Med (Berl) 86 2008 1197 1204
30. S. Postel-Vinay, A.S. Véron, and F. Tirode et al. Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma Nat Genet 44 2012 323 327
31. F. Lang, N. Perrotti, and C. Stournaras Colorectal carcinoma cells - regulation of survival and growth by SGK1 Int J Biochem Cell Biol 42 2010 1571 1575
32. J. Graw Genetics of crystallins: cataract and beyond Exp Eye Res 88 2009 173 189
33. C. Folio, M.I. Mora, and M. Zalacain et al. Proteomic analysis of chemonaive pediatric osteosarcomas and corresponding normal bone reveals multiple altered molecular targets J Proteome Res 8 2009 3882 3888
34. M. Kandouz, and G. Batist Gap junctions and connexins as therapeutic targets in cancer Expert Opin Ther Targets 14 2010 681 692
35. M.M. Bui, G. Han, and G. Acs et al. Connexin 43 is a potential prognostic biomarker for Ewing sarcoma/primitive neuroectodermal tumor Sarcoma 2011 2011 971050