메뉴 건너뛰기




Volumn 14, Issue 7, 2010, Pages 681-692

Gap junctions and connexins as therapeutic targets in cancer

Author keywords

Bystander effect; Cancer; Chemosensitization; Connexin; Gap junction

Indexed keywords

4 AMINO 5 (4 CHLOROPHENYL) 7 (TERT BUTYL)PYRAZOLO[3,4 D]PYRAMIDINE; 4 PHENYLBUTYRIC ACID; 5 AZA 2' DEOXYCYTIDINE; ALPHA GLYCYRREHETINIC ACID; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ATRASENTAN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BREFELDIN A; BUTYRIC ACID; CARBENOXOLONE; CARMUSTINE; CISPLATIN; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); DOCETAXEL; DOXORUBICIN; ETOPOSIDE; GAP JUNCTION PROTEIN; GEMCITABINE; MELPHALAN; NAVELBINE; PACLITAXEL; PROTEIN INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; QUINOLINE DERIVATIVE; QUINOLINE PQ1; TAMOXIFEN; TRICHOSTATIN A; TYRPHOSTIN; TYRPHOSTIN 25; UNCLASSIFIED DRUG; VINBLASTINE; ANTINEOPLASTIC AGENT; CONNEXIN 43; MICRORNA; TUMOR MARKER;

EID: 77953585288     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.2010.487866     Document Type: Review
Times cited : (123)

References (97)
  • 1
    • 8444245596 scopus 로고    scopus 로고
    • Connexins and cell signaling in development and disease
    • Wei CJ, Xu X, Lo CW. Connexins and cell signaling in development and disease. Annu Rev Cell Dev Biol 2004;20:811-838
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 811-838
    • Wei, C.J.1    Xu, X.2    Lo, C.W.3
  • 2
    • 35548930792 scopus 로고    scopus 로고
    • Gap junction channel structure in the early 21st century: Facts and fantasies
    • Yeager M, Harris AL. Gap junction channel structure in the early 21st century: facts and fantasies. Curr Opin Cell Biol 2007;19:521-528
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 521-528
    • Yeager, M.1    Harris, A.L.2
  • 3
    • 64249170988 scopus 로고    scopus 로고
    • Connexin43 phosphorylation: Structural changes and biological effects
    • Solan JL, Lampe PD. Connexin43 phosphorylation: structural changes and biological effects. Biochem J 2009;419:261-272
    • (2009) Biochem J , vol.419 , pp. 261-272
    • Solan, J.L.1    Lampe, P.D.2
  • 4
    • 0033566985 scopus 로고    scopus 로고
    • Deficiency of connexin43 gap junctions is an independent marker for breast tumors
    • Laird DW, Fistouris P, Batist G, et al. Deficiency of connexin43 gap junctions is an independent marker for breast tumors. Cancer Res 1999;59:4104-4110
    • (1999) Cancer Res , vol.59 , pp. 4104-4110
    • Laird, D.W.1    Fistouris, P.2    Batist, G.3
  • 5
    • 0030567963 scopus 로고    scopus 로고
    • Reduced connexin 43 expression in high grade, human prostatic adenocarcinoma cells
    • Tsai H, Werber J, Davia MO, et al. Reduced connexin 43 expression in high grade, human prostatic adenocarcinoma cells. Biochem Biophys Res Commun 1996;227:64-69
    • (1996) Biochem Biophys Res Commun , vol.227 , pp. 64-69
    • Tsai, H.1    Werber, J.2    Davia, M.O.3
  • 6
    • 28944441155 scopus 로고    scopus 로고
    • Defective gap junctional intercellular communication in the carcinogenic process
    • Mesnil M, Crespin S, Avanzo JL, Zaidan-Dagli ML. Defective gap junctional intercellular communication in the carcinogenic process. Biochim Biophys Acta 2005;1719:125-145
    • (2005) Biochim Biophys Acta , vol.1719 , pp. 125-145
    • Mesnil, M.1    Crespin, S.2    Avanzo, J.L.3    Zaidan-Dagli, M.L.4
  • 7
    • 0026045904 scopus 로고
    • The tumor promoter 12-Otetradecanoylphorbol- 13-acetate and the ras oncogene modulate expression and phosphorylation of gap junction proteins
    • Brissette JL, Kumar NM, Gilula NB, Dotto GP. The tumor promoter 12-Otetradecanoylphorbol- 13-acetate and the ras oncogene modulate expression and phosphorylation of gap junction proteins. Mol Cell Biol 1991;11:5364-5371
    • (1991) Mol Cell Biol , vol.11 , pp. 5364-5371
    • Brissette, J.L.1    Kumar, N.M.2    Gilula, N.B.3    Dotto, G.P.4
  • 8
    • 1842426943 scopus 로고    scopus 로고
    • Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43
    • Leithe E, Rivedal E. Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43. J Cell Sci 2004;117:1211-1220
    • (2004) J Cell Sci , vol.117 , pp. 1211-1220
    • Leithe, E.1    Rivedal, E.2
  • 9
    • 33947214073 scopus 로고    scopus 로고
    • Cigarette smoke components inhibited intercellular communication and differentiation in human pancreatic ductal epithelial cells
    • Tai MH, Upham BL, Olson LK, et al. Cigarette smoke components inhibited intercellular communication and differentiation in human pancreatic ductal epithelial cells. Int J Cancer 2007;120:1855-1862
    • (2007) Int J Cancer , vol.120 , pp. 1855-1862
    • Tai, M.H.1    Upham, B.L.2    Olson, L.K.3
  • 10
    • 65949102997 scopus 로고    scopus 로고
    • Src-Induced cisplatin resistance mediated by cell-to-cell communication
    • Peterson-Roth E, Brdlik CM, Glazer PM. Src-Induced cisplatin resistance mediated by cell-to-cell communication. Cancer Res 2009;69:3619-3624
    • (2009) Cancer Res , vol.69 , pp. 3619-3624
    • Peterson-Roth, E.1    Brdlik, C.M.2    Glazer, P.M.3
  • 11
    • 0036075938 scopus 로고    scopus 로고
    • Neoplastic reversal of human ovarian carcinoma cells transfected with connexin43
    • Fernstrom MJ, Koffler LD, bou-Rjaily G, et al. Neoplastic reversal of human ovarian carcinoma cells transfected with connexin43. Exp Mol Pathol 2002;73:54-60
    • (2002) Exp Mol Pathol , vol.73 , pp. 54-60
    • Fernstrom, M.J.1    Koffler, L.D.2    Bou-Rjaily, G.3
  • 12
    • 69949090953 scopus 로고    scopus 로고
    • Connexins: A myriad of functions extending beyond assembly of gap junction channels
    • published online 12 March 2009, doi:10.1186/1478-811X-7-4
    • Dbouk HA, Mroue RM, El-Sabban ME, Talhouk RS. Connexins: a myriad of functions extending beyond assembly of gap junction channels. Cell Commun Signal 2009;7:4: published online 12 March 2009, doi:10.1186/1478-811X-7-4
    • (2009) Cell Commun Signal , vol.7 , pp. 4
    • Dbouk, H.A.1    Mroue, R.M.2    El-Sabban, M.E.3    Talhouk, R.S.4
  • 13
    • 36249001676 scopus 로고    scopus 로고
    • Connexins and gap junctions in mammary gland development and breast cancer progression
    • McLachlan E, Shao Q, Laird DW. Connexins and gap junctions in mammary gland development and breast cancer progression. J Membr Biol 2007;218:107-121
    • (2007) J Membr Biol , vol.218 , pp. 107-121
    • McLachlan, E.1    Shao, Q.2    Laird, D.W.3
  • 14
    • 33644991492 scopus 로고    scopus 로고
    • Increased expression of connexin 26 in the invasive component of lung squamous cell carcinoma: Significant correlation with poor prognosis
    • Ito A, Koma Y, Uchino K, et al. Increased expression of connexin 26 in the invasive component of lung squamous cell carcinoma: significant correlation with poor prognosis. Cancer Lett 2006;234:239-248
    • (2006) Cancer Lett , vol.234 , pp. 239-248
    • Ito, A.1    Koma, Y.2    Uchino, K.3
  • 15
    • 33750572911 scopus 로고    scopus 로고
    • Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis
    • McLachlan E, Shao Q, Wang HL, et al. Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis. Cancer Res 2006;66:9886-9894
    • (2006) Cancer Res , vol.66 , pp. 9886-9894
    • McLachlan, E.1    Shao, Q.2    Wang, H.L.3
  • 16
    • 48649102225 scopus 로고    scopus 로고
    • Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium
    • published online 22 July 2008, doi:10.1186/1741-7015-6-20
    • Elzarrad MK, Haroon A, Willecke K, et al. Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium. BMC Med 2008;6:20: published online 22 July 2008, doi:10.1186/1741-7015-6-20
    • (2008) BMC Med , vol.6 , pp. 20
    • Elzarrad, M.K.1    Haroon, A.2    Willecke, K.3
  • 17
    • 12944281757 scopus 로고    scopus 로고
    • A role for heterologous gap junctions between melanoma and endothelial cells in metastasis
    • Ito A, Katoh F, Kataoka TR, et al. A role for heterologous gap junctions between melanoma and endothelial cells in metastasis. J Clin Invest 2000;105:1189-1197
    • (2000) J Clin Invest , vol.105 , pp. 1189-1197
    • Ito, A.1    Katoh, F.2    Kataoka, T.R.3
  • 18
    • 42449155085 scopus 로고    scopus 로고
    • Alterations in Cx43 and OB-cadherin affect breast cancer cell metastatic potential
    • Li Z, Zhou Z, Donahue HJ. Alterations in Cx43 and OB-cadherin affect breast cancer cell metastatic potential. Clin Exp Metastasis 2008;25:265-272
    • (2008) Clin Exp Metastasis , vol.25 , pp. 265-272
    • Li, Z.1    Zhou, Z.2    Donahue, H.J.3
  • 19
    • 57049158673 scopus 로고    scopus 로고
    • Expressing connexin 43 in breast cancer cells reduces their metastasis to lungs
    • Li Z, Zhou Z, Welch DR, Donahue HJ. Expressing connexin 43 in breast cancer cells reduces their metastasis to lungs. Clin Exp Metastasis 2008;25:893-901
    • (2008) Clin Exp Metastasis , vol.25 , pp. 893-901
    • Li, Z.1    Zhou, Z.2    Welch, D.R.3    Donahue, H.J.4
  • 20
    • 33645695606 scopus 로고    scopus 로고
    • Increased expression of connexins 26 and 43 in lymph node metastases of breast cancer
    • Kanczuga-Koda L, Sulkowski S, Lenczewski A, et al. Increased expression of connexins 26 and 43 in lymph node metastases of breast cancer. J Clin Pathol 2006;59:429-433
    • (2006) J Clin Pathol , vol.59 , pp. 429-433
    • Kanczuga-Koda, L.1    Sulkowski, S.2    Lenczewski, A.3
  • 21
    • 33751189144 scopus 로고    scopus 로고
    • SDF-1alpha regulation in breast cancer cells contacting bone marrow stroma is critical for normal hematopoiesis
    • Moharita AL, Taborga M, Corcoran KE, et al. SDF-1alpha regulation in breast cancer cells contacting bone marrow stroma is critical for normal hematopoiesis. Blood 2006;108:3245-3252
    • (2006) Blood , vol.108 , pp. 3245-3252
    • Moharita, A.L.1    Taborga, M.2    Corcoran, K.E.3
  • 23
    • 64649084383 scopus 로고    scopus 로고
    • Radiation-induced bystander signalling in cancer therapy
    • Prise KM, O'Sullivan JM. Radiation-induced bystander signalling in cancer therapy. Nat Rev Cancer 2009;9:351-360
    • (2009) Nat Rev Cancer , vol.9 , pp. 351-360
    • Prise, K.M.1    O'Sullivan, J.M.2
  • 24
    • 0032505770 scopus 로고    scopus 로고
    • Lack of bystander killing in herpes simplex virus thymidine kinase-transduced colon cell lines due to deficient connexin43 gap junction formation
    • McMasters RA, Saylors RL, Jones KE, et al. Lack of bystander killing in herpes simplex virus thymidine kinase-transduced colon cell lines due to deficient connexin43 gap junction formation. Hum Gene Ther 1998;9:2253-2261
    • (1998) Hum Gene Ther , vol.9 , pp. 2253-2261
    • McMasters, R.A.1    Saylors, R.L.2    Jones, K.E.3
  • 25
    • 0029913138 scopus 로고    scopus 로고
    • Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro
    • Elshami AA, Saavedra A, Zhang H, et al. Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro. Gene Ther 1996;3:85-92
    • (1996) Gene Ther , vol.3 , pp. 85-92
    • Elshami, A.A.1    Saavedra, A.2    Zhang, H.3
  • 26
    • 0032954435 scopus 로고    scopus 로고
    • Cyclic-AMP induction of gap junctional intercellular communication increases bystander effect in suicide gene therapy
    • Carystinos GD, Katabi MM, Laird DW, et al. Cyclic-AMP induction of gap junctional intercellular communication increases bystander effect in suicide gene therapy. Clin Cancer Res 1999;5:61-68
    • (1999) Clin Cancer Res , vol.5 , pp. 61-68
    • Carystinos, G.D.1    Katabi, M.M.2    Laird, D.W.3
  • 27
    • 1042278763 scopus 로고    scopus 로고
    • Radiation-induced bystander effects-implications for cancer
    • Mothersill C, Seymour CB. Radiation-induced bystander effects-implications for cancer. Nat Rev Cancer 2004;4:158-164
    • (2004) Nat Rev Cancer , vol.4 , pp. 158-164
    • Mothersill, C.1    Seymour, C.B.2
  • 28
    • 0035059979 scopus 로고    scopus 로고
    • Induction of a bystander effect in HeLa cells by using a bigenic vector carrying viral thymidine kinase and connexin32 genes
    • Tanaka T, Yamasaki H, Mesnil M. Induction of a bystander effect in HeLa cells by using a bigenic vector carrying viral thymidine kinase and connexin32 genes. Mol Carcinog 2001;30:176-180
    • (2001) Mol Carcinog , vol.30 , pp. 176-180
    • Tanaka, T.1    Yamasaki, H.2    Mesnil, M.3
  • 29
    • 0035895240 scopus 로고    scopus 로고
    • Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells
    • Azzam EI, de Toledo SM, Little JB. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells. Proc Natl Acad Sci USA 2001;98:473-478
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 473-478
    • Azzam, E.I.1    De Toledo, S.M.2    Little, J.B.3
  • 30
    • 28944449931 scopus 로고    scopus 로고
    • Connexins as targets for cancer chemoprevention and chemotherapy
    • King TJ, Bertram JS. Connexins as targets for cancer chemoprevention and chemotherapy. Biochim Biophys Acta 2005;1719:146-160
    • (2005) Biochim Biophys Acta , vol.1719 , pp. 146-160
    • King, T.J.1    Bertram, J.S.2
  • 31
    • 0037098293 scopus 로고    scopus 로고
    • (-)-Epicatechin effects in rat liver epithelial cells: Stimulation of gap junctional communication and counteraction of its loss due to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate
    • le-Agha N, Stahl W, Sies H. (-)-Epicatechin effects in rat liver epithelial cells: stimulation of gap junctional communication and counteraction of its loss due to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Biochem Pharmacol 2002;63:2145-2149
    • (2002) Biochem Pharmacol , vol.63 , pp. 2145-2149
    • Le-Agha, N.1    Stahl, W.2    Sies, H.3
  • 32
    • 0025955567 scopus 로고
    • Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: Relationship to their cancer chemopreventive action
    • Zhang LX, Cooney RV, Bertram JS. Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action. Carcinogenesis 1991;12:2109-2114
    • (1991) Carcinogenesis , vol.12 , pp. 2109-2114
    • Zhang, L.X.1    Cooney, R.V.2    Bertram, J.S.3
  • 33
    • 0034618738 scopus 로고    scopus 로고
    • Resveratrol reverses tumor-promoter-induced inhibition of gap-junctional intercellular communication
    • Nielsen M, Ruch RJ, Vang O. Resveratrol reverses tumor-promoter-induced inhibition of gap-junctional intercellular communication. Biochem Biophys Res Commun 2000;275:804-809
    • (2000) Biochem Biophys Res Commun , vol.275 , pp. 804-809
    • Nielsen, M.1    Ruch, R.J.2    Vang, O.3
  • 34
    • 0034925106 scopus 로고    scopus 로고
    • Upregulation of gap junctional intercellular communication and connexin 43 expression by cyclic-AMP and all-trans-retinoic acid is associated with glutathione depletion and chemosensitivity in neuroblastoma cells
    • Carystinos GD, Alaoui-Jamali MA, Phipps J, et al. Upregulation of gap junctional intercellular communication and connexin 43 expression by cyclic-AMP and all-trans-retinoic acid is associated with glutathione depletion and chemosensitivity in neuroblastoma cells. Cancer Chemother Pharmacol 2001;47:126-132
    • (2001) Cancer Chemother Pharmacol , vol.47 , pp. 126-132
    • Carystinos, G.D.1    Alaoui-Jamali, M.A.2    Phipps, J.3
  • 36
    • 51349083548 scopus 로고    scopus 로고
    • Identification of a novel switch in the dominant forms of cell adhesion-mediated drug resistance in glioblastoma cells
    • Westhoff MA, Zhou S, Bachem MG, et al. Identification of a novel switch in the dominant forms of cell adhesion-mediated drug resistance in glioblastoma cells. Oncogene 2008;27:5169-5181
    • (2008) Oncogene , vol.27 , pp. 5169-5181
    • Westhoff, M.A.1    Zhou, S.2    Bachem, M.G.3
  • 38
    • 35348841286 scopus 로고    scopus 로고
    • Combination of non-viral connexin 43 gene therapy and docetaxel inhibits the growth of human prostate cancer in mice
    • Fukushima M, Hattori Y, Yoshizawa T, Maitani Y. Combination of non-viral connexin 43 gene therapy and docetaxel inhibits the growth of human prostate cancer in mice. Int J Oncol 2007;30:225-231
    • (2007) Int J Oncol , vol.30 , pp. 225-231
    • Fukushima, M.1    Hattori, Y.2    Yoshizawa, T.3    Maitani, Y.4
  • 39
    • 33846948256 scopus 로고    scopus 로고
    • Connexin43 increases the sensitivity of prostate cancer cells to TNFalpha-induced apoptosis
    • Wang M, Berthoud VM, Beyer EC. Connexin43 increases the sensitivity of prostate cancer cells to TNFalpha-induced apoptosis. J Cell Sci 2007;120:320-329
    • (2007) J Cell Sci , vol.120 , pp. 320-329
    • Wang, M.1    Berthoud, V.M.2    Beyer, E.C.3
  • 40
    • 74349092183 scopus 로고    scopus 로고
    • Combinational treatment of gap junctional activator and tamoxifen in breast cancer cells
    • Gakhar G, Hua DH, Nguyen TA. Combinational treatment of gap junctional activator and tamoxifen in breast cancer cells. Anticancer Drugs 2010;21:77-88
    • (2010) Anticancer Drugs , vol.21 , pp. 77-88
    • Gakhar, G.1    Hua, D.H.2    Nguyen, T.A.3
  • 41
    • 0035140516 scopus 로고    scopus 로고
    • Regulation of the gap junction connexin 43 gene by androgens in the prostate
    • Huynh HT, Alpert L, Laird DW, et al. Regulation of the gap junction connexin 43 gene by androgens in the prostate. J Mol Endocrinol 2001;26:1-10
    • (2001) J Mol Endocrinol , vol.26 , pp. 1-10
    • Huynh, H.T.1    Alpert, L.2    Laird, D.W.3
  • 42
    • 28344438305 scopus 로고    scopus 로고
    • Dendritic cell immunizations alone or combined with low doses of interleukin-2 induce specific immune responses in melanoma patients
    • Escobar A, Lopez M, Serrano A, et al. Dendritic cell immunizations alone or combined with low doses of interleukin-2 induce specific immune responses in melanoma patients. Clin Exp Immunol 2005;142:555-568
    • (2005) Clin Exp Immunol , vol.142 , pp. 555-568
    • Escobar, A.1    Lopez, M.2    Serrano, A.3
  • 43
    • 34249811507 scopus 로고    scopus 로고
    • Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells
    • Mendoza-Naranjo A, Saez PJ, Johansson CC, et al. Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells. J Immunol 2007;178:6949-6957
    • (2007) J Immunol , vol.178 , pp. 6949-6957
    • Mendoza-Naranjo, A.1    Saez, P.J.2    Johansson, C.C.3
  • 44
    • 34247862218 scopus 로고    scopus 로고
    • Gene expression response to cisplatin treatment in drug-sensitive and drug-resistant ovarian cancer cells
    • Li J, Wood WH III, Becker KG, et al. Gene expression response to cisplatin treatment in drug-sensitive and drug-resistant ovarian cancer cells. Oncogene 2007;26:2860-2872
    • (2007) Oncogene , vol.26 , pp. 2860-2872
    • Li, J.1    Wood III, W.H.2    Becker, K.G.3
  • 45
    • 6444221366 scopus 로고    scopus 로고
    • A derivative of oleamide potently inhibits the spontaneous metastasis of mouse melanoma BL6 cells
    • Ito A, Morita N, Miura D, et al. A derivative of oleamide potently inhibits the spontaneous metastasis of mouse melanoma BL6 cells. Carcinogenesis 2004;25:2015-2022
    • (2004) Carcinogenesis , vol.25 , pp. 2015-2022
    • Ito, A.1    Morita, N.2    Miura, D.3
  • 46
    • 33748681711 scopus 로고    scopus 로고
    • Gap junctions remain open during cytochrome c-induced cell death: Relationship of conductance to 'bystander' cell killing
    • Cusato K, Ripps H, Zakevicius J, Spray DC. Gap junctions remain open during cytochrome c-induced cell death: relationship of conductance to 'bystander' cell killing. Cell Death Differ 2006;13:1707-1714
    • (2006) Cell Death Differ , vol.13 , pp. 1707-1714
    • Cusato, K.1    Ripps, H.2    Zakevicius, J.3    Spray, D.C.4
  • 48
    • 1942469377 scopus 로고    scopus 로고
    • Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions
    • Jensen R, Glazer PM. Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions. Proc Natl Acad Sci USA 2004;101:6134-6139
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6134-6139
    • Jensen, R.1    Glazer, P.M.2
  • 49
    • 14544292915 scopus 로고    scopus 로고
    • Cross-presentation by intercellular peptide transfer through gap junctions
    • Neijssen J, Herberts C, Drijfhout JW, et al. Cross-presentation by intercellular peptide transfer through gap junctions. Nature 2005;434:83-88
    • (2005) Nature , vol.434 , pp. 83-88
    • Neijssen, J.1    Herberts, C.2    Drijfhout, J.W.3
  • 50
    • 70249098513 scopus 로고    scopus 로고
    • Direct antigen presentation and gap junction mediated cross-presentation during apoptosis
    • Pang B, Neijssen J, Qiao X, et al. Direct antigen presentation and gap junction mediated cross-presentation during apoptosis. J Immunol 2009;183:1083-1090
    • (2009) J Immunol , vol.183 , pp. 1083-1090
    • Pang, B.1    Neijssen, J.2    Qiao, X.3
  • 51
    • 68849090740 scopus 로고    scopus 로고
    • A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phagemediated, vascular-targeted suicide gene transfer
    • Trepel M, Stoneham CA, Eleftherohorinou H, et al. A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phagemediated, vascular-targeted suicide gene transfer. Mol Cancer Ther 2009;8:2383-2391
    • (2009) Mol Cancer Ther , vol.8 , pp. 2383-2391
    • Trepel, M.1    Stoneham, C.A.2    Eleftherohorinou, H.3
  • 52
    • 64849089227 scopus 로고    scopus 로고
    • Gap junction communication between autologous endothelial and tumor cells induce cross-recognition and elimination by specific CTL
    • Benlalam H, Jalil A, Hasmim M, et al. Gap junction communication between autologous endothelial and tumor cells induce cross-recognition and elimination by specific CTL. J Immunol 2009;182:2654-2664
    • (2009) J Immunol , vol.182 , pp. 2654-2664
    • Benlalam, H.1    Jalil, A.2    Hasmim, M.3
  • 53
    • 2942515209 scopus 로고    scopus 로고
    • Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis
    • Seul KH, Kang KY, Lee KS, et al. Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis. Biochem Biophys Res Commun 2004;319:1144-1151
    • (2004) Biochem Biophys Res Commun , vol.319 , pp. 1144-1151
    • Seul, K.H.1    Kang, K.Y.2    Lee, K.S.3
  • 54
    • 76749093047 scopus 로고    scopus 로고
    • The anti-glioma effect of suicide gene therapy using BMSC expressing HSV/TK combined with overexpression of Cx43 in glioma cells
    • Huang Q, Liu XZ, Kang CS, et al. The anti-glioma effect of suicide gene therapy using BMSC expressing HSV/TK combined with overexpression of Cx43 in glioma cells. Cancer Gene Ther 2010;17:192-202
    • (2010) Cancer Gene Ther , vol.17 , pp. 192-202
    • Huang, Q.1    Liu, X.Z.2    Kang, C.S.3
  • 55
    • 77249122967 scopus 로고    scopus 로고
    • HSV-tk expressing mesenchymal stem cells exert bystander effect on human glioblastoma cells
    • Matuskova M, Hlubinova K, Pastorakova A, et al. HSV-tk expressing mesenchymal stem cells exert bystander effect on human glioblastoma cells. Cancer Lett 2010;290:58-67
    • (2010) Cancer Lett , vol.290 , pp. 58-67
    • Matuskova, M.1    Hlubinova, K.2    Pastorakova, A.3
  • 56
    • 4043150786 scopus 로고    scopus 로고
    • Breast cancer metastatic potential: Correlation with increased heterotypic gap junctional intercellular communication between breast cancer cells and osteoblastic cells
    • Kapoor P, Saunders MM, Li Z, et al. Breast cancer metastatic potential: correlation with increased heterotypic gap junctional intercellular communication between breast cancer cells and osteoblastic cells. Int J Cancer 2004;111:693-697
    • (2004) Int J Cancer , vol.111 , pp. 693-697
    • Kapoor, P.1    Saunders, M.M.2    Li, Z.3
  • 57
    • 33645000812 scopus 로고    scopus 로고
    • Bone marrow connexin-43 expression is critical for hematopoietic regeneration after chemotherapy
    • Presley CA, Lee AW, Kastl B, et al. Bone marrow connexin-43 expression is critical for hematopoietic regeneration after chemotherapy. Cell Commun Adhes 2005;12:307-317
    • (2005) Cell Commun Adhes , vol.12 , pp. 307-317
    • Presley, C.A.1    Lee, A.W.2    Kastl, B.3
  • 58
    • 0042914307 scopus 로고    scopus 로고
    • Bone marrow stroma inhibits proliferation and apoptosis in leukemic cells through gap junction-mediated cell communication
    • Paraguassu-Braga FH, Borojevic R, Bouzas LF, et al. Bone marrow stroma inhibits proliferation and apoptosis in leukemic cells through gap junction-mediated cell communication. Cell Death Differ 2003;10:1101-1108
    • (2003) Cell Death Differ , vol.10 , pp. 1101-1108
    • Paraguassu-Braga, F.H.1    Borojevic, R.2    Bouzas, L.F.3
  • 59
    • 0037047365 scopus 로고    scopus 로고
    • Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication
    • Qin H, Shao Q, Curtis H, et al. Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication. J Biol Chem 2002;277:29132-29138
    • (2002) J Biol Chem , vol.277 , pp. 29132-29138
    • Qin, H.1    Shao, Q.2    Curtis, H.3
  • 60
    • 0032533831 scopus 로고    scopus 로고
    • Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43)
    • Huang RP, Fan Y, Hossain MZ, et al. Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43). Cancer Res 1998;58:5089-5096
    • (1998) Cancer Res , vol.58 , pp. 5089-5096
    • Huang, R.P.1    Fan, Y.2    Hossain, M.Z.3
  • 61
    • 0031785706 scopus 로고    scopus 로고
    • Mutated connexin43 proteins inhibit rat glioma cell growth suppression mediated by wild-type connexin43 in a dominant-negative manner
    • Omori Y, Yamasaki H. Mutated connexin43 proteins inhibit rat glioma cell growth suppression mediated by wild-type connexin43 in a dominant-negative manner. Int J Cancer 1998;78:446-453
    • (1998) Int J Cancer , vol.78 , pp. 446-453
    • Omori, Y.1    Yamasaki, H.2
  • 62
    • 0037382614 scopus 로고    scopus 로고
    • Beyond the gap: Functions of unpaired connexon channels
    • Goodenough DA, Paul DL. Beyond the gap: functions of unpaired connexon channels. Nat Rev Mol Cell Biol 2003;4:285-294
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 285-294
    • Goodenough, D.A.1    Paul, D.L.2
  • 63
    • 33745528139 scopus 로고    scopus 로고
    • The gap junction cellular internet: Connexin hemichannels enter the signalling limelight
    • Evans WH, De VE, Leybaert L. The gap junction cellular internet: connexin hemichannels enter the signalling limelight. Biochem J 2006;397:1-14
    • (2006) Biochem J , vol.397 , pp. 1-14
    • Evans, W.H.1    De Ve Leybaert, L.2
  • 64
    • 57649183942 scopus 로고    scopus 로고
    • Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model
    • Decrock E, De VE, Vinken M, et al. Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model. Cell Death Differ 2009;16:151-163
    • (2009) Cell Death Differ , vol.16 , pp. 151-163
    • Decrock, E.1    De Ve Vinken, M.2
  • 65
    • 34250373313 scopus 로고    scopus 로고
    • Cx43 mediates TGF-beta signaling through competitive Smads binding to microtubules
    • Dai P, Nakagami T, Tanaka H, et al. Cx43 mediates TGF-beta signaling through competitive Smads binding to microtubules. Mol Biol Cell 2007;18:2264-2273
    • (2007) Mol Biol Cell , vol.18 , pp. 2264-2273
    • Dai, P.1    Nakagami, T.2    Tanaka, H.3
  • 66
    • 0029819595 scopus 로고    scopus 로고
    • Activation of protein kinase C in human uterine smooth muscle induces connexin-43 gene transcription through an AP-1 site in the promoter sequence
    • Geimonen E, Jiang W, Ali M, et al. Activation of protein kinase C in human uterine smooth muscle induces connexin-43 gene transcription through an AP-1 site in the promoter sequence. J Biol Chem 1996;271:23667-23674
    • (1996) J Biol Chem , vol.271 , pp. 23667-23674
    • Geimonen, E.1    Jiang, W.2    Ali, M.3
  • 67
    • 0037382251 scopus 로고    scopus 로고
    • Unexpected induction of the human connexin 43 promoter by the ras signaling pathway is mediated by a novel putative promoter sequence
    • Carystinos GD, Kandouz M, Alaoui-Jamali MA, Batist G. Unexpected induction of the human connexin 43 promoter by the ras signaling pathway is mediated by a novel putative promoter sequence. Mol Pharmacol 2003;63:821-831
    • (2003) Mol Pharmacol , vol.63 , pp. 821-831
    • Carystinos, G.D.1    Kandouz, M.2    Alaoui-Jamali, M.A.3    Batist, G.4
  • 68
    • 33846239420 scopus 로고    scopus 로고
    • Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells
    • Ammerpohl O, Trauzold A, Schniewind B, et al. Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells. Br J Cancer 2007;96:73-81
    • (2007) Br J Cancer , vol.96 , pp. 73-81
    • Ammerpohl, O.1    Trauzold, A.2    Schniewind, B.3
  • 69
    • 4744370942 scopus 로고    scopus 로고
    • HDACi phenylbutyrate increases bystander killing of HSV-tk transfected glioma cells
    • Ammerpohl O, Thormeyer D, Khan Z, et al. HDACi phenylbutyrate increases bystander killing of HSV-tk transfected glioma cells. Biochem Biophys Res Commun 2004;324:8-14
    • (2004) Biochem Biophys Res Commun , vol.324 , pp. 8-14
    • Ammerpohl, O.1    Thormeyer, D.2    Khan, Z.3
  • 70
    • 33746794230 scopus 로고    scopus 로고
    • A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells
    • Hernandez M, Shao Q, Yang XJ, et al. A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells. Prostate 2006;66:1151-1161
    • (2006) Prostate , vol.66 , pp. 1151-1161
    • Hernandez, M.1    Shao, Q.2    Yang, X.J.3
  • 71
    • 33746771364 scopus 로고    scopus 로고
    • Effects of the histone deacetylases inhibitors sodium butyrate and trichostatin A on the inhibition of gap junctional intercellular communication by
    • Jung JW, Cho SD, Ahn NS, et al. Effects of the histone deacetylases inhibitors sodium butyrate and trichostatin A on the inhibition of gap junctional intercellular communication by. Cancer Lett 2006;241:301-308
    • (2006) Cancer Lett , vol.241 , pp. 301-308
    • Jung, J.W.1    Cho, S.D.2    Ahn, N.S.3
  • 72
    • 41649107484 scopus 로고    scopus 로고
    • 5-Aza-2¢-deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up-regulation of the connexin 32 gene
    • Hagiwara H, Sato H, Ohde Y, et al. 5-Aza-2¢-deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up-regulation of the connexin 32 gene. Br J Pharmacol 2008;153:1373-1381
    • (2008) Br J Pharmacol , vol.153 , pp. 1373-1381
    • Hagiwara, H.1    Sato, H.2    Ohde, Y.3
  • 73
    • 33947492471 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression
    • Gao FH, Wang Q, Wu YL, et al. c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression. Biochem Biophys Res Commun 2007;356:505-511
    • (2007) Biochem Biophys Res Commun , vol.356 , pp. 505-511
    • Gao, F.H.1    Wang, Q.2    Wu, Y.L.3
  • 74
    • 69249096952 scopus 로고    scopus 로고
    • Overexpression of protease-activated receptor-1 contributes to melanoma metastasis via regulation of connexin 43
    • Villares GJ, Dobroff AS, Wang H, et al. Overexpression of protease-activated receptor-1 contributes to melanoma metastasis via regulation of connexin 43. Cancer Res 2009;69:6730-6737
    • (2009) Cancer Res , vol.69 , pp. 6730-6737
    • Villares, G.J.1    Dobroff, A.S.2    Wang, H.3
  • 75
    • 36348968263 scopus 로고    scopus 로고
    • Ubiquitination of gap junction proteins
    • Leithe E, Rivedal E. Ubiquitination of gap junction proteins. J Membr Biol 2007;217:43-51
    • (2007) J Membr Biol , vol.217 , pp. 43-51
    • Leithe, E.1    Rivedal, E.2
  • 76
    • 77949652115 scopus 로고    scopus 로고
    • Gap junctions sensitize cancer cells to proteasome inhibitor MG132-induced apoptosis
    • Huang T, Zhu Y, Fang X, et al. Gap junctions sensitize cancer cells to proteasome inhibitor MG132-induced apoptosis. Cancer Sci 2010;101:713-721
    • (2010) Cancer Sci , vol.101 , pp. 713-721
    • Huang, T.1    Zhu, Y.2    Fang, X.3
  • 77
    • 36048932052 scopus 로고    scopus 로고
    • Phosphorylation of connexin43 induced by Src: Regulation of gap junctional communication between transformed cells
    • Pahujaa M, Anikin M, Goldberg GS. Phosphorylation of connexin43 induced by Src: regulation of gap junctional communication between transformed cells. Exp Cell Res 2007;313:4083-4090
    • (2007) Exp Cell Res , vol.313 , pp. 4083-4090
    • Pahujaa, M.1    Anikin, M.2    Goldberg, G.S.3
  • 78
    • 16244375571 scopus 로고    scopus 로고
    • Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells
    • Nakamura Y, Chang CC, Mori T, et al. Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells. Carcinogenesis 2005;26:665-671
    • (2005) Carcinogenesis , vol.26 , pp. 665-671
    • Nakamura, Y.1    Chang, C.C.2    Mori, T.3
  • 79
    • 0142135067 scopus 로고    scopus 로고
    • Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells
    • Spinella F, Rosano L, Di Castro V, et al. Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells. J Biol Chem 2003;278:41294-41301
    • (2003) J Biol Chem , vol.278 , pp. 41294-41301
    • Spinella, F.1    Rosano, L.2    Di Castro, V.3
  • 80
    • 18144377787 scopus 로고    scopus 로고
    • Restoration of functional gap junctions through internal ribosome entry site-dependent synthesis of endogenous connexins in density-inhibited cancer cells
    • Lahlou H, Fanjul M, Pradayrol L, et al. Restoration of functional gap junctions through internal ribosome entry site-dependent synthesis of endogenous connexins in density-inhibited cancer cells. Mol Cell Biol 2005;25:4034-4045
    • (2005) Mol Cell Biol , vol.25 , pp. 4034-4045
    • Lahlou, H.1    Fanjul, M.2    Pradayrol, L.3
  • 82
    • 33845677227 scopus 로고    scopus 로고
    • MIR-206 regulates connexin43 expression during skeletal muscle development
    • Anderson C, Catoe H, Werner R. MIR-206 regulates connexin43 expression during skeletal muscle development. Nucleic Acids Res 2006;34:5863-5871
    • (2006) Nucleic Acids Res , vol.34 , pp. 5863-5871
    • Anderson, C.1    Catoe, H.2    Werner, R.3
  • 83
    • 34147095310 scopus 로고    scopus 로고
    • The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
    • Yang B, Lin H, Xiao J, et al. The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nat Med 2007;13:486-491
    • (2007) Nat Med , vol.13 , pp. 486-491
    • Yang, B.1    Lin, H.2    Xiao, J.3
  • 84
    • 38349118916 scopus 로고    scopus 로고
    • RNA-binding protein Dnd1 inhibits microRNA access to target mRNA
    • Kedde M, Strasser MJ, Boldajipour B, et al. RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell 2007;131:1273-1286
    • (2007) Cell , vol.131 , pp. 1273-1286
    • Kedde, M.1    Strasser, M.J.2    Boldajipour, B.3
  • 85
    • 28444469246 scopus 로고    scopus 로고
    • Silencing of microRNAs in vivo with 'antagomirs'
    • Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 2005;438:685-689
    • (2005) Nature , vol.438 , pp. 685-689
    • Krutzfeldt, J.1    Rajewsky, N.2    Braich, R.3
  • 86
    • 2942702193 scopus 로고    scopus 로고
    • Connexin43 pseudogene is expressed in tumor cells and inhibits growth
    • Kandouz M, Bier A, Carystinos GD, et al. Connexin43 pseudogene is expressed in tumor cells and inhibits growth. Oncogene 2004;23:4763-4770
    • (2004) Oncogene , vol.23 , pp. 4763-4770
    • Kandouz, M.1    Bier, A.2    Carystinos, G.D.3
  • 87
    • 66449127912 scopus 로고    scopus 로고
    • Connexin43 pseudogene in breast cancer cells offers a novel therapeutic target
    • Bier A, Oviedo-Landaverde I, Zhao J, et al. Connexin43 pseudogene in breast cancer cells offers a novel therapeutic target. Mol Cancer Ther 2009;8:786-793
    • (2009) Mol Cancer Ther , vol.8 , pp. 786-793
    • Bier, A.1    Oviedo-Landaverde, I.2    Zhao, J.3
  • 88
    • 0034097698 scopus 로고    scopus 로고
    • Identification of connexin-interacting proteins: Application of the yeast two-hybrid screen
    • Jin C, Lau AF, Martyn KD. Identification of connexin-interacting proteins: application of the yeast two-hybrid screen. Methods 2000;20:219-231
    • (2000) Methods , vol.20 , pp. 219-231
    • Jin, C.1    Lau, A.F.2    Martyn, K.D.3
  • 89
    • 68649119781 scopus 로고    scopus 로고
    • Connexin 33 impairs gap junction functionality by accelerating connexin 43 gap junction plaque endocytosis
    • Carette D, Gilleron J, Decrouy X, et al. Connexin 33 impairs gap junction functionality by accelerating connexin 43 gap junction plaque endocytosis. Traffic 2009;10:1272-1285
    • (2009) Traffic , vol.10 , pp. 1272-1285
    • Carette, D.1    Gilleron, J.2    Decrouy, X.3
  • 90
    • 67349209224 scopus 로고    scopus 로고
    • The role of the cytoskeleton in the formation of gap junctions by Connexin 30
    • Qu C, Gardner P, Schrijver I. The role of the cytoskeleton in the formation of gap junctions by Connexin 30. Exp Cell Res 2009;315:1683-1692
    • (2009) Exp Cell Res , vol.315 , pp. 1683-1692
    • Qu, C.1    Gardner, P.2    Schrijver, I.3
  • 91
    • 68849123924 scopus 로고    scopus 로고
    • Enhanced effect of connexin 43 on cisplatin-induced cytotoxicity in mesothelioma cells
    • Sato H, Iwata H, Takano Y, et al. Enhanced effect of connexin 43 on cisplatin-induced cytotoxicity in mesothelioma cells. J Pharmacol Sci 2009;110:466-475
    • (2009) J Pharmacol Sci , vol.110 , pp. 466-475
    • Sato, H.1    Iwata, H.2    Takano, Y.3
  • 92
    • 34447288748 scopus 로고    scopus 로고
    • Non-viral delivery of the connexin 43 gene with histone deacetylase inhibitor to human nasopharyngeal tumor cells enhances gene expression and inhibits in vivo tumor growth
    • Hattori Y, Fukushima M, Maitani Y. Non-viral delivery of the connexin 43 gene with histone deacetylase inhibitor to human nasopharyngeal tumor cells enhances gene expression and inhibits in vivo tumor growth. Int J Oncol 2007;30:1427-1439
    • (2007) Int J Oncol , vol.30 , pp. 1427-1439
    • Hattori, Y.1    Fukushima, M.2    Maitani, Y.3
  • 93
    • 34250678986 scopus 로고    scopus 로고
    • Enhancing effect of connexin 32 gene on vinorelbine-induced cytotoxicity in A549 lung adenocarcinoma cells
    • Sato H, Fukumoto K, Hada S, et al. Enhancing effect of connexin 32 gene on vinorelbine-induced cytotoxicity in A549 lung adenocarcinoma cells. Cancer Chemother Pharmacol 2007;60:449-457
    • (2007) Cancer Chemother Pharmacol , vol.60 , pp. 449-457
    • Sato, H.1    Fukumoto, K.2    Hada, S.3
  • 94
    • 0035693396 scopus 로고    scopus 로고
    • Connexin 26 gene therapy of human bladder cancer: Induction of growth suppression, apoptosis, and synergy with Cisplatin
    • Tanaka M, Grossman HB. Connexin 26 gene therapy of human bladder cancer: induction of growth suppression, apoptosis, and synergy with Cisplatin. Hum Gene Ther 2001;12:2225-2236
    • (2001) Hum Gene Ther , vol.12 , pp. 2225-2236
    • Tanaka, M.1    Grossman, H.B.2
  • 95
    • 3242816322 scopus 로고    scopus 로고
    • Connexin 26 induces growth suppression, apoptosis and increased efficacy of doxorubicin in prostate cancer cells
    • Tanaka M, Grossman HB. Connexin 26 induces growth suppression, apoptosis and increased efficacy of doxorubicin in prostate cancer cells. Oncol Rep 2004;11:537-541
    • (2004) Oncol Rep , vol.11 , pp. 537-541
    • Tanaka, M.1    Grossman, H.B.2
  • 96
    • 27644547807 scopus 로고    scopus 로고
    • Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration
    • Thomas T, Jordan K, Simek J, et al. Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration. J Cell Sci 2005;118:4451-4462
    • (2005) J Cell Sci , vol.118 , pp. 4451-4462
    • Thomas, T.1    Jordan, K.2    Simek, J.3
  • 97
    • 33846817049 scopus 로고    scopus 로고
    • Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process
    • Piehl M, Lehmann C, Gumpert A, et al. Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process. Mol Biol Cell 2007;18:337-347
    • (2007) Mol Biol Cell , vol.18 , pp. 337-347
    • Piehl, M.1    Lehmann, C.2    Gumpert, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.