GYY4137, a novel hydrogen sulfide-releasing molecule, likely protects against high glucose-induced cytotoxicity by activation of the AMPK/mTOR signal pathway in H9c2 cells

Molecular and Cellular Biochemistry

Volumn 389, Issue 1-2, 2014, Pages 249-256

  Wei, Wen Bin ^a   Hu, Xun ^b   Zhuang, Xiao Dong ^b   Liao, Li Zhen ^c   Li, Wei Dong ^c  

^a the Fourth Hospital   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

AMPK mTOR; Diabetic cardiomyopathy; GYY4137; High glucose; Hydrogen sulfide

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENYLATE KINASE; CARDIOVASCULAR AGENT; GLUCOSE; GYY 4137; HYDROGEN SULFIDE; LACTATE DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; UNCLASSIFIED DRUG; VIDARABINE;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DIABETIC CARDIOMYOPATHY; DRUG EFFECT; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HEART PROTECTION; HYPERGLYCEMIA; IN VITRO STUDY; INCUBATION TIME; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; RAT;

ARA;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CARDIOTONIC AGENTS; CELL LINE; CELL SURVIVAL; CYTOPROTECTION; GLUCOSE; HYDROGEN SULFIDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MORPHOLINES; MYOCYTES, CARDIAC; ORGANOTHIOPHOSPHORUS COMPOUNDS; PHOSPHORYLATION; PROTECTIVE AGENTS; RATS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84896543525     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1946-6     Document Type: Article

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