Simultaneous quantification of methylene blue and its major metabolite, azure B, in plasma by LC-MS/MS and its application for a pharmacokinetic study

Biomedical Chromatography

Volumn 28, Issue 4, 2014, Pages 518-524

  Kim, Soo Jin ^a   Ha, Dong Jin ^a   Koo, Tae Sung ^b  

^a SK Biopharmaceuticals Co   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

Azure B; LC MS MS; Methylene blue; Pharmacokinetics; Rat plasma

Indexed keywords

AROMATIC COMPOUNDS; BODY FLUIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; RATS; WATER INJECTION;

AZURE B; ITS APPLICATIONS; LC-MS-MS; LC.MS/MS; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; METHYLENE BLUE; PHARMACOKINETIC STUDIES; RAT PLASMA; SENSITIVE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; SIMPLE++;

PHARMACOKINETICS;

ACETONITRILE; AMMONIUM ACETATE; AZURE B; METHANOL; METHYLENE BLUE; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; COLUMN CHROMATOGRAPHY; DRUG HALF LIFE; ELECTROSPRAY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; IONIZATION; MALE; MAXIMUM PLASMA CONCENTRATION; MEASUREMENT ACCURACY; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRECIPITATION; RAT; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

RATTUS;

AZURE B; LC/MS/MS; METHYLENE BLUE; PHARMACOKINETICS; RAT PLASMA;

ADMINISTRATION, ORAL; ANIMALS; AZURE STAINS; BLOOD CHEMICAL ANALYSIS; CHROMATOGRAPHY, LIQUID; LINEAR MODELS; MALE; METHYLENE BLUE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84896542337     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3063     Document Type: Article

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