Determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine and B6C3F1 mouse urine

Journal of Analytical Toxicology

Volumn 29, Issue 1, 2005, Pages 28-33

  Gaudette, Norman F ^a   Lodge, Jon W ^a  

^a RTI INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZURE B; LEUCOMETHYLENE BLUE; METHYLENE BLUE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CALIBRATION; CONTROLLED STUDY; DEMETHYLATION; DRUG TRANSFORMATION; DRUG URINE LEVEL; FEMALE; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MOUSE; NONHUMAN; RAT; REPRODUCIBILITY; TOXICOKINETICS; VALIDATION PROCESS;

ANIMALIA; RODENTIA;

EID: 12344304237     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/29.1.28     Document Type: Article

References (14)

1. A.R. DiSanto and J.G. Wagner. Pharmacokinetics of highly ionized drugs I: methylene blue whole blood, urine, and tissue analysis. J. Pharm. Sci. 61(4): 598-602 (1972).
2. S. Brownstein, A.D. Liszaur, and W.B. Jackson. Ocular complications of a topical methylene blue-vasoconstrictor-anesthetic preparation. Can. J. Ophthalmol. 24(7): 317-324 (1989).
3. K.T. Chung, G.E. Fulk, and A.W. Andrews. Mutagenicity testing of some commonly used dyes. Appl. Envir. Microbiol. 42(4): 641-648 (1981).
4. C.C. Coddington, T.L. Anderson, C.R. Accetta, J. Swanson, T. Kruger, and G.D. Hodgen. Adverse effects of methylene blue on human sperm motility, components of human reproductive tract fluids, and mouse embryo cleavage. Fertil. Steril. 51(3): 480-485 (1989).
5. B. Gutter, W.T. Speck, and H.S. Rosencranz. A study of the photoinduced mutagenicity of methylene blue. Mut. Res. 44: 177-182 (1977).
6. J.K. McEnerney and L.N. McEnerney. Unfavorable neonatal outcome after intraamniotic injection of methylene blue. Obstet. Cynecol. 61(3suppl): 35S-37S (1983).
7. P.J. Poppers, A.R. Mastri, M.L. LeBeaux, and B.G. Covino. The effects of methylene blue on neural tissue. Anesthesiology 33(3): 336-340 (1970).
8. N. Sharon, G. Puente, and L.B. Cohen. Phenazopyridine pyridium poisoning: possible toxicity of methylene blue administration in renal failure. Mt. Sinai J. Med. 53(4): 280-282 (1986).
9. M.M. Sharr, R.O. Weller, and J.G. Brice. Spinal cord necrosis after intrathecal injection of methylene blue. J. Neurol. Neurosurg. Psychiatry 41 (4): 384-386 (1978).
10. A.R. DiSanto and J.C. Wagner. Pharmacokinetics of highly ionized drugs II: methylene blue absorption, metabolism, and excretion in man and dog after oral administration. J. Pharm. Sci. 61(7): 1086-1089 (1972).
11. N. Belaz-David, L.A. Decosterd, M. Appenzeller, Y.A. Ruetsch, R. Chiolero, T. Buclin, and J. Biollaz. Spectrometric determination of methylene blue in biological fluids after ion-pair extraction and evidence of its absorption on plastic polymers. Eur. J. Pharm. Sci. 5(6): 335-345 (1997).
12. J. Watanabe and R. Fujita. Elimination of methylene blue in dogs after oral or intravenous administration. Chem. Pharm. Bull. 25(10): 2561-2567 (1977).
13. C. Burrows. Methylene blue: effects and disposition in sheep. J. Vet. Pharmacol. Ther. 7(3): 225-231 (1984).
14. S.J. Gulp, L.R. Blankenship, D.F. Kusewitt, D.R. Doerge, L.T. Milligan, and F.A. Beland. Toxicity and metabolism of malachite green and leucomalachite green during short-term feeding to Fischer 344 rats and B6C3F1 mice. Chem. Biol. Interact. 122: 153-170 (1999).