Macromolecular bipill of gemcitabine and methotrexate facilitates tumor-specific dual drug therapy with higher benefit-to-risk ratio

Bioconjugate Chemistry

Volumn 25, Issue 3, 2014, Pages 501-509

  Das, Manasmita ^a   Jain, Roopal ^a   Agrawal, Ashish Kumar ^a   Thanki, Kaushik ^a   Jain, Sanyog ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CYTOTOXICITY; DRUG INTERACTIONS; PLASMA STABILITY; RATS; TUMORS;

ANTI-CANCER AGENTS; BIOLOGICAL EVALUATION; DRUG MOLECULES; GEMCITABINE; IN-VITRO; LONG CIRCULATING; PEG SPACERS; SYNTHESIS EVALUATION; SYNTHESISED; VITRO CYTOTOXICITIES;

POLYETHYLENE GLYCOLS;

CYTOTOXIC AGENT; GEMCITABINE; MACROGOL; METHOTREXATE; PEGYLATED GEMCITABINE METHOTREXATE; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIMETABOLITE; DEOXYCYTIDINE; MACROGOL DERIVATIVE; MACROMOLECULE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL STRAIN MCF 7; CONTROLLED STUDY; COVALENT BOND; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG FORMULATION; DRUG POTENTIATION; DRUG SOLUBILITY; DRUG SPECIFICITY; DRUG STABILITY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER TOXICITY; MACROMOLECULAR BIPILL; NEPHROTOXICITY; NONHUMAN; PILL; RAT; RISK BENEFIT ANALYSIS; TARGET ORGAN; ANALOGS AND DERIVATIVES; ANIMAL; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; KIDNEY; LIVER; MACROMOLECULE; MAMMARY NEOPLASMS, EXPERIMENTAL; MCF 7 CELL LINE; METABOLISM; MOUSE; PATHOLOGY; PHARMACOLOGY; RISK FACTOR; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CELL PROLIFERATION; CELL SURVIVAL; DEOXYCYTIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; KIDNEY; LIVER; MACROMOLECULAR SUBSTANCES; MAMMARY NEOPLASMS, EXPERIMENTAL; MCF-7 CELLS; METHOTREXATE; MICE; MOLECULAR STRUCTURE; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; RISK FACTORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84896529615     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc400477q     Document Type: Article

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