메뉴 건너뛰기




Volumn 9, Issue 2, 2014, Pages

NAC, tiron and trolox impair survival of cell cultures containing glioblastoma tumorigenic initiating cells by inhibition of cell cycle progression massimiliano monticone1

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; GEFITINIB; REACTIVE OXYGEN METABOLITE; TIRON; TROLOX C; VEMURAFENIB;

EID: 84896525100     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090085     Document Type: Article
Times cited : (24)

References (61)
  • 1
    • 0020427486 scopus 로고
    • Biology of disease. Free radicals and tissue injury
    • Freeman BA, Crapo JD (1982) Biology of disease: free radicals and tissue injury. Lab Invest 47: 412-426. (Pubitemid 13229679)
    • (1982) Laboratory Investigation , vol.47 , Issue.5 , pp. 412-426
    • Freeman, B.A.1    Crapo, J.D.2
  • 2
    • 25844520458 scopus 로고    scopus 로고
    • Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism
    • DOI 10.1016/j.biocel.2005.05.013, PII S1357272505001998
    • Jezek P, Hlavata L (2005) Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism. Int J Biochem Cell Biol 37: 2478-2503. (Pubitemid 41400319)
    • (2005) International Journal of Biochemistry and Cell Biology , vol.37 , Issue.12 , pp. 2478-2503
    • Jezek, P.1    Hlavata, L.2
  • 4
    • 84859897794 scopus 로고    scopus 로고
    • Regulation of reactive oxygen species generation in cell signaling
    • Bae YS, Oh H, Rhee SG, Yoo YD (2011) Regulation of reactive oxygen species generation in cell signaling. Mol Cells 32: 491-509.
    • (2011) Mol Cells , vol.32 , pp. 491-509
    • Bae, Y.S.1    Oh, H.2    Rhee, S.G.3    Yoo, Y.D.4
  • 6
    • 77950365197 scopus 로고    scopus 로고
    • Reactive oxygen species mediate mitogenic growth factor signaling pathways in human leiomyoma smooth muscle cells
    • Mesquita FS, Dyer SN, Heinrich DA, Bulun SE, Marsh EE, et al. (2010) Reactive oxygen species mediate mitogenic growth factor signaling pathways in human leiomyoma smooth muscle cells. Biol Reprod 82: 341-351.
    • (2010) Biol Reprod , vol.82 , pp. 341-351
    • Mesquita, F.S.1    Dyer, S.N.2    Heinrich, D.A.3    Bulun, S.E.4    Marsh, E.E.5
  • 7
    • 0028973482 scopus 로고
    • Requirement for generation of H2O2 for platelet-derived growth factor signal transduction
    • Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T (1995) Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270: 296-299.
    • (1995) Science , vol.270 , pp. 296-299
    • Sundaresan, M.1    Yu, Z.X.2    Ferrans, V.J.3    Irani, K.4    Finkel, T.5
  • 8
    • 0033813282 scopus 로고    scopus 로고
    • Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: Dual regulation by reactive oxygen species
    • Deshpande SS, Angkeow P, Huang J, Ozaki M, Irani K (2000) Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species. FASEB J 14: 1705-1714.
    • (2000) FASEB J , vol.14 , pp. 1705-1714
    • Deshpande, S.S.1    Angkeow, P.2    Huang, J.3    Ozaki, M.4    Irani, K.5
  • 10
    • 60749137151 scopus 로고    scopus 로고
    • NADPH oxidase-dependent signaling in endothelial cells: Role in physiology and pathophysiology
    • Frey RS, Ushio-Fukai M, Malik AB (2009) NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiology. Antioxid Redox Signal 11: 791-810.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 791-810
    • Frey, R.S.1    Ushio-Fukai, M.2    Malik, A.B.3
  • 12
    • 0034190327 scopus 로고    scopus 로고
    • Oxidative stress and cell cycle checkpoint function
    • DOI 10.1016/S0891-5849(00)00224-0, PII S0891584900002240
    • Shackelford RE, Kaufmann WK, Paules RS (2000) Oxidative stress and cell cycle checkpoint function. Free Radic Biol Med 28: 1387-1404. (Pubitemid 30621482)
    • (2000) Free Radical Biology and Medicine , vol.28 , Issue.9 , pp. 1387-1404
    • Shackelford, R.E.1    Kaufmann, W.K.2    Paules, R.S.3
  • 14
    • 0026021362 scopus 로고
    • Production of large amounts of hydrogen peroxide by human tumor cells
    • Szatrowski TP, Nathan CF (1991) Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 51: 794-798.
    • (1991) Cancer Res , vol.51 , pp. 794-798
    • Szatrowski, T.P.1    Nathan, C.F.2
  • 15
    • 59849084800 scopus 로고    scopus 로고
    • Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation
    • Aykin-Burns N, Ahmad IM, Zhu Y, Oberley LW, Spitz DR (2009) Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation. Biochem J 418: 29-37.
    • (2009) Biochem J , vol.418 , pp. 29-37
    • Aykin-Burns, N.1    Ahmad, I.M.2    Zhu, Y.3    Oberley, L.W.4    Spitz, D.R.5
  • 16
    • 33744828248 scopus 로고    scopus 로고
    • Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes
    • DOI 10.1158/1541-7786.MCR-05-0061
    • Jelluma N, Yang X, Stokoe D, Evan GI, Dansen TB, et al. (2006) Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes. Mol Cancer Res 4: 319-330. (Pubitemid 43837333)
    • (2006) Molecular Cancer Research , vol.4 , Issue.5 , pp. 319-330
    • Jelluma, N.1    Yang, X.2    Stokoe, D.3    Evan, G.I.4    Dansen, T.B.5    Haas-Kogan, D.A.6
  • 18
    • 0032101138 scopus 로고    scopus 로고
    • Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells
    • Chinery R, Beauchamp RD, Shyr Y, Kirkland SC, Coffey RJ, et al. (1998) Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells. Cancer Res 58: 2323-2327. (Pubitemid 28252686)
    • (1998) Cancer Research , vol.58 , Issue.11 , pp. 2323-2327
    • Chinery, R.1    Beauchamp, R.D.2    Shyr, Y.3    Kirkland, S.C.4    Coffey, R.J.5    Morrow, J.D.6
  • 20
    • 84861407512 scopus 로고    scopus 로고
    • Antioxidant alpha-tocopherol checks lymphoma promotion via regulation of expression of protein kinase C-alpha and c-Myc genes and glycolytic metabolism
    • Sharma R, Vinayak M (2012) Antioxidant alpha-tocopherol checks lymphoma promotion via regulation of expression of protein kinase C-alpha and c-Myc genes and glycolytic metabolism. Leuk Lymphoma 53: 1203-1210.
    • (2012) Leuk Lymphoma , vol.53 , pp. 1203-1210
    • Sharma, R.1    Vinayak, M.2
  • 21
    • 33645243020 scopus 로고    scopus 로고
    • Prostate cancer prevention through pomegranate fruit
    • Malik A, Mukhtar H (2006) Prostate cancer prevention through pomegranate fruit. Cell Cycle 5: 371-373.
    • (2006) Cell Cycle , vol.5 , pp. 371-373
    • Malik, A.1    Mukhtar, H.2
  • 22
    • 84859864623 scopus 로고    scopus 로고
    • Upsides and downsides of reactive oxygen species for cancer: The roles of reactive oxygen species in tumorigenesis, prevention, and therapy
    • Gupta SC, Hevia D, Patchva S, Park B, Koh W, et al. (2012) Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy. Antioxid Redox Signal 16: 1295-1322.
    • (2012) Antioxid Redox Signal , vol.16 , pp. 1295-1322
    • Gupta, S.C.1    Hevia, D.2    Patchva, S.3    Park, B.4    Koh, W.5
  • 24
    • 84878862679 scopus 로고    scopus 로고
    • Antioxidants: Friends or foe in prevention or treatment of cancer: The debate of the century
    • Saeidnia S, Abdollahi M (2013) Antioxidants: Friends or foe in prevention or treatment of cancer: The debate of the century. Toxicol Appl Pharmacol.
    • (2013) Toxicol Appl Pharmacol
    • Saeidnia, S.1    Abdollahi, M.2
  • 25
    • 84875181661 scopus 로고    scopus 로고
    • Oxidants, antioxidants and the current incurability of metastatic cancers
    • Watson J (2013) Oxidants, antioxidants and the current incurability of metastatic cancers. Open Biol 3: 120144.
    • (2013) Open Biol , vol.3 , pp. 120144
    • Watson, J.1
  • 26
    • 80053954605 scopus 로고    scopus 로고
    • Vitamin e and the risk of prostate cancer: The Selenium and Vitamin e Cancer Prevention Trial (SELECT)
    • Klein EA, Thompson IM, Jr., Tangen CM, Crowley JJ, Lucia MS, et al. (2011) Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 306: 1549-1556.
    • (2011) JAMA , vol.306 , pp. 1549-1556
    • Klein, E.A.1    Thompson Jr., I.M.2    Tangen, C.M.3    Crowley, J.J.4    Lucia, M.S.5
  • 27
    • 84867542182 scopus 로고    scopus 로고
    • Antioxidant treatment promotes prostate epithelial proliferation in Nkx3.1 mutant mice
    • Martinez EE, Anderson PD, Logan M, Abdulkadir SA (2012) Antioxidant treatment promotes prostate epithelial proliferation in Nkx3.1 mutant mice. PLoS One 7: e46792.
    • (2012) PLoS One , vol.7
    • Martinez, E.E.1    Anderson, P.D.2    Logan, M.3    Abdulkadir, S.A.4
  • 28
    • 84861903788 scopus 로고    scopus 로고
    • N-Acetylcysteine mucolysis in the management of chronic obstructive pulmonary disease
    • Sadowska AM (2012) N-Acetylcysteine mucolysis in the management of chronic obstructive pulmonary disease. Ther Adv Respir Dis 6: 127-135.
    • (2012) Ther Adv Respir Dis , vol.6 , pp. 127-135
    • Sadowska, A.M.1
  • 29
    • 0022462274 scopus 로고
    • Acetyl-homocysteine-thiolactone-induced increase of superoxide dismutase counteracts the effect of subdiabetogenic doses of streptozocin
    • Papaccio G, Pisanti FA, Frascatore S (1986) Acetyl-homocysteine- thiolactoneinduced increase of superoxide dismutase counteracts the effect of subdiabetogenic doses of streptozocin. Diabetes 35: 470-474. (Pubitemid 16078461)
    • (1986) Diabetes , vol.35 , Issue.4 , pp. 470-474
    • Papaccio, G.1    Pisanti, F.A.2    Frascatore, S.3
  • 31
    • 0026576564 scopus 로고
    • The catecholic metal sequestering agent 1,2-dihydroxybenzene-3,5- disulfonate confers protection against oxidative cell damage
    • Krishna CM, Liebmann JE, Kaufman D, DeGraff W, Hahn SM, et al. (1992) The catecholic metal sequestering agent 1,2-dihydroxybenzene-3,5-disulfonate confers protection against oxidative cell damage. Arch Biochem Biophys 294: 98-106.
    • (1992) Arch Biochem Biophys , vol.294 , pp. 98-106
    • Krishna, C.M.1    Liebmann, J.E.2    Kaufman, D.3    Degraff, W.4    Hahn, S.M.5
  • 32
    • 84865054553 scopus 로고    scopus 로고
    • Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells
    • Monticone M, Daga A, Candiani S, Romeo F, Mirisola V, et al. (2012) Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells. BMC Cancer 12: 358.
    • (2012) BMC Cancer , vol.12 , pp. 358
    • Monticone, M.1    Daga, A.2    Candiani, S.3    Romeo, F.4    Mirisola, V.5
  • 33
    • 59849125142 scopus 로고    scopus 로고
    • SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity
    • Gangemi RM, Griffero F, Marubbi D, Perera M, Capra MC, et al. (2009) SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity. Stem Cells 27: 40-48.
    • (2009) Stem Cells , vol.27 , pp. 40-48
    • Gangemi, R.M.1    Griffero, F.2    Marubbi, D.3    Perera, M.4    Capra, M.C.5
  • 34
    • 65449177238 scopus 로고    scopus 로고
    • NK cells recognize and kill human glioblastoma cells with stem cell-like properties
    • Castriconi R, Daga A, Dondero A, Zona G, Poliani PL, et al. (2009) NK cells recognize and kill human glioblastoma cells with stem cell-like properties. J Immunol 182: 3530-3539.
    • (2009) J Immunol , vol.182 , pp. 3530-3539
    • Castriconi, R.1    Daga, A.2    Dondero, A.3    Zona, G.4    Poliani, P.L.5
  • 35
    • 0025971498 scopus 로고
    • Lack of HLA class i antigen expression by cultured melanoma cells FO-1 due to a defect in B2m gene expression
    • D'Urso CM, Wang ZG, Cao Y, Tatake R, Zeff RA, et al. (1991) Lack of HLA class I antigen expression by cultured melanoma cells FO-1 due to a defect in B2m gene expression. J Clin Invest 87: 284-292.
    • (1991) J Clin Invest , vol.87 , pp. 284-292
    • D'urso, C.M.1    Wang, Z.G.2    Cao, Y.3    Tatake, R.4    Zeff, R.A.5
  • 36
    • 67649864077 scopus 로고    scopus 로고
    • Natural killer cells kill human melanoma cells with characteristics of cancer stem cells
    • Pietra G, Manzini C, Vitale M, Balsamo M, Ognio E, et al. (2009) Natural killer cells kill human melanoma cells with characteristics of cancer stem cells. Int Immunol 21: 793-801.
    • (2009) Int Immunol , vol.21 , pp. 793-801
    • Pietra, G.1    Manzini, C.2    Vitale, M.3    Balsamo, M.4    Ognio, E.5
  • 37
    • 77649294054 scopus 로고    scopus 로고
    • In vitro and in vivo characterization of highly purified human mesothelioma derived cells
    • Melotti A, Daga A, Marubbi D, Zunino A, Mutti L, et al. (2010) In vitro and in vivo characterization of highly purified human mesothelioma derived cells. BMC Cancer 10: 54.
    • (2010) BMC Cancer , vol.10 , pp. 54
    • Melotti, A.1    Daga, A.2    Marubbi, D.3    Zunino, A.4    Mutti, L.5
  • 38
    • 77249119762 scopus 로고    scopus 로고
    • The landscape of somatic copy-number alteration across human cancers
    • Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, et al. (2010) The landscape of somatic copy-number alteration across human cancers. Nature 463: 899-905.
    • (2010) Nature , vol.463 , pp. 899-905
    • Beroukhim, R.1    Mermel, C.H.2    Porter, D.3    Wei, G.4    Raychaudhuri, S.5
  • 40
    • 77954901691 scopus 로고    scopus 로고
    • Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cells
    • Cassano S, Agnese S, D'Amato V, Papale M, Garbi C, et al. (2010) Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cells. J Biol Chem 285: 24141-24153.
    • (2010) J Biol Chem , vol.285 , pp. 24141-24153
    • Cassano, S.1    Agnese, S.2    D'amato, V.3    Papale, M.4    Garbi, C.5
  • 43
    • 0028693143 scopus 로고
    • High-resolution analysis of nuclear DNA employing the fluorochrome DAPI
    • Otto FJ (1994) High-resolution analysis of nuclear DNA employing the fluorochrome DAPI. Methods Cell Biol 41: 211-217.
    • (1994) Methods Cell Biol , vol.41 , pp. 211-217
    • Otto, F.J.1
  • 44
    • 0022185452 scopus 로고
    • Cytochemistry for bromodeoxyuridine/DNA analysis: Stoichiometry and sensitivity
    • Dolbeare F, Beisker W, Pallavicini MG, Vanderlaan M, Gray JW (1985) Cytochemistry for bromodeoxyuridine/DNA analysis: stoichiometry and sensitivity. Cytometry 6: 521-530. (Pubitemid 16257682)
    • (1985) Cytometry , vol.6 , Issue.6 , pp. 521-530
    • Dolbeare, F.1    Beisker, W.2    Pallavicini, M.G.3
  • 45
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da W, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57.
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • Huang Da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 46
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • Huang da W, Sherman BT, Lempicki RA (2009) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37: 1-13.
    • (2009) Nucleic Acids Res , vol.37 , pp. 1-13
    • Huang Da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 47
    • 72449168031 scopus 로고    scopus 로고
    • Z-Leucinylleucinyl-norleucinal induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response
    • Monticone M, Biollo E, Fabiano A, Fabbi M, Daga A, et al. (2009) z-Leucinylleucinyl-norleucinal induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response. Mol Cancer Res 7: 1822-1834.
    • (2009) Mol Cancer Res , vol.7 , pp. 1822-1834
    • Monticone, M.1    Biollo, E.2    Fabiano, A.3    Fabbi, M.4    Daga, A.5
  • 48
    • 0032823875 scopus 로고    scopus 로고
    • 1 prolongation by the chemopreventive agent N-acetylcysteine
    • DOI 10.1093/carcin/20.9.1869
    • Liu M, Wikonkal NM, Brash DE (1999) Induction of cyclin-dependent kinase inhibitors and G(1) prolongation by the chemopreventive agent N-acetylcysteine. Carcinogenesis 20: 1869-1872. (Pubitemid 29410570)
    • (1999) Carcinogenesis , vol.20 , Issue.9 , pp. 1869-1872
    • Liu, M.1    Wikonkal, N.M.2    Brash, D.E.3
  • 49
    • 33644620740 scopus 로고    scopus 로고
    • NO restores HIF-1alpha hydroxylation during hypoxia: Role of reactive oxygen species
    • Callapina M, Zhou J, Schmid T, Kohl R, Brune B (2005) NO restores HIF-1alpha hydroxylation during hypoxia: role of reactive oxygen species. Free Radic Biol Med 39: 925-936.
    • (2005) Free Radic Biol Med , vol.39 , pp. 925-936
    • Callapina, M.1    Zhou, J.2    Schmid, T.3    Kohl, R.4    Brune, B.5
  • 50
    • 0032522798 scopus 로고    scopus 로고
    • Antioxidant action via p53-mediated apoptosis
    • Liu M, Pelling JC, Ju J, Chu E, Brash DE (1998) Antioxidant action via p53-mediated apoptosis. Cancer Res 58: 1723-1729. (Pubitemid 28215100)
    • (1998) Cancer Research , vol.58 , Issue.8 , pp. 1723-1729
    • Liu, M.1    Pelling, J.C.2    Ju, J.3    Chu, E.4    Brash, D.E.5
  • 51
    • 0033287224 scopus 로고    scopus 로고
    • P53-independent inhibition of proliferation and p21(WAF1/Cip1)-modulated induction of cell death by the antioxidants N-acetylcysteine and vitamin e
    • Nargi JL, Ratan RR, Griffin DE (1999) p53-independent inhibition of proliferation and p21(WAF1/Cip1)-modulated induction of cell death by the antioxidants N-acetylcysteine and vitamin E. Neoplasia 1: 544-556.
    • (1999) Neoplasia , vol.1 , pp. 544-556
    • Nargi, J.L.1    Ratan, R.R.2    Griffin, D.E.3
  • 55
    • 0023372129 scopus 로고
    • An improved method for the immunocytochemical detection of bromodeoxyuridine labeled nuclei using flow cytometry
    • Schutte B, Reynders MM, van Assche CL, Hupperets PS, Bosman FT, et al. (1987) An improved method for the immunocytochemical detection of bromodeoxyuridine labeled nuclei using flow cytometry. Cytometry 8: 372-376.
    • (1987) Cytometry , vol.8 , pp. 372-376
    • Schutte, B.1    Reynders, M.M.2    Van Assche, C.L.3    Hupperets, P.S.4    Bosman, F.T.5
  • 57
    • 0022215656 scopus 로고
    • The labelling index of human and mouse tumours assessed by bromodeoxyuridine staining in vitro and in vivo and flow cytometry
    • Wilson GD, McNally NJ, Dunphy E, Karcher H, Pfragner R (1985) The labelling index of human and mouse tumours assessed by bromodeoxyuridine staining in vitro and in vivo and flow cytometry. Cytometry 6: 641-647. (Pubitemid 16257697)
    • (1985) Cytometry , vol.6 , Issue.6 , pp. 641-647
    • Wilson, G.D.1    McNally, N.J.2    Dunphy, E.3
  • 58
    • 0027514419 scopus 로고
    • Induction of quiescent S-phase cells by irradiation and/or hyperthermia. II. Correlation with colony forming ability
    • Zolzer F, Streffer C, Pelzer T (1993) Induction of quiescent S-phase cells by irradiation and/or hyperthermia. II. Correlation with colony forming ability. Int J Radiat Biol 63: 77-82. (Pubitemid 23025133)
    • (1993) International Journal of Radiation Biology , vol.63 , Issue.1 , pp. 77-82
    • Zolzer, F.1    Streffer, C.2    Pelzer, T.3
  • 60
    • 78751535908 scopus 로고    scopus 로고
    • Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through downregulation of E2A-p21 by HIF-TWIST
    • Tsai CC, Chen YJ, Yew TL, Chen LL, Wang JY, et al. (2011) Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through downregulation of E2A-p21 by HIF-TWIST. Blood 117: 459-469.
    • (2011) Blood , vol.117 , pp. 459-469
    • Tsai, C.C.1    Chen, Y.J.2    Yew, T.L.3    Chen, L.L.4    Wang, J.Y.5
  • 61
    • 33646544066 scopus 로고    scopus 로고
    • Effects of Tiron, 4,5-dihydroxy-1,3-benzene disulfonic acid, on human promyelotic HL-60 leukemia cell differentiation and death
    • DOI 10.1016/j.tox.2006.03.004, PII S0300483X06001521
    • Kim JS, Cho EW, Chung HW, Kim IG (2006) Effects of Tiron, 4,5-dihydroxy-1,3-benzene disulfonic acid, on human promyelotic HL-60 leukemia cell differentiation and death. Toxicology 223: 36-45. (Pubitemid 43728617)
    • (2006) Toxicology , vol.223 , Issue.1-2 , pp. 36-45
    • Kim, J.S.1    Cho, E.W.2    Chung, H.W.3    Kim, I.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.