Antioxidant α-tocopherol checks lymphoma promotion via regulation of expression of protein kinase C-α and c-Myc genes and glycolytic metabolism

Leukemia and Lymphoma

Volumn 53, Issue 6, 2012, Pages 1203-1210

  Sharma, Renu ^a   Vinayak, Manjula ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

Tocopherol; C Myc; LDH A; Lymphoma; PKC

Indexed keywords

ALPHA TOCOPHEROL; LACTATE DEHYDROGENASE; PROTEIN KINASE C ALPHA; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; GLYCOLYSIS; LYMPHOMA; MALE; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALPHA-TOCOPHEROL; ANIMALS; ANTIOXIDANTS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MYC; GLYCOLYSIS; ISOENZYMES; L-LACTATE DEHYDROGENASE; LYMPHOMA; MALE; MICE; MICE, INBRED AKR; PROTEIN KINASE C-ALPHA;

EID: 84861407512     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2011.637213     Document Type: Article

References (43)

1. Burdon RH. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Rad Biol Med 1995;18:775-794.
2. Dorward A, Sweet S, Moorehead R, et al. Mitochondrial contributions to cancer cell physiology: redox balance, cell cycle, and drug resistance. J Bioenerget Biomemb 1997;29:385-392. (Pubitemid 27498418)
3. Bauer G. Signaling and proapoptotic functions of transformed cellderived reactive oxygen species. Prostaglandins Leukot Essent Fatty Acids 2002;66:41-56. (Pubitemid 34717687)
4. Behrend L, Henderson G, Zwacka RM. Reactive oxygen species in oncogenic transformation. Biochem Soc Trans 2003;31:1441-1444. (Pubitemid 38030996)
5. Kamata H, Honda S, Maeda S, et al. Reactive oxygen species promote TNF- induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005;120:649-661. (Pubitemid 40343077)
6. Gopalkrishna R, Jaken S. Protein kinase C signalling and oxidative stress. Free Rad Biol Med 2000;28:1349-1361. (Pubitemid 30621479)
7. Martindale JL, Holbrook NJ. Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 2002;192:1-15. (Pubitemid 34587382)
8. Wang XW, Hussain SP, Huo T, et al. Molecular pathogenesis of human hepatocellular carcinoma. Toxicology 2002;181:43-47. (Pubitemid 36015671)
9. Harris SL, Levine AJ. The p53 pathway: positive and negative feedback loops. Oncogene 2005;24:2899-2908. (Pubitemid 40638098)
10. Vasavi H, Th angaraju M, Sachdanandam R. Effect of α?-tocopherol on lipid peroxidation and antioxidant system in fi brosarcoma bearing rats. Mol Cell Biochem 1994;131:125-129.
11. Urano S, Yano K, Matsuo M. Membrane-stabilizing Effect of vitamin E: Effect of α?-tocopherol and its model compounds on fl uidity of lecithin liposomes. Biochem Biophys Res Commun 1988;150:469-475. (Pubitemid 18036256)
12. Yoshida Y, Niki E, Noguchi N. Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical Effects. Chem Phys Lipids 2003;123:63-75. (Pubitemid 36287652)
13. Yamamoto K, Niki E. Interaction of α?-tocopherol with iron: antioxidant and prooxidant Effects of α?-tocopherol in the oxidation of lipids in aqueous dispersions in the presence of iron. Biochem Biophys Acta Lipids Lipid Metabol 1988;958:19-23. (Pubitemid 18021544)
14. Faux SR, Howden PJ. Possible role of lipid peroxidation in the induction of NF-KB and AP-1 in RFL-6 cells by crocidolite asbestos: evidence following protection by vitamin E. Environ Health Perspect 1997;105:1127-1130.
15. Koivunena J, Aaltonena V, Peltonen J. Protein kinase C (PKC) family in cancer progression. Cancer Lett 2006;235:1-10.
16. Nakashima S. Protein kinase Ca (PKCa): regulation and biological function. J Biochem 2002;132:669-675. (Pubitemid 35408487)
17. Bouchard C, Staller P, Eilers M. Control of cell proliferation by Myc. Trends Cell Biol 1998;8:202-206. (Pubitemid 28188115)
18. Wang Y, Liu S, Zhang G, et al. Knockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo. Breast Cancer Res 2005;7:R220-R228.
19. Marampon F, Ciccarelli C, Zani BM. Down-regulation of c-Myc following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors. Mol Cancer 2006;5:31.
20. Grandori C, Cowley SM, James LP, et al. The Myc/Max/Mad network and the transcriptional control of cell behavior. Annu Rev Cell Dev Biol 2002;16:653-699.
21. Kim JW, Dang CV. Cancer ' s molecular sweet tooth and the Warburg Effect. Cancer Res 2006;66:8927-8930. (Pubitemid 44521105)
22. Lea A, Coopera CR, Gouwb AM, et al. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci USA 2010;107:2037-2042.
23. Bonilaa GP, Alvarez DF, Al-Mehdi A, et al. Critical role for lactate dehydrogenase A in aerobic glycolysis that sustains pulmonary microvascular endothelial cell proliferation. Am J Physiol Lung Cell Mol Physiol 2010;299:L513-L522.
24. Stubbs M, Sheehy MJ, Griffi ths JR, et al. Causes and consequences of tumour acidity and implications for treatment. Mol Med Today 2000;6:15-19. (Pubitemid 30010232)
25. Koukourakis MI, Giatromanolaki A, Sivridis E, et al. Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway - a report of the Tumour Angiogenesis Research Group. J Clin Oncol 2006;24:4301-4307.
26. Brenda M, Wilson DJ. A study of metabolites as intermediate Effectors in angiogenesis. Angiogenesis 2004;4:71-77.
27. Verma N, Vinayak M. Semecarpus anacardium promotes antioxidant defense system and inhibits anaerobic metabolism during development of lymphoma. Biosci Rep 2009;29:151-164.
28. Soo CYC, Haqqani AS, Hidiroglou N, et al. Dose-dependent Effects of dietary ?- and ?-tocopherols on genetic instability in mouse mutatect tumors. J Natl Cancer Inst 2004;96:796-800. (Pubitemid 38771825)
29. Schwartz MK, Bodansky O. Lactic dehydrogenase (clinical aspects). Methods Enzymol 1966;9:294-302.
30. Pathak C, Vinayak M. Modulation of lactate dehydrogenase isozymes by modifi ed base queuine. Mol Biol Rep 2005;32:191-196. (Pubitemid 41374361)
31. Pathak C, Jaiswal YK, Vinayak M. Modulation in the activity of lactate dehydrogenase and level of c-Myc and c-Fos by modifi ed base queuine in cancer. Cancer Biol Ther 2008;7:85-91. (Pubitemid 351590458)
32. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding. Anal Biochem 1976;72:248-254.
33. Sladowaski D, Steer SJ, Clothier RH, et al. An improved MTT assay. J Immunol Methods 1993;157:203-207. (Pubitemid 23028092)
34. Pathak CM, Jaiswal YK, Vinayak M. Possible involvement of queuine in regulation of cell proliferation. Biofactors 2007;29:159-173. (Pubitemid 350177952)
35. Black JD. Protein kinase C mediated regulation of the cell cycle. Front Biosci 2000;5:406-423.
36. Mishra S, Vinayak M. Anti-carcinogenic action of ellagic acid mediated via modulation of oxidative stress regulated genes in Dalton lymphoma bearing mice. Leuk Lymphoma 2011;52:2155-2161.
37. Lonne GK, Cornmark L, Zahirovic IO, et al. PKC?expression is a marker for breast cancer aggressiveness. Mol Cancer 2010;9:76.
38. Sharma S, Stutzman JD, Kelloff GJ, et al. Screening of potential chemopreventive agents using biochemical markers of carcinogenesis. Cancer Res 1994;54:5848-5855. (Pubitemid 24375218)
39. Brandvold KA, Neiman P, Ruddell A. Angiogenesis is an early event in the generation of myc induced lymphomas. Oncogene 2000;19:251-274.
40. Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature 2001;411:342-348. (Pubitemid 32467043)
41. Dang CV. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 1999;19:1-11. (Pubitemid 29018404)
42. Shim H, Dolde C, Lewis BC, et al. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc Natl Acad Sci 1997;94:6658-6663. (Pubitemid 27281920)
43. Pathak C, Jaiswal YK, Vinayak M. Modifi ed base queuine promotes cellular antioxidant defense system in cancer. Biosci Rep 2008;28:73-81.