Cx43 in mesenchymal stem cells promotes angiogenesis of the infarcted heart independent of gap junctions

Molecular Medicine Reports

Volumn 9, Issue 4, 2014, Pages 1095-1102

  Wang, De Guo ^a,b   Zhang, Feng Xiang ^b   Chen, Ming Long ^b   Zhu, Hong Jun ^b   Yang, Bing ^b   Cao, Ke Jiang ^b  

^a WANNAN MEDICAL COLLEGE   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Angiogenic cytokines; Connexins; Gap junction; Mesenchymal stem cells; Myocardial infarction

Indexed keywords

ANTIARRHYTHMIC PEPTIDE; CONNEXIN 43; FIBROBLAST GROWTH FACTOR 2; SMALL INTERFERING RNA; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL HYPOXIA; CONTROLLED STUDY; CORONARY ARTERY LIGATION; GAP JUNCTION; GENE OVEREXPRESSION; GENE SILENCING; HEART FUNCTION; HEART HEMODYNAMICS; HEART INFARCTION; HEART INFARCTION SIZE; IN VITRO STUDY; IN VIVO STUDY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MESENCHYMAL STEM CELL; NONHUMAN; RAT; VASCULAR ENDOTHELIUM;

ANIMALS; CONNEXIN 43; CYTOKINES; FEMALE; FIBROBLAST GROWTH FACTOR 2; GAP JUNCTIONS; HEART FUNCTION TESTS; HEMODYNAMICS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MYOCARDIAL INFARCTION; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, SPRAGUE-DAWLEY; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VON WILLEBRAND FACTOR;

EID: 84896513295     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.1923     Document Type: Article

References (34)

1. Nagaya N, Kangawa K, Itoh T, et al: Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation 112: 1128-1135, 2005. (Pubitemid 41216119)
2. Tse HF, Thambar S, Kwong YL, et al: Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases (PROTECT-CAD trial). Eur Heart J 28: 2998-3005, 2007. (Pubitemid 350262782)
3. Müller-Ehmsen J, Krausgrill B, Burst V, et al: Effective engraftment but poor mid-term persistence of mononuclear and mesenchymal bone marrow cells in acute and chronic rat myocardial infarction. J Mol Cell Cardiol 41: 876-884, 2006. (Pubitemid 44635568)
4. Leobon B, Garcin I, Menasche P, Vilquin JT, Audinat E and Charpak S: Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host. Proc Natl Acad Sci USA 100: 7808-7811, 2003. (Pubitemid 36760051)
5. Grauss RW, van Tuyn J, Steendijk P, et al: Forced myocardin expression enhances the therapeutic effect of human mesenchymal stem cells after transplantation in ischemic mouse hearts. Stem Cells 26: 1083-1093, 2008.
6. Hahn JY, Cho HJ, Kang HJ, et al: Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction. J Am Coll Cardiol 51: 933-943, 2008.
7. Rosová I, Dao M, Capoccia B, Link D and Nolta JA: Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells. Stem Cells 26: 2173-2182, 2008.
8. Contreras JE, Sánchez HA, Véliz LP, Bukauskas FF, Bennett MV and Saéz JC: Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue. Brain Res Brain Res Rev 47: 290-303, 2004. (Pubitemid 39574326)
9. Yasui K, Kada K, Hojo M, et al: Cell-to-cell interaction prevents cell death in cultured neonatal rat ventricular myocytes. Cardiovasc Res 48: 68-76, 2000.
10. Giardina SF, Mikami M, Goubaeva F and Yang J: Connexin 43 confers resistance to hydrogen peroxide-mediated apoptosis. Biochem Biophys Res Commun 362: 747-752, 2007. (Pubitemid 47368157)
11. Goubaeva F, Mikami M, Giardina S, Ding B, Abe J and Yang J: Cardiac mitochondrial connexin 43 regulates apoptosis. Biochem Biophys Res Commun 352: 97-103, 2007. (Pubitemid 44821099)
12. Pijnappels DA, Schalij MJ, van Tuyn J, et al: Progressive increase in conduction velocity across human mesenchymal stem cells is mediated by enhanced electrical coupling. Cardiovasc Res 72: 282-291, 2006. (Pubitemid 44511913)
13. Lu G, Haider HK, Jiang S and Ashraf M: Sca-1+ stem cell survival and engraftment in the infarcted heart: dual role for preconditioning-induced connexin-43. Circulation 119: 2587-2596, 2009.
14. Wang D, Shen W, Zhang F, Chen M, Chen H and Cao K: Connexin43 promotes survival of mesenchymal stem cells in ischemic heart. Cell Biol Int 34: 415-423, 2010.
15. Crisostomo PR, Wang Y, Markel TA, Wang M, Lahm T and Meldrum DR: Human mesenchymal stem cells stimulated by TNF-alpha, LPS, or hypoxia produce growth factors by an NF kappa B- but not JNK-dependent mechanism. Am J Physiol Cell Physiol 294: C675-C682, 2008. (Pubitemid 351468685)
16. Yoon YS, Wecker A, Heyd L, et al: Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. J Clin Invest 115: 326-338, 2005. (Pubitemid 40385474)
17. Jia G, Cheng G, Gangahar DM and Agrawal DK: Involvement of connexin 43 in angiotensin II-induced migration and proliferation of saphenous vein smooth muscle cells via the MAPK-AP-1 signaling pathway. J Mol Cell Cardiol 44: 882-890, 2008.
18. Gnecchi M, He H, Noiseux N, et al: Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J 20: 661-669, 2006. (Pubitemid 44933310)
19. Dai W, Hale SL, Martin BJ, et al: Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects. Circulation 112: 214-223, 2005. (Pubitemid 40982304)
20. Jiang S, Haider H, Idris NM, Salim A and Ashraf M: Supportive interaction between cell survival signaling and angiocompetent factors enhances donor cell survival and promotes angiomyogenesis for cardiac repair. Circ Res 99: 776-784, 2006. (Pubitemid 44498311)
21. Evans WH and Leybaert L: Mimetic peptides as blockers of connexin channel-facilitated intercellular communication. Cell Commun Adhes 14: 265-273, 2007.
22. Martin PE, Wall C and Griffith TM: Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cells. Br J Pharmacol 144: 617-627, 2005. (Pubitemid 40445609)
23. Hagen A, Dietze A and Dhein S: Human cardiac gap-junction coupling: effects of antiarrhythmic peptide AAP10. Cardiovasc Res 83: 405-415, 2009.
24. Jansen JA, van Veen TA, de Bakker JM and van Rijen HV: Cardiac connexins and impulse propagation. J Mol Cell Cardiol 48: 76-82, 2010.
25. Roell W, Lewalter T, Sasse P, et al : Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia. Nature 450: 819-824, 2007. (Pubitemid 350237591)
26. Abraham MR, Henrikson CA, Tung L, et al: Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circ Res 97: 159-167, 2005. (Pubitemid 41033472)
27. Valiunas V, Doronin S, Valiuniene L, et al: Human mesenchymal stem cells make cardiac connexins and form functional gap junctions. J Physiol 555: 617-626, 2004. (Pubitemid 38404584)
28. Hare JM, Traverse JH, Henry TD, et al : A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol 54: 2277-2286, 2009.
29. Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissman IL and Robbins RC: Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 428: 668-673, 2004. (Pubitemid 38524811)
30. Nygren JM, Jovinge S, Breitbach M, et al: Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med 10: 494-501, 2004. (Pubitemid 38667908)
31. Gnecchi M, He H, Liang OD, et al: Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med 11: 367-368, 2005. (Pubitemid 40562318)
32. Grunewald M, Avraham I, Dor Y, et al: VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 124: 175-189, 2006. (Pubitemid 43069318)
33. Langer HF, Stellos K, Steingen C, et al: Platelet derived bFGF mediates vascular integrative mechanisms of mesenchymal stem cells in vitro. J Mol Cell Cardiol 47: 315-325, 2009.
34. Lu G, Haider HKh, Porollo A and Ashraf M: Mitochondria-specific transgenic overexpression of connexin-43 simulates preconditioning-induced cytoprotection of stem cells. Cardiovasc Res 88: 277-286, 2010.