Comparison of the adjuvant activity of aluminum hydroxide and calcium phosphate on the antibody response towards Bothrops asper snake venom

Journal of Immunotoxicology

Volumn 11, Issue 1, 2014, Pages 44-49

  Olmedo, Hidekel ^a   Herrera, María ^a   Rojas, Leonardo ^a   Villalta, Mauren ^a   Vargas, Mariángela ^a   Leiguez, Elbio ^b   Teixeira, Catarina ^b   Estrada, Ricardo ^a   Gutiérrez, José María ^a   León, Guillermo ^a   Montero, Mavis L ^a  

^a UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^b INSTITUTO BUTANTAN   (Brazil)

Author keywords

Aluminum hydroxide; Anti venom; Antibody response; Calcium phosphate; Immunological adjuvant; Snake venom

Indexed keywords

ALUMINUM HYDROXIDE; ANTIBODY; CALCIUM PHOSPHATE; INORGANIC SALT; MINERAL SALT; PHOSPHOLIPASE A2; PROTEIN; SNAKE VENOM; UNCLASSIFIED DRUG; VENOM PROTEIN; IMMUNOLOGICAL ADJUVANT; PROTEIN BINDING; VENOM ANTISERUM;

ACUTE TOXICITY; ADSORPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; BOTHROPS; BOTHROPS ASPER; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNIZATION; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INTERNALIZATION; LEUKOCYTE; MACROPHAGE ACTIVATION; MALE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRECIPITATION; PRIORITY JOURNAL; PROTEIN SECRETION; ANIMAL; ANTIBODY PRODUCTION; BIOSYNTHESIS; CELL CULTURE; CELL MOTION; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECTS; IMMUNOLOGY; INBRED MOUSE STRAIN; MACROPHAGE; METABOLISM;

ADJUVANTS, IMMUNOLOGIC; ALUMINUM HYDROXIDE; ANIMALS; ANTIBODY FORMATION; ANTIVENINS; BOTHROPS; CALCIUM PHOSPHATES; CELL MOVEMENT; CELLS, CULTURED; CROTALID VENOMS; LEUKOCYTES; MACROPHAGES; MALE; MICE; MICE, INBRED STRAINS; PHAGOCYTOSIS; PROTEIN BINDING;

EID: 84896500891     PISSN: 1547691X     EISSN: None     Source Type: Journal    
DOI: 10.3109/1547691X.2013.772267     Document Type: Article

References (25)

1. Al-Shakhshir, R. H., Regnier, F. E., White, J. L., and Hem, S. L. 1995. Contribution of electrostatic and hydrophobic interactions to the adsorption of proteins by aluminum-containing adjuvants. Vaccine 13: 41-44.
2. Alape-Girón, A., Sanz, L., Escolano, L., et al. 2008. Snake venomics of the lancead pitviper Bothrops asper: geographic, individual, and ontogenic variations. J. Proteome Res. 7:3556-3571.
3. Angulo, Y., and Lomonte, B. 2009. Biochemistry and toxicology of toxins purified from the venom of the snake Bothrops asper. Toxicon 54: 949-957.
4. Chotwiwatthanakun, C., Pratanaphon, R., Akesowan, S., et al. 2001. Production of potent polyvalent anti-venom against three elapid venoms using a low dose, low volume, multi-site immunization protocol. Toxicon 39:1487-1494.
5. Costa Rosa, L. F., Safi, D. A., and Curi, R. 1994. Effect of thioglycollate and BCG stimuli on glucose and glutamine metabolism in rat macrophages. J. Leukocyte Biol. 56:10-14.
6. Council of International Organizations of Medical Sciences (CIOMS). 1985. The International Guiding Principles for Biomedical Research Involving Animals. CIOMS [online]. Available at: http://www.cioms.ch/images/stories/CIOMS/ guidelines/1985-texts-of-guide lines.htm [last accessed 23 Feb 2012].
7. de Veer, M., Kemp, J., Chatelier, J., et al. 2010. The kinetics of soluble and particulate antigen trafficking in the afferent lymph, and its modulation by aluminum-based adjuvant. Vaccine 14:6597-6602.
8. Freitas, T. V., Fortes-Dias, C. L., Diniz, C. R., et al. 1991. Immunization of horses with Crotalus durissus terrificus (South American rattlesnake) venom. A comparison of four different procedures. Braz. J. Med. Biol. Res. 24:281-290.
9. Gutiérrez, J. M., León, G., Lomonte, B., and Angulo, Y. 2011. Antivenoms for snakebite envenomings. Inflamm. Allergy Drug Targets 10: 369-380.
10. Harrison, R. A., Hasson, S. S., Harmsen, M., et al. 2006. Neutralization of venom-induced haemorrhage by IgG from camels and llamas immunized with viper venom and also by endogenous, non-IgG components in camelid sera. Toxicon 47:364-368.
11. He, Q., Mitchell, A. R., Johnson, S. L., et al. 2000. Calcium phosphate nanoparticle adjuvant. Clin. Diag. Lab. Immunol. 7:899-903.
12. HogenEsch, H. 2002. Mechanisms of stimulation of the immune response by aluminum adjuvants. Vaccine 20:S34-39.
13. Iyer, S., HogenEsch, H., and Hem, S. L. 2003. Relationship between the degree of antigen adsorption to aluminum hydroxide adjuvant in interstitial fluid and antibody production. Vaccine 21:1219-1223.
14. Jiang, D., Premachandra, G. S., Johnston, C., and Hem, S. L. 2004. Structure and adsorption properties of commercial calcium phosphate adjuvant. Vaccine 23:693-698.
15. León, G., Sánchez, L., Hernández, A., et al. 2011. Immune response towards snake venoms. Inflamm. Allergy Drug Targets 10:381-398.
16. Montero, M. L., Sáenz, A., Rodŕguez, J. G., et al. 2006. Electrochemical synthesis of nanosized hydroxyapatite. J. Mater. Sci. 41:2141-2144.
17. Noe, S. M., Green, M. A., HogenEsch, H., and Hem, S. L. 2010. Mechanism of immunopotentiation by aluminum-containing adjuvants elucidated by the relationship between antigen retention at the inoculation site and the immune response. Vaccine 28:3588-3594.
18. Petrovsky, N., and Aguilar, J. C., 2004. Vaccine adjuvants: current state and future trends. Immunol. Cell Biol. 82:488-496.
19. Rinella, J. V., White, J. L., and Hem, S. L. 1995. Effect of anions on model aluminum-adjuvant-containing vaccines. J. Colloid. Interf. Sci. 172:121-130.
20. Rinella, J. V., White, J. L., and Hem, S. L. 1996. Treatment of aluminum hydroxide adjuvant to optimize the adsorption of basic proteins. Vaccine 14:298-300.
21. Romero, I. Z., Shi, Y., HogenEsch, H., and Hem, S. L. 2007. Potentiation of the immune response to non-adsorbed antigens by aluminum-containing adjuvants. Vaccine 25:825-833.
22. Shi, Y., HogenEsch, H., and Hem, S. L. 2002. Change in the degree of adsorption of proteins by aluminum-containing adjuvants following exposure to interstitial fluid: freshly prepared and aged model vaccines. Vaccine 20:80-85.
23. Solano, G., Segura, A., Herrera, M., et al. 2010. Study of the design and analytical properties of the lethality neutralization assay used to estimate anti-venom potency against Bothrops asper snake venom. Biologicals 38:577-585.
24. Sunthornandh, P., and Ratanabanangkoon, K. 1994. A comparative study of three vehicles on antibody responses against elapid snake neurotoxin immunogens. Toxicon 32:561-571.
25. Teixeiria, C., Cury, Y., Moreira, V., et al. 2009. Inflammation induced by Bothrops asper venom. Toxicon 54:988-997.