Relationship between the degree of antigen adsorption to aluminum hydroxide adjuvant in interstitial fluid and antibody production

Vaccine

Volumn 21, Issue 11-12, 2003, Pages 1219-1223

  Iyer, Seema ^a   HogenEsch, Harm ^b   Hem, Stanley L ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Aluminum hydroxide adjuvant; Degree of antigen adsorption; Immunopotentiation; Interstitial fluid

Indexed keywords

ADJUVANT; ALUMINUM; ALUMINUM HYDROXIDE; ANTIBODY; ANTIGEN; CASEIN; OVALBUMIN; VACCINE;

ADSORPTION; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; DESORPTION; ELUTION; EXPOSURE; FEMALE; IMMUNE RESPONSE; IMMUNOPOTENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; TIME;

ADJUVANTS, IMMUNOLOGIC; ADSORPTION; ALUMINUM HYDROXIDE; ANIMALS; ANTIGENS; CASEINS; CATTLE; EXTRACELLULAR SPACE; FEMALE; HYDROXIDES; INJECTIONS, SUBCUTANEOUS; MICE; MICE, INBRED BALB C; OVALBUMIN; PHOSPHATES; PHOSPHORYLATION; VACCINES;

EID: 0037424107     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(02)00556-X     Document Type: Article

References (15)

1. World Health Organization, Immunological adjuvants. World Health Organization Technical Report Series No. 595. Geneva: World Health Organization; 1976. p. 6-8.
2. Rinella J.V. Jr., White J.L., Hem S.L. Effect of anions on model aluminum-adjuvant-containing vaccines. J. Colloid Interf. Sci. 172:1995;121-130.
3. Seeber S.J., White J.L., Hem S.L. Solubilization of aluminum-containing adjuvants by constituents of interstitial fluid. J. Parenter. Sci. Technol. 45:1991;156-160.
4. Flarend R.E., Hem S.L., White J.L., Elmore D., Suckow M.A., Rudy A.C.et al. In vivo absorption of aluminium-containing vaccine adjuvants using 26Al. Vaccine. 15:1997;1314-1318.
5. Heimlich J.M., Regnier F.E., White J.L., Hem S.L. The in vitro displacement of adsorbed model antigens from aluminum-containing adjuvants by interstitial proteins. Vaccine. 17:1999;2873-2881.
6. Shi Y., HogenEsch H., Hem S.L. Change in the degree of adsorption of proteins by aluminum-containing adjuvants following exposure to interstitial fluid: freshly prepared and aged model vaccines. Vaccine. 20:2002;80-85.
7. Chang M.-F., Shi Y., Nail S.L., HogenEsch H., Adams S.B., White J.L.et al. Degree of antigen adsorption in the vaccine or interstitial fluid and its effect on the antibody response in rabbits. Vaccine. 19:2001;2884-2889.
8. Righetti D.G., Caravaggio T. Isoelectric points and molecular weights of proteins: a table. J. Chromatogr. 127:1976;12-28.
9. Swaisgood HE. In: Advanced dairy chemistry: proteins, vol. 1. New York: Elsevier; 1992. p. 63-110.
10. Bigham E. Jr., Farrell H.L., Dahl K.J. Removal of phosphate groups from casein with potato acid phosphatase. Biochim. Biophys. Acta. 429:1976;448-460.
11. Tortotra GJ, Anagnostakos NP. In: Principles of anatomy and physiology, 6th ed. New York: Harper and Row; 1990. p. 565-6.
12. Liu J.-C., Feldkamp J.R., White J.L., Hem S.L. Adsorption of phosphate by aluminum hydroxy carbonate. J. Pharm. Sci. 73:1984;1355-1358.
13. Lanzavecchia A. Mechanisms of antigen uptake for presentation. Curr. Opin. Immunol. 10:1996;348-354.
14. Manhalter J.W., Neychev H.O., Zlabinger G.J., Ahmad R., Eibl M.M. Modulation of the human immune response by the non-toxic and non-pyrogenic adjuvant aluminum hydroxide: effect of antigen uptake and antigen presentation. Clin. Exp. Immunol. 61:1985;143-151.
15. Watts C. Capture and processing of exogenous antigens for presentation on MHC molecules. Ann. Rev. Immunol. 15:1997;821-850.