Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment

Bioconjugate Chemistry

Volumn 25, Issue 3, 2014, Pages 611-617

  Bryden, Francesca ^a   Maruani, Antoine ^b   Savoie, Huguette ^a   Chudasama, Vijay ^b   Smith, Mark E B ^b   Caddick, Stephen ^b   Boyle, Ross W ^a  

^a UNIVERSITY OF HULL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CELL CULTURE; CONTROLLED DRUG DELIVERY; PHOTODYNAMIC THERAPY; PORPHYRINS; STABILITY; SULFUR COMPOUNDS; TISSUE;

'CURRENT; ANTI-CANCER AGENTS; ANTIBODY-DRUG CONJUGATES; ANTIBODY-FRAGMENT; HEALTHY TISSUES; PHOTOSENSITISER; POWER; REGIO-SELECTIVE; SENSITISER; TARGET TISSUES;

PHOTOSENSITIZERS;

ALKYNE; ANTIBODY CONJUGATE; AZIDE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; IMMUNOGLOBULIN F(AB) FRAGMENT; MALEIMIDE; PORPHYRIN; TRASTUZUMAB; DISULFIDE; MONOCLONAL ANTIBODY; PHOTOSENSITIZING AGENT;

ARTICLE; CONTROLLED STUDY; CYCLOADDITION; CYTOTOXICITY; DRUG CONJUGATION; DRUG SELECTIVITY; HUMAN; HUMAN CELL; PHOTODYNAMIC THERAPY; STOICHIOMETRY; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE;

ANTIBODIES, MONOCLONAL, HUMANIZED; DISULFIDES; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MOLECULAR STRUCTURE; PHOTOSENSITIZING AGENTS; PORPHYRINS; RECEPTOR, ERBB-2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84896500653     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc5000324     Document Type: Article

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