Modern Radiation Therapy Techniques for Pancreatic Cancer

Gastroenterology Clinics of North America

Volumn 41, Issue 1, 2012, Pages 223-235

  Trakul, Nicholas ^a   Koong, Albert C ^a   Maxim, Peter G ^a   Chang, Daniel T ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Image guided radiation therapy; Intensity modulated radiation therapy; Pancreatic adenocarcinoma; Radiation therapy; Stereotactic body radiotherapy

Indexed keywords

ERLOTINIB; FLUORODEOXYGLUCOSE F 18; GEMCITABINE;

CANCER CONTROL; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER SIZE; CLINICAL TRIAL (TOPIC); COMPUTER ASSISTED RADIOTHERAPY; COMPUTER ASSISTED TOMOGRAPHY; ENDOSCOPIC ECHOGRAPHY; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; EVIDENCE BASED MEDICINE; EXTERNAL BEAM RADIOTHERAPY; FOUR DIMENSIONAL COMPUTER ASSISTED TOMOGRAPHY; HUMAN; IMAGE GUIDED RADIOTHERAPY; IMAGE QUALITY; INTENSITY MODULATED RADIATION THERAPY; NUCLEAR MAGNETIC RESONANCE IMAGING; OVERALL SURVIVAL; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PANCREATICODUODENECTOMY; PATIENT POSITIONING; POSITRON EMISSION TOMOGRAPHY; PREOPERATIVE RADIOTHERAPY; RADIATION DOSE; RESPIRATORY GATED IMAGING; REVIEW; STEREOTACTIC BODY RADIATION THERAPY; STEREOTACTIC RADIOSURGERY; SURVIVAL RATE; TREATMENT INDICATION; TREATMENT PLANNING;

DIAGNOSTIC IMAGING; HUMANS; PANCREATIC NEOPLASMS; RADIOTHERAPY;

EID: 84857070579     PISSN: 08898553     EISSN: 15581942     Source Type: Journal    
DOI: 10.1016/j.gtc.2011.12.011     Document Type: Review

References (50)

1. Jemal A., Siegel R., Xu J., et al. Cancer statistics. 2010. CA Cancer J Clin 2010, 60(5):277-300.
2. Vincent A., Herman J., Schulick R., et al. Pancreatic cancer. Lancet 2011, 378(9791):607-620.
3. Saif M.W. Pancreatic neoplasm in 2011: an update. JOP 2011, 12(4):316-321.
4. Wagner M., Redaelli C., Lietz M., et al. Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma. Br J Surg 2004, 91(5):586-594.
5. Abbott D.E., Baker M.S., Talamonti M.S. Neoadjuvant therapy for pancreatic cancer: a current review. J Surg Oncol 2010, 101(4):315-320.
6. Kalser M.H., Ellenberg S.S. Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 1985, 120(8):899-903.
7. Regine W.F., Winter K.A., Abrams R., et al. Fluorouracil-based chemoradiation with either gemcitabine or fluorouracil chemotherapy after resection of pancreatic adenocarcinoma: 5-year analysis of the U.S. Intergroup/RTOG 9704 phase III trial. Ann Surg Oncol 2011, 18(5):1319-1326.
8. Smeenk H.G., van Eijck C.H., Hop W.C., et al. Long-term survival and metastatic pattern of pancreatic and periampullary cancer after adjuvant chemoradiation or observation: long-term results of EORTC trial 40891. Ann Surg 2007, 246(5):734-740.
9. Neoptolemos J.P., Stocken D.D., Dunn J.A., et al. Influence of resection margins on survival for patients with pancreatic cancer treated by adjuvant chemoradiation and/or chemotherapy in the ESPAC-1 randomized controlled trial. Ann Surg 2001, 234(6):758-768.
10. Oettle H., Post S., Neuhaus P., et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA 2007, 297(3):267-277.
11. Neoptolemos J.P., Stocken D.D., Bassi C., et al. Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA 2010, 304(10):1073-1081.
12. Willett C.G., Czito B.G. Chemoradiotherapy in gastrointestinal malignancies. Clin Oncol (R Coll Radiol) 2009, 21(7):543-556.
13. Palta M., Willett C., Czito B. Role of radiation therapy in patients with resectable pancreatic cancer. Oncology (Williston Park) 2011, 25(8):715-721. 727.
14. Aloia T.A., Lee J.E., Vauthey J.N., et al. Delayed recovery after pancreaticoduodenectomy: a major factor impairing the delivery of adjuvant therapy?. J Am Coll Surg 2007, 204(3):347-355.
15. Arvold N.D., Niemierko A., Mamon H.J., et al. Pancreatic cancer tumor size on CT scan versus pathologic specimen: implications for radiation treatment planning. Int J Radiat Oncol Biol Phys 2011, 80(5):1383-1390.
16. Ford E.C., Herman J., Yorke E., et al. 18F-FDG PET/CT for image-guided and intensity-modulated radiotherapy. J Nucl Med 2009, 50(10):1655-1665.
17. Murphy J.D., Christman-Skieller C., Kim J., et al. A dosimetric model of duodenal toxicity after stereotactic body radiotherapy for pancreatic cancer. Int J Radiat Oncol Biol Phys 2010, 78(5):1420-1426.
18. Schellenberg D., Quon A., Minn A.Y., et al. 18Fluorodeoxyglucose PET is prognostic of progression-free and overall survival in locally advanced pancreas cancer treated with stereotactic radiotherapy. Int J Radiat Oncol Biol Phys 2010, 77(5):1420-1425.
19. Bussels B., Goethals L., Feron M., et al. Respiration-induced movement of the upper abdominal organs: a pitfall for the three-dimensional conformal radiation treatment of pancreatic cancer. Radiother Oncol 2003, 68(1):69-74.
20. Chang S.D., Main W., Martin D.P., et al. An analysis of the accuracy of the CyberKnife: a robotic frameless stereotactic radiosurgical system. Neurosurgery 2003, 52(1):140-146. discussion: 146-7.
21. Park W.G., Yan B.M., Schellenberg D., et al. EUS-guided gold fiducial insertion for image-guided radiation therapy of pancreatic cancer: 50 successful cases without fluoroscopy. Gastrointest Endosc 2010, 71(3):513-518.
22. Kothary N., Dieterich S., Louie J.D., et al. Percutaneous implantation of fiducial markers for imaging-guided radiation therapy. AJR Am J Roentgenol 2009, 192(4):1090-1096.
23. Taremi M., Ringash J., Dawson L.A. Upper abdominal malignancies: intensity-modulated radiation therapy. Front Radiat Ther Oncol 2007, 40:272-288.
24. Landry J.C., Yang G.Y., Ting J.Y., et al. Treatment of pancreatic cancer tumors with intensity-modulated radiation therapy (IMRT) using the volume at risk approach (VARA): employing dose-volume histogram (DVH) and normal tissue complication probability (NTCP) to evaluate small bowel toxicity. Med Dosim 2002, 27(2):121-129.
25. Milano M.T., Chmura S.J., Garofalo M.C., et al. Intensity-modulated radiotherapy in treatment of pancreatic and bile duct malignancies: toxicity and clinical outcome. Int J Radiat Oncol Biol Phys 2004, 59(2):445-453.
26. Ben-Josef E., Shields A.F., Vaishampayan U., et al. Intensity-modulated radiotherapy (IMRT) and concurrent capecitabine for pancreatic cancer. Int J Radiat Oncol Biol Phys 2004, 59(2):454-459.
27. Yovino S., Poppe M., Jabbour S., et al. Intensity-modulated radiation therapy significantly improves acute gastrointestinal toxicity in pancreatic and ampullary cancers. Int J Radiat Oncol Biol Phys 2011, 79(1):158-162.
28. Bockbrader M., Kim E. Role of intensity-modulated radiation therapy in gastrointestinal cancer. Expert Rev Anticancer Ther 2009, 9(5):637-647.
29. Brown M.W., Ning H., Arora B., et al. A dosimetric analysis of dose escalation using two intensity-modulated radiation therapy techniques in locally advanced pancreatic carcinoma. Int J Radiat Oncol Biol Phys 2006, 65(1):274-283.
30. Yu C.X., Tang G. Intensity-modulated arc therapy: principles, technologies and clinical implementation. Physics in medicine and biology 2011, 56(5):R31-R54.
31. Duthoy W., De Gersem W., Vergote K., et al. Clinical implementation of intensity-modulated arc therapy (IMAT) for rectal cancer. International journal of radiation oncology, biology, physics 2004, 60(3):794-806.
32. Yu C.X., Li X.A., Ma L., et al. Clinical implementation of intensity-modulated arc therapy. International journal of radiation oncology, biology, physics 2002, 53(2):453-463.
33. Yu C.X., Tang G. Intensity-modulated arc therapy: principles, technologies and clinical implementation. Phys Med Biol 2011, 56(5):R31-R54.
34. Timmerman R., Paulus R., Galvin J., et al. Stereotactic body radiation therapy for inoperable early stage lung cancer. JAMA 2010, 303(11):1070-1076.
35. Rusthoven K.E., Kavanagh B.D., Cardenes H., et al. Multi-institutional phase I/II trial of stereotactic body radiation therapy for liver metastases. J Clin Oncol 2009, 27(10):1572-1578.
36. Nagata Y., Wulf J., Lax I., et al. Stereotactic radiotherapy of primary lung cancer and other targets: results of consultant meeting of the International Atomic Energy Agency. Int J Radiat Oncol Biol Phys 2011, 79(3):660-669.
37. Lax I., Blomgren H., Naslund I., et al. Stereotactic radiotherapy of malignancies in the abdomen: methodological aspects. Acta Oncol 1994, 33:677-683.
38. Willett C.G., Czito B.G., Bendell J.C., et al. Locally advanced pancreatic cancer. J Clin Oncol 2005, 23(20):4538-4544.
39. Koong A.C., Le Q.T., Ho A., et al. Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 2004, 58(4):1017-1021.
40. Hoyer M., Roed H., Sengelov L., et al. Phase-II study on stereotactic radiotherapy of locally advanced pancreatic carcinoma. Radiother Oncol 2005, 76(1):48-53.
41. Koong A.C., Christofferson E., Le Q.T., et al. Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 2005, 63(2):320-323.
42. Schellenberg D., Goodman K.A., Lee F., et al. Gemcitabine chemotherapy and single-fraction stereotactic body radiotherapy for locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 2008, 72(3):678-686.
43. Didolkar M.S., Coleman C.W., Brenner M.J., et al. Image-guided stereotactic radiosurgery for locally advanced pancreatic adenocarcinoma results of first 85 patients. J Gastrointest Surg 2010, 14(10):1547-1559.
44. Mahadevan A., Jain S., Goldstein M., et al. Stereotactic body radiotherapy and gemcitabine for locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 2010, 78(3):735-742.
45. Mahadevan A., Miksad R., Goldstein M., et al. Induction gemcitabine and stereotactic body radiotherapy for locally advanced nonmetastatic pancreas cancer. Int J Radiat Oncol Biol Phys 2011, 81(4):e615-e622.
46. Polistina F., Costantin G., Casamassima F., et al. Unresectable locally advanced pancreatic cancer: a multimodal treatment using neoadjuvant chemoradiotherapy (gemcitabine plus stereotactic radiosurgery) and subsequent surgical exploration. Ann Surg Oncol 2010, 17(8):2092-2101.
47. Rwigema J.C., Parikh S.D., Heron D.E., et al. Stereotactic body radiotherapy in the treatment of advanced adenocarcinoma of the pancreas. Am J Clin Oncol 2011, 34(1):63-69.
48. Chang B.W., Saif M.W. Stereotactic body radiation therapy (SBRT) in pancreatic cancer: is it ready for prime time?. JOP 2008, 9(6):676-682.
49. Minn A.Y., Koong A.C., Chang D.T. Stereotactic body radiation therapy for gastrointestinal malignancies. Front Radiat Ther Oncol 2011, 43:412-427.
50. Schellenberg D., Kim J., Christman-Skieller C., et al. Single-fraction stereotactic body radiation therapy and sequential gemcitabine for the treatment of locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 2011, 81(1):181-188.