Stress-related hormone norepinephrine induces interleukin-6 expression in GES-1 cells

Brazilian Journal of Medical and Biological Research

Volumn 47, Issue 2, 2014, Pages 101-109

  Yang, R ^a   Lin, Q ^a   Gao, H B ^a   Zhang, P ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

GES 1 cells; Interleukin 6; Norepinephrine

Indexed keywords

BETA ADRENERGIC RECEPTOR; CCAAT ENHANCER BINDING PROTEIN BETA; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIMETHYL SULFOXIDE; INTERLEUKIN 6; NORADRENALIN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; STRESS HORMONE; TRANSCRIPTION FACTOR AP 1; UPSTREAM STIMULATORY FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; TRANSCRIPTION FACTOR;

ARTICLE; CHRONIC STRESS; CONSENSUS SEQUENCE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; GENE DELETION; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSFECTION; HORMONAL REGULATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LUCIFERASE ASSAY; MRNA EXPRESSION ASSAY; PROMOTER REGION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY SEQUENCE; RNA ISOLATION; SITE DIRECTED MUTAGENESIS; STOMACH EPITHELIUM; UPREGULATION; CELL LINE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; STOMACH MUCOSA;

CELL LINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; GASTRIC MUCOSA; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-6; NF-KAPPA B; NOREPINEPHRINE; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ADRENERGIC, BETA; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84896485388     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/1414-431X20133346     Document Type: Article

References (36)

1. Ben-Eliyahu S, Yirmiya R, Liebeskind JC, Taylor AN, Gale RP. Stress increases metastatic spread of a mammary tumor in rats: evidence for mediation by the immune system. Brain Behav Immun 1991; 5: 193-205, doi: 10.1016/0889-1591(91)90016-4.
2. Ben-Eliyahu S, Shakhar G, Page GG, Stefanski V, Shakhar K. Suppression of NK cell activity and of resistance to metastasis by stress: a role for adrenal catecholamines and b-adrenoceptors. Neuroimmunomodulation 2000; 8: 154-164, doi: 10.1159/000054276.
3. Reiche EM, Nunes SO, Morimoto HK. Stress, depression, the immune system, and cancer. Lancet Oncol 2004; 5: 617-625, doi: 10.1016/S1470-2045(04)01597-9.
4. Yang EV, Donovan EL, Benson DM, Glaser R. VEGF is differentially regulated in multiple myeloma-derived cell lines by norepinephrine. Brain Behav Immun 2008; 22: 318-323, doi: 10.1016/j.bbi.2007.09.010.
5. Lutgendorf SK, Cole S, Costanzo E, Bradley S, Coffin J, Jabbari S, et al. Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines. Clin Cancer Res 2003; 9: 4514-4521.
6. Bernabe DG, Tamae AC, Biasoli ER, Oliveira SH. Stress hormones increase cell proliferation and regulates interleukin-6 secretion in human oral squamous cell carcinoma cells. Brain Behav Immun 2011; 25: 574-583, doi: 10.1016/ j.bbi.2010.12.012.
7. Nilsson MB, Armaiz-Pena G, Takahashi R, Lin YG, Trevino J, Li Y, et al. Stress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanism. J Biol Chem 2007; 282: 29919-29926, doi: 10.1074/jbc.M611539200.
8. Yang EV, Kim SJ, Donovan EL, Chen M, Gross AC, Webster Marketon JI, et al. Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression. Brain Behav Immun 2009; 23: 267-275, doi: 10.1016/j.bbi.2008.10.005.
9. Lutgendorf SK, Lamkin DM, Jennings NB, Arevalo JM, Penedo F, DeGeest K, et al. Biobehavioral influences on matrix metalloproteinase expression in ovarian carcinoma. Clin Cancer Res 2008; 14: 6839-6846, doi: 10.1158/1078-0432.CCR-08-0230.
10. Chan C, Lin HJ, Lin J. Stress-associated hormone, norepinephrine, increases proliferation and IL-6 levels of human pancreatic duct epithelial cells and can be inhibited by the dietary agent, sulforaphane. Int J Oncol 2008; 33: 415-419.
11. Watabe K, Nishi M, Miyake H, Hirata K. Lifestyle and gastric cancer: a case-control study. Oncol Rep 1998; 5: 1191-1194.
12. Jansson C, Johansson AL, Jeding K, Dickman PW, Nyren O, Lagergren J. Psychosocial working conditions and the risk of esophageal and gastric cardia cancers. Eur J Epidemiol 2004; 19: 631-641, doi: 10.1023/B:EJEP.0000036806.51918.40.
13. Oh DY, Choi KS, Shin HR, Bang YJ. Public awareness of gastric cancer risk factors and disease screening in a high risk region: a population-based study. Cancer Res Treat 2009; 41: 59-66, doi: 10.4143/crt.2009.41.2.59.
14. Ke Y, Ning T, Wang B. Establishment and characterization of a SV40 transformed human fetal gastric epithelial cell line-GES-1. Zhonghua Zhong Liu Za Zhi 1994; 16: 7-10.
15. Hodge DR, Hurt EM, Farrar WL. The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 2005; 41: 2502-2512, doi: 10.1016/j.ejca.2005.08.016.
16. Bromberg J, Wang TC. Inflammation and cancer: IL-6 and STAT3 complete the link. Cancer Cell 2009; 15: 79-80, doi: 10.1016/j.ccr.2009.01.009.
17. Kishimoto T. IL-6: from its discovery to clinical applications. Int Immunol 2010; 22: 347-352, doi: 10.1093/intimm/dxq030.
18. Kai H, Kitadai Y, Kodama M, Cho S, Kuroda T, Ito M, et al. Involvement of proinflammatory cytokines IL-1β and IL-6 in progression of human gastric carcinoma. Anticancer Res 2005; 25: 709-713.
19. Heikkila K, Ebrahim S, Lawlor DA. Systematic review of the association between circulating interleukin-6 (IL-6) and cancer. Eur J Cancer 2008; 44: 937-945, doi: 10.1016/ j.ejca.2008.02.047.
20. Tsujimoto H, Ono S, Ichikura T, Matsumoto Y, Yamamoto J, Hase K. Roles of inflammatory cytokines in the progression of gastric cancer: friends or foes? Gastric Cancer 2010; 13: 212-221, doi: 10.1007/s10120-010-0568-x.
21. Kiecolt-Glaser JK, Preacher KJ, MacCallum RC, Atkinson C, Malarkey WB, Glaser R. Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci U S A 2003; 100: 9090-9095, doi: 10.1073/pnas. 1531903100.
22. Costanzo ES, Lutgendorf SK, Sood AK, Anderson B, Sorosky J, Lubaroff DM. Psychosocial factors and interleukin-6 among women with advanced ovarian cancer. Cancer 2005; 104: 305-313, doi: 10.1002/cncr.21147.
23. LeMay LG, Vander AJ, Kluger MJ. The effects of psychological stress on plasma interleukin-6 activity in rats. Physiol Behav 1990; 47: 957-961, doi: 10.1016/0031-9384(90)90024-X.
24. 2 interferon/hepatocyte-stimulating factor/interleukin 6" promoter by cytokines, viruses, and second messenger agonists. Proc Natl Acad Sci U S A 1988; 85: 6701-6705, doi: 10.1073/pnas.85.18.6701.
25. Xiao W, Hodge DR, Wang L, Yang X, Zhang X, Farrar WL. Co-operative functions between nuclear factors NFκB and CCAT/enhancer-binding protein-β (C/EBP-β) regulate the IL-6 promoter in autocrine human prostate cancer cells. Prostate 2004; 61: 354-370, doi: 10.1002/pros.20113.
26. Rohrbach S, Engelhardt S, Lohse MJ, Werdan K, Holtz J, Muller-Werdan U. Activation of AP-1 contributes to the badrenoceptor-mediated myocardial induction of interleukin-6. Mol Med 2007; 13: 605-614, doi: 10.2119/2007-00071. Rohrbach.
27. Ray A, Sassone-Corsi P, Sehgal PB. A multiple cytokine-and second messenger-responsive element in the enhancer of the human interleukin-6 gene: similarities with c-fos gene regulation. Mol Cell Biol 1989; 9: 5537-5547.
28. Libermann TA, Baltimore D. Activation of interleukin-6 gene expression through the NF-κB transcription factor. Mol Cell Biol 1990; 10: 2327-2334.
29. Sands WA, Palmer TM. Regulating gene transcription in response to cyclic AMP elevation. Cell Signal 2008; 20: 460-466, doi: 10.1016/j.cellsig.2007.10.005.
30. Shaywitz AJ, Greenberg ME. CREB: a stimulus-induced transcription factor activated by a diverse array of extra-cellular signals. Annu Rev Biochem 1999; 68: 821-861, doi: 10.1146/annurev.biochem.68.1.821.
31. de Groot RP, Sassone-Corsi P. Activation of Jun/AP-1 by protein kinase A. Oncogene 1992; 7: 2281-2286.
32. Metz R, Ziff E. cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription. Genes Dev 1991; 5: 1754-1766, doi: 10.1101/gad.5.10.1754.
33. Shirakawa F, Mizel SB. In vitro activation and nuclear translocation of NF-κB catalyzed by cyclic AMP-dependent protein kinase and protein kinase C. Mol Cell Biol 1989; 9: 2424-2430.
34. Kondo A, Mogi M, Koshihara Y, Togari A. Signal transduction system for interleukin-6 and interleukin-11 synthesis stimulated by epinephrine in human osteoblasts and human osteogenic sarcoma cells. Biochem Pharmacol 2001; 61: 319-326, doi: 10.1016/S0006-2952(00)00544-X.
35. Wang P, Zhu F, Konstantopoulos K. Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A-and phosphatidylinositol 3-kinase-dependent NF-κB activation. Am J Physiol Cell Physiol 2010; 298: C1445-C1456, doi: 10.1152/ajpcell.00508.2009.
36. Ajuwon KM, Spurlock ME. Palmitate activates the NF-κB transcription factor and induces IL-6 and TNF-α expression in 3T3-L1 adipocytes. J Nutr 2005; 135: 1841-1846.