메뉴 건너뛰기




Volumn 15, Issue 3, 2014, Pages 4415-4430

Carvacrol and trans-cinnamaldehyde reduce Clostridium difficile toxin production and cytotoxicity in vitro

Author keywords

Clostridium difficile; Gene expression; Plant compounds; Toxins

Indexed keywords

BACTERIAL TOXIN; CARVACROL; CINNAMALDEHYDE; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; ACROLEIN; BACTERIAL PROTEIN; TERPENE;

EID: 84896473782     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15034415     Document Type: Article
Times cited : (56)

References (50)
  • 1
    • 0031022628 scopus 로고    scopus 로고
    • Clostridium difficile infection: Pathophysiology and diagnosis
    • Bartlett, J. G. Clostridium difficile infection: Pathophysiology and diagnosis. Semin. Gastrointest. Dis. 1997, 8, 12-21.
    • (1997) Semin. Gastrointest. Dis , vol.8 , pp. 12-21
    • Bartlett, J.G.1
  • 2
    • 71849085180 scopus 로고    scopus 로고
    • Clostridium difficile in food-Innocent bystander or serious threat?
    • Weese, J. S. Clostridium difficile in food-Innocent bystander or serious threat? Clin. Microbiol. Infect. 2010, 16, 3-10.
    • (2010) Clin. Microbiol. Infect , vol.16 , pp. 3-10
    • Weese, J.S.1
  • 3
    • 34249891873 scopus 로고    scopus 로고
    • Transcutaneous immunization with Clostridium difficile toxoid A induces systemic and mucosal immune responses and toxin a-neutralizing antibodies in mice
    • Ghose, C.; Kalsy, A.; Sheikh, A.; Rollenhagen, J.; John, M.; Young, J.; Rollins, S. M.; Qadri, F.; Calderwood, S. B.; Kelly, C. P.; et al. Transcutaneous immunization with Clostridium difficile toxoid A induces systemic and mucosal immune responses and toxin a-neutralizing antibodies in mice. Infect. Immun. 2007, 75, 2826-2832.
    • (2007) Infect. Immun , vol.75 , pp. 2826-2832
    • Ghose, C.1    Kalsy, A.2    Sheikh, A.3    Rollenhagen, J.4    John, M.5    Young, J.6    Rollins, S.M.7    Qadri, F.8    Calderwood, S.B.9    Kelly, C.P.10
  • 4
    • 0037312024 scopus 로고    scopus 로고
    • Clostridium difficile testing: After 20 years, still challenging
    • Wilkins, T. D.; Lyerly, D. M. Clostridium difficile testing: After 20 years, still challenging. J. Clin. Microbiol. 2003, 41, 531-534.
    • (2003) J. Clin. Microbiol , vol.41 , pp. 531-534
    • Wilkins, T.D.1    Lyerly, D.M.2
  • 5
    • 34447094682 scopus 로고    scopus 로고
    • The challenges posed by reemerging Clostridium difficile infection
    • Blossom, D. B.; McDonald, L. C. The challenges posed by reemerging Clostridium difficile infection. Clin. Infect. Dis. 2007, 45, 222-227.
    • (2007) Clin. Infect. Dis , vol.45 , pp. 222-227
    • Blossom, D.B.1    McDonald, L.C.2
  • 6
    • 64549163185 scopus 로고    scopus 로고
    • Clostridium difficile associated infection, diarrhea and colitis
    • Hookman, P.; Barkin, J. S. Clostridium difficile associated infection, diarrhea and colitis. World J. Gastroenterol. 2009, 15, 1554-1580.
    • (2009) World J. Gastroenterol , vol.15 , pp. 1554-1580
    • Hookman, P.1    Barkin, J.S.2
  • 7
    • 33644974808 scopus 로고    scopus 로고
    • Clostridium difficile-associated disease: New challenges from an established pathogen
    • Sunenshine, R. H.; McDonald, L. C. Clostridium difficile-associated disease: New challenges from an established pathogen. Clevel. Clin. J. Med. 2006, 73, 187-197.
    • (2006) Clevel. Clin. J. Med , vol.73 , pp. 187-197
    • Sunenshine, R.H.1    McDonald, L.C.2
  • 8
    • 29144473282 scopus 로고    scopus 로고
    • Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease
    • Dial, S.; Delaney, J. A.; Barkun, A. N.; Suissa, S. Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease. JAMA 2005, 294, 2989-2995.
    • (2005) JAMA , vol.294 , pp. 2989-2995
    • Dial, S.1    Delaney, J.A.2    Barkun, A.N.3    Suissa, S.4
  • 9
    • 33646439545 scopus 로고    scopus 로고
    • The comparative pathology of Clostridium difficile-associated disease
    • Keel, M. K.; Songer, J. G. The comparative pathology of Clostridium difficile-associated disease. Vet. Pathol. 2006, 43, 225-240.
    • (2006) Vet. Pathol , vol.43 , pp. 225-240
    • Keel, M.K.1    Songer, J.G.2
  • 10
    • 0032780795 scopus 로고    scopus 로고
    • A nonsense mutation abrogates production of a functional enterotoxin A in Clostridium difficile toxinotype VIII strains of serogroups F and X
    • Von Eichel-Streiber, C.; Zec-Pirnat, I.; Grabnar, M.; Rupnik, M. A nonsense mutation abrogates production of a functional enterotoxin A in Clostridium difficile toxinotype VIII strains of serogroups F and X. FEMS Microbiol. Lett. 1999, 178, 163-168.
    • (1999) FEMS Microbiol. Lett , vol.178 , pp. 163-168
    • Von Eichel-Streiber, C.1    Zec-Pirnat, I.2    Grabnar, M.3    Rupnik, M.4
  • 11
    • 33644523410 scopus 로고    scopus 로고
    • Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003
    • McDonald, L. C.; Owings, M.; Jernigan, D. B. Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003. Emerg. Infect. Dis. 2006, 12, 409-415.
    • (2006) Emerg. Infect. Dis , vol.12 , pp. 409-415
    • McDonald, L.C.1    Owings, M.2    Jernigan, D.B.3
  • 12
    • 79551662947 scopus 로고    scopus 로고
    • CcpA-mediated repression of Clostridium difficile toxin gene expression
    • Antunes, A.; Martin-Verstraete, I.; Dupuy, B. CcpA-mediated repression of Clostridium difficile toxin gene expression. Mol. Microbiol. 2011, 79, 882-899.
    • (2011) Mol. Microbiol , vol.79 , pp. 882-899
    • Antunes, A.1    Martin-Verstraete, I.2    Dupuy, B.3
  • 14
    • 77957834634 scopus 로고    scopus 로고
    • Integration of metabolism and virulence by Clostridium difficile CodY
    • Dineen, S. S.; McBride, S. M.; Sonenshein, A. L. Integration of metabolism and virulence by Clostridium difficile CodY. J. Bacteriol. 2010, 192, 5350-5362.
    • (2010) J. Bacteriol , vol.192 , pp. 5350-5362
    • Dineen, S.S.1    McBride, S.M.2    Sonenshein, A.L.3
  • 16
    • 0026746192 scopus 로고
    • Antibiotic-associated diarrhea
    • Bartlett, J. G. Antibiotic-associated diarrhea. Clin. Infect. Dis. 1992, 15, 573-581.
    • (1992) Clin. Infect. Dis , vol.15 , pp. 573-581
    • Bartlett, J.G.1
  • 18
    • 80052727726 scopus 로고    scopus 로고
    • Trends in antimicrobial resistance in intensive care units in the United States
    • Prabaker, K.; Weinstein, R. A. Trends in antimicrobial resistance in intensive care units in the United States. Curr. Opin. Crit. Care 2011, 17, 472-479.
    • (2011) Curr. Opin. Crit. Care , vol.17 , pp. 472-479
    • Prabaker, K.1    Weinstein, R.A.2
  • 19
    • 80052882560 scopus 로고    scopus 로고
    • European study group on Clostridium difficile (ESGCD). Multidrug resistance in European Clostridium difficile clinical isolates
    • Spigaglia, P.; Barbanti, F.; Mastrantonio, P. European study group on Clostridium difficile (ESGCD). Multidrug resistance in European Clostridium difficile clinical isolates. J. Antimicrob. Chemother. 2011, 66, 2227-2234.
    • (2011) J. Antimicrob. Chemother , vol.66 , pp. 2227-2234
    • Spigaglia, P.1    Barbanti, F.2    Mastrantonio, P.3
  • 20
    • 77958105240 scopus 로고    scopus 로고
    • Effect of Subinhibitory concentrations of plant-derived molecules in increasing the sensitivity of multidrug-resistant salmonella enterica serovar typhimurium DT104 to antibiotics
    • Johny, A. K.; Hoagland, T.; Venkitanarayanan, K. Effect of Subinhibitory concentrations of plant-derived molecules in increasing the sensitivity of multidrug-resistant salmonella enterica serovar typhimurium DT104 to antibiotics. Foodborne Pathog. Dis. 2010, 7, 1165-1170.
    • (2010) Foodborne Pathog. Dis , vol.7 , pp. 1165-1170
    • Johny, A.K.1    Hoagland, T.2    Venkitanarayanan, K.3
  • 21
    • 58849121486 scopus 로고    scopus 로고
    • Biological and pharmacological activities of carvacrol and carvacrol bearing essential oils
    • Baser, K. H. Biological and pharmacological activities of carvacrol and carvacrol bearing essential oils. Curr. Pharm. Des. 2008, 14, 3106-3119.
    • (2008) Curr. Pharm. Des , vol.14 , pp. 3106-3119
    • Baser, K.H.1
  • 22
    • 79952699823 scopus 로고    scopus 로고
    • Trans-cinnamaldehyde decreases attachment and invasion of uropathogenic escherichia coli in urinary tract epithelial cells by modulating virulence gene expression
    • Amalaradjou, M. A.; Narayanan, A.; Venkitanarayanan, K. Trans-cinnamaldehyde decreases attachment and invasion of uropathogenic escherichia coli in urinary tract epithelial cells by modulating virulence gene expression. J. Urol. 2011, 185, 1526-1531.
    • (2011) J. Urol , vol.185 , pp. 1526-1531
    • Amalaradjou, M.A.1    Narayanan, A.2    Venkitanarayanan, K.3
  • 23
    • 77953123901 scopus 로고    scopus 로고
    • Antibiofilm effect of trans-cinnamaldehyde on uropathogenic Escherichia coli
    • Amalaradjou, M. A.; Narayanan, A.; Baskaran, S. A.; Venkitanarayanan, K. Antibiofilm effect of trans-cinnamaldehyde on uropathogenic Escherichia coli. J. Urol. 2010, 184, 358-363.
    • (2010) J. Urol , vol.184 , pp. 358-363
    • Amalaradjou, M.A.1    Narayanan, A.2    Baskaran, S.A.3    Venkitanarayanan, K.4
  • 25
    • 21244433196 scopus 로고    scopus 로고
    • Effects of piperacillin/tazobactam on Clostridium difficile growth and toxin production in a human gut model
    • Baines, S. D.; Freeman, J.; Wilcox, M. H. Effects of piperacillin/tazobactam on Clostridium difficile growth and toxin production in a human gut model. J. Antimicrob. Chemother. 2005, 55, 974-982.
    • (2005) J. Antimicrob. Chemother , vol.55 , pp. 974-982
    • Baines, S.D.1    Freeman, J.2    Wilcox, M.H.3
  • 26
    • 0036207579 scopus 로고    scopus 로고
    • Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation
    • He, D.; Sougioultzis, S.; Hagen, S.; Liu, J.; Keates, S.; Keates, A. C.; Pothoulakis, C.; Lamont, J. T. Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation. Gastroenterology 2002, 122, 1048-1057.
    • (2002) Gastroenterology , vol.122 , pp. 1048-1057
    • He, D.1    Sougioultzis, S.2    Hagen, S.3    Liu, J.4    Keates, S.5    Keates, A.C.6    Pothoulakis, C.7    Lamont, J.T.8
  • 27
    • 0034546376 scopus 로고    scopus 로고
    • Clostridium difficile toxins A and B can alter epithelial permeability and promote bacterial paracellular migration through HT-29 enterocytes
    • Feltis, B. A.; Wiesner, S. M.; Kim, A. S.; Erlandsen, S. L.; Lyerly, D. L.; Wilkins, T. D.; Wells, C. L. Clostridium difficile toxins A and B can alter epithelial permeability and promote bacterial paracellular migration through HT-29 enterocytes. Shock 2000, 14, 629-634.
    • (2000) Shock , vol.14 , pp. 629-634
    • Feltis, B.A.1    Wiesner, S.M.2    Kim, A.S.3    Erlandsen, S.L.4    Lyerly, D.L.5    Wilkins, T.D.6    Wells, C.L.7
  • 30
    • 75949092121 scopus 로고    scopus 로고
    • Anti-virulence strategies to combat bacteria-mediated disease
    • Rasko, D. A.; Sperandio, V. Anti-virulence strategies to combat bacteria-mediated disease. Nat. Rev. Drug Discov. 2010, 9, 117-128.
    • (2010) Nat. Rev. Drug Discov , vol.9 , pp. 117-128
    • Rasko, D.A.1    Sperandio, V.2
  • 32
    • 27344443267 scopus 로고    scopus 로고
    • Small-molecule inhibitor of vibrio cholerae virulence and intestinal colonization
    • Hung, D. T.; Shakhnovich, E. A.; Pierson, E.; Mekalanos, J. J. Small-molecule inhibitor of vibrio cholerae virulence and intestinal colonization. Science 2005, 310, 670-674.
    • (2005) Science , vol.310 , pp. 670-674
    • Hung, D.T.1    Shakhnovich, E.A.2    Pierson, E.3    Mekalanos, J.J.4
  • 33
    • 38349127277 scopus 로고    scopus 로고
    • Inter-Kingdom signalling: Communication between bacteria and their hosts
    • Hughes, D. T.; Sperandio, V. Inter-Kingdom signalling: Communication between bacteria and their hosts. Nat. Rev. Microbiol. 2008, 6, 111-120.
    • (2008) Nat. Rev. Microbiol , vol.6 , pp. 111-120
    • Hughes, D.T.1    Sperandio, V.2
  • 34
    • 4644248905 scopus 로고    scopus 로고
    • Dual effects of MLS antibiotics: Transcriptional modulation and interactions on the ribosome
    • Tsui, W. H.; Yim, G.; Wang, H. H.; McClure, J. E.; Surette, M. G.; Davies, J. Dual effects of MLS antibiotics: Transcriptional modulation and interactions on the ribosome. Chem. Biol. 2004, 11, 1307-1316.
    • (2004) Chem. Biol , vol.11 , pp. 1307-1316
    • Tsui, W.H.1    Yim, G.2    Wang, H.H.3    McClure, J.E.4    Surette, M.G.5    Davies, J.6
  • 35
    • 84865620384 scopus 로고    scopus 로고
    • Recent advances in the role of probiotics in human inflammation and gut health
    • Rupa, P.; Mine, Y. Recent advances in the role of probiotics in human inflammation and gut health. J. Agric. Food Chem. 2012, 60, 8249-8256.
    • (2012) J. Agric. Food Chem , vol.60 , pp. 8249-8256
    • Rupa, P.1    Mine, Y.2
  • 36
    • 24644503241 scopus 로고    scopus 로고
    • Use of active substances of plant origin in chicken diets based on maize and locally grown cereals
    • Jamroz, D.; Wiliczkiewicz, A.; Wertelecki, T.; Orda, J.; Skorupinska, J. Use of active substances of plant origin in chicken diets based on maize and locally grown cereals. Br. Poult. Sci. 2005, 46, 485-493.
    • (2005) Br. Poult. Sci , vol.46 , pp. 485-493
    • Jamroz, D.1    Wiliczkiewicz, A.2    Wertelecki, T.3    Orda, J.4    Skorupinska, J.5
  • 37
    • 33750838301 scopus 로고    scopus 로고
    • In Vitro assessment of antimicrobial activity of carvacrol, thymol and cinnamaldehyde towards salmonella serotype typhimurium DT104: Effects of pig diets and emulsification in hydrocolloids
    • Si, W.; Gong, J.; Chanas, C.; Cui, S.; Yu, H.; Caballero, C.; Friendship, R. M. In Vitro assessment of antimicrobial activity of carvacrol, thymol and cinnamaldehyde towards salmonella serotype typhimurium DT104: Effects of pig diets and emulsification in hydrocolloids. J. Appl. Microbiol. 2006, 101, 1282-1291.
    • (2006) J. Appl. Microbiol , vol.101 , pp. 1282-1291
    • Si, W.1    Gong, J.2    Chanas, C.3    Cui, S.4    Yu, H.5    Caballero, C.6    Friendship, R.M.7
  • 38
    • 0035916975 scopus 로고    scopus 로고
    • Influence of carvacrol on growth and toxin production by bacillus cereus
    • Ultee, A.; Smid, E. J. Influence of carvacrol on growth and toxin production by bacillus cereus. Int. J. Food Microbiol. 2001, 64, 373-378.
    • (2001) Int. J. Food Microbiol , vol.64 , pp. 373-378
    • Ultee, A.1    Smid, E.J.2
  • 39
    • 84861760525 scopus 로고    scopus 로고
    • Plant-derived antimicrobials reduce listeria monocytogenes virulence factors in vitro, and down-regulate expression of virulence genes
    • Upadhyay, A.; Johny, A. K.; Amalaradjou, M. A.; Ananda Baskaran, S.; Kim, K. S.; Venkitanarayanan, K. Plant-derived antimicrobials reduce listeria monocytogenes virulence factors in vitro, and down-regulate expression of virulence genes. Int. J. Food Microbiol. 2012, 157, 88-94.
    • (2012) Int. J. Food Microbiol , vol.157 , pp. 88-94
    • Upadhyay, A.1    Johny, A.K.2    Amalaradjou, M.A.3    Ananda Baskaran, S.4    Kim, K.S.5    Venkitanarayanan, K.6
  • 40
    • 0036837792 scopus 로고    scopus 로고
    • Environmental response and autoregulation of Clostridium difficile TxeR, a sigma factor for toxin gene expression
    • Mani, N.; Lyras, D.; Barroso, L.; Howarth, P.; Wilkins, T.; Rood, J. I.; Sonenshein, A. L.; Dupuy, B. Environmental response and autoregulation of Clostridium difficile TxeR, a sigma factor for toxin gene expression. J. Bacteriol. 2002, 184, 5971-5978.
    • (2002) J. Bacteriol , vol.184 , pp. 5971-5978
    • Mani, N.1    Lyras, D.2    Barroso, L.3    Howarth, P.4    Wilkins, T.5    Rood, J.I.6    Sonenshein, A.L.7    Dupuy, B.8
  • 41
    • 0034978593 scopus 로고    scopus 로고
    • Pleiotropic transcriptional repressor CodY senses the intracellular pool of branched-chain amino acids in lactococcus lactis
    • Guedon, E.; Serror, P.; Ehrlich, S. D.; Renault, P.; Delorme, C. Pleiotropic transcriptional repressor CodY senses the intracellular pool of branched-chain amino acids in lactococcus lactis. Mol. Microbiol. 2001, 40, 1227-1239.
    • (2001) Mol. Microbiol , vol.40 , pp. 1227-1239
    • Guedon, E.1    Serror, P.2    Ehrlich, S.D.3    Renault, P.4    Delorme, C.5
  • 44
    • 84855978197 scopus 로고    scopus 로고
    • The impact of CodY on virulence determinant production in community-associated methicillin-resistant staphylococcus aureus
    • Rivera, F. E.; Miller, H. K.; Kolar, S. L.; Stevens, S. M., Jr.; Shaw, L. N. The impact of CodY on virulence determinant production in community-associated methicillin-resistant staphylococcus aureus. Proteomics 2012, 12, 263-268.
    • (2012) Proteomics , vol.12 , pp. 263-268
    • Rivera, F.E.1    Miller, H.K.2    Kolar, S.L.3    Stevens Jr., S.M.4    Shaw, L.N.5
  • 45
    • 84864822520 scopus 로고    scopus 로고
    • CodY deletion enhances in vivo virulence of community-associated methicillin-resistant staphylococcus aureus clone USA300
    • Montgomery, C. P.; Boyle-Vavra, S.; Roux, A.; Ebine, K.; Sonenshein, A. L.; Daum, R. S. CodY deletion enhances in vivo virulence of community-associated methicillin-resistant staphylococcus aureus clone USA300. Infect. Immun. 2012, 80, 2382-2389.
    • (2012) Infect. Immun , vol.80 , pp. 2382-2389
    • Montgomery, C.P.1    Boyle-Vavra, S.2    Roux, A.3    Ebine, K.4    Sonenshein, A.L.5    Daum, R.S.6
  • 46
    • 79955752437 scopus 로고    scopus 로고
    • Comparison of toxin and spore production in clinically relevant strains of Clostridium difficile
    • Vohra, P.; Poxton, I. R. Comparison of toxin and spore production in clinically relevant strains of Clostridium difficile. Microbiology 2011, 157, 1343-1353.
    • (2011) Microbiology , vol.157 , pp. 1343-1353
    • Vohra, P.1    Poxton, I.R.2
  • 47
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) method
    • Livak, K. J.; Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) method. Methods 2001, 25, 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 48
    • 84878518519 scopus 로고    scopus 로고
    • Bile acid recognition by the Clostridium difficile germinant receptor, CspC, is important for establishing infection
    • Francis, M. B.; Allen, C. A.; Shrestha, R.; Sorg, J. A. Bile acid recognition by the Clostridium difficile germinant receptor, CspC, is important for establishing infection. PLoS Pathog. 2013, 9, e1003356.
    • (2013) PLoS Pathog , vol.9
    • Francis, M.B.1    Allen, C.A.2    Shrestha, R.3    Sorg, J.A.4
  • 49
    • 84873551319 scopus 로고    scopus 로고
    • Proline-dependent regulation of Clostridium difficile stickland metabolism
    • Bouillaut, L.; Self, W. T.; Sonenshein, A. L. Proline-dependent regulation of Clostridium difficile stickland metabolism. J. Bacteriol. 2013, 195, 844-854.
    • (2013) J. Bacteriol , vol.195 , pp. 844-854
    • Bouillaut, L.1    Self, W.T.2    Sonenshein, A.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.