Redox regulation of MMP-3/TIMP-1 ratio in intestinal myofibroblasts: Effect of N-acetylcysteine and curcumin

Experimental Cell Research

Volumn 323, Issue 1, 2014, Pages 77-86

  Fontani, Filippo ^a   Marcucci, Tommaso ^b   Picariello, Lucia ^a   Tonelli, Francesco ^b   Vincenzini, Maria Teresa ^a   Iantomasi, Teresa ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Dipartimento di Chirurgia e Medicina Traslazionale (DCMT) Largo Brambilla 3   (Italy)

Author keywords

Crohn's disease; Curcumin; MMP 3; N acetylcysteine; Oxidative state

Indexed keywords

ACETYLCYSTEINE; BUTHIONINE SULFOXIMINE; CURCUMIN; GLUTATHIONE; GLUTATHIONE DISULFIDE; MESALAZINE; STEROID; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; CASE REPORT; CELL ISOLATION; CELL STIMULATION; COLON CANCER; COLON RESECTION; CONTROLLED STUDY; CROHN DISEASE; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; INTESTINAL SUBEPITHELIAL MYOFIBROBLAST; INTESTINE CELL; INTESTINE MUCOSA; MIDDLE AGED; MYOFIBROBLAST; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; UPREGULATION; YOUNG ADULT;

CROHNS DISEASE; CURCUMIN; MMP-3; N-ACETYLCYSTEINE; OXIDATIVE STATE;

ACETYLCYSTEINE; ADULT; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BUTHIONINE SULFOXIMINE; CELLS, CULTURED; COLON; CROHN DISEASE; CURCUMIN; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; INTESTINAL MUCOSA; MATRIX METALLOPROTEINASE 3; MIDDLE AGED; MYOFIBROBLASTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION; YOUNG ADULT;

EID: 84896469351     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2014.02.019     Document Type: Article

References (49)

1. MacDonald T.T., Monteleone G., Pender S.L. Recent developments in the immunology of inflammatory bowel disease. Scand. J. Immunol. 2000, 51:2-9.
2. Sternlicht M.D., Werb Z. How matrix metalloproteinases regulate cell behaviour. Annu. Rev. Cell Dev. Biol. 2001, 17:463-516.
3. Ogata Y., Enghild J.J., Nagase H. Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9. J. Biol. Chem. 1992, 267:3581-3584.
4. Gill S.E., Parks W.C. Metalloproteinases and their inhibitors: regulators of wound healing. Int. J. Biochem. Cell Biol. 2008, 40:1334-1347.
5. Naito Y., Yoshikawa T. Role of matrix metalloproteinases in inflammatory bowel disease. Mol. Asp. Med. 2005, 26:379-390.
6. Louis E., Ribbens C., Godon A., Franchimont D., De Groote D., Hardy N., Boniver J., Belaiche J., Malaise M. Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease. Clin. Exp. Immunol. 2000, 120:241-246.
7. von Lampe B., Barthel B., Coupland S.E., Riecken E.O., Rosewicz S. Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease. Gut 2000, 47:63-73.
8. Meijer M.J., Mieremet-Ooms M.A., van der Zon A.M., van Duijn W., van Hogezand R.A., Sier C.F., Hommes D.W., Lamers C.B., Verspaget H.W. Increased mucosal matrix metalloproteinase-1, -2, -3 and -9 activity in patients with inflammatory bowel disease and the relation with Crohn[U+05F3]s disease phenotype. Dig. Liver Dis. 2007, 39:733-739.
9. Nagase H., Woessner J.F. Matrix metalloproteinases. J. Biol. Chem. 1999, 274:21491-21494.
10. Catarzi S., Favilli F., Romagnoli C., Marcucci T., Picariello L., Tonelli F., Vincenzini M.T., Iantomasi T. Oxidative state and IL-6 production in intestinal myofibroblasts of Crohn's disease patients. Inflamm. Bowel Dis. 2011, 17:1674-1684.
11. Pinto M.A.S., Soares-Mota S., Lopes M., Bastos S.T.O., Reigada C.L.L., Dantas R.F., Neto J.C.B., Luna A.S., Madi K., Nunes T., Zaltman C. Does active Crohn's disease have decreased intestinal antioxidant capacity?. J. Crohns Colitis 2013, 7:e358-e366.
12. Alge-Priglinger C.S., Kreutze T., Obholzer K., Wolf A., Mempel M., Kernt M., Kampik A., Priglinger S.G. Oxidative stress-mediated induction of MMP-1 and MMP-3 in human RPE cells. Investig. Ophthalmol. Vis. Sci. 2009, 50:5495-5503.
13. Romagnoli C., Marcucci T., Picariello L., Tonelli F., Vincenzini M.T., Iantomasi T. Role of N-acetylcysteine and GSH redox system on total and active MMP-2 in intestinal myofibroblasts of Crohn[U+05F3]s disease patients. J. Colorectal Dis. 2013, 28:915-924.
14. Ra H.J., Parks W.C. Control of matrix metalloproteinase catalytic activity. Matrix Biol. 2007, 26:587-596.
15. Rieder F., Brenmoehl J., Leeb S., Schölmerich J., Rogler G. Wound healing and fibrosis in intestinal disease. Gut 2007, 56:130-139.
16. Di Sabatino A., Jackson C.L., Pickard K.M., Buckley M., Rovedatti L., Leakey N.A., Picariello L., Cazzola P., Monteleone G., Tonelli F., Corazza G.R., MacDonald T.T., Pender S.L. Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn[U+05F3]s disease strictures. Gut 2009, 58:777-789.
17. Armaka M., Apostolaki M., Jacques P., Kontoyiannis D.L., Elewaut D., Kollias G. Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J. Exp. Med. 2008, 205:331-337.
18. Medina C., Radomski M.W. Role of matrix metalloproteinases in intestinal inflammation. J Pharmacol. Exp. Ther. 2006, 318:933-938.
19. Best W.R., Becktel J.M., Singleton J.W., Kern F. Development of a Crohn[U+05F3]s disease activity index. National Cooperative Crohn[U+05F3]s Disease Study. Gastroenterology 1976, 70:439-444.
20. Mahida Y.R., Galvin A.M., Gray T., Makh S., McAlindon M.E., Sewell H.F., Podolsky D.K. Migration of human intestinal lamina propria lymphocytes, macrophages and eosinophils following the loss of surface epithelial cells. Clin. Exp. Immunol. 1997, 109:377-386.
21. Di Sabatino A., Pender S.L., Jackson C.L., Prothero J.D., Gordon J.N., Picariello L., Rovedatti L., Docena G., Monteleone G., Rampton D.S., Tonelli F., Corazza G.R., MacDonald T.T. Functional modulation of Crohn[U+05F3]s disease myofibroblasts by anti-tumor necrosis factor antibodies. Gastroenterology 2007, 133:137-149.
22. Valentich J.D., Popov V., Saada J.I., Powell D.W. Phenotypic characterization of an intestinal subepithelial myofibroblast cell line. Am. J. Physiol. 1997, 272:C1513-C1524.
23. Papadakis K.A., Targan S.R. Tumor necrosis factor: biology and therapeutic inhibitors. Gastroenterology 2000, 119:1148-1157.
24. Bamba S., Andoh A., Yasui H., Araki Y., Bamba T., Fujiyama Y. Matrix metalloproteinase-3 secretion from human colonic subepithelial myofibroblasts: role of interleukin-17. J. Gastroenterol. 2003, 38:548-554.
25. Balzary R.W., Cocks T.M. Lipopolysaccharide induces epithelium- and prostaglandin E(2)-dependent relaxation of mouse isolated trachea through activation of cyclooxygenase (COX)-1 and COX-2. J. Pharmacol. Exp. Ther. 2006, 317:806-812.
26. Epstein J., Docena G., MacDonald T.T., Sanderson I.R. Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease. Br. J. Nutr. 2010, 103:824-832.
27. Iantomasi T., Favilli F., Degl'Innocenti D., Vincenzini M.T. Increased glutathione synthesis associated with platelet-derived growth factor stimulation of NIH3T3 fibroblasts. Biochim. Biophys. Acta 1999, 1452:303-312.
28. Catarzi S., Romagnoli C., Marcucci G., Favilli F., Iantomasi T., Vincenzini M.T. Redox regulation of ERK1/2 activation induced by sphingosine 1-phosphate in fibroblasts: involvement of NADPH oxidase and platelet-derived growth factor receptor. Biochim. Biophys. Acta 2011, 1810:446-456.
29. Lavoie S., Chen Y., Dalton T.P., Gysin R., Cuénod M., Steullet P., Do K.Q. Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit. J. Neurochem. 2009, 108:1410-1422.
30. Camacho-Barquero L., Villegas I., Sánchez-Calvo J.M., Talero E., Sánchez-Fidalgo S., Motilva V., Alarcón de la Lastra C. Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis. Int. Immunopharmacol. 2007, 7:333-342.
31. Aggarwal S., Ichikawa H., Takada Y., Sandur S.K., Shishodia S., Aggarwal B.B. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Mol. Pharmacol. 2006, 69:195-206.
32. Vincenti M.P., Brinckerhoff C.E. Signal transduction and cell-type specific regulation of matrix metalloproteinase gene expression: can MMPs be good for you?. J. Cell Physiol. 2007, 213:355-364.
33. Matsuzawa A., Ichijo H. Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signalling. Biochim. Biophys. Acta 2008, 1780:1325-1336.
34. Hata K., Andoh A., Shimada M., Fujino S., Bamba S., Araki Y., Okuno T., Fujiyama Y., Bamba T. IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts. Am. J. Physiol. Gastrointest Liver Physiol. 2002, 282:G1035-G1044.
35. Hotokezaka H., Sakai E., Kanaoka K., Saito K., Matsuo K., Kitaura H., Yoshida N., Nakayama K. U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells. J. Biol. Chem. 2002, 277:47366-47372.
36. Guo R.X., Zhang.M., Liu W., Zhao C.M., Cui Y., Wang C.H., Feng J.Q., Chen P.X. NMDA receptors are involved in upstream of the spinal JNK activation in morphine antinociceptive tolerance. Neurosci. Lett. 2009, 467:95-99.
37. Rossa C., Liu M., Patil C., Kirkwood K.L. MKK3/6-p38 MAPK negatively regulates murine MMP-13 gene expression induced by IL-1beta and TNF-alpha in immortalized periodontal ligament fibroblasts. Matrix Biol. 2005, 24:478-488.
38. McKaig B.C., McWilliams D., Watson S.A., Mahida Y.R. Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease. Am. J. Pathol. 2003, 162:1355-1360.
39. Yoo J., Rodriguez Perez C.E., Nie W., Sinnett-Smith J., Rozengurt E. Protein kinase D1 mediates synergistic MMP-3 expression induced by TNF-α and bradykinin in human colonic myofibroblasts. Biochem. Biophys. Res. Commun. 2011, 413:30-35.
40. Knight D.M., Trinh H., Le J., Siegel S., Shealy D., McDonough M., Scallon B., Moore M.A., Vilcek J., Daddona P., et al. Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol. Immunol. 1993, 30:1443-1453.
41. Blikslager A.T., Moeser A.J., Gookin J.L., Jones S.L., Odle J. Restoration of barrier function in injured intestinal mucosa. Physiol. Rev. 2007, 87:545-564.
42. Radisky D.C., Levy D.D., Littlepage L.E., Liu H., Nelson C.M., Fata J.E., Leake D., Godden E.L., Albertson D.G., Nieto M.A., Werb Z., Bissell M.J. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 2005, 436:123-127.
43. Selman M., Pardo A., Kaminski N. Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs?. PLoS Med. 2008, 5:e62.
44. McCubrey J.A., Lahair M.M., Franklin R.A. Reactive oxygen species-induced activation of the MAP kinase signaling pathways. Antioxid. Redox Signal. 2006, 8:1775-1789.
45. Yan C., Boyd D.D. Regulation of matrix metalloproteinase gene expression. J. Cell Physiol. 2007, 211:19-26.
46. Shishodia S. Molecular mechanisms of curcumin action: gene expression. Biofactors 2013, 39:37-55.
47. Ali T., Shakir F., Morton J. Curcumin and inflammatory bowel disease: biological mechanisms and clinical implication. Digestion 2012, 85:249-255.
48. Chu W.M. Tumor necrosis factor. Cancer Lett. 2013, 328:222-225.
49. Rezaei A., Ardestani S.K., Forouzandeh M., Tavangar S.M., Khorramizadeh M.R., Payabvash S., Nezami B.G., Jahanshiri Z., Tavakoli Z., Shariftabrizi A., Dehpour A.R. The effects of N-acetylcysteine on the expression of matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 in hepatic fibrosis in bile duct ligated rats. Hepatol. Res. 2008, 38:1252-1263.