The trans-activator RNF12 and cis-acting elements effectuate X chromosome inactivation independent of X-pairing

Molecular Cell

Volumn 53, Issue 6, 2014, Pages 965-978

  Barakat, Tahsin Stefan ^a   Loos, Friedemann ^a   Van Staveren, Selma ^a   Myronova, Elvira ^a   Ghazvini, Mehrnaz ^a   Grootegoed, J Anton ^a   Gribnau, Joost ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CIS ACTING ELEMENT; RNF12 PROTEIN; TRANS ACTING FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; GENOMIC DNA; MACROGOL; PROTEIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; CHROMOSOME DELETION; CHROMOSOME PAIRING; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; FEMALE; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE SILENCING; HETEROKARYON; HOMOLOGOUS RECOMBINATION; KARYOTYPE 46,XX; MALE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSIENT EXPRESSION; X CHROMOSOME; X CHROMOSOME INACTIVATION; ANIMAL CELL CULTURE; CELL NUCLEUS MEMBRANE; CELL PROLIFERATION ASSAY; CELL SURVIVAL; DNA RNA HYBRIDIZATION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MUTATION; IMMUNOFLUORESCENCE; MORPHOLOGY; QUANTITATIVE ANALYSIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TRANSGENICS; UPREGULATION; X CHROMOSOME PAIRING;

EUTHERIA;

ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; CHROMOSOME PAIRING; EMBRYONIC STEM CELLS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MICE, KNOCKOUT; RNA, LONG NONCODING; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES; X CHROMOSOME; X CHROMOSOME INACTIVATION;

EID: 84896403930     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2014.02.006     Document Type: Article

References (30)

1. Augui S., Filion G.J., Huart S., Nora E., Guggiari M., Maresca M., Stewart A.F., Heard E. Sensing X chromosome pairs before X inactivation via a novel X-pairing region of the Xic. Science 2007, 318:1632-1636.
2. Augui S., Nora E.P., Heard E. Regulation of X-chromosome inactivation by the X-inactivation centre. Nat. Rev. Genet. 2011, 12:429-442.
3. Bacher C.P., Guggiari M., Brors B., Augui S., Clerc P., Avner P., Eils R., Heard E. Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation. Nat. Cell Biol. 2006, 8:293-299.
4. Barakat T.S., Jonkers I., Monkhorst K., Gribnau J. X-changing information on X inactivation. Exp. Cell Res. 2010, 316:679-687.
5. Barakat T.S., Gunhanlar N., Pardo C.G., Achame E.M., Ghazvini M., Boers R., Kenter A., Rentmeester E., Grootegoed J.A., Gribnau J. RNF12 activates Xist and is essential for X chromosome inactivation. PLoS Genet. 2011, 7:e1002001.
6. Barakat T.S., Rentmeester E., Sleutels F., Grootegoed J.A., Gribnau J. Precise BAC targeting of genetically polymorphic mouse ES cells. Nucleic Acids Res. 2011, 39:e121.
7. Borsani G., Tonlorenzi R., Simmler M.C., Dandolo L., Arnaud D., Capra V., Grompe M., Pizzuti A., Muzny D., Lawrence C., et al. Characterization of a murine gene expressed from the inactive X chromosome. Nature 1991, 351:325-329.
8. Brockdorff N., Ashworth A., Kay G.F., Cooper P., Smith S., McCabe V.M., Norris D.P., Penny G.D., Patel D., Rastan S. Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome. Nature 1991, 351:329-331.
9. Chureau C., Chantalat S., Romito A., Galvani A., Duret L., Avner P., Rougeulle C. Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region. Hum. Mol. Genet. 2011, 20:705-718.
10. Csankovszki G., Panning B., Bates B., Pehrson J.R., Jaenisch R. Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation. Nat. Genet. 1999, 22:323-324.
11. de Wit E., Bouwman B.A., Zhu Y., Klous P., Splinter E., Verstegen M.J., Krijger P.H., Festuccia N., Nora E.P., Welling M., et al. The pluripotent genome in three dimensions is shaped around pluripotency factors. Nature 2013, 501:227-231.
12. Dixon J.R., Selvaraj S., Yue F., Kim A., Li Y., Shen Y., Hu M., Liu J.S., Ren B. Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature 2012, 485:376-380.
13. Donohoe M.E., Silva S.S., Pinter S.F., Xu N., Lee J.T. The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting. Nature 2009, 460:128-132.
14. Gontan C., Achame E.M., Demmers J., Barakat T.S., Rentmeester E., van IJcken W., Grootegoed J.A., Gribnau J. RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation. Nature 2012, 485:386-390.
15. Gribnau J., Grootegoed J.A. Origin and evolution of X chromosome inactivation. Curr. Opin. Cell Biol. 2012, 24:397-404.
16. Jonkers I., Monkhorst K., Rentmeester E., Grootegoed J.A., Grosveld F., Gribnau J. Xist RNA is confined to the nuclear territory of the silenced X chromosome throughout the cell cycle. Mol. Cell. Biol. 2008, 28:5583-5594.
17. Jonkers I., Barakat T.S., Achame E.M., Monkhorst K., Kenter A., Rentmeester E., Grosveld F., Grootegoed J.A., Gribnau J. RNF12 is an X-Encoded dose-dependent activator of X chromosome inactivation. Cell 2009, 139:999-1011.
18. Lee J.T., Davidow L.S., Warshawsky D. Tsix, a gene antisense to Xist at the X-inactivation centre. Nat. Genet. 1999, 21:400-404.
19. Masui O., Bonnet I., Le Baccon P., Brito I., Pollex T., Murphy N., Hupé P., Barillot E., Belmont A.S., Heard E. Live-cell chromosome dynamics and outcome of X chromosome pairing events during ES cell differentiation. Cell 2011, 145:447-458.
20. Monkhorst K., Jonkers I., Rentmeester E., Grosveld F., Gribnau J. X inactivation counting and choice is a stochastic process: evidence for involvement of an X-linked activator. Cell 2008, 132:410-421.
21. Navarro P., Oldfield A., Legoupi J., Festuccia N., Dubois A., Attia M., Schoorlemmer J., Rougeulle C., Chambers I., Avner P. Molecular coupling of Tsix regulation and pluripotency. Nature 2010, 468:457-460.
22. Nora E.P., Lajoie B.R., Schulz E.G., Giorgetti L., Okamoto I., Servant N., Piolot T., van Berkum N.L., Meisig J., Sedat J., et al. Spatial partitioning of the regulatory landscape of the X-inactivation centre. Nature 2012, 485:381-385.
23. Schoenfelder S., Sexton T., Chakalova L., Cope N.F., Horton A., Andrews S., Kurukuti S., Mitchell J.A., Umlauf D., Dimitrova D.S., et al. Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells. Nat. Genet. 2010, 42:53-61.
24. Shin J., Bossenz M., Chung Y., Ma H., Byron M., Taniguchi-Ishigaki N., Zhu X., Jiao B., Hall L.L., Green M.R., et al. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature 2010, 467:977-981.
25. Sun S., Del Rosario B.C., Szanto A., Ogawa Y., Jeon Y., Lee J.T. Jpx RNA activates Xist by evicting CTCF. Cell 2013, 153:1537-1551.
26. Tian D., Sun S., Lee J.T. The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation. Cell 2010, 143:390-403.
27. Tsai C.L., Rowntree R.K., Cohen D.E., Lee J.T. Higher order chromatin structure at the X-inactivation center via looping DNA. Dev. Biol. 2008, 319:416-425.
28. Wutz A. Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation. Nature Rev. Genet. 2011, 12:542-553.
29. Xu N., Tsai C.L., Lee J.T. Transient homologous chromosome pairing marks the onset of X inactivation. Science 2006, 311:1149-1152.
30. Xu N., Donohoe M.E., Silva S.S., Lee J.T. Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein. Nat. Genet. 2007, 39:1390-1396.