Modulation of protein adsorption by poloxamer 188 in relation to polysorbates 80 and 20 at solid surfaces

Journal of Pharmaceutical Sciences

Volumn 103, Issue 4, 2014, Pages 1043-1049

  Kim, Hyojin L ^a,b   McAuley, Arnold ^b   Livesay, Brynn ^a   Gray, Warren D ^a   McGuire, Joseph ^a  

^a Oregon State University   (United States)

^b AMGEN INC   (United States)

Author keywords

adsorption; excipients; kinetics; optical waveguide lightmode spectroscopy (OWLS); poloxamer; polysorbate; protein; recombinant protein stabilization; surfactants

Indexed keywords

LYSOZYME; POLOXAMER; POLYSORBATE 20; POLYSORBATE 80; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT PROTEIN; SILICON DIOXIDE; SURFACTANT; TITANIUM;

ADSORPTION; ARTICLE; BINDING AFFINITY; CELL ADHESION; COLLOID; COMPLEX FORMATION; HYDROPHILICITY; KINETICS; OPTICAL WAVEGUIDE LIGHTMODE SPECTROSCOPY; PROTEIN STABILITY; SOLID; SPECTROSCOPY;

ADSORPTION; EXCIPIENTS; KINETICS; OPTICAL WAVEGUIDE LIGHTMODE SPECTROSCOPY (OWLS); POLOXAMER; POLYSORBATE; PROTEIN; RECOMBINANT PROTEIN STABILIZATION; SURFACTANTS;

ADSORPTION; ANIMALS; CHICKENS; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; MURAMIDASE; POLOXAMER; POLYSORBATES; PROTEIN STABILITY; RECOMBINANT PROTEINS; SILICON DIOXIDE; SURFACE PROPERTIES; SURFACE-ACTIVE AGENTS; TITANIUM;

EID: 84896393021     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23907     Document Type: Article

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