Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides

Neurogastroenterology and Motility

Volumn 26, Issue 4, 2014, Pages 470-481

  Fichna, J ^a,b,c   Salaga M ^c   Stuart, J ^d   Saur, D ^e   Sobczak, M ^c   Zatorski, H ^c   Timmermans, J P ^f   Bradshaw, H B ^d   Ahn, K ^g   Storr, M A ^a,b,h  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c MEDICAL UNIVERSITY OF LODZ   (Poland)

^d INDIANA UNIVERSITY   (United States)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f UNIVERSITY OF ANTWERP   (Belgium)

^g PFIZER INC   (United States)

^h UNIVERSITY OF MUNICH   (Germany)

Author keywords

Anandamide; Diarrhea predominant irritable bowel syndrome; Endocannabinoid system; Fatty acid amide hydrolase; Visceral pain

Indexed keywords

ANTIDIARRHEAL AGENT; ANTINOCICEPTIVE AGENT; ENDOCANNABINOID; FATTY ACID AMIDASE; FATTY ACID AMIDASE INHIBITOR; PF 3845; UNCLASSIFIED DRUG; AMIDASE; ANALGESIC AGENT; CANNABINOID 1 RECEPTOR; FATTY-ACID AMIDE HYDROLASE; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIARRHEAL ACTIVITY; ANTINOCICEPTION; ARTICLE; CENTRAL NERVOUS SYSTEM; COLON MOTILITY; CONTROLLED STUDY; ENZYME INHIBITION; GASTROINTESTINAL MOTILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTESTINAL DYSMOTILITY; INTESTINE MOTILITY; LOCOMOTION; MALE; MOUSE; NONHUMAN; PAIN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; COLON; DRUG EFFECTS; ILEUM; METABOLISM; PHYSIOLOGY;

AMIDOHYDROLASES; ANALGESICS; ANIMALS; ANTIDIARRHEALS; COLON; ENDOCANNABINOIDS; GASTROINTESTINAL MOTILITY; ILEUM; MALE; MICE; PIPERIDINES; PYRIDINES; RECEPTOR, CANNABINOID, CB1;

EID: 84896389674     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/nmo.12272     Document Type: Article

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