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Volumn 17, Issue 4, 2014, Pages 675-684

Nalmefene for the treatment of alcohol dependence: A current update

Author keywords

Alcohol; alcoholism; nalmefene; opioid antagonists; opioid receptors

Indexed keywords

NALMEFENE; PLACEBO; NALTREXONE; NARCOTIC ANTAGONIST;

EID: 84896388884     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145713001284     Document Type: Review
Times cited : (29)

References (116)
  • 3
    • 38949103745 scopus 로고    scopus 로고
    • An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: Results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study
    • Anton RF, Oroszi G, O'Malley S, Couper D, Swift R, Pettinati H, Goldman D (2008) An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry 65:135-144.
    • (2008) Arch Gen Psychiatry , vol.65 , pp. 135-144
    • Anton, R.F.1    Oroszi, G.2    O'Malley, S.3    Couper, D.4    Swift, R.5    Pettinati, H.6    Goldman, D.7
  • 4
    • 84868201122 scopus 로고    scopus 로고
    • Naltrexone modification of drinking effects in a subacute treatment and bar-lab paradigm: Influence of OPRM1 and dopamine transporter (SLC6A3) genes
    • Anton RF, Voronin KK, Randall PK, Myrick H, Tiffany A (2012) Naltrexone modification of drinking effects in a subacute treatment and bar-lab paradigm: influence of OPRM1 and dopamine transporter (SLC6A3) genes. Alcohol Clin Exp Res 36:2000-2007.
    • (2012) Alcohol Clin Exp Res , vol.36 , pp. 2000-2007
    • Anton, R.F.1    Voronin, K.K.2    Randall, P.K.3    Myrick, H.4    Tiffany, A.5
  • 6
    • 84866490007 scopus 로고    scopus 로고
    • Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol
    • Ashenhurst JR, Bujarski S, Ray LA (2012) Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol. Pharmacol Biochem Behav 103:253-259.
    • (2012) Pharmacol Biochem Behav , vol.103 , pp. 253-259
    • Ashenhurst, J.R.1    Bujarski, S.2    Ray, L.A.3
  • 7
    • 84884412326 scopus 로고    scopus 로고
    • Emerging pharmacotherapies for alcohol dependence: A systematic review focusing on reduction in consumption
    • Aubin HJ, Daeppen JB (2013) Emerging pharmacotherapies for alcohol dependence: a systematic review focusing on reduction in consumption. Drug Alcohol Depend 133:15-29.
    • (2013) Drug Alcohol Depend , vol.133 , pp. 15-29
    • Aubin, H.J.1    Daeppen, J.B.2
  • 8
    • 33847704911 scopus 로고    scopus 로고
    • Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques
    • Barr CS, Schwandt M, Lindell SG, Chen SA, Goldman D, Suomi SJ, Higley JD, Heilig M (2007) Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques. Arch Gen Psychiatry 64:369-376.
    • (2007) Arch Gen Psychiatry , vol.64 , pp. 369-376
    • Barr, C.S.1    Schwandt, M.2    Lindell, S.G.3    Chen, S.A.4    Goldman, D.5    Suomi, S.J.6    Higley, J.D.7    Heilig, M.8
  • 10
    • 27844519330 scopus 로고    scopus 로고
    • Nalmefene induced elevation in serum prolactin in normal human volunteers: Partial kappa opioid agonist activity?
    • Bart G, Schluger JH, Borg L, Ho A, Bidlack JM, Kreek MJ (2005a) Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity? Neuropsychopharmacology 30:2254-2262.
    • (2005) Neuropsychopharmacology , vol.30 , pp. 2254-2262
    • Bart, G.1    Schluger, J.H.2    Borg, L.3    Ho, A.4    Bidlack, J.M.5    Kreek, M.J.6
  • 11
    • 12344265724 scopus 로고    scopus 로고
    • Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden
    • Bart G, Kreek MJ, Ott J, LaForge KS, Proudnikov D, Pollak L, Heilig M (2005b) Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden. Neuropsychopharmacology 30:417-422.
    • (2005) Neuropsychopharmacology , vol.30 , pp. 417-422
    • Bart, G.1    Kreek, M.J.2    Ott, J.3    Laforge, K.S.4    Proudnikov, D.5    Pollak, L.6    Heilig, M.7
  • 12
    • 0017623919 scopus 로고
    • Enkephalin may mediate euphoria and drive-reduction reward
    • Belluzzi JD, Stein L (1977) Enkephalin may mediate euphoria and drive-reduction reward. Nature 266:556-558.
    • (1977) Nature , vol.266 , pp. 556-558
    • Belluzzi, J.D.1    Stein, L.2
  • 13
    • 1642482761 scopus 로고    scopus 로고
    • Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependence
    • Bencherif B, Wand GS, McCaul ME, Kim YK, Ilgin N, Dannals RF, Frost JJ (2004) Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependence. Biol Psychiatry 55:255-262.
    • (2004) Biol Psychiatry , vol.55 , pp. 255-262
    • Bencherif, B.1    Wand, G.S.2    McCaul, M.E.3    Kim, Y.K.4    Ilgin, N.5    Dannals, R.F.6    Frost, J.J.7
  • 17
    • 84860257642 scopus 로고    scopus 로고
    • Association of micro-opioid receptor (OPRM1) gene polymorphism with response to naltrexone in alcohol dependence: A systematic review and meta-analysis
    • Chamorro AJ, Marcos M, Miron-Canelo JA, Pastor I, Gonzalez-Sarmiento R, Laso FJ (2012) Association of micro-opioid receptor (OPRM1) gene polymorphism with response to naltrexone in alcohol dependence: a systematic review and meta-analysis. Addict Biol 17:505-512.
    • (2012) Addict Biol , vol.17 , pp. 505-512
    • Chamorro, A.J.1    Marcos, M.2    Miron-Canelo, J.A.3    Pastor, I.4    Gonzalez-Sarmiento, R.5    Laso, F.J.6
  • 18
    • 0034028920 scopus 로고    scopus 로고
    • Effect of chronic ethanol and withdrawal on the mu-opioid receptor-and 5-Hydroxytryptamine(1A) receptor-stimulated binding of [(35) S]Guanosine-5′-O-(3-thio)triphosphate in the fawn-hooded rat brain: A quantitative autoradiography study
    • Chen F, Lawrence AJ (2000) Effect of chronic ethanol and withdrawal on the mu-opioid receptor-and 5-Hydroxytryptamine(1A) receptor-stimulated binding of [(35) S]Guanosine-5′-O-(3-thio)triphosphate in the fawn-hooded rat brain: a quantitative autoradiography study. J Pharmacol Exp Ther 293:159-165.
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 159-165
    • Chen, F.1    Lawrence, A.J.2
  • 19
    • 0036710854 scopus 로고    scopus 로고
    • Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats
    • Ciccocioppo R, Martin-Fardon R, Weiss F (2002) Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats. Neuropsychopharmacology 27:391-399.
    • (2002) Neuropsychopharmacology , vol.27 , pp. 391-399
    • Ciccocioppo, R.1    Martin-Fardon, R.2    Weiss, F.3
  • 20
    • 0033212713 scopus 로고    scopus 로고
    • The role of opioid-dopamine interactions in the induction and maintenance of ethanol consumption
    • Cowen MS, Lawrence AJ (1999) The role of opioid-dopamine interactions in the induction and maintenance of ethanol consumption. Prog Neuropsychopharmacol Biol Psychiatry 23:1171-1212.
    • (1999) Prog Neuropsychopharmacol Biol Psychiatry , vol.23 , pp. 1171-1212
    • Cowen, M.S.1    Lawrence, A.J.2
  • 21
    • 0034863007 scopus 로고    scopus 로고
    • Alterations in central preproenkephalin mRNA expression after chronic free-choice ethanol consumption by fawn-hooded rats
    • Cowen MS, Lawrence AJ (2001) Alterations in central preproenkephalin mRNA expression after chronic free-choice ethanol consumption by fawn-hooded rats. Alcohol Clin Exp Res 25:1126-1133.
    • (2001) Alcohol Clin Exp Res , vol.25 , pp. 1126-1133
    • Cowen, M.S.1    Lawrence, A.J.2
  • 22
    • 29044435185 scopus 로고    scopus 로고
    • Differences in the peripheral levels of beta-endorphin in response to alcohol and stress as a function of alcohol dependence and family history of alcoholism
    • Dai X, Thavundayil J, Gianoulakis C (2005) Differences in the peripheral levels of beta-endorphin in response to alcohol and stress as a function of alcohol dependence and family history of alcoholism. Alcohol Clin Exp Res 29:1965-1975.
    • (2005) Alcohol Clin Exp Res , vol.29 , pp. 1965-1975
    • Dai, X.1    Thavundayil, J.2    Gianoulakis, C.3
  • 23
    • 84871943577 scopus 로고    scopus 로고
    • Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders
    • Davies DL, Bortolato M, Finn DA, Ramaker MJ, Barak S, Ron D, Liang J, Olsen RW (2013) Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. Alcohol Clin Exp Res 37:8-15.
    • (2013) Alcohol Clin Exp Res , vol.37 , pp. 8-15
    • Davies, D.L.1    Bortolato, M.2    Finn, D.A.3    Ramaker, M.J.4    Barak, S.5    Ron, D.6    Liang, J.7    Olsen, R.W.8
  • 25
    • 0023551360 scopus 로고
    • Nalmefene: Safety and kinetics after single and multiple oral doses of a new opioid antagonist
    • Dixon R, Gentile J, Hsu HB, Hsiao J, Howes J, Garg D, Weidler D (1987) Nalmefene: safety and kinetics after single and multiple oral doses of a new opioid antagonist. J Clin Pharmacol 27:233-239.
    • (1987) J Clin Pharmacol , vol.27 , pp. 233-239
    • Dixon, R.1    Gentile, J.2    Hsu, H.B.3    Hsiao, J.4    Howes, J.5    Garg, D.6    Weidler, D.7
  • 26
    • 0037712812 scopus 로고    scopus 로고
    • A clinical laboratory paradigm for evaluating medication effects on alcohol consumption: Naltrexone and nalmefene
    • Drobes DJ, Anton RF, Thomas SE, Voronin K (2003) A clinical laboratory paradigm for evaluating medication effects on alcohol consumption: naltrexone and nalmefene. Neuropsychopharmacology 28:755-764.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 755-764
    • Drobes, D.J.1    Anton, R.F.2    Thomas, S.E.3    Voronin, K.4
  • 27
    • 4544346571 scopus 로고    scopus 로고
    • Effects of naltrexone and nalmefene on subjective response to alcohol among non-treatment-seeking alcoholics and social drinkers
    • Drobes DJ, Anton RF, Thomas SE, Voronin K (2004) Effects of naltrexone and nalmefene on subjective response to alcohol among non-treatment-seeking alcoholics and social drinkers. Alcohol Clin Exp Res 28:1362-1370.
    • (2004) Alcohol Clin Exp Res , vol.28 , pp. 1362-1370
    • Drobes, D.J.1    Anton, R.F.2    Thomas, S.E.3    Voronin, K.4
  • 28
    • 0028109622 scopus 로고
    • Binding affinity and selectivity of opioids at mu, delta and kappa receptors in monkey brain membranes
    • Emmerson PJ, Liu MR, Woods JH, Medzihradsky F (1994) Binding affinity and selectivity of opioids at mu, delta and kappa receptors in monkey brain membranes. J Pharmacol Exp Ther 271:1630-1637.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 1630-1637
    • Emmerson, P.J.1    Liu, M.R.2    Woods, J.H.3    Medzihradsky, F.4
  • 32
    • 84896392101 scopus 로고    scopus 로고
    • European Medicines Agency EMEA/HIL/002583-IAIN10002
    • European Medicines Agency (2013) Selincro (Nalmefene) product information. EMEA/HIL/002583-IAIN10002.
    • (2013) Selincro (Nalmefene) Product Information
  • 33
    • 0023003262 scopus 로고
    • Prolonged blockade of opioid effect with oral nalmefene
    • Gal TJ, DiFazio CA, Dixon R (1986) Prolonged blockade of opioid effect with oral nalmefene. Clin Pharmacol Ther 40:537-542.
    • (1986) Clin Pharmacol Ther , vol.40 , pp. 537-542
    • Gal, T.J.1    Difazio, C.A.2    Dixon, R.3
  • 34
    • 33947289675 scopus 로고    scopus 로고
    • Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: Results from the VA Cooperative Study
    • Gelernter J, Gueorguieva R, Kranzler HR, Zhang H, Cramer J, Rosenheck R, Krystal JH (2007) Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study. Alcohol Clin Exp Res 31:555-563.
    • (2007) Alcohol Clin Exp Res , vol.31 , pp. 555-563
    • Gelernter, J.1    Gueorguieva, R.2    Kranzler, H.R.3    Zhang, H.4    Cramer, J.5    Rosenheck, R.6    Krystal, J.H.7
  • 35
    • 2142817953 scopus 로고    scopus 로고
    • Endogenous opioids and addiction to alcohol and other drugs of abuse
    • Gianoulakis C (2004) Endogenous opioids and addiction to alcohol and other drugs of abuse. Curr Top Med Chem 4:39-50.
    • (2004) Curr Top Med Chem , vol.4 , pp. 39-50
    • Gianoulakis, C.1
  • 36
    • 0021240670 scopus 로고
    • Self-administration of methionine enkephalin into the nucleus accumbens
    • Goeders NE, Lane JD, Smith JE (1984) Self-administration of methionine enkephalin into the nucleus accumbens. Pharmacol Biochem Behav 20:451-455.
    • (1984) Pharmacol Biochem Behav , vol.20 , pp. 451-455
    • Goeders, N.E.1    Lane, J.D.2    Smith, J.E.3
  • 37
    • 1842476125 scopus 로고    scopus 로고
    • Co-occurrence of 12-month alcohol and drug use disorders and personality disorders in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions
    • Grant BF, Stinson FS, Dawson DA, Chou SP, Ruan WJ, Pickering RP (2004) Co-occurrence of 12-month alcohol and drug use disorders and personality disorders in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch Gen Psychiatry 61:361-368.
    • (2004) Arch Gen Psychiatry , vol.61 , pp. 361-368
    • Grant, B.F.1    Stinson, F.S.2    Dawson, D.A.3    Chou, S.P.4    Ruan, W.J.5    Pickering, R.P.6
  • 38
    • 84886798117 scopus 로고    scopus 로고
    • A randomised, double-blind, placebo-controlled, efficacy study of nalmefene, as-needed use, in patients with alcohol dependence
    • doi: 10.1016/j. euroneuro.2013.02.006
    • Gual A, He Y, Torup L, van den Brink W, Mann K (2013) A randomised, double-blind, placebo-controlled, efficacy study of nalmefene, as-needed use, in patients with alcohol dependence. Eur Neuropsychopharmacol. doi: 10.1016/j. euroneuro.2013.02.006.
    • (2013) Eur Neuropsychopharmacol
    • Gual, A.1    He, Y.2    Torup, L.3    Van Den Brink, W.4    Mann, K.5
  • 39
    • 33746325472 scopus 로고    scopus 로고
    • Pharmacological treatment of alcohol dependence: Target symptoms and target mechanisms
    • Heilig M, Egli M (2006) Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. Pharmacol Ther 111:855-876.
    • (2006) Pharmacol Ther , vol.111 , pp. 855-876
    • Heilig, M.1    Egli, M.2
  • 40
    • 19944426685 scopus 로고    scopus 로고
    • Correlation of stable elevations in striatal mu-opioid receptor availability in detoxified alcoholic patients with alcohol craving: A positron emission tomography study using carbon 11-labeled carfentanil
    • Heinz A, Reimold M, Wrase J, Hermann D, Croissant B, Mundle G, Dohmen BM, Braus DF, Schumann G, Machulla HJ, Bares R, Mann K (2005) Correlation of stable elevations in striatal mu-opioid receptor availability in detoxified alcoholic patients with alcohol craving: a positron emission tomography study using carbon 11-labeled carfentanil. Arch Gen Psychiatry 62:57-64.
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 57-64
    • Heinz, A.1    Reimold, M.2    Wrase, J.3    Hermann, D.4    Croissant, B.5    Mundle, G.6    Dohmen, B.M.7    Braus, D.F.8    Schumann, G.9    Machulla, H.J.10    Bares, R.11    Mann, K.12
  • 41
    • 0031037561 scopus 로고    scopus 로고
    • Endogenous opioid systems and alcohol addiction
    • Herz A (1997) Endogenous opioid systems and alcohol addiction. Psychopharmacology (Berl) 129:99-111.
    • (1997) Psychopharmacology (Berl) , vol.129 , pp. 99-111
    • Herz, A.1
  • 43
    • 0028171967 scopus 로고
    • Immunohistochemical localization of mu-opioid receptors in rat brain using antibodies generated against a peptide sequence present in a purified mu-opioid binding protein
    • Hiller JM, Zhang Y, Bing G, Gioannini TL, Stone EA, Simon EJ (1994) Immunohistochemical localization of mu-opioid receptors in rat brain using antibodies generated against a peptide sequence present in a purified mu-opioid binding protein. Neuroscience 62:829-841.
    • (1994) Neuroscience , vol.62 , pp. 829-841
    • Hiller, J.M.1    Zhang, Y.2    Bing, G.3    Gioannini, T.L.4    Stone, E.A.5    Simon, E.J.6
  • 44
    • 0022591828 scopus 로고
    • Consumption of ethanol solution is potentiated by morphine and attenuated by naloxone persistently across repeated daily administrations
    • Hubbell CL, Czirr SA, Hunter GA, Beaman CM, LeCann NC, Reid LD (1986) Consumption of ethanol solution is potentiated by morphine and attenuated by naloxone persistently across repeated daily administrations. Alcohol 3:39-54.
    • (1986) Alcohol , vol.3 , pp. 39-54
    • Hubbell, C.L.1    Czirr, S.A.2    Hunter, G.A.3    Beaman, C.M.4    Lecann, N.C.5    Reid, L.D.6
  • 45
    • 0024158716 scopus 로고
    • Constant infusions of morphine and intakes of sweetened ethanol solution among rats
    • Hubbell CL, Abelson ML, Burkhardt CA, Herlands SE, Reid LD (1988) Constant infusions of morphine and intakes of sweetened ethanol solution among rats. Alcohol 5:409-415.
    • (1988) Alcohol , vol.5 , pp. 409-415
    • Hubbell, C.L.1    Abelson, M.L.2    Burkhardt, C.A.3    Herlands, S.E.4    Reid, L.D.5
  • 47
    • 66549117005 scopus 로고    scopus 로고
    • Effect of acute ethanol administration on the release of opioid peptides from the midbrain including the ventral tegmental area
    • Jarjour S, Bai L, Gianoulakis C (2009) Effect of acute ethanol administration on the release of opioid peptides from the midbrain including the ventral tegmental area. Alcohol Clin Exp Res 33:1033-1043.
    • (2009) Alcohol Clin Exp Res , vol.33 , pp. 1033-1043
    • Jarjour, S.1    Bai, L.2    Gianoulakis, C.3
  • 48
    • 34548147088 scopus 로고    scopus 로고
    • Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: Evidence of genotype specific sexual dimorphic epistasis
    • Job MO, Tang A, Hall FS, Sora I, Uhl GR, Bergeson SE, Gonzales RA (2007) Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis. Biol Psychiatry 62:627-634.
    • (2007) Biol Psychiatry , vol.62 , pp. 627-634
    • Job, M.O.1    Tang, A.2    Hall, F.S.3    Sora, I.4    Uhl, G.R.5    Bergeson, S.E.6    Gonzales, R.A.7
  • 50
    • 34250616600 scopus 로고    scopus 로고
    • Targeted nalmefene with simple medical management in the treatment of heavy drinkers: A randomized double-blind placebo-controlled multicenter study
    • Karhuvaara S, Simojoki K, Virta A, Rosberg M, Loyttyniemi E, Nurminen T, Kallio A, Makela R (2007) Targeted nalmefene with simple medical management in the treatment of heavy drinkers: a randomized double-blind placebo-controlled multicenter study. Alcohol Clin Exp Res 31:1179-1187.
    • (2007) Alcohol Clin Exp Res , vol.31 , pp. 1179-1187
    • Karhuvaara, S.1    Simojoki, K.2    Virta, A.3    Rosberg, M.4    Loyttyniemi, E.5    Nurminen, T.6    Kallio, A.7    Makela, R.8
  • 51
    • 20344374645 scopus 로고    scopus 로고
    • Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication
    • Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE (2005) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:617-627.
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 617-627
    • Kessler, R.C.1    Chiu, W.T.2    Demler, O.3    Merikangas, K.R.4    Walters, E.E.5
  • 54
    • 84863775013 scopus 로고    scopus 로고
    • Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: Relationship to alcohol dependence symptoms
    • Koller G, Zill P, Rujescu D, Ridinger M, Pogarell O, Fehr C, Wodarz N, Bondy B, Soyka M, Preuss UW (2012) Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol dependence symptoms. Alcohol Clin Exp Res 36:1230-1236.
    • (2012) Alcohol Clin Exp Res , vol.36 , pp. 1230-1236
    • Koller, G.1    Zill, P.2    Rujescu, D.3    Ridinger, M.4    Pogarell, O.5    Fehr, C.6    Wodarz, N.7    Bondy, B.8    Soyka, M.9    Preuss, U.W.10
  • 55
    • 0026507628 scopus 로고
    • Drugs of abuse: Anatomy, pharmacology and function of reward pathways
    • Koob GF (1992) Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol Sci 13:177-184.
    • (1992) Trends Pharmacol Sci , vol.13 , pp. 177-184
    • Koob, G.F.1
  • 58
    • 84871803891 scopus 로고    scopus 로고
    • Variation in OPRM1 moderates the effect of desire to drink on subsequent drinking and its attenuation by naltrexone treatment
    • Kranzler HR, Armeli S, Covault J, Tennen H (2013) Variation in OPRM1 moderates the effect of desire to drink on subsequent drinking and its attenuation by naltrexone treatment. Addict Biol 18:193-201.
    • (2013) Addict Biol , vol.18 , pp. 193-201
    • Kranzler, H.R.1    Armeli, S.2    Covault, J.3    Tennen, H.4
  • 59
    • 0015834982 scopus 로고
    • Regional distribution of opiate receptor binding in monkey and human brain
    • Kuhar MJ, Pert CB, Snyder SH (1973) Regional distribution of opiate receptor binding in monkey and human brain. Nature 245:447-450.
    • (1973) Nature , vol.245 , pp. 447-450
    • Kuhar, M.J.1    Pert, C.B.2    Snyder, S.H.3
  • 61
    • 0038587675 scopus 로고    scopus 로고
    • Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence
    • Littleton J, Zieglgansberger W (2003) Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence. Am J Addict 12 (Suppl. 1): S3-S11.
    • (2003) Am J Addict , vol.12 , Issue.SUPPL. 1
    • Littleton, J.1    Zieglgansberger, W.2
  • 62
    • 13244298667 scopus 로고    scopus 로고
    • Are mu-opioid receptor polymorphisms important for clinical opioid therapy?
    • Lotsch J, Geisslinger G (2005) Are mu-opioid receptor polymorphisms important for clinical opioid therapy? Trends Mol Med 11:82-89.
    • (2005) Trends Mol Med , vol.11 , pp. 82-89
    • Lotsch, J.1    Geisslinger, G.2
  • 63
    • 69449097288 scopus 로고    scopus 로고
    • Cognitive-behavioral treatment with adult alcohol and illicit drug users: A meta-analysis of randomized controlled trials
    • Magill M, Ray LA (2009) Cognitive-behavioral treatment with adult alcohol and illicit drug users: a meta-analysis of randomized controlled trials. J Stud Alcohol Drugs 70:516-527.
    • (2009) J Stud Alcohol Drugs , vol.70 , pp. 516-527
    • Magill, M.1    Ray, L.A.2
  • 64
    • 84872605970 scopus 로고    scopus 로고
    • Meta-analysis of naltrexone and acamprosate for treating alcohol use disorders: When are these medications most helpful?
    • Maisel NC, Blodgett JC, Wilbourne PL, Humphreys K, Finney JW (2013) Meta-analysis of naltrexone and acamprosate for treating alcohol use disorders: when are these medications most helpful? Addiction 108:275-293.
    • (2013) Addiction , vol.108 , pp. 275-293
    • Maisel, N.C.1    Blodgett, J.C.2    Wilbourne, P.L.3    Humphreys, K.4    Finney, J.W.5
  • 66
    • 84875713675 scopus 로고    scopus 로고
    • Extending the treatment options in alcohol dependence: A randomized controlled study of as-needed nalmefene
    • Mann K, Bladstrom A, Torup L, Gual A, van den Brink W (2013) Extending the treatment options in alcohol dependence: a randomized controlled study of as-needed nalmefene. Biol Psychiatry 73:706-713.
    • (2013) Biol Psychiatry , vol.73 , pp. 706-713
    • Mann, K.1    Bladstrom, A.2    Torup, L.3    Gual, A.4    Van Den Brink, W.5
  • 67
    • 3342943177 scopus 로고    scopus 로고
    • An in vivo profile of beta-endorphin release in the arcuate nucleus and nucleus accumbens following exposure to stress or alcohol
    • Marinelli PW, Quirion R, Gianoulakis C (2004) An in vivo profile of beta-endorphin release in the arcuate nucleus and nucleus accumbens following exposure to stress or alcohol. Neuroscience 127:777-784.
    • (2004) Neuroscience , vol.127 , pp. 777-784
    • Marinelli, P.W.1    Quirion, R.2    Gianoulakis, C.3
  • 68
    • 27644457033 scopus 로고    scopus 로고
    • A microdialysis profile of Met-enkephalin release in the rat nucleus accumbens following alcohol administration
    • Marinelli PW, Bai L, Quirion R, Gianoulakis C (2005) A microdialysis profile of Met-enkephalin release in the rat nucleus accumbens following alcohol administration. Alcohol Clin Exp Res 29:1821-1828.
    • (2005) Alcohol Clin Exp Res , vol.29 , pp. 1821-1828
    • Marinelli, P.W.1    Bai, L.2    Quirion, R.3    Gianoulakis, C.4
  • 69
    • 33744724648 scopus 로고    scopus 로고
    • A microdialysis profile of dynorphin A(1-8) release in the rat nucleus accumbens following alcohol administration
    • Marinelli PW, Lam M, Bai L, Quirion R, Gianoulakis C (2006) A microdialysis profile of dynorphin A(1-8) release in the rat nucleus accumbens following alcohol administration. Alcohol Clin Exp Res 30:982-990.
    • (2006) Alcohol Clin Exp Res , vol.30 , pp. 982-990
    • Marinelli, P.W.1    Lam, M.2    Bai, L.3    Quirion, R.4    Gianoulakis, C.5
  • 70
    • 0027943602 scopus 로고
    • A double-blind, placebo-controlled pilot study to evaluate the efficacy and safety of oral nalmefene HCl for alcohol dependence
    • Mason BJ, Ritvo EC, Morgan RO, Salvato FR, Goldberg G, Welch B, Mantero-Atienza E (1994) A double-blind, placebo-controlled pilot study to evaluate the efficacy and safety of oral nalmefene HCl for alcohol dependence. Alcohol Clin Exp Res 18:1162-1167.
    • (1994) Alcohol Clin Exp Res , vol.18 , pp. 1162-1167
    • Mason, B.J.1    Ritvo, E.C.2    Morgan, R.O.3    Salvato, F.R.4    Goldberg, G.5    Welch, B.6    Mantero-Atienza, E.7
  • 72
    • 80053536581 scopus 로고    scopus 로고
    • Effect of nalmefene 20 and 80mg on the corrected QT interval and T-wave morphology: A randomized, double-blind, parallel-group, placebo-and moxifloxacin-controlled, single-centre study
    • Matz J, Graff C, Vainio PJ, Kallio A, Hojer AM, Struijk JJ, Kanters JK, Andersen MP, Toft E (2011) Effect of nalmefene 20 and 80mg on the corrected QT interval and T-wave morphology: a randomized, double-blind, parallel-group, placebo-and moxifloxacin-controlled, single-centre study. Clin Drug Investig 31:799-811.
    • (2011) Clin Drug Investig , vol.31 , pp. 799-811
    • Matz, J.1    Graff, C.2    Vainio, P.J.3    Kallio, A.4    Hojer, A.M.5    Struijk, J.J.6    Kanters, J.K.7    Andersen, M.P.8    Toft, E.9
  • 75
    • 0036200317 scopus 로고    scopus 로고
    • Mesa Grande: A methodological analysis of clinical trials of treatments for alcohol use disorders
    • Miller WR, Wilbourne PL (2002) Mesa Grande: a methodological analysis of clinical trials of treatments for alcohol use disorders. Addiction 97:265-277.
    • (2002) Addiction , vol.97 , pp. 265-277
    • Miller, W.R.1    Wilbourne, P.L.2
  • 76
    • 0035064736 scopus 로고    scopus 로고
    • Regulations of opioid dependence by opioid receptor types
    • Narita M, Funada M, Suzuki T (2001) Regulations of opioid dependence by opioid receptor types. Pharmacol Ther 89:1-15.
    • (2001) Pharmacol Ther , vol.89 , pp. 1-15
    • Narita, M.1    Funada, M.2    Suzuki, T.3
  • 77
    • 84885462805 scopus 로고    scopus 로고
    • Targeted Opioid Receptor Antagonists in the treatment of Alcohol Use Disorders
    • doi: 10.1007/S40263-013-0096-4
    • Niciu MJ, Arias AJ (2013) Targeted Opioid Receptor Antagonists in the treatment of Alcohol Use Disorders. CNS Drugs. doi: 10.1007/S40263-013-0096-4.
    • (2013) CNS Drugs
    • Niciu, M.J.1    Arias, A.J.2
  • 78
  • 82
  • 83
    • 33646174681 scopus 로고    scopus 로고
    • Currently active and remitted alcohol dependence in a nationwide adult general population-results from the Finnish Health 2000 study
    • Pirkola SP, Poikolainen K, Lonnqvist JK (2006) Currently active and remitted alcohol dependence in a nationwide adult general population-results from the Finnish Health 2000 study. Alcohol Alcohol 41:315-320.
    • (2006) Alcohol Alcohol , vol.41 , pp. 315-320
    • Pirkola, S.P.1    Poikolainen, K.2    Lonnqvist, J.K.3
  • 84
    • 33749530075 scopus 로고    scopus 로고
    • Contingency management for treatment of substance use disorders: A meta-analysis
    • Prendergast M, Podus D, Finney J, Greenwell L, Roll J (2006) Contingency management for treatment of substance use disorders: a meta-analysis. Addiction 101:1546-1560.
    • (2006) Addiction , vol.101 , pp. 1546-1560
    • Prendergast, M.1    Podus, D.2    Finney, J.3    Greenwell, L.4    Roll, J.5
  • 85
    • 0000777258 scopus 로고    scopus 로고
    • Project MATCH secondary a priori hypotheses
    • Project MATCH Research Group
    • Project MATCH Research Group (1997) Project MATCH secondary a priori hypotheses. Addiction 92:1671-1698.
    • (1997) Addiction , vol.92 , pp. 1671-1698
  • 86
    • 19244369081 scopus 로고    scopus 로고
    • Ethanol withdrawal enhances the prodynorphin system activity in the rat nucleus accumbens
    • Przewlocka B, Turchan J, Lason W, Przewlocki R (1997) Ethanol withdrawal enhances the prodynorphin system activity in the rat nucleus accumbens. Neurosci Lett 238:13-16.
    • (1997) Neurosci Lett , vol.238 , pp. 13-16
    • Przewlocka, B.1    Turchan, J.2    Lason, W.3    Przewlocki, R.4
  • 87
    • 19844371837 scopus 로고    scopus 로고
    • Alcohol use disorders in EU countries and Norway: An overview of the epidemiology
    • Rehm J, Room R, van den Brink W, Jacobi F (2005) Alcohol use disorders in EU countries and Norway: an overview of the epidemiology. Eur Neuropsychopharmacol 15:377-388.
    • (2005) Eur Neuropsychopharmacol , vol.15 , pp. 377-388
    • Rehm, J.1    Room, R.2    Van Den Brink, W.3    Jacobi, F.4
  • 88
    • 67649116613 scopus 로고    scopus 로고
    • Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders
    • Rehm J, Mathers C, Popova S, Thavorncharoensap M, Teerawattananon Y, Patra J (2009) Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet 373:2223-2233.
    • (2009) Lancet , vol.373 , pp. 2223-2233
    • Rehm, J.1    Mathers, C.2    Popova, S.3    Thavorncharoensap, M.4    Teerawattananon, Y.5    Patra, J.6
  • 90
    • 84873524078 scopus 로고    scopus 로고
    • Modeling the impact of alcohol dependence on mortality burden and the effect of available treatment interventions in the European Union
    • Rehm J, Shield KD, Gmel G, Rehm MX, Frick U (2013) Modeling the impact of alcohol dependence on mortality burden and the effect of available treatment interventions in the European Union. European Neuropsychopharmacology 23:89-97.
    • (2013) European Neuropsychopharmacology , vol.23 , pp. 89-97
    • Rehm, J.1    Shield, K.D.2    Gmel, G.3    Rehm, M.X.4    Frick, U.5
  • 91
    • 0030047293 scopus 로고    scopus 로고
    • Endogenous opioids and alcohol dependence: Opioid alkaloids and the propensity to drink alcoholic beverages
    • Reid LD (1996) Endogenous opioids and alcohol dependence: opioid alkaloids and the propensity to drink alcoholic beverages. Alcohol 13:5-11.
    • (1996) Alcohol , vol.13 , pp. 5-11
    • Reid, L.D.1
  • 92
    • 0032870007 scopus 로고    scopus 로고
    • Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens
    • Rosin A, Lindholm S, Franck J, Georgieva J (1999) Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens. Neurosci Lett 275:1-4.
    • (1999) Neurosci Lett , vol.275 , pp. 1-4
    • Rosin, A.1    Lindholm, S.2    Franck, J.3    Georgieva, J.4
  • 96
    • 0031756195 scopus 로고    scopus 로고
    • Nalmefene causes greater hypothalamic-pituitary-adrenal axis activation than naloxone in normal volunteers: Implications for the treatment of alcoholism
    • Schluger JH, Ho A, Borg L, Porter M, Maniar S, Gunduz M, Perret G, King A, Kreek MJ (1998) Nalmefene causes greater hypothalamic-pituitary-adrenal axis activation than naloxone in normal volunteers: implications for the treatment of alcoholism. Alcohol Clin Exp Res 22:1430-1436.
    • (1998) Alcohol Clin Exp Res , vol.22 , pp. 1430-1436
    • Schluger, J.H.1    Ho, A.2    Borg, L.3    Porter, M.4    Maniar, S.5    Gunduz, M.6    Perret, G.7    King, A.8    Kreek, M.J.9
  • 97
    • 84865312343 scopus 로고    scopus 로고
    • Influence of the OPRM1 A118G polymorphism on alcohol-induced euphoria, risk for alcoholism and the clinical efficacy of naltrexone
    • Setiawan E, Pihl RO, Benkelfat C, Leyton M (2012) Influence of the OPRM1 A118G polymorphism on alcohol-induced euphoria, risk for alcoholism and the clinical efficacy of naltrexone. Pharmacogenomics 13:1161-1172.
    • (2012) Pharmacogenomics , vol.13 , pp. 1161-1172
    • Setiawan, E.1    Pihl, R.O.2    Benkelfat, C.3    Leyton, M.4
  • 101
    • 77958479285 scopus 로고    scopus 로고
    • Emerging drugs to treat alcoholism
    • Soyka M, Rosner S (2010) Emerging drugs to treat alcoholism. Expert Opin Emerg Drugs 15:695-711.
    • (2010) Expert Opin Emerg Drugs , vol.15 , pp. 695-711
    • Soyka, M.1    Rosner, S.2
  • 102
    • 39149099789 scopus 로고    scopus 로고
    • World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of substance use and related disorders, part 1: Alcoholism
    • Soyka M, Kranzler HR, Berglund M, Gorelick D, Hesselbrock V, Johnson BA, Moller HJ (2008) World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of substance use and related disorders, part 1: alcoholism. World J Biol Psychiatry 9:6-23.
    • (2008) World J Biol Psychiatry , vol.9 , pp. 6-23
    • Soyka, M.1    Kranzler, H.R.2    Berglund, M.3    Gorelick, D.4    Hesselbrock, V.5    Johnson, B.A.6    Moller, H.J.7
  • 103
    • 67649985942 scopus 로고    scopus 로고
    • Alcoholism: A systems approach from molecular physiology to addictive behavior
    • Spanagel R (2009) Alcoholism: a systems approach from molecular physiology to addictive behavior. Physiol Rev 89:649-705.
    • (2009) Physiol Rev , vol.89 , pp. 649-705
    • Spanagel, R.1
  • 104
    • 39749088094 scopus 로고    scopus 로고
    • Drugs for relapse prevention of alcoholism: Ten years of progress
    • Spanagel R, Kiefer F (2008) Drugs for relapse prevention of alcoholism: ten years of progress. Trends Pharmacol Sci 29:109-115.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 109-115
    • Spanagel, R.1    Kiefer, F.2
  • 105
    • 84868666534 scopus 로고    scopus 로고
    • New pharmacological treatment strategies for relapse prevention
    • Spanagel R, Vengeliene V (2013) New pharmacological treatment strategies for relapse prevention. Curr Top Behav Neurosci 13:583-609.
    • (2013) Curr Top Behav Neurosci , vol.13 , pp. 583-609
    • Spanagel, R.1    Vengeliene, V.2
  • 106
    • 84875725865 scopus 로고    scopus 로고
    • Naltrexone and nalmefene: Any meaningful difference?
    • Swift RM (2013) Naltrexone and nalmefene: any meaningful difference? Biol Psychiatry 73:700-701.
    • (2013) Biol Psychiatry , vol.73 , pp. 700-701
    • Swift, R.M.1
  • 107
    • 0032913423 scopus 로고    scopus 로고
    • The effect of repeated administration of morphine, cocaine and ethanol on mu and delta opioid receptor density in the nucleus accumbens and striatum of the rat
    • Turchan J, Przewlocka B, Toth G, Lason W, Borsodi A, Przewlocki R (1999) The effect of repeated administration of morphine, cocaine and ethanol on mu and delta opioid receptor density in the nucleus accumbens and striatum of the rat. Neuroscience 91:971-977.
    • (1999) Neuroscience , vol.91 , pp. 971-977
    • Turchan, J.1    Przewlocka, B.2    Toth, G.3    Lason, W.4    Borsodi, A.5    Przewlocki, R.6
  • 108
    • 0031473537 scopus 로고    scopus 로고
    • Use of positron emission tomography to measure the effects of nalmefene on D1 and D2 dopamine receptors in rat brain
    • Unterwald EM, Tsukada H, Kakiuchi T, Kosugi T, Nishiyama S, Kreek MJ (1997) Use of positron emission tomography to measure the effects of nalmefene on D1 and D2 dopamine receptors in rat brain. Brain Res 775:183-188.
    • (1997) Brain Res , vol.775 , pp. 183-188
    • Unterwald, E.M.1    Tsukada, H.2    Kakiuchi, T.3    Kosugi, T.4    Nishiyama, S.5    Kreek, M.J.6
  • 109
    • 84883015520 scopus 로고    scopus 로고
    • Efficacy of as-needed nalmefene in alcohol-dependent patients with at least a high drinking risk level: Results from a subgroup analysis of two randomized controlled 6-month studies
    • van den Brink W, Aubin HJ, Bladstrom A, Torup L, Gual A, Mann K (2013) Efficacy of as-needed nalmefene in alcohol-dependent patients with at least a high drinking risk level: results from a subgroup analysis of two randomized controlled 6-month studies. Alcohol and alcoholism 48:570-578.
    • (2013) Alcohol and Alcoholism , vol.48 , pp. 570-578
    • Van Den Brink, W.1    Aubin, H.J.2    Bladstrom, A.3    Torup, L.4    Gual, A.5    Mann, K.6
  • 111
    • 38149072294 scopus 로고    scopus 로고
    • Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence
    • Walker BM, Koob GF (2008) Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence. Neuropsychopharmacology 33:643-652.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 643-652
    • Walker, B.M.1    Koob, G.F.2
  • 112
    • 78649910013 scopus 로고    scopus 로고
    • Systemic kappa-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats
    • Walker BM, Zorrilla EP, Koob GF (2011) Systemic kappa-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats. Addict Biol 16:116-119.
    • (2011) Addict Biol , vol.16 , pp. 116-119
    • Walker, B.M.1    Zorrilla, E.P.2    Koob, G.F.3
  • 113
    • 84861188841 scopus 로고    scopus 로고
    • Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence
    • Walker BM, Valdez GR, McLaughlin JP, Bakalkin G (2012) Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence. Alcohol 46:359-370.
    • (2012) Alcohol , vol.46 , pp. 359-370
    • Walker, B.M.1    Valdez, G.R.2    McLaughlin, J.P.3    Bakalkin, G.4


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