Epigenetic analysis of neurocognitive development at 1 year of age in a community-based pregnancy cohort

Behavior Genetics

Volumn 44, Issue 2, 2014, Pages 113-125

  Krushkal, Julia ^a   Murphy, Laura E ^a   Palmer, Frederick B ^a   Graff, J Carolyn ^a,b   Sutter, Thomas R ^c   Mozhui, Khyobeni ^a   Hovinga, Collin A ^a   Thomas, Fridtjof ^a   Park, Vicki ^a   Tylavsky, Frances A ^a   Adkins, Ronald M ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b and Fellow Transcultural Nursing Society Scholars   (United States)

^c UNIVERSITY OF MEMPHIS   (United States)

Author keywords

DNA methylation; Genome wide association study; Neurocognitive development; Umbilical cord blood

Indexed keywords

SOMATOMEDIN B;

ADULT; APGAR SCORE; ARTICLE; BAYLEY SCALES OF INFANT DEVELOPMENT; CHILD; COGNITIVE DEVELOPMENT; DISEASE ASSOCIATION; DNA METHYLATION; EDUCATIONAL STATUS; EPIGENETICS; FEMALE; GENETIC VARIABILITY; HOSTILITY; HUMAN; INCOME; INFANCY; INTERPERSONAL COMMUNICATION; IRRITABILITY; LANGUAGE ABILITY; LANGUAGE DEVELOPMENT; MAJOR CLINICAL STUDY; MALE; PARANOIA; PARENTAL STRESS; PHOBIA; PREGNANCY; PREGNANCY OUTCOME; PRESCHOOL CHILD; SOCIAL ADAPTATION; TEMPERAMENT; UMBILICAL CORD BLOOD;

COGNITION; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; FETAL BLOOD; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INFANT; LANGUAGE DEVELOPMENT; PREGNANCY;

EID: 84896387930     PISSN: 00018244     EISSN: 15733297     Source Type: Journal    
DOI: 10.1007/s10519-014-9641-2     Document Type: Article

References (106)

1. Abidin RR (2002) Parenting stress index-short form. Psychological Assessment Resources, Lutz
2. Acton BV, Biggs WSG, Creighton DE, Penner KAH, Switzer HN, Thomas JHP, Joffe AR, Robertson CMT (2011) Overestimating neurodevelopment using the Bayley-III after early complex cardiac surgery. Pediatrics 128:e794-e800
3. Adkins RM, Krushkal J, Tylavsky FA, Thomas F (2011a) Racial differences in gene-specific DNA methylation levels are present at birth. Birth Defects Res A Clin Mol Teratol 91:728-736
4. Adkins RM, Thomas F, Tylavsky FA, Krushkal J (2011b) Parental ages and levels of DNA methylation in the newborn are correlated. BMC Med Genet 12:47
5. Ahn S, Wang T (2013) A powerful statistical method for identifying differentially methylated markers in complex diseases. Pac Symp Biocomput. http://www.ncbi.nlm.nih.gov/pubmed/23424113
6. Akiskal HS, Akiskal KK, Haykal RF, Manning JS, Connor PD (2005) TEMPS-A: progress towards validation of a self-rated clinical version of the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire. J Affect Disord 85:3-16
7. Anderson PJ, De Luca CR, Hutchinson E, Roberts G, Doyle LW, Group VIC (2010) Underestimation of developmental delay by the new Bayley-III scale. Arch Pediatr Adolesc Med 164:352-356
8. Andreassen OA, Djurovic S, Thompson WK, Schork AJ, Kendler KS, O'Donovan MC, Rujescu D, Werge T, van de Bunt M, Morris MI, McCarthy MI, International Consortium for Blood Pressure G, Diabetes Genetics R, Meta-analysis C, Psychiatric Genomics Consortium Schizophrenia Working G, Roddey JC, McEvoy LK, Desikan RS, Dale AM (2013) Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. Am J Hum Genet 92:197-209
9. Bayley NB (2006) Bayley scales of infant and toddler development, 3rd edn. Screening Test Manual, Pearson Education, Inc, San Antonio
10. Bender A, Weber M (2013) DNA methylation: an identity card for brain cells. Genome Biol 14:131
11. Benton D (2010) The influence of dietary status on the cognitive performance of children. Mol Nutr Food Res 54:457-470
12. Betancur C (2011) Etiological heterogeneity in autism spectrum disorders: more than 100 genetic and genomic disorders and still counting. Brain Res 1380:42-77
13. Bethell CD, Read D, Stein REK, Blumberg SJ, Wells N, Newacheck PW (2002) Identifying children with special health care needs: development and evaluation of a short screening instrument. Ambul Pediatr 2(1):38-47
14. Bilder RM, Howe A, Novak N, Sabb FW, Parker DS (2011) The genetics of cognitive impairment in schizophrenia: a phenomic perspective. Trends Cognit Sci 15:428-435
15. Bishop DV (2009) Genes, cognition, and communication: insights from neurodevelopmental disorders. Ann NY Acad Sci 1156:1-18
16. Bradley-Johnson S, Johnson M (2007) Infant and toddler assessment. In: Bracken B, Nagle R (eds) Psychoeducational assessment of preschool children. Lawrence Erlbaum Associates, Mahwah, pp 325-357
17. Breton CV, Byun HM, Wenten M, Pan F, Yang A, Gilliland FD (2009) Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. Am J Respir Crit Care Med 180:462-467
18. Briggs-Gowan MJ, Carter AS (2006) Brief infant-toddler social and emotional assessment examiner's manual. PsychCorp, San Antonio
19. Chen X, Ender P, Mitchell M, Wells C (2003) Regression with Stata. http://www.ats.ucla.edu/stat/stata/webbooks/reg/default.htm. Accessed 4 April 2011
20. Chen Z, Huang H, Liu J, Tony Ng HK, Nadarajah S, Huang X, Deng Y (2013) Detecting differentially methylated loci for Illumina Array methylation data based on human ovarian cancer data. BMC Med Genomics 6(Suppl 1):S9
21. Christensen BC, Houseman EA, Marsit CJ, Zheng S, Wrensch MR, Wiemels JL, Nelson HH, Karagas MR, Padbury JF, Bueno R, Sugarbaker DJ, Yeh RF, Wiencke JK, Kelsey KT (2009) Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet 5:e1000602
22. Covic M, Karaca E, Lie DC (2010) Epigenetic regulation of neurogenesis in the adult hippocampus. Heredity 105:122-134
23. Cox JL, Holden JM, Sagovsky R (1987) Detection of postnatal depression: development of the 10-item Edinburgh Postnatal Depression Scale. Br J Psychiatry 150:782-786
24. Deffenbacher KE, Kenyon JB, Hoover DM, Olson RK, Pennington BF, DeFries JC, Smith SD (2004) Refinement of the 6p21.3 quantitative trait locus influencing dyslexia: linkage and association analyses. Hum Genet 115:128-138
25. Derogatis LR (1993) BSI Brief Symptom Inventory. Administration, scoring, and procedures manual. National Computer Systems, Minneapolis
26. Dickens WT, Flynn JR (2001) Heritability estimates versus large environmental effects: the IQ paradox resolved. Psychol Rev 108:346-369
27. Docherty SJ, Davis OS, Kovas Y, Meaburn EL, Dale PS, Petrill SA, Schalkwyk LC, Plomin R (2010) A genome-wide association study identifies multiple loci associated with mathematics ability and disability. Genes Brain Behav 9(2):234-247
28. Feinberg AP, Irizarry RA, Fradin D, Aryee MJ, Murakami P, Aspelund T, Eiriksdottir G, Harris TB, Launer L, Gudnason V, Fallin MD (2010) Personalized epigenomic signatures that are stable over time and covary with body mass index. Sci Transl Med 2:49ra67
29. Gibbs JR, van der Brug MP, Hernandez DG, Traynor BJ, Nalls MA, Lai SL, Arepalli S, Dillman A, Rafferty IP, Troncoso J, Johnson R, Zielke HR, Ferrucci L, Longo DL, Cookson MR, Singleton AB (2010) Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet 6:e1000952
30. Gottlieb DJ (1996) Developmental psychobiological theory. In: Cairns RB, Elder GH, Costello EJ (eds) Developmental Science. Cambridge University Press, New York, pp 63-77
31. Grafodatskaya D, Chung B, Szatmari P, Weksberg R (2010) Autism spectrum disorders and epigenetics. J Am Acad Child Adolesc Psychiatry 49:794-809
32. Guerrero-Preston R, Goldman LR, Brebi-Mieville P, Ili-Gangas C, Lebron C, Witter FR, Apelberg BJ, Hernandez-Roystacher M, Jaffe A, Halden RU, Sidransky D (2010) Global DNA hypomethylation is associated with in utero exposure to cotinine and perfluorinated alkyl compounds. Epigenetics 5:539-546
33. Hack M, Taylor HG, Drotar D, Schluchter M, Cartar L, Andreias L, Wilson-Costello D, Klein N (2005) Chronic conditions, functional limitations, and special health care needs of school-aged children born with extremely low-birth-weight in the 1990s. JAMA 294:318-325
34. Haggarty P, Hoad G, Harris SE, Starr JM, Fox HC, Deary IJ, Whalley LJ (2010) Human intelligence and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking. PLoS ONE 5:e11329
35. Haworth CM, Plomin R (2010) Quantitative genetics in the era of molecular genetics: learning abilities and disabilities as an example. J Am Acad Child Adolesc Psychiatry 49:783-793
36. Hayiou-Thomas ME (2008) Genetic and environmental influences on early speech, language and literacy development. J Commun Disord 41:397-408
37. Heijmans BT, Tobi EW, Lumey LH, Slagboom PE (2009) The epigenome: archive of the prenatal environment. Epigenetics 4:526-531
38. Hoffmann R, Valencia A (2004) A gene network for navigating the literature. Nat Genet 36:664
39. Houston I, Peter CJ, Mitchell A, Straubhaar J, Rogaev E, Akbarian S (2013) Epigenetics in the human brain. Neuropsychopharmacology 38:183-197
40. Ivanovic DM, Leiva BP, Perez HT, Olivares MG, Diaz NS, Urrutia MS, Almagia AF, Toro TD, Miller PT, Bosch EO, Larrain CG (2004) Head size and intelligence, learning, nutritional status and brain development. Head, IQ, learning, nutrition and brain. Neuropsychologia 42:1118-1131
41. Kamiya K, Kaneda M, Sugawara T, Mazaki E, Okamura N, Montal M, Makita N, Tanaka M, Fukushima K, Fujiwara T, Inoue Y, Yamakawa K (2004) A nonsense mutation of the sodium channel gene SCN2A in a patient with intractable epilepsy and mental decline. J Neurosci 24:2690-2698
42. Kaufman L, Ayub M, Vincent JB (2010) The genetic basis of non-syndromic intellectual disability: a review. J Neurodev Disord 2:182-209
43. Keverne EB (2013) Importance of the matriline for genomic imprinting, brain development and behaviour. Philos Trans R Soc Lond B Biol Sci 368:20110327
44. King S, Laplante D, Joober R (2005) Understanding putative risk factors for schizophrenia: retrospective and prospective studies. J Psychiatr Neurosci 30:342-348
45. Kubany ES, Hyanes SN, Leisen MB, Owens JA, Kaplan AS, Watson SB, Burns K (2000) Development and preliminary validation of a brief broad-spectrum measure of trauma exposure: the Traumatic Life Events Questionnaire. Psychol Assess 12:210-224
46. Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, Ferreira T, Wood AR, Weyant RJ, Segre AV, Speliotes EK, Wheeler E, Soranzo N, Park JH, Yang J, Gudbjartsson D, Heard-Costa NL, Randall JC, Qi L, Vernon Smith A, Magi R, Pastinen T, Liang L, Heid IM, Luan J, Thorleifsson G, Winkler TW, Goddard ME, Sin Lo K, Palmer C, Workalemahu T, Aulchenko YS, Johansson A, Zillikens MC, Feitosa MF, Esko T, Johnson T, Ketkar S, Kraft P, Mangino M, Prokopenko I, Absher D, Albrecht E, Ernst F, Glazer NL, Hayward C, Hottenga JJ, Jacobs KB, Knowles JW, Kutalik Z, Monda KL, Polasek O, Preuss M, Rayner NW, Robertson NR, Steinthorsdottir V, Tyrer JP, Voight BF, Wiklund F, Xu J, Zhao JH, Nyholt DR, Pellikka N, Perola M, Perry JR, Surakka I, Tammesoo ML, Altmaier EL, Amin N, Aspelund T, Bhangale T, Boucher G, Chasman DI, Chen C, Coin L, Cooper MN, Dixon AL, Gibson Q, Grundberg E, Hao K, Juhani Junttila M, Kaplan LM, Kettunen J, Konig IR, Kwan T, Lawrence RW, Levinson DF, Lorentzon M, McKnight B, Morris AP, Muller M, Suh Ngwa J, Purcell S, Rafelt S, Salem RM, Salvi E, Sanna S, Shi J, Sovio U, Thompson JR, Turchin MC, Vandenput L, Verlaan DJ, Vitart V, White CC, Ziegler A, Almgren P, Balmforth AJ, Campbell H, Citterio L, De Grandi A, Dominiczak A, Duan J, Elliott P, Elosua R, Eriksson JG, Freimer NB, Geus EJ, Glorioso N, Haiqing S, Hartikainen AL, Havulinna AS, Hicks AA, Hui J, Igl W, Illig T, Jula A, Kajantie E, Kilpelainen TO, Koiranen M, Kolcic I, Koskinen S, Kovacs P, Laitinen J, Liu J, Lokki ML, Marusic A, Maschio A, Meitinger T, Mulas A, Pare G, Parker AN, Peden JF, Petersmann A, Pichler I, Pietilainen KH, Pouta A, Ridderstrale M, Rotter JI, Sambrook JG, Sanders AR, Schmidt CO, Sinisalo J, Smit JH, Stringham HM, Bragi Walters G, Widen E, Wild SH, Willemsen G, Zagato L, Zgaga L, Zitting P, Alavere H, Farrall M, McArdle WL, Nelis M, Peters MJ, Ripatti S, van Meurs JB, Aben KK, Ardlie KG, Beckmann JS, Beilby JP, Bergman RN, Bergmann S, Collins FS, Cusi D, den Heijer M, Eiriksdottir G, Gejman PV, Hall AS, Hamsten A, Huikuri HV, Iribarren C, Kahonen M, Kaprio J, Kathiresan S, Kiemeney L, Kocher T, Launer LJ, Lehtimaki T, Melander O, Mosley TH Jr, Musk AW, Nieminen MS, O'Donnell CJ, Ohlsson C, Oostra B, Palmer LJ, Raitakari O, Ridker PM, Rioux JD, Rissanen A, Rivolta C, Schunkert H, Shuldiner AR, Siscovick DS, Stumvoll M, Tonjes A, Tuomilehto J, van Ommen GJ, Viikari J, Heath AC, Martin NG, Montgomery GW, Province MA, Kayser M, Arnold AM, Atwood LD, Boerwinkle E, Chanock SJ, Deloukas P, Gieger C, Gronberg H, Hall P, Hattersley AT, Hengstenberg C, Hoffman W, Lathrop GM, Salomaa V, Schreiber S, Uda M, Waterworth D, Wright AF, Assimes TL, Barroso I, Hofman A, Mohlke KL, Boomsma DI, Caulfield MJ, Cupples LA, Erdmann J, Fox CS, Gudnason V, Gyllensten U, Harris TB, Hayes RB, Jarvelin MR, Mooser V, Munroe PB, Ouwehand WH, Penninx BW, Pramstaller PP, Quertermous T, Rudan I, Samani NJ, Spector TD, Volzke H, Watkins H, Wilson JF, Groop LC, Haritunians T, Hu FB, Kaplan RC, Metspalu A, North KE, Schlessinger D, Wareham NJ, Hunter DJ, O'Connell JR, Strachan DP, Wichmann HE, Borecki IB, van Duijn CM, Schadt EE, Thorsteinsdottir U, Peltonen L, Uitterlinden AG, Visscher PM, Chatterjee N, Loos RJ, Boehnke M, McCarthy MI, Ingelsson E, Lindgren CM, Abecasis GR, Stefansson K, Frayling TM, Hirschhorn JN (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467:832-838
47. Lister R, Mukamel EA, Nery JR, Urich M, Puddifoot CA, Johnson ND, Lucero J, Huang Y, Dwork AJ, Schultz MD, Yu M, Tonti-Filippini J, Heyn H, Hu S, Wu JC, Rao A, Esteller M, He C, Haghighi FG, Sejnowski TJ, Behrens MM, Ecker JR (2013) Global epigenomic reconfiguration during mammalian brain development. Science 341:1237905
48. Liu L, van Groen T, Kadish I, Tollefsbol TO (2009) DNA methylation impacts on learning and memory in aging. Neurobiol Aging 30:549-560
49. Macleod AK, Davies G, Payton A, Tenesa A, Harris SE, Liewald D, Ke X, Luciano M, Lopez LM, Gow AJ, Corley J, Redmond P, McNeill G, Pickles A, Ollier W, Horan M, Starr JM, Pendleton N, Thomson PA, Porteous DJ, Deary IJ (2012) Genetic copy number variation and general cognitive ability. PLoS ONE 7:e37385
50. MacPhee D (1981) Knowledge of infant development inventory. Educational Testing Service Princeton, Princeton
51. Millan MJ (2013) An epigenetic framework for neurodevelopmental disorders: from pathogenesis to potential therapy. Neuropharmacology 68:2-82
52. Milner JS (1986) The child abuse potential inventory: manual. Psytec, DeKalb
53. Moore LD, Le T, Fan G (2013) DNA methylation and its basic function. Neuropsychopharmacology 38:23-38
54. Neggers YH, Goldenberg RL, Ramey SL, Cliver SP (2003) Maternal prepregnancy body mass index and psychomotor development in children. Acta Obstet Gynecol Scand 82:235-240
55. Newson RB (2010) Frequentist q-values for multiple-test procedures. Stata J 10:568-584
56. Nguyen A, Rauch TA, Pfeifer GP, Hu VW (2010) Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain. FASEB J 24:3036-3051
57. Nicholls RD (2000) The impact of genomic imprinting for neurobehavioral and developmental disorders. J Clin Invest 105:413-418
58. Numata S, Ye T, Hyde TM, Guitart-Navarro X, Tao R, Wininger M, Colantuoni C, Weinberger DR, Kleinman JE, Lipska BK (2012) DNA methylation signatures in development and aging of the human prefrontal cortex. Am J Hum Genet 90:260-272
59. Nunnally JC, Bernstein IH (1994) Psychometric theory. McGraw-Hill, Inc, New York
60. Ogiwara I, Ito K, Sawaishi Y, Osaka H, Mazaki E, Inoue I, Montal M, Hashikawa T, Shike T, Fujiwara T, Inoue Y, Kaneda M, Yamakawa K (2009) De novo mutations of voltage-gated sodium channel alphaII gene SCN2A in intractable epilepsies. Neurology 73:1046-1053
61. Palmer FB, Anand KJ, Graff JC, Murphy LE, Qu Y, Volgyi E, Rovnaghi CR, Moore A, Tran QT, Tylavsky FA (2013) Early adversity, socioemotional development, and stress in urban 1-year-old children. J Pediatr 163(6):1733-1739. doi: 10.01016/j.jpeds.02013.01008.01030
62. Pilsner JR, Hu H, Ettinger A, Sanchez BN, Wright RO, Cantonwine D, Lazarus A, Lamadrid-Figueroa H, Mercado-Garcia A, Tellez-Rojo MM, Hernandez-Avila M (2009) Influence of prenatal lead exposure on genomic methylation of cord blood DNA. Environ Health Perspect 117:1466-1471
63. Portela A, Esteller M (2010) Epigenetic modifications and human disease. Nat Biotechnol 28:1057-1068
64. Posthuma D, Luciano M, Geus EJ, Wright MJ, Slagboom PE, Montgomery GW, Boomsma DI, Martin NG (2005) A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p. Am J Hum Genet 77:318-326
65. Poulsen P, Esteller M, Vaag A, Fraga MF (2007) The epigenetic basis of twin discordance in age-related diseases. Pediatr Res 61:38R-42R
66. Rakyan VK, Hildmann T, Novik KL, Lewin J, Tost J, Cox AV, Andrews TD, Howe KL, Otto T, Olek A, Fischer J, Gut IG, Berlin K, Beck S (2004) DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project. PLoS Biol 2:e405
67. Rakyan VK, Down TA, Balding DJ, Beck S (2011) Epigenome-wide association studies for common human diseases. Nat Rev Genet 12:529-541
68. Rauh VA, Garfinkel R, Perera FP, Andrews HF, Hoepner L, Barr DB, Whitehead R, Tang D, Whyatt RW (2006) Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children. Pediatrics 118:e1845-e1859
69. Rauh V, Arunajadai S, Horton M, Perera F, Hoepner L, Barr DB, Whyatt R (2011) 7-Year neurodevelopmental scores and prenatal exposure to chlorpyrifos, a common agricultural pesticide. Environ Health Perspect 119:1196-1201
70. Rees S, Harding R, Walker D (2008) An adverse intrauterine environment: implications for injury and altered development of the brain. Int J Dev Neurosci 26:3-11
71. Relton CL, Davey Smith G (2010) Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment. PLoS Med 7:e1000356
72. Relton CL, Groom A, St Pourcain B, Sayers AE, Swan DC, Embleton ND, Pearce MS, Ring SM, Northstone K, Tobias JH, Trakalo J, Ness AR, Shaheen SO, Davey Smith G (2012) DNA methylation patterns in cord blood DNA and body size in childhood. PLoS ONE 7:e31821
73. Riccio A (2010) Dynamic epigenetic regulation in neurons: enzymes, stimuli and signaling pathways. Nat Neurosci 13:1330-1337
74. Rosenberg M (1965) Society and the adolescent self-image. Princeton University Press, Princeton
75. Sarason IG, Sarason BR, Shearin EN, Pierce GR (1987) A brief measure of social support: practical and theoretical implications. J Pers Soc Relationsh 4:497-510
76. Sattler JM (2008) Assessment of children: cognitive foundations. Jerome M. Sattler Publisher Inc, San Diego
77. Shonkoff JP, Phillips DA (2000) From neurons to neighborhoods: the science of early childhood development. National Academy Press, Washington DC
78. Simes RJ (1986) An improved Bonferroni procedure for multiple tests of significance. Biometrika 73:751-754
79. Song F, Smith JF, Kimura MT, Morrow AD, Matsuyama T, Nagase H, Held WA (2005) Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression. Proc Natl Acad Sci USA 102:3336-3341
80. Spinath FM, Harlaar N, Ronald A, Plomin R (2004a) Substantial genetic influence on mild mental impairment in early childhood. Am J Ment Retard 109:34-43
81. Spinath FM, Price TS, Dale PS, Plomin R (2004b) The genetic and environmental origins of language disability and ability. Child Dev 75:445-454
82. Stadler F, Kolb G, Rubusch L, Baker SP, Jones EG, Akbarian S (2005) Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brain. J Neurochem 94:324-336
83. Stelzer G, Dalah I, Stein TI, Satanower Y, Rosen N, Nativ N, Oz-Levi D, Olender T, Belinky F, Bahir I, Krug H, Perco P, Mayer B, Kolker E, Safran M, Lancet D (2011) In-silico human genomics with GeneCards. Human Genomics 5:709-717
84. Stromswold K (2006) Why aren't identical twins linguistically identical? Genetic, prenatal and postnatal factors. Cognition 101:333-384
85. Sullivan PF, Daly MJ, O'Donovan M (2012) Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat Rev Genet 13:537-551
86. Sumner G, Spietz A (1994) NCAST-AVENUW: Caregiver/parent-child interaction teaching manual. NCAST-AVENUW Publications, Seattle
87. Sun J, Ming GL, Song H (2011) Epigenetic regulation of neurogenesis in the adult mammalian brain. Eur J Neurosci 33:1087-1093
88. The SLI Consortium (2002) A genomewide scan identifies two novel loci involved in specific language impairment. Am J Hum Genet 70:384-398
89. Urdinguio RG, Sanchez-Mut JV, Esteller M (2009) Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies. Lancet Neurol 8:1056-1072
90. van Hoek M, Langendonk JG, de Rooij SR, Sijbrands EJ, Roseboom TJ (2009) Genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolism. Diabetes 58:1440-1444
91. Vig S, Sanders M (2007) Cognitive assessment. In: Brassard MR, Boehm AE (eds) Preschool assessment: principles and practices. Guilford Press, New York, pp 383-419
92. Volgyi E, Carroll KN, Hare ME, Ringwald-Smith K, Piyathilake C, Yoo W, Tylavsky FA (2013) Dietary patterns in pregnancy and effects on nutrient intake in the Mid-South: the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) study. Nutrients 5:1511-1530
93. Wainwright MA, Wright MJ, Luciano M, Montgomery GW, Geffen GM, Martin NG (2006) A linkage study of academic skills defined by the Queensland core skills test. Behav Genet 36:56-64
94. Wang LW, Berry-Kravis E, Hagerman RJ (2010) Fragile X: leading the way for targeted treatments in autism. Neurotherapeutics 7:264-274
95. Wang S, Dorsey TH, Terunuma A, Kittles RA, Ambs S, Kwabi-Addo B (2012a) Relationship between tumor DNA methylation status and patient characteristics in African-American and European-American women with breast cancer. PLoS ONE 7:e37928
96. Wang T, Pan Q, Lin L, Szulwach KE, Song CX, He C, Wu H, Warren ST, Jin P, Duan R, Li X (2012b) Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum. Hum Mol Genet 21:5500-5510
97. Wechsler D (1999) Wechsler abbreviated scale of intelligenceTM (WASITM). PsychCorp, San Antonio
98. Weiss LA, Escayg A, Kearney JA, Trudeau M, MacDonald BT, Mori M, Reichert J, Buxbaum JD, Meisler MH (2003) Sodium channels SCN1A, SCN2A and SCN3A in familial autism. Mol Psychiatry 8:186-194
99. Wild KT, Betancourt LM, Brodsky NL, Hurt H (2013) The effect of socioeconomic status on the language outcome of preterm infants at toddler age. Early Human Dev 89:743-746
100. Wilson AS, Power BE, Molloy PL (2007) DNA hypomethylation and human diseases. Biochim Biophys Acta 1775:138-162
101. Wu H, Coskun V, Tao J, Xie W, Ge W, Yoshikawa K, Li E, Zhang Y, Sun YE (2010) Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science 329:444-448
102. Yuen RK, Neumann SM, Fok AK, Penaherrera MS, McFadden DE, Robinson WP, Kobor MS (2011) Extensive epigenetic reprogramming in human somatic tissues between fetus and adult. Epigenetics Chromatin 4:7
103. Zhang FF, Cardarelli R, Carroll J, Fulda KG, Kaur M, Gonzalez K, Vishwanatha JK, Santella RM, Morabia A (2011) Significant differences in global genomic DNA methylation by gender and race/ethnicity in peripheral blood. Epigenetics 6:623-629
104. Zhang H, Wang F, Kranzler HR, Zhao H, Gelernter J (2013a) Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls. PLoS ONE 8:e65648
105. Zhang X, Hui L, Liu Y, Wang ZQ, You Y, Miao LN, Sun SL, Guan SL, Xiang Y, Kosten TR, Zhang XY (2013b) The type 2 diabetes mellitus susceptibility gene IGF2BP2 is associated with schizophrenia in a Han Chinese population. J Clin Psychiatry 74:e287-e292
106. Zhuang J, Widschwendter M, Teschendorff AE (2012) A comparison of feature selection and classification methods in DNA methylation studies using the Illumina Infinium platform. BMC Bioinformatics 13:59