4-methoxycarbonyl curcumin: A unique inhibitor of both inflammatory mediators and periodontal inflammation

Mediators of Inflammation

Volumn 2013, Issue , 2013, Pages

  Gu, Ying ^a   Lee, Hsi Ming ^a   Napolitano, Nicole ^a   Clemens, McKenzie ^a   Zhang, Yazhou ^a   Sorsa, Timo ^b   Zhang, Yu ^a   Johnson, Francis ^a   Golub, Lorne M ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

1,10 PHENANTHROLINE; 4 METHOXYCARBONYL CURCUMIN; COLLAGENASE 3; CURCUMIN; ENZYME INHIBITOR; GELATINASE A; GELATINASE B; HEMOGLOBIN A1C; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; UNCLASSIFIED DRUG; ZINC; 4-METHOXYCARBONYL CURCUMIN; ANTIINFLAMMATORY AGENT; AUTACOID; DRUG DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG SOLUBILITY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GINGIVA; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IC 50; MALE; MONOCYTE; MONOCYTE CULTURE; NONHUMAN; PERIODONTITIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; CURCUMIN; DIABETES MELLITUS, EXPERIMENTAL; HUMANS; INFLAMMATION MEDIATORS; MALE; MATRIX METALLOPROTEINASE 9; NF-KAPPA B; PERIODONTITIS; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84896385584     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2013/329740     Document Type: Article

References (33)

1. Van Dyke T. E., Van Winkelhoff A. J., Infection and inflammatory mechanisms. Journal of Periodontology 2013 84 supplement 14 4 S1 S7 10.1111/jcpe.12088
2. Gu Y., Ryan M. E., Williams R., Genco R., Overview of periodontal diseases: causes, pathogenesis, and characteristics. Periodontal Diseases and Overall Health: A Clinician's Guide 2009 Yardley, Pa, USA Professional Audience Communications 5 23
3. Aggarwal B. B., Harikumar K. B., Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. International Journal of Biochemistry and Cell Biology 2009 41 1 40 59 2-s2.0-55949117806 10.1016/j.biocel.2008.06.010
4. Sikora E., Bielak-Zmijewska A., Mosieniak G., Piwocka K., The promise of slow down ageing may come from curcumin. Current Pharmaceutical Design 2010 16 7 884 892 2-s2.0-77249109022 10.2174/138161210790883507
5. Queen B. L., Tollefsbol T. O., Polyphenols and aging. Current Aging Science 2010 3 1 34 42 2-s2.0-77953762857 10.2174/1874609811003010034
6. Aggarwal B. B., Kumar A., Bharti A. C., Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Research 2003 23 1A 363 398 2-s2.0-0037236792 (Pubitemid 36361976)
7. Sharma O. P., Antioxidant activity of curcumin and related compounds. Biochemical Pharmacology 1976 25 15 1811 1812 2-s2.0-0017075410 10.1016/0006-2952(76)90421-4
8. Ruby A. J., Kuttan G., Dinesh Babu K., Rajasekharan K. N., Kuttan R., Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Letters 1995 94 1 79 83 2-s2.0-0029648973 10.1016/0304-3835(95)03827-J
9. Begum A. N., Jones M. R., Lim G. P., Morihara T., Kim P., Heath D. D., Rock C. L., Pruitt M. A., Yang F., Hudspeth B., Hu S., Faull K. F., Teter B., Cole G. M., Frautschy S. A., Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. Journal of Pharmacology and Experimental Therapeutics 2008 326 1 196 208 2-s2.0-45749089694 10.1124/jpet.108.137455 (Pubitemid 351872144)
10. Anand P., Kunnumakkara A. B., Newman R. A., Aggarwal B. B., Bioavailability of curcumin: problems and promises. Molecular Pharmaceutics 2007 4 6 807 818 2-s2.0-37549051274 10.1021/mp700113r
11. Zhang Y., Golub L. M., Johnson F., Wishnia A., pKa, zinc- and serum albumin-binding of curcumin and two novel biologically-active chemically-modified curcumins. Current Medicinal Chemistry 2012 19 25 4367 4375 10.2174/092986712802884240
12. Zhang Y., Gu Y., Lee H. M., Design, synthesis and biological activity of new polyenolic inhibitors of matrix metalloproteinases: a focus on chemically-modified curcumins. Current Medicinal Chemistry 2012 19 25 4348 4358 10.2174/092986712802884295
13. Tesseromatis C., Kotsiou A., Parara H., Vairaktaris E., Tsamouri M., Morphological changes of gingiva in streptozotocin diabetic rats. International Journal of Dentistry 2009 2009 4 725628 10.1155/2009/725628
14. Ryan M. E., Ramamurthy N. S., Sorsa T., Golub L. M., MMP-mediated events in diabetes. Annals of the New York Academy of Sciences 1999 878 311 334 2-s2.0-0032815865 10.1111/j.1749-6632.1999.tb07692.x (Pubitemid 29353578)
15. Chang K. M., Ryan M. E., Golub L. M., Ramamurthy N. S., McNamara T. F., Local and systemic factors in periodontal disease increase matrix-degrading enzyme activities in rat gingiva: effect of micocycline therapy. Research Communications in Molecular Pathology and Pharmacology 1996 91 3 303 318 2-s2.0-0029981796 (Pubitemid 26149051)
16. Toker H., Ozdemir H., Balc H., Ozer H., N -acetylcysteine decreases alveolar bone loss on experimental periodontitis in streptozotocin-induced diabetic rats. Journal of Periodontal Research 2012 47 6 793 799 10.1111/j.1600-0765.2012.01497.x
17. Elburki M., Goren A., Lee H., Chemically-modified curcumins and alveolar bone loss in diabetic rats. Journal of Dental Research 2011 90 abstract 2295
18. Tornatore L., Thotakura A. K., Bennett J., Moretti M., Franzoso G., The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation. Trends in Cell Biology 2012 22 11 557 566 10.1016/j.tcb.2012.08. 001
19. Lee H.-M., Ciancio S. G., Tüter G., Ryan M. E., Komaroff E., Golub L. M., Subantimicrobial dose doxycycline efficacy as a matrix metalloproteinase inhibitor in chronic periodontitis patients is enhanced when combined with a non-steriodal anti-inflammatory drug. Journal of Periodontology 2004 75 3 453 463 2-s2.0-1842738493 10.1902/jop.2004.75.3.453 (Pubitemid 38461128)
20. Golub L.M., Lee H.-M., Stoner J. A., Sorsa T., Reinhardt R. A., Wolff M. S., Ryan M. E., Nummikoski P. V., Payne J. B., Subantimicrobial-dose doxycycline modulates gingival crevicular fluid biomarkers of periodontitis in postmenopausal osteopenic women. Journal of Periodontology 2008 79 8 1409 1418 2-s2.0-49149123468 10.1902/jop.2008.070623
21. Gu Y., Lee H.-M., Sorsa T., Simon S. R., Golub L. M., Doxycyline inhibits mononuclear cell-mediated connective tissue breakdown. FEMS Immunology and Medical Microbiology 2010 58 2 218 225 2-s2.0-76349120589 10.1111/j.1574-695X. 2009.00625.x
22. Brown D. L., Desai K. K., Vakili B. A., Nouneh C., Lee H.-M., Golub L. M., Clinical and biochemical results of the metalloproteinase inhibition with subantimicrobial doses of doxycycline to prevent acute coronary syndromes (MIDAS) pilot trial. Arteriosclerosis, Thrombosis, and Vascular Biology 2004 24 4 733 738 2-s2.0-1842527873 10.1161/01.ATV.0000121571.78696.dc (Pubitemid 38451612)
23. Naderi A., Teschendorff A. E., Beigel J., Cariati M., Ellis I. O., Brenton J. D., Caldas C., BEX2 is overexpressed in a subset of primary breast cancers and mediates nerve growth factor/nuclear factor- B inhibition of apoptosis in breast cancer cell lines. Cancer Research 2007 67 14 6725 6736 2-s2.0-34547110396 10.1158/0008-5472.CAN-06-4394 (Pubitemid 47105519)
24. Mitchell P. G., Magna H. A., Reeves L. M., Lopresti-Morrow L. L., Yocum S. A., Rosner P. J., Geoghegan K. F., Hambor J. E., Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. Journal of Clinical Investigation 1996 97 3 761 768 2-s2.0-0030032444 10.1172/JCI118475 (Pubitemid 26060542)
25. Anand P., Thomas S. G., Kunnumakkara A. B., Sundaram C., Harikumar K. B., Sung B., Tharakan S. T., Misra K., Priyadarsini I. K., Rajasekharan K. N., Aggarwal B. B., Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochemical Pharmacology 2008 76 11 1590 1611 2-s2.0-55949084512 10.1016/j.bcp.2008.08.008
26. Golub L. M., Lee H. M., Ryan M. E., Giannobile W. V., Payne J., Sorsa T., Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Advances in Dental Research 1998 12 2 12 26 2-s2.0-0032200444
27. Monaco C., Andreakos E., Kiriakidis S., Mauri C., Bicknell C., Foxwell B., Cheshire N., Paleolog E., Feldmann M., Canonical pathway of nuclear factor B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America 2004 101 15 5634 5639 2-s2.0-1842681951 10.1073/pnas.0401060101 (Pubitemid 38481208)
28. Ivanenkov Y. A., Balakin K. V., Tkachenko S. E., New approaches to the treatment of inflammatory disease: focus on small-molecule inhibitors of signal transduction pathways. Drugs in R & D 2008 9 6 397 434 2-s2.0-55749090490 10.2165/0126839-200809060-00005
29. Santos V. R., Lima J. A., Miranda T. S., Full-mouth disinfection as a therapeutic protocol for type-2 diabetic subjects with chronic periodontitis: twelve-month clinical outcomes: a randomized controlled clinical trial. Journal of Clinical Periodontology 2013 40 2 155 162 10.1111/jcpe.12040
30. Golub L. M., Payne J. B., Reinhardt R. A., Nieman G., Can systemic diseases co-induce (not just exacerbate) periodontitis? a hypothetical "two-hit" model. Journal of Dental Research 2006 85 2 102 105 2-s2.0-33744810316 10.1177/154405910608500201 (Pubitemid 43827741)
31. Claudino M., Gennaro G., Cestari T. M., Spontaneous periodontitis development in diabetic rats involves an unrestricted expression of inflammatory cytokines and tissue destructive factors in the absence of major changes in commensal oral microbiota. Experimental Diabetes Research 2012 2012 10 356841 10.1155/2012/356841
32. Uitto V.-J., Airola K., Vaalamo M., Johansson N., Putnins E. E., Firth J. D., Salonen J., López-Otín C., Saarialho-Kere U., Kähäri V.-M., Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation. American Journal of Pathology 1998 152 6 1489 1499 2-s2.0-0031749739 (Pubitemid 28275007)
33. Gu Y., Lee H.-M., Callen H., A novel chemically-modified-curcumin "Normalizes" impaired leukocyte competence in diabetic rats. Journal of Dental Research. In press