Disrupting the ipsilateral motor cortex interferes with training of a complex motor task in older adults

Cerebral Cortex

Volumn 24, Issue 4, 2014, Pages 1030-1036

  Zimerman, Máximo ^a   Heise, Kirstin F ^a   Gerloff, Christian ^a   Cohen, Leonardo G ^b   Hummel, Friedhelm C ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

aging; brain stimulation; motor cortex; neuroplasticity; tDCS

Indexed keywords

ADAPTATION; ADULT; AGE; AGED; ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; HEMISPHERE; HUMAN; HUMAN EXPERIMENT; MALE; MOTOR CONTROL; MOTOR CORTEX; MOTOR PERFORMANCE; NERVE CELL EXCITABILITY; NEUROMODULATION; NORMAL HUMAN; PRIORITY JOURNAL; TRAINING; TRANSCRANIAL DIRECT CURRENT STIMULATION; VERY ELDERLY;

AGING; BRAIN STIMULATION; MOTOR CORTEX; NEUROPLASTICITY; TDCS;

ADULT; AGE FACTORS; AGED; AGING; ATTENTION; FATIGUE; FEMALE; FUNCTIONAL LATERALITY; HUMANS; MALE; MIDDLE AGED; MOTOR CORTEX; PSYCHOMOTOR PERFORMANCE; QUESTIONNAIRES; RETENTION (PSYCHOLOGY); TEACHING; TRANSCRANIAL MAGNETIC STIMULATION; VISUAL ANALOG SCALE; YOUNG ADULT;

EID: 84896350093     PISSN: 10473211     EISSN: 14602199     Source Type: Journal    
DOI: 10.1093/cercor/bhs385     Document Type: Article

References (55)

1. Anderson B, Rutledge V. 1996. Age and hemisphere effects on dendritic structure. Brain. 119(Pt 6):1983-1990.
2. Bartus RT, Dean RL 3rd, Beer B, Lippa AS. 1982. The cholinergic hypothesis of geriatric memory dysfunction. Science. 217:408-414.
3. Burke SN, Barnes CA. 2006. Neural plasticity in the ageing brain. Nat Rev Neurosci. 7:30-40.
4. Cabeza R. 2002. Hemispheric asymmetry reduction in older adults: the HAROLD model. Psychol Aging. 17:85-100.
5. Cabeza R, McIntosh AR, Tulving E, Nyberg L, Grady CL. 1997 Age-related differences in effective neural connectivity during encoding and recall. Neuroreport. 8:3479-3483.
6. Carp J, Park J, Hebrank A, Park DC, Polk TA. 2011. Age-related neural dedifferentiation in the motor system. PLoS One. 6:e29411.
7. Folstein MF, Folstein SE, McHugh PR. 1975. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 12:189-198.
8. Fregni F, Pascual-Leone A. 2007. Technology insight: noninvasive brain stimulation in neurology-perspectives on the therapeutic potential of rTMS and tDCS. Nat Clin Pract Neurol. 3:383-393.
9. Gandiga PC, Hummel FC, Cohen LG. 2006. Transcranial DC stimulation (tDCS): a tool for double-blind sham-controlled clinical studies in brain stimulation. Clin Neurophysiol. 117:845-850.
10. Giampaoli S, Ferrucci L, Cecchi F, Lo Noce C, Poce A, Dima F, Santaqui-lani A, Vescio MF, Menotti A. 1999. Hand-grip strength predicts incident disability in non-disabled older men. Age Ageing. 28:283-288.
11. Hallett M. 2007. Transcranial magnetic stimulation: a primer. Neuron. 55:187-199.
12. Heuninckx S, Wenderoth N, Debaere F, Peeters R, Swinnen SP. 2005. Neural basis of aging: the penetration of cognition into action control. J Neurosci. 25:6787-6796.
13. Heuninckx S, Wenderoth N, Swinnen SP. 2008. Systems neuroplasticity in the aging brain: recruiting additional neural resources for successful motor performance in elderly persons. J Neurosci. 28:91-99.
14. Houx PJ, Jolles J. 1993. Age-related decline of psychomotor speed: effects of age, brain health, sex, and education. Percept Mot Skills. 76:195-211.
15. Hummel F, Celnik P, Giraux P, Floel A, Wu WH, Gerloff C, Cohen LG. 2005. Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. Brain. 128:490-499.
16. Hummel F, Celnik P, Pascual-Leone A, Fregni F, Byblow WD, Buete-fisch C, Rothwell JC, Cohen L, Gerloff C. 2008. Controversy: non-invasive and invasive cortical stimulation show efficacy in treating stroke patients. Brain stimul. 1:370-382.
17. Hummel FC, Cohen LG. 2005. Drivers of brain plasticity. Curr Opin Neurol. 18:667-674.
18. Hummel FC, Cohen LG. 2006. Non-invasive brain stimulation: a new strategy to improve neurorehabilitation after stroke? Lancet Neurol. 5:708-712.
19. Hummel F, Erb M, Grodd W, Gerloff C. 2003. Ipsilateral activation during complex movements is determined by movement difficulty and not by motor memory load: An fMRI study. NeuroImage. 19: S1079.
20. Hutchinson S, Kobayashi M, Horkan CM, Pascual-Leone A, Alexander MP, Schlaug G. 2002. Age-related differences in movement representation. Neuroimage. 17:1720-1728.
21. Kaasinen V, Rinne JO. 2002. Functional imaging studies of dopamine system and cognition in normal aging and Parkinson's disease. Neurosci Biobehav Rev. 26:785-793.
22. Karni A, Meyer G, Jezzard P, Adams MM, Turner R, Ungerleider LG. 1995. Functional MRI evidence for adult motor cortex plasticity during motor skill learning. Nature. 377:155-158.
23. Karni A, Meyer G, Rey-Hipolito C, Jezzard P, Adams MM, Turner R, Ungerleider LG. 1998. The acquisition of skilled motor performance: fast and slow experience-driven changes in primary motor cortex. Proc Natl Acad Sci USA. 95:861-868.
24. Kobayashi M, Theoret H, Pascual-Leone A. 2009. Suppression of ipsi-lateral motor cortex facilitates motor skill learning. Eur J Neurosci. 29:833-836.
25. Langan J, Peltier SJ, Bo J, Fling BW, Welsh RC, Seidler RD. 2010. Functional implications of age differences in motor system connectivity. Front Syst Neurosci. 4:17.
26. Lempel A, Ziv J. 1976. On the complexity of finite sequences. IEEE Trans Inform Theory. 22:75-81.
27. Madden DJ, Whiting WL, Huettel SA, White LE, MacFall JR, Provenzale JM. 2004. Diffusion tensor imaging of adult age differences in cerebral white matter: relation to response time. Neuroimage. 21:1174-1181.
28. Mattay VS, Fera F, Tessitore A, Hariri AR, Das S, Callicott JH, Weinberger DR. 2002. Neurophysiological correlates of age-related changes in human motor function. Neurology. 58:630-635.
29. Naccarato M, Calautti C, Jones PS, Day DJ, Carpenter TA, Baron JC. 2006. Does healthy aging affect the hemispheric activation balance during paced index-to-thumb opposition task? An fMRI study. Neuroimage. 32:1250-1256.
30. Nitsche MA, Cohen L, Wassermann E, Priori A, Lang N, Antal A, Paulus W, Hummel F, Boggio S, Fregni F, Pascual-Leone A. 2008. Transcranial direct current stimulation: State of the art 2008. Brain stimul. 1:206-223.
31. Nitsche MA, Doemkes S, Karakose T, Antal A, Liebetanz D, Lang N, Tergau F, Paulus W. 2007. Shaping the effects of transcranial direct current stimulation of the human motor cortex. J Neurophysiol. 97:3109-3117.
32. Oldfield RC. 1971. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 9:97-113.
33. Park DC, Reuter-Lorenz P. 2009. The adaptive brain: aging and neuro-cognitive scaffolding. Annu Rev Psychol. 60:173-196.
34. Plewnia C, Lotze M, Gerloff C. 2003. Disinhibition of the contralateral motor cortex by low-frequency rTMS. Neuroreport. 14:609-612.
35. Resnick SM, Pham DL, Kraut MA, Zonderman AB, Davatzikos C. 2003. Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain. J Neurosci. 23:3295-3301.
36. Riecker A, Groschel K, Ackermann H, Steinbrink C, Witte O, Kastrup A. 2006. Functional significance of age-related differences in motor activation patterns. Neuroimage. 32:1345-1354.
37. Rossini PM, Rossi S, Babiloni C, Polich J. 2007. Clinical neurophysiol-ogy of aging brain: from normal aging to neurodegeneration. Prog Neurobiol. 83:375-400.
38. Rothwell JC. 2010. Plasticity in the human motor system. Folia Pho-niatr Logop. 62:153-157.
39. Sailer A, Dichgans J, Gerloff C. 2000. The influence of normal aging on the cortical processing of a simple motor task. Neurology. 55:979-985.
40. Salat DH, Buckner RL, Snyder AZ, Greve DN, Desikan RS, Busa E, Morris JC, Dale AM, Fischl B. 2004. Thinning of the cerebral cortex in aging. Cereb Cortex. 14:721-730.
41. Schambra HM, Sawaki L, Cohen LG. 2003. Modulation of excitability of human motor cortex (M1) by 1 Hz transcranial magnetic stimulation of the contralateral M1. Clin Neurophysiol. 114:130-133.
42. Schulz R, Gerloff C, Hummel FC. 2013. Non-invasive brain stimulation in neurological diseases. Neuropharmacology. 64(1):579-587.
43. Seidler RD, Alberts JL, Stelmach GE. 2002. Changes in multi-joint performance with age. Motor Control. 6:19-31.
44. Seidler RD, Bernard JA, Burutolu TB, Fling BW, Gordon MT, Gwin JT, Kwak Y, Lipps DB. 2011. Motor control and aging: links to age-related brain structural, functional, and biochemical effects. Neurosci Biobehav Rev. 34:721-733.
45. Siebner HR, Rothwell J. 2003. Transcranial magnetic stimulation: new insights into representational cortical plasticity. Exp Brain Res. 148:1-16.
46. Smith CD, Umberger GH, Manning EL, Slevin JT, Wekstein DR, Schmitt FA, Markesbery WR, Zhang Z, Gerhardt GA, Kryscio RJ, Gash DM. 1999. Critical decline in fine motor hand movements in human aging. Neurology. 53:1458-1461.
47. Talelli P, Ewas A, Waddingham W, Rothwell JC, Ward NS. 2008. Neural correlates of age-related changes in cortical neurophysiol-ogy. Neuroimage. 40:1772-1781.
48. Vines BW, Nair DG, Schlaug G. 2006. Contralateral and ipsilateral motor effects after transcranial direct current stimulation. Neurore-port. 17:671-674.
49. Wagner T, Fregni F, Fecteau S, Grodzinsky A, Zahn M, Pascual-Leone A. 2007. Transcranial direct current stimulation: a computer-based human model study. Neuroimage. 35:1113-1124.
50. Walker MP, Brakefield T, Hobson JA, Stickgold R. 2003. Dissociable stages of human memory consolidation and reconsolidation. Nature. 425:616-620.
51. Ward NS, Frackowiak RS. 2003. Age-related changes in the neural correlates of motor performance. Brain. 126:873-888.
52. Ward NS, Swayne OB, Newton JM. 2008. Age-dependent changes in the neural correlates of force modulation: an fMRI study. Neuro-biol Aging. 29:1434-1446.
53. Wassermann EM, Epstein CM, Ziemann U, Walsh V, Paus T, Lisanby SH, eds. 2008. The Oxford handbook of transcranial stimulation. New York: Oxford University Press.
54. Wu T, Hallett M. 2005. The influence of normal human ageing on automatic movements. J Physiol. 562:605-615.
55. Zimerman M, Heise KF, Hoppe J, Cohen LG, Gerloff C, Hummel FC. 2012. Modulation of training by single-session transcranial direct current stimulation to the intact motor cortex enhances motor skill acquisition of the paretic hand. Stroke. 43:2185-2191.