Age-related neural dedifferentiation in the motor system

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Carp, Joshua ^a   Park, Joonkoo ^a   Hebrank, Andrew ^b   Park, Denise C ^b   Polk, Thad A ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; AGING; ANALYTIC METHOD; ARTICLE; BRAIN FUNCTION; BRAIN SIZE; CONTROLLED STUDY; FEMALE; GRAY MATTER; HUMAN; HUMAN EXPERIMENT; MALE; MOTOR CONTROL; MOTOR SYSTEM; MULTI VOXEL PATTERN ANALYSIS; NERVOUS SYSTEM DEVELOPMENT; NEUROANATOMY; NORMAL HUMAN; SENSORIMOTOR FUNCTION; ADOLESCENT; BRAIN; CELL DIFFERENTIATION; CYTOLOGY; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSIOLOGY;

ADOLESCENT; ADULT; AGED; AGING; BRAIN; CELL DIFFERENTIATION; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 84055216980     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029411     Document Type: Article

References (34)

1. Li S, Lindenberger U, Sikström S, (2001) Aging cognition: From neuromodulation to representation. Trends in Cognitive Sciences 5: 479-486.
2. Park DC, Polk TA, Park R, Minear M, Savage A, et al. (2004) Aging reduces neural specialization in ventral visual cortex.Proceedings of the National Academy of Sciences of the United States of America 101: 13091-13095.
3. Bennett PJ, Sekuler R, Sekuler AB, (2007) The effects of aging on motion detection and direction identification. Vision Research 47: 799-809.
4. Roudaia E, Bennett PJ, Sekuler AB, (2008) The effect of aging on contour integration. Vision Research 48: 2767-2774.
5. Owsley C, Sekuler R, Boldt C, (1981) Aging and low-contrast vision: Face perception. Investigative Ophthalmology & Visual Science 21: 362-365.
6. Leventhal AG, Wang Y, Pu M, Zhou Y, Ma Y, (2003) GABA and its agonists improved visual cortical function in senescent monkeys. Science 300: 812-815.
7. Schmolesky MT, Wang Y, Pu M, Leventhal AG, (2000) Degradation of stimulus selectivity of visual cortical cells in senescent rhesus monkeys. Nature Neuroscience 3: 384-390.
8. Grady CL, Maisog JM, Horwitz B, Ungerleider LG, Mentis MJ, et al. (1994) Age-related changes in cortical blood flow activation during visual processing of faces and location. The Journal of Neuroscience 14: 1450-1462.
9. Goh J, Suzuki A, Park D, (2010) Reduced neural selectivity increases fMRI adaptation with age during face discrimination. NeuroImage 51: 336-344.
10. Carp J, Park J, Polk T, Park D, (2011) Age differences in neural distinctiveness revealed by multi-voxel pattern analysis. NeuroImage 56: 736-743.
11. Park J, Carp J, Hebrank A, Park D, Polk T, (2010) Neural specificity predicts fluid processing ability in older adults. The Journal of Neuroscience 30: 9253-9259.
12. Carp J, Gmeindl L, Reuter-Lorenz P, (2010) Age differences in the neural representation of working memory revealed by multi-voxel pattern analysis. Frontiers in Human Neuroscience 4.
13. Seidler R, Bernard J, Burutolu T, Fling B, Gordon M, et al. (2010) Motor control and aging: Links to age-related brain structural, functional, and biochemical effects. Neuroscience and Biobehavioral Reviews 34: 721-733.
14. Ward NS, Frackowiak RS, (2003) Age-related changes in the neural correlates of motor performance. Brain 126: 873-888.
15. Mattay VS, Fera F, Tessitore A, Hariri AR, Das S, et al. (2002) Neurophysiological correlates of age-related changes in human motor function. Neurology 58: 630-635.
16. Heuninckx S, Wenderoth N, Debaere F, Peeters R, Swinnen S, (2005) Neural basis of aging: the penetration of cognition into action control. The Journal of Neuroscience 25: 6787-6796.
17. Heuninckx S, Wenderoth N, Swinnen S, (2008) Systems neuroplasticity in the aging brain: recruiting additional neural resources for successful motor performance in elderly persons. The Journal of Neuroscience 28: 91-99.
18. Bernard J, Seidler R, (2011) Evidence for motor cortex dedifferentiation in older adults. Neurobiology of Aging.
19. Park DC, Reuter-Lorenz P, (2009) The adaptive brain: Aging and neurocognitive scaffolding. Annual Review of Psychology 60: 173-196.
20. Haynes JD, Rees G, (2006) Decoding mental states from brain activity in humans. Nature Reviews Neuroscience 7: 523-534.
21. Li S-C, Sikström S, (2002) Integrative neurocomputational perspectives on cognitive aging, neuromodulation, and representation. Neuroscience and Biobehavioral Reviews 26: 795-808.
22. Folstein MF, Folstein SE, McHugh PR, (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 12: 189-198.
23. Haxby J, Gobbini I, Furey M, Ishai A, Schouten J, et al. (2001) Distributed and overlapping representations of faces and objects in ventral temporal cortex. Science 293: 2425-2430.
24. Haushofer J, Livingstone M, Kanwisher N, (2008) Multivariate patterns in object-selective cortex dissociate perceptual and physical shape similarity. PLoS Biology 6: e187.
25. Kriegeskorte N, Goebel R, Bandettini P, (2006) Information-based functional brain mapping.Proceedings of the National Academy of Sciences of the United States of America 103: 3863-3868.
26. Raz N, Lindenberger U, Rodrigue K, Kennedy K, Head D, et al. (2005) Regional brain changes in aging healthy adults: General trends, individual differences and modifiers. Cerebral Cortex 15: 1676-1689.
27. Kalpouzos G, Persson J, Nyberg L, (2011) Local brain atrophy accounts for functional activity differences in normal aging. Neurobiology of Aging.
28. Zhou X, Merzenich M, (2007) Intensive training in adults refines A1 representations degraded in an early postnatal critical period.Proceedings of the National Academy of Sciences of the United States of America 104: 15935-15940.
29. David-Jürgens M, Churs L, Berkefeld T, Zepka R, Dinse H, (2008) Differential effects of aging on fore- and hindpaw maps of rat somatosensory cortex. PLoS ONE 3: e3399.
30. Park J, Carp J, Kennedy KM, Rodrigue KM, Bischof GN, et al. (under review) Neural broadening or neural attenuation? Mechanisms underlying age-related dedifferentiation in the face network in a large lifespan sample.
31. van Dyck C, Avery R, MacAvoy M, Marek K, Quinlan D, et al. (2008) Striatal dopamine transporters correlate with simple reaction time in elderly subjects. Neurobiology of Aging 29: 1237-1246.
32. Floel A, Vomhof P, Lorenzen A, Roesser N, Breitenstein C, et al. (2008) Levodopa improves skilled hand functions in the elderly. The European Journal of Neuroscience 27: 1301-1307.
33. Hua T, Kao C, Sun Q, Li X, Zhou Y, (2008) Decreased proportion of GABA neurons accompanies age-related degradation of neuronal function in cat striate cortex. Brain Research Bulletin 75: 119-125.
34. Boy F, Evans J, Edden R, Singh K, Husain M, et al. (2010) Individual differences in subconscious motor control predicted by GABA concentration in SMA. Current Biology 20: 1779-1785.