The therapeutic effects of anti-oxidant and anti-inflammatory drug quercetin on aspiration-induced lung injury in rats

Journal of Molecular Histology

Volumn 45, Issue 2, 2014, Pages 195-203

  Yilmaz, Mehmet Ziya ^a   Guzel, Aygul ^a   Torun, Aysun Caglar ^a   Okuyucu, Ali ^a   Salis, Osman ^a   Karli, Rifat ^a   Gacar, Ayhan ^a   Guvenc, Tolga ^a   Paksu, Sule ^a   Urey, Volkan ^b   Murat, Naci ^a   Alacam, Hasan ^a  

^a ONDOKUZ MAYIS UNIVERSITY   (Turkey)

^b CIZRE STATE HOSPITAL   (Turkey)

Author keywords

Aspiration pneumonitis; CC 16; iNOS; Lung injury; Quercetin

Indexed keywords

ADVANCED OXIDATION PROTEIN PRODUCT; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CATALASE; CLARA CELL PROTEIN 16; HYDROCHLORIC ACID; NITRIC OXIDE SYNTHASE; QUERCETIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ACID ASPIRATION; ANIMAL EXPERIMENT; ARTICLE; ASPIRATION PNEUMONIA; CELL INFILTRATION; CONTROLLED STUDY; FEMALE; HISTIOCYTE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; TREATMENT DURATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CATALASE; FEMALE; NITRIC OXIDE SYNTHASE TYPE II; PNEUMONIA, ASPIRATION; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 84896339249     PISSN: 15672379     EISSN: 15672387     Source Type: Journal    
DOI: 10.1007/s10735-013-9542-3     Document Type: Article

References (33)

1. Alacam H, KarlI R, AlIcI O, AvcIl B, Guzel A, Kozan A, Mertoglu C, Murat N, SalIs O, Guzel A, Sahin M (2013) The effects of a-tocopherol on oxidative damage and serum levels of Clara cell protein 16 in aspiration pneumonitis induced by bile acids. Hum Exp Toxicol 32:53-61
2. Beck-Schimmer B, Bonvini JM (2011) Bronchoaspiration: incidence, consequences and management. Eur J Anaesthesiol 28:78-84
3. Benson M, Jansson L, Adner M, Luts A, Uddman R, Cardell LO (2005) Gene profiling reveals decreased expression of uteroglobin and other anti-infl ammatory genes in nasal fluid cells from patients with intermittent allergic rhinitis. Clin Exp Allergy 35:473-478
4. Bond GR (2002) The role of activated charcoal and gastric emptying in gastrointestinal decontamination: a state-of-the-art review. Ann Emerg Med 39:273-286
5. Broeckaert F, Bernard A (2000) Clara cell secretory protein (CC16): characteristics and perspectives as lung peripheral biomarker. Clin Exp Allergy 30:469-475
6. Choi J, Hoffman LA, Rodway GW, Sethi JM (2006) Markers of lung disease in exhaled breath: nitric oxide. Biol Res Nurs 7:241-255
7. Chu SJ, Chang DM, Wang D, Lin HI, Lin SH, Hsu K (2004) Protective effect of U74500A on phorbol myristate acetate-induced acute lung injury. Clin Exp Pharmacol Physiol 31:523-529
8. Di Filippo A, Ciapetti M, Prencipe D, Casucci A, Ciuti R, Messeri D, Falchi S, Dani C (2006) Experimentally induced acute lung injury: the protective effect of hydroxyethyl starch. Ann Clin Lab Sci 36:345-352
9. Dickens JA, Lomas DA (2012) CC-16 as a biomarker in chronic obstructive pulmonary disease. COPD 9:574-575
10. Francis RCE, Schefold JC, Bercker S, Temmesfeld-Wollbrück B, Weichert W, Spies CD, Weber-Carstens S (2009) Acute respiratory failure after aspiration of activated charcoal with recurrent deposition and release from an intrapulmonary cavern. Intensive Care Med 35:360-363
11. GünaydIn M, Güzel A, Güzel A, Alaçam H, Salis O, Murat N, Gacar A, Güvenç T (2012) The effect of curcumin on lung injuries in a rat model induced by aspirating gastrointestinal decontamination agents. J Pediatr Surg 47:1669-1676
12. Güzel A, Güzel A, Alaçam H, Salis O, Paksu MS, Murat N, Gacar A, Güvenç T (2012) The role of iNOS inhibitors on lung injury induced by gastrointestinal decontamination agents aspiration. J Mol Histol 43:351-360
13. Hassan AE, Chaudhry SA, Zacharatos H, Khatri R, Akbar U, Suri MF, Qureshi AI (2012) Increased rate of aspiration pneumonia and poor discharge outcome among acute ischemic stroke patients following intubation for endovascular treatment. Neurocrit Care 16:246-250
14. Hauser B, Bracht H, Matejovic M, Radermacher P, Venkatesh B (2005) Nitric oxide synthase inhibition in sepsis? Lessons learned from large-animal studies. Anesth Analg 101:488-498
15. Jin HB, Yang YB, Song YL, Zhang YC, Li YR (2012) Protective roles of quercetin in acute myocardial ischemia and reperfusion injury in rats. Mol Biol Rep 39:11005-11009
16. Kalpana C, Menon VP (2004) Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative study. J Med Food 7:467-471
17. Kovacic P, Cooksy A (2005) Iminium metabolite mechanism for nicotine toxicity and addiction: oxidative stress and electron transfer. Med Hypotheses 64:104-111
18. Krakowiak A, Hałatek T, Nowakowska-Świrta E, Winnicka R, Politański P, Świderska-Kiełbik S (2013) Clara Cell protein and myeloperoxidase levels in serum of subjects after exposure to fire smoke. Pneumonol Alergol Pol 81:16-23
19. Lakind JS, Holgate ST, Ownby DR, Mansur AH, Helms PJ, Pyatt D, Hays SM (2007) A critical review of the use of Clara cell secretory protein (CC16) as a biomarker of acute or chronic pulmonary effects. Biomarkers 12:445-467
20. Marik PE, Kaplan D (2003) Aspiration pneumonia and dysphagia in the elderly. Chest 124:328-336
21. Muthukumaran S, Sudheer AR, Menon VP, Nalini N (2008) Protective effect of quercetin on nicotine-induced prooxidant and antioxidant imbalance and DNA damage in Wistar rats. Toxicology 243:207-215
22. Nair MP, Mahajan S, Reynolds JL, Aalinkeel R, Nair H, Schwartz SA, Kandaswami C (2006) The flavonoid quercetin inhibits proinflammatory cytokine (Tumor necrosis factor alpha) gene expression in normal peripheral mononuclear cells via modulation of the NF-kB system. Clin Vaccine Immunol 13:319-328
23. Nayyar SA, Khan M, Kr V, Suman B, GayItrI HC, AnItha M (2012) Serum total protein, albumin and advanced oxidation protein products (AOPP) implications in oral squamous cell carcinoma. Malays J Pathol 34:47-52
24. Piwowar A, Knapik-Kordecka M, Warwas M (2007) AOPP and its relations with selected markers of oxidative/antioxidative system in type 2 diabetes mellitus. Diabetes Res Clin Pract 77:188-192
25. Ray G, Husain SA (2002) Oxidants, antioxidants and carcinogenesis. Indian J Exp Biol 42:1213-1232
26. Sakaguchi S, Furusawa S (2006) Oxidative stres and septic shock: metabolic aspects of oxygen-derived free radicals generated in the liver endotoxemia. Immunol Med Microbiol 47:167-177
27. Song Y, Liu J, Zhang J, Shi T, Zeng Z (2013) Antioxidant effect of quercetin against acute spinal cord injury in rats and its correlation with the p38MAPK/iNOS signaling pathway. Life Sci 92:1215-1221
28. TakIl A, Umuroglu T, Gogus YF, Eti Z, YIldIzeli B, Ahiskali R (2003) Histopathologic effects of lipid content of enteral solutions after pulmonary aspiration in rats. Nutrition 19:666-669
29. Toouli J, Smith BM, Bassi C, Locke CD, Telford J, Freeny P (2002) Guidelines for the management of acute pancreatitis. Gastroenterol Hepatol 17:5-39
30. Victor VM, Rocha M, De la Fuente M (2004) Immune cells: free radicals and antioxidants in sepsis. Int Immunopharmacol 4:327-347
31. Wong A, Briars GL (2002) Acute pulmonary oedema complicating polyethylene glycol intestinal lavage. Arch Dis Child 87:537-538
32. Yousef MI, Omar SA, El-Guendi MI, Abdelmegid LA (2010) Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat. Food Chem Toxicol 48:3246-3261
33. Zhou Q, Wu S, JIang J, TIan J, Chen J, Yu X, Chen P, MeI C, XIong F, ShI W, Zhou W, lIu X, Sun S, XIe D, LIu J, Xu X, LIang M, Hou F (2012) Accumulation of circulating advanced oxidation protein products is an independent risk factor for ischaemic heart disease in maintenance haemodialysis patients. Nephrology 17:642-649