Autophagy gene polymorphism is associated with susceptibility to leprosy by affecting inflammatory cytokines

Inflammation

Volumn 37, Issue 2, 2014, Pages 593-598

  Yang, Degang ^a   Chen, Jia ^a   Shi, Chao ^a   Jing, Zhichun ^a   Song, Ningjing ^a  

^a Shanghai Dermatological and Venereal Hospital   (China)

Author keywords

autophagy; cytokine; IRGM; polymorphism

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6;

ADULT; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DNA POLYMORPHISM; ERYTHEMA NODOSUM LEPROSUM; FEMALE; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HUMAN CELL; IRGM GENE; LEPROSY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MYCOBACTERIUM LEPRAE; NEURITIS; PERIPHERAL BLOOD MONONUCLEAR CELL; REVERSAL REACTION;

AUTOPHAGY; CASE-CONTROL STUDIES; CELLS, CULTURED; CHI-SQUARE DISTRIBUTION; CYTOKINES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GTP-BINDING PROTEINS; HUMANS; INFLAMMATION MEDIATORS; INTERFERON-GAMMA; INTERLEUKIN-4; LEPROSY; LEUKOCYTES, MONONUCLEAR; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; PHENOTYPE; POLYMORPHISM, GENETIC; RISK ASSESSMENT; RISK FACTORS; UP-REGULATION;

EID: 84896324999     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-013-9773-1     Document Type: Article

References (24)

1. Bochud, P.Y.; D. Sinsimer, A. Aderem, M.R. Siddiqui, P. Saunderson, S. Britton, et al. 2009. Polymorphisms in toll-like receptor 4 (TLR4) are associated with protection against leprosy. European Journal of Clinical Microbiology & Infectious Diseases 28: 1055-1065.
2. Geluk, A. 2013. Biomarkers for leprosy: would you prefer T (cells)? Leprosy Review 84: 3-12.
3. Singh, P.K.; A.V. Singh, and D.S. Chauhan. 2000. Current understanding on micro RNAs and its regulation in response to Mycobacterial infections. Journal of Biomedical Science 20: 14.
4. Williams, D.L.; and T.P. Gillis. 2012. Drug-resistant leprosy: monitoring and current status. Leprosy Review 83: 269-281.
5. Yang, D.; H. Song, W. Xu, H. Long, C. Shi, Z. Jing, et al. 2011. Interleukin 4-590 T/C polymorphism and susceptibility to leprosy. Genetic Testing and Molecular Biomarkers 15: 877-881.
6. Yang, Q.; H. Liu, H.Q. Low, H. Wang, Y. Yu, X. Fu, et al. 2012. Chromosome 2p14 is linked to susceptibility to leprosy. PLoS One 7: e29747.
7. Latz, E.; T.S. Xiao, and A. Stutz. 2013. Activation and regulation of the inflammasomes. Nature Reviews Immunology 13: 397-411.
8. Athanasiou, D.M.; M.D. Aguilà, S.S. Bevilacqua, D.A. Novoselov, Parfitt, and M.E. Cheetham. 2013. The cell stress machinery and retinal degeneration. FEBS Letters 587: 2008-2017.
9. Baxt, L.A.; A.C. Garza-Mayers, and M.B. Goldberg. 2013. Bacterial subversion of host innate immune pathways. Science 340: 697-701.
10. Choi, A.M.; S.W. Ryter, and B. Levine. 2013. Autophagy in human health and disease. New England Journal of Medicine 368: 651-662.
11. Ghadimi, D.; M. de Vrese, K.J. Heller, and J. Schrezenmeir. 2010. Lactic acid bacteria enhance autophagic ability of mononuclear phagocytes by increasing Th1 autophagy-promoting cytokine (IFN-gamma) and nitric oxide (NO) levels and reducing Th2 autophagy-restraining cytokines (IL-4 and IL-13) in response to Mycobacterium tuberculosis antigen. International Immunopharmacology 10: 694-706.
12. Harris, J.; J.C. Hope, and E.C. Lavelle. 2009. Autophagy and the immune response to TB. Transboundary Emerging Diseases 56: 248-254.
13. Grégoire, I.P.; C. Rabourdin-Combe, and M. Faure. 2012. Autophagy and RNA virus interactomes reveal IRGM as a common target. Autophagy 8: 1136-1137.
14. Kim, B.H.; A.R. Shenoy, P. Kumar, C.J. Bradfield, and J.D. MacMicking. 2012. IFN-inducible GTPases in host cell defense. Cell Host & Microbe 12: 432-444.
15. Roberts, R.L.; J.E. Hollis-Moffatt, R.B. Gearry, M.A. Kennedy, M.L. Barclay, and T.R. Merriman. 2008. Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort. Genes and Immunity 9: 561-565.
16. Che, N.; S. Li, T. Gao, Z. Zhang, Y. Han, X. Zhang, et al. 2010. Identification of a novel IRGM promoter single nucleotide polymorphism associated with tuberculosis. Clinica Chimica Acta 411: 1645-1659.
17. Lahiri, R.; B. Randhawa, and J. Krahenbuhl. 2005. Application of a viability-staining method for Mycobacterium leprae derived from the athymic (nu/nu) mouse foot pad. Journal of Medical Microbiology 54: 235-242.
18. Suzuki, K.; Y. Fukutomi, M. Matsuoka, K. Torii, H. Hayashi, T. Takii, et al. 1993. Differential production of interleukin 1 (IL-1), IL-6, tumor necrosis factor, and IL-1 receptor antagonist by human monocytes stimulated with Mycobacterium leprae and M. bovis BCG. International Journal of Leprosy and Other Mycobacterial Diseases 61: 609-618.
19. Murray, R.A.; M.R. Siddiqui, M. Mendillo, J. Krahenbuhl, and G. Kaplan. 2007. Mycobacterium leprae inhibits dendritic cell activation and maturation. Journal of Immunology 178: 338-344.
20. MacMicking, J.D.; G.A. Taylor, and J.D. McKinney. 2003. Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science 302: 654-659.
21. Ling, Y.M.; M.H. Shaw, C. Ayala, I. Coppens, G.A. Taylor, D.J. Ferguson, et al. 2006. Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. The Journal of Experimental Medicine 203: 2063-2071.
22. Duerr, R.H.; K.D. Taylor, S.R. Brant, J.D. Rioux, M.S. Silverberg, M.J. Daly, et al. 2006. Science 314: 1461-1463.
23. Kugathasan, S.; R. Baldassano, J. Bradfield, P. Sleiman, M. Imielinski, S. Guthery, et al. 2008. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nature Genetics 40: 1211-1215.
24. Zhernakova, A.; E. Festen, L. Franke, G. Trynka, C. van Diemen, A. Monsuur, et al. 2008. Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. American Journal of Human Genetics 82: 1202-1210.