메뉴 건너뛰기




Volumn 49, Issue 4, 2014, Pages 224-235

Ultrasound molecular imaging of transient acute myocardial ischemia with a clinically translatable P- and E-selectin targeted contrast agent: Correlation with the expression of selectins

Author keywords

inflammation; molecular imaging; myocardial ischemia memory; selectin; ultrasound contrast agent

Indexed keywords

ECHO CONTRAST MEDIUM; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; PADGEM PROTEIN; STREPTAVIDIN;

EID: 84896319406     PISSN: 00209996     EISSN: 15360210     Source Type: Journal    
DOI: 10.1097/RLI.0000000000000018     Document Type: Article
Times cited : (30)

References (48)
  • 1
    • 84872091789 scopus 로고    scopus 로고
    • Heart disease and stroke statisticsV2013 update: A report from the American Heart Association
    • Go AS, Mozaffarian D, Roger VL, et al. Heart disease and stroke statisticsV2013 update: A report from the American Heart Association. Circulation. 2013;127:e6Ye245
    • (2013) Circulation , vol.127
    • Go, A.S.1    Mozaffarian, D.2    Roger, V.L.3
  • 2
    • 0034690309 scopus 로고    scopus 로고
    • Missed diagnoses of acute cardiac ischemia in the emergency department
    • Pope JH, Aufderheide TP, Ruthazer R, et al. Missed diagnoses of acute cardiac ischemia in the emergency department. N Engl J Med. 2000;342:1163-1170
    • (2000) N Engl J Med , vol.342 , pp. 1163-1170
    • Pope, J.H.1    Aufderheide, T.P.2    Ruthazer, R.3
  • 3
    • 84856158305 scopus 로고    scopus 로고
    • ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent STsegment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC
    • Hamm CW, Bassand JP, Agewall S, et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent STsegment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2011;32: 2999-3054
    • (2011) Eur Heart J. , vol.32 , pp. 2999-3054
    • Hamm, C.W.1    Bassand, J.P.2    Agewall, S.3
  • 4
    • 0037299616 scopus 로고    scopus 로고
    • Frequency, characteristics, and outcome of patients hospitalized with acute coronary syndromes with undetermined electrocardiographic patterns
    • Lev EI, Battler A, Behar S, et al. Frequency, characteristics, and outcome of patients hospitalized with acute coronary syndromes with undetermined electrocardiographic patterns. Am J Cardiol. 2003;91:224-227
    • (2003) Am J Cardiol , vol.91 , pp. 224-227
    • Lev, E.I.1    Battler, A.2    Behar, S.3
  • 5
    • 37549005567 scopus 로고    scopus 로고
    • Silent myocardial ischemia: Current perspectives and future directions
    • Ahmed AH, Shankar K, Eftekhari H, et al. Silent myocardial ischemia: Current perspectives and future directions. Exp Clin Cardiol. 2007;12:189-196
    • (2007) Exp Clin Cardiol , vol.12 , pp. 189-196
    • Ahmed, A.H.1    Shankar, K.2    Eftekhari, H.3
  • 6
    • 65649118890 scopus 로고    scopus 로고
    • Silent myocardial ischemia
    • Gutterman DD. Silent myocardial ischemia. Circ J. 2009;73:785-797
    • (2009) Circ J. , vol.73 , pp. 785-797
    • Gutterman, D.D.1
  • 8
    • 69349100568 scopus 로고    scopus 로고
    • Sensitive troponin i assay in early diagnosis of acute myocardial infarction
    • Keller T, Zeller T, Peetz D, et al. Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med. 2009;361:868-877
    • (2009) N Engl J Med , vol.361 , pp. 868-877
    • Keller, T.1    Zeller, T.2    Peetz, D.3
  • 9
    • 84863609086 scopus 로고    scopus 로고
    • High-sensitivity cardiac troponin in the distinction of acute myocardial infarction from acute cardiac noncoronary artery disease
    • Haaf P, Drexler B, Reichlin T, et al. High-sensitivity cardiac troponin in the distinction of acute myocardial infarction from acute cardiac noncoronary artery disease. Circulation. 2012;126:31-40
    • (2012) Circulation , vol.126 , pp. 31-40
    • Haaf, P.1    Drexler, B.2    Reichlin, T.3
  • 10
    • 49649104098 scopus 로고    scopus 로고
    • Noninvasive coronary artery imaging: Magnetic resonance angiography and multidetector computed tomography angiography: A scientific statement from the American Heart Association committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, and the councils on clinical cardiology and cardiovascular disease in the young
    • Bluemke DA, Achenbach S, Budoff M, et al. Noninvasive coronary artery imaging: Magnetic resonance angiography and multidetector computed tomography angiography: A scientific statement from the American Heart Association committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, and the councils on clinical cardiology and cardiovascular disease in the young. Circulation. 2008;118:586-606
    • (2008) Circulation , vol.118 , pp. 586-606
    • Bluemke, D.A.1    Achenbach, S.2    Budoff, M.3
  • 11
    • 0037417848 scopus 로고    scopus 로고
    • Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imaging
    • Kwong RY, Schussheim AE, Rekhraj S, et al. Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imaging. Circulation. 2003;107:531-537
    • (2003) Circulation , vol.107 , pp. 531-537
    • Kwong, R.Y.1    Schussheim, A.E.2    Rekhraj, S.3
  • 12
    • 65249142315 scopus 로고    scopus 로고
    • Coronary computed tomography angiography for early triage of patients with acute chest pain: The ROMICAT (rule out myocardial infarction using computer assisted tomography) trial
    • Hoffmann U, Bamberg F, Chae CU, et al. Coronary computed tomography angiography for early triage of patients with acute chest pain: The ROMICAT (rule out myocardial infarction using computer assisted tomography) trial. J Am Coll Cardiol. 2009;53:1642-1650
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1642-1650
    • Hoffmann, U.1    Bamberg, F.2    Chae, C.U.3
  • 13
    • 0041784903 scopus 로고    scopus 로고
    • ACC/AHA/ASE 2003 guideline update for the clinical application of echocardiography: Summary article: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASE Committee to Update the 1997 Guidelines for the Clinical Application of Echocardiography
    • Cheitlin MD, Armstrong WF, Aurigemma GP, et al. ACC/AHA/ASE 2003 guideline update for the clinical application of echocardiography: Summary article: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASE Committee to Update the 1997 Guidelines for the Clinical Application of Echocardiography). Circulation. 2003;108:1146-1162
    • (2003) Circulation , vol.108 , pp. 1146-1162
    • Cheitlin, M.D.1    Armstrong, W.F.2    Aurigemma, G.P.3
  • 14
    • 0025949691 scopus 로고
    • Value of regional wall motion abnormality in the emergency room diagnosis of acute myocardial infarction A prospective study using two-dimensional echocardiography
    • Sabia P, Afrookteh A, Touchstone DA, et al. Value of regional wall motion abnormality in the emergency room diagnosis of acute myocardial infarction. A prospective study using two-dimensional echocardiography. Circulation. 1991;84:I85YI92
    • (1991) Circulation , vol.84
    • Sabia, P.1    Afrookteh, A.2    Touchstone, D.A.3
  • 15
    • 34247620819 scopus 로고    scopus 로고
    • Prognostic value of myocardial contrast echocardiography in patients presenting to hospital with acute chest pain and negative troponin
    • Jeetley P, Burden L, Greaves K, et al. Prognostic value of myocardial contrast echocardiography in patients presenting to hospital with acute chest pain and negative troponin. Am J Cardiol. 2007;99:1369-1373
    • (2007) Am J Cardiol , vol.99 , pp. 1369-1373
    • Jeetley, P.1    Burden, L.2    Greaves, K.3
  • 16
    • 58449106005 scopus 로고    scopus 로고
    • Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: Two phase 3 international trials in comparison with radionuclide perfusion imaging
    • Senior R, Monaghan M, Main ML, et al. Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: Two phase 3 international trials in comparison with radionuclide perfusion imaging. Eur J Echocardiogr. 2009;10:26-35
    • (2009) Eur J Echocardiogr , vol.10 , pp. 26-35
    • Senior, R.1    Monaghan, M.2    Main, M.L.3
  • 17
    • 68949124019 scopus 로고    scopus 로고
    • Contrast ultrasound molecular imaging of inflammation in cardiovascular disease
    • Lindner JR. Contrast ultrasound molecular imaging of inflammation in cardiovascular disease. Cardiovasc Res. 2009;84:182-189
    • (2009) Cardiovasc Res , vol.84 , pp. 182-189
    • Lindner, J.R.1
  • 18
    • 84858590089 scopus 로고    scopus 로고
    • Ultrasound microbubbles for molecular diagnosis, therapy, and theranostics
    • Kiessling F, Fokong S, Koczera P, et al. Ultrasound microbubbles for molecular diagnosis, therapy, and theranostics. J Nucl Med. 2012;53:345-348
    • (2012) J Nucl Med , vol.53 , pp. 345-348
    • Kiessling, F.1    Fokong, S.2    Koczera, P.3
  • 19
    • 12344323482 scopus 로고    scopus 로고
    • Ligand-carrying gas-filled microbubbles: Ultrasound contrast agents for targeted molecular imaging
    • Klibanov AL. Ligand-carrying gas-filled microbubbles: Ultrasound contrast agents for targeted molecular imaging. Bioconjug Chem. 2005;16:9-17
    • (2005) Bioconjug Chem , vol.16 , pp. 9-17
    • Klibanov, A.L.1
  • 20
    • 18844382464 scopus 로고    scopus 로고
    • Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression
    • Leong-Poi H, Christiansen J, Heppner P, et al. Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression. Circulation. 2005;111:3248-3254
    • (2005) Circulation , vol.111 , pp. 3248-3254
    • Leong-Poi, H.1    Christiansen, J.2    Heppner, P.3
  • 21
    • 34547580851 scopus 로고    scopus 로고
    • Molecular imaging of inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule-1
    • Kaufmann BA, Sanders JM, Davis C, et al. Molecular imaging of inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule-1. Circulation. 2007;116:276-284
    • (2007) Circulation , vol.116 , pp. 276-284
    • Kaufmann, B.A.1    Sanders, J.M.2    Davis, C.3
  • 22
    • 84874525887 scopus 로고    scopus 로고
    • Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition
    • Liu Y, Davidson BP, Yue Q, et al. Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition. Circ Cardiovasc Imaging. 2013;6:74-82
    • (2013) Circ Cardiovasc Imaging , vol.6 , pp. 74-82
    • Liu, Y.1    Davidson, B.P.2    Yue, Q.3
  • 23
    • 0034987955 scopus 로고    scopus 로고
    • Adhesion molecules and their role in vascular disease
    • Krieglstein CF, Granger DN. Adhesion molecules and their role in vascular disease. Am J Hypertens. 2001;14:44SY54S.
    • (2001) Am J Hypertens , vol.14
    • Krieglstein, C.F.1    Granger, D.N.2
  • 24
    • 28844504450 scopus 로고    scopus 로고
    • Targeted ultrasound contrast agents: In vitro assessment of endothelial dysfunction and multi-Targeting to ICAM-1 and sialyl Lewisx
    • Weller GE, Villanueva FS, Tom EM, et al. Targeted ultrasound contrast agents: In vitro assessment of endothelial dysfunction and multi-Targeting to ICAM-1 and sialyl Lewisx. Biotechnol Bioeng. 2005;92:780-788
    • (2005) Biotechnol Bioeng , vol.92 , pp. 780-788
    • Weller, G.E.1    Villanueva, F.S.2    Tom, E.M.3
  • 25
    • 79953796140 scopus 로고    scopus 로고
    • Molecular imaging of activated von Willebrand factor to detect high-risk atherosclerotic phenotype
    • McCarty OJ, Conley RB, Shentu W, et al. Molecular imaging of activated von Willebrand factor to detect high-risk atherosclerotic phenotype. JACC Cardiovasc imaging. 2010;3:947-955
    • (2010) JACC Cardiovasc Imaging , vol.3 , pp. 947-955
    • McCarty, O.J.1    Conley, R.B.2    Shentu, W.3
  • 26
    • 0035940372 scopus 로고    scopus 로고
    • Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin
    • Lindner JR, Song J, Christiansen J, et al. Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation. 2001;104:2107-2112
    • (2001) Circulation , vol.104 , pp. 2107-2112
    • Lindner, J.R.1    Song, J.2    Christiansen, J.3
  • 27
    • 84867570937 scopus 로고    scopus 로고
    • Detection of antecedent myocardial ischemia with multiselectin molecular imaging
    • Davidson BP, Kaufmann BA, Belcik JT, et al. Detection of antecedent myocardial ischemia with multiselectin molecular imaging. J Am Coll Cardiol. 2012;60:1690-1697
    • (2012) J Am Coll Cardiol , vol.60 , pp. 1690-1697
    • Davidson, B.P.1    Kaufmann, B.A.2    Belcik, J.T.3
  • 28
    • 48349128136 scopus 로고    scopus 로고
    • Ultrasound molecular imaging of cardiovascular disease
    • Villanueva FS, Wagner WR. Ultrasound molecular imaging of cardiovascular disease. Nat Clin Pract Cardiovasc Med. 2008;5(suppl 2):S26YS32
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , Issue.SUPPL. 2
    • Villanueva, F.S.1    Wagner, W.R.2
  • 29
    • 78650427584 scopus 로고    scopus 로고
    • Late-phase detection of recent myocardial ischaemia using ultrasound molecular imaging targeted to intercellular adhesion molecule-1
    • Yan Y, Liao Y, Yang L, et al. Late-phase detection of recent myocardial ischaemia using ultrasound molecular imaging targeted to intercellular adhesion molecule-1. Cardiovasc Res. 2011;89:175-183
    • (2011) Cardiovasc Res , vol.89 , pp. 175-183
    • Yan, Y.1    Liao, Y.2    Yang, L.3
  • 30
    • 0028919320 scopus 로고
    • Sequential contribution of L-And Pselectin to leukocyte rolling in vivo
    • Ley K, Bullard DC, Arbones ML, et al. Sequential contribution of L-And Pselectin to leukocyte rolling in vivo. J Exp Med. 1995;181:669-675
    • (1995) J Exp Med , vol.181 , pp. 669-675
    • Ley, K.1    Bullard, D.C.2    Arbones, M.L.3
  • 31
    • 33750389664 scopus 로고    scopus 로고
    • Selectin ligands promote ultrasound contrast agent adhesion under shear flow
    • Rychak JJ, Li B, Acton ST, et al. Selectin ligands promote ultrasound contrast agent adhesion under shear flow. Mol Pharm. 2006;3:516-524
    • (2006) Mol Pharm , vol.3 , pp. 516-524
    • Rychak, J.J.1    Li, B.2    Acton, S.T.3
  • 32
    • 84859142311 scopus 로고    scopus 로고
    • Use of intravital microscopy to study the microvascular behavior of microbubble-based ultrasound contrast agents
    • Schneider M, Broillet A, Tardy I, et al. Use of intravital microscopy to study the microvascular behavior of microbubble-based ultrasound contrast agents. Microcirculation. 2012;19:245-259
    • (2012) Microcirculation , vol.19 , pp. 245-259
    • Schneider, M.1    Broillet, A.2    Tardy, I.3
  • 33
    • 33846421119 scopus 로고    scopus 로고
    • Myocardial ischemic memory imaging with molecular echocardiography
    • Villanueva FS, Lu E, Bowry S, et al. Myocardial ischemic memory imaging with molecular echocardiography. Circulation. 2007;115:345-352
    • (2007) Circulation , vol.115 , pp. 345-352
    • Villanueva, F.S.1    Lu, E.2    Bowry, S.3
  • 34
    • 84864883881 scopus 로고    scopus 로고
    • Ultrasound molecular imaging contrast agent binding to both E-And P-selectin in different species
    • Bettinger T, Bussat P, Tardy I, et al. Ultrasound molecular imaging contrast agent binding to both E-And P-selectin in different species. Invest Radiol. 2012;47:516-523
    • (2012) Invest Radiol , vol.47 , pp. 516-523
    • Bettinger, T.1    Bussat, P.2    Tardy, I.3
  • 35
    • 84878324332 scopus 로고    scopus 로고
    • Molecular imaging of inflammation in inflammatory bowel disease with a clinically translatable dual-selectin-Targeted US contrast agent: Comparison with FDG PET/CT in a mouse model
    • Wang H, Machtaler S, Bettinger T, et al. Molecular imaging of inflammation in inflammatory bowel disease with a clinically translatable dual-selectin-Targeted US contrast agent: Comparison with FDG PET/CT in a mouse model. Radiology. 2013;267:818-829
    • (2013) Radiology , vol.267 , pp. 818-829
    • Wang, H.1    Machtaler, S.2    Bettinger, T.3
  • 36
    • 70349741332 scopus 로고    scopus 로고
    • Short-And long-Term cardioprotective effect of darbepoetin-Alpha: Role of Bcl-2 family proteins
    • Schlecht-Bauer D, Antier D, Machet MC, et al. Short-And long-Term cardioprotective effect of darbepoetin-Alpha: Role of Bcl-2 family proteins. J Cardiovasc Pharmacol. 2009;54:223-231
    • (2009) J Cardiovasc Pharmacol , vol.54 , pp. 223-231
    • Schlecht-Bauer, D.1    Antier, D.2    Machet, M.C.3
  • 37
  • 38
    • 0029830192 scopus 로고    scopus 로고
    • Core2 beta-1,6-Nacetylglucosaminyltransferase enzyme activity is critical for P-selectin glycoprotein ligand-1 binding to P-selectin
    • Kumar R, Camphausen RT, Sullivan FX, et al. Core2 beta-1,6- Nacetylglucosaminyltransferase enzyme activity is critical for P-selectin glycoprotein ligand-1 binding to P-selectin. Blood. 1996;88:3872-3879
    • (1996) Blood , vol.88 , pp. 3872-3879
    • Kumar, R.1    Camphausen, R.T.2    Sullivan, F.X.3
  • 39
    • 84880311732 scopus 로고    scopus 로고
    • Use of ultrasound contrast agent microbubbles in preclinical research: Recommendations for small animal imaging
    • Hyvelin JM, Tardy I, Arbogast C, et al. Use of ultrasound contrast agent microbubbles in preclinical research: Recommendations for small animal imaging. Invest Radiol. 2013;48:570-583
    • (2013) Invest Radiol , vol.48 , pp. 570-583
    • Hyvelin, J.M.1    Tardy, I.2    Arbogast, C.3
  • 40
    • 33846909478 scopus 로고    scopus 로고
    • Molecular imaging with targeted contrast ultrasound
    • Kaufmann BA, Lindner JR. Molecular imaging with targeted contrast ultrasound. Curr Opin Biotechnol. 2007;18:11-16
    • (2007) Curr Opin Biotechnol , vol.18 , pp. 11-16
    • Kaufmann, B.A.1    Lindner, J.R.2
  • 41
    • 0029848827 scopus 로고    scopus 로고
    • Heterogeneity of expression of E-And P-selectins in vivo
    • Eppihimer MJ,Wolitzky B, Anderson DC, et al. Heterogeneity of expression of E-And P-selectins in vivo. Circ Res. 1996;79:560-569
    • (1996) Circ Res , vol.79 , pp. 560-569
    • Eppihimer, M.J.1    Wolitzky, B.2    Anderson, D.C.3
  • 42
    • 0029849580 scopus 로고    scopus 로고
    • E-selectin expression in experimental models of inflammation in mice
    • Henseleit U, Steinbrink K, Goebeler M, et al. E-selectin expression in experimental models of inflammation in mice. J Pathol. 1996;180:317-325
    • (1996) J Pathol , vol.180 , pp. 317-325
    • Henseleit, U.1    Steinbrink, K.2    Goebeler, M.3
  • 43
    • 0024364675 scopus 로고
    • GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies
    • McEver RP, Beckstead JH, Moore KL, et al. GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J Clin Invest. 1989;84:92-99
    • (1989) J Clin Invest , vol.84 , pp. 92-99
    • McEver, R.P.1    Beckstead, J.H.2    Moore, K.L.3
  • 44
    • 40949093071 scopus 로고    scopus 로고
    • VCAM-1 directed immunoliposomes selectively target tumor vasculature in vivo
    • Gosk S,Moos T, Gottstein C, et al. VCAM-1 directed immunoliposomes selectively target tumor vasculature in vivo. Biochim Biophys Acta. 2008;1778:854-863
    • (2008) Biochim Biophys Acta , vol.1778 , pp. 854-863
    • Gosk, S.1    Moos, T.2    Gottstein, C.3
  • 45
    • 84876779047 scopus 로고    scopus 로고
    • Effects of the P-selectin antagonist inclacumab on myocardial damage after percutaneous coronary intervention for non-ST-segment elevation myocardial infarction: Results of the SELECTACS Trial
    • Tardif JC, Tanguay JF, Wright SS, et al. Effects of the P-selectin antagonist inclacumab on myocardial damage after percutaneous coronary intervention for non-ST-segment elevation myocardial infarction: Results of the SELECTACS Trial. J Am Coll Cardiol. 2013;61:2048-2055
    • (2013) J Am Coll Cardiol , vol.61 , pp. 2048-2055
    • Tardif, J.C.1    Tanguay, J.F.2    Wright, S.S.3
  • 46
    • 0036484364 scopus 로고    scopus 로고
    • Elevated soluble P-selectin levels are associated with an increased risk of early adverse events in patients with presumed myocardial ischemia
    • Hillis GS, Terregino C, Taggart P, et al. Elevated soluble P-selectin levels are associated with an increased risk of early adverse events in patients with presumed myocardial ischemia. Am Heart J. 2002;143:235-241
    • (2002) Am Heart J. , vol.143 , pp. 235-241
    • Hillis, G.S.1    Terregino, C.2    Taggart, P.3
  • 47
    • 0033911052 scopus 로고    scopus 로고
    • Vascular adhesion protein-1, intercellular adhesion molecule-1 and P-selectin mediate leukocyte binding to ischemic heart in humans
    • Jaakkola K, Jalkanen S, Kaunismaki K, et al. Vascular adhesion protein-1, intercellular adhesion molecule-1 and P-selectin mediate leukocyte binding to ischemic heart in humans. J Am Coll Cardiol. 2000;36:122-129
    • (2000) J Am Coll Cardiol , vol.36 , pp. 122-129
    • Jaakkola, K.1    Jalkanen, S.2    Kaunismaki, K.3
  • 48
    • 0033848671 scopus 로고    scopus 로고
    • Gene expression of inflammatory mediators in different chambers of the human heart
    • Valen G, Paulsson G, Bennet AM, et al. Gene expression of inflammatory mediators in different chambers of the human heart. Ann Thorac Surg. 2000;70:562-567
    • (2000) Ann Thorac Surg , vol.70 , pp. 562-567
    • Valen, G.1    Paulsson, G.2    Bennet, A.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.