JAZF1 can regulate the expression of lipid metabolic genes and inhibit lipid accumulation in adipocytes

Biochemical and Biophysical Research Communications

Volumn 445, Issue 3, 2014, Pages 673-680

  Ming, Guang feng ^a,b   Xiao, Di ^a   Gong, Wei jing ^a   Liu, Hui xia ^b   Liu, Jun ^b   Zhou, Hong hao ^a   Liu, Zhao qian ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

3T3 L1; Adipocytes; JAZF1; Lipid accumulation; SREBP1; TAK1

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; FATTY ACID SYNTHASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; DISORDERS OF LIPID AND LIPOPROTEIN METABOLISM; DRUG TARGETING; GENE; GENE CONTROL; GENE EXPRESSION; JUXTAPOSED WITH ANOTHER ZINC FINGER GENE 1; LIPID METABOLISM; LIPID STORAGE; LIPOGENESIS; METABOLIC DISORDER; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROADIPOCYTE; REPRESSOR GENE; UPREGULATION;

3T3-L1; ADIPOCYTES; JAZF1; LIPID ACCUMULATION; SREBP1; TAK1;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; CARRIER PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUCOSE; LIPID METABOLISM; LIPIDS; MICE; NUCLEAR PROTEINS; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UP-REGULATION;

EID: 84896318809     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.02.088     Document Type: Article

References (30)

1. Zeggini E., Scott L.J., Saxena R., et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat. Genet. 2008, 40:638-645.
2. Grarup N., Andersen G., Krarup N.T., et al. Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes. Diabetes 2008, 57:2534-2540.
3. Pulizzi N., Lyssenko V., Jonsson A., et al. Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes. Diabetologia 2009, 52:825-829.
4. Nakajima T., Fujino S., Nakanishi G., et al. TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4. Nucleic Acids Res. 2004, 32:4194-4204.
5. Hirose T., Fujimoto W., Tamaai T., et al. TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily. Mol. Endocrinol. 1994, 8:1667-1680.
6. Johansson A., Marroni F., Hayward C., et al. Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide association analysis. Hum. Mol. Genet. 2009, 18:373-380.
7. Liu N.C., Lin W.J., Kim E., et al. Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis. Diabetes 2007, 56:2901-2909.
8. Collins L.L., Lee Y.F., Heinlein C.A., et al. Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4. Proc. Natl. Acad. Sci. USA 2004, 101:15058-15063.
9. Kang H.S., Okamoto K., Kim Y.S., et al. Nuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance. Diabetes 2011, 60:177-188.
10. Marselli L., Thorne J., Dahiya S., et al. Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes. PLoS One 2010, 5:e11499.
11. Yan Z.H., Karam W.G., Staudinger J.L., et al. Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4. J. Biol. Chem. 1998, 273:10948-10957.
12. Chinetti G., Gbaguidi F.G., Griglio S., et al. CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors. Circulation 2000, 101:2411-2417.
13. Haraguchi G., Kobayashi Y., Brown M.L., et al. PPAR(alpha) and PPAR(gamma) activators suppress the monocyte-macrophage apoB-48 receptor. J. Lipid Res. 2003, 44:1224-1231.
14. Thomas G., Jacobs K.B., Yeager M., et al. Multiple loci identified in a genome-wide association study of prostate cancer. Nat. Genet. 2008, 40:310-315.
15. Amador-Ortiz C., Roma A.A., Huettner P.C., et al. JAZF1 and JJAZ1 gene fusion in primary extrauterine endometrial stromal sarcoma. Hum. Pathol. 2011, 42:939-946.
16. Fogarty M.P., Panhuis T.M., Vadlamudi S., et al. Allele-specific transcriptional activity at type 2 diabetes-associated single nucleotide polymorphisms in regions of pancreatic islet open chromatin at the JAZF1 locus. Diabetes 2013, 62:1756-1762.
17. Ohtera A., Miyamae Y., Nakai N., et al. Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor γ agonist. Biochem. Biophys. Res. Commun. 2013, 440:204-209.
18. Li L., Yang Y., Yang G., et al. The role of JAZF1 on lipid metabolism and related genes in vitro. Metabolism 2011, 60:523-530.
19. Wood I.S., Trayhurn P. Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br. J. Nutr. 2003, 89:3-9.
20. Edwards P.A., Tabor D., Kast H.R., et al. Regulation of gene expression by SREBP and SCAP. Biochim. Biophys. Acta 2000, 1529:103-113.
21. Kim E., Liu N.C., Yu I.C., et al. Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity. Diabetes 2011, 60:1493-1503.
22. Kim J.B., Spiegelman B.M. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev. 1996, 10:1096-1107.
23. Amemiya-Kudo M., Shimano H., Hasty A.H., et al. Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes. J. Lipid Res. 2002, 43:1220-1235.
24. Kim Y.M., Shin H.T., Seo Y.H., et al. Sterol regulatory element-binding protein (SREBP)-1-mediated lipogenesis is involved in cell senescence. J. Biol. Chem. 2010, 285:29069-29077.
25. Chirala S.S., Wakil S.J. Structure and function of animal fatty acid synthase. Lipids 2004, 39:1045-1053.
26. Barber M.C., Price N.T., Travers M.T. Structure and regulation of acetyl-CoA carboxylase genes of metazoa. Biochim. Biophys. Acta 2005, 1733:1-28.
27. Shen W.J., Patel S., Miyoshi H., et al. Functional interaction of hormone-sensitive lipase and perilipin in lipolysis. J. Lipid Res. 2009, 50:2306-2313.
28. Zimmermann R., Strauss J.G., Haemmerle G., et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 2004, 306:1383-1386.
29. Galic S., Oakhill J.S., Steinberg G.R. Adipose tissue as an endocrine organ. Mol. Cell. Endocrinol. 2010, 316:129-139.
30. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 2005, 115:911-919. (quiz 920).