Association between p16, hMLH1 and E-cadherin promoter hypermethylation and intake of local hot salted tea and sun-dried foods in kashmiris with gastric tumors

Asian Pacific Journal of Cancer Prevention

Volumn 13, Issue 1, 2012, Pages 181-186

  Mir, Manzoor R ^a   Shabir, Nadeem ^a   Wani, Khursheed A ^b   Shaffi, Sheikh ^a   Hussain, Ishraq ^a   Banday, Manzoor A ^b   Chikan, Naveed A ^c   Bilal, S ^a   Aejaz, Sheikh ^b  

^a SHER E KASHMIR UNIVERSITY OF AGRICULTURAL SCIENCES AND TECHNOLOGY OF KASHMIR   (India)

^b SHER I KASHMIR INSTITUTE OF MEDICAL SCIENCES   (India)

^c VIT UNIVERSITY   (India)

Author keywords

Gastric carcinoma; Kashmir; Methylation

Indexed keywords

CADHERIN; DNA; MLH1 PROTEIN, HUMAN; NUCLEAR PROTEIN; P16 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CPG ISLAND; DNA METHYLATION; FEMALE; FOOD PRESERVATION; GENETICS; HEAT; HUMAN; INDIA; INFANT; MALE; MIDDLE AGED; NEWBORN; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PROGNOSIS; PROMOTER REGION; STOMACH TUMOR; SUNLIGHT; TEA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CADHERINS; CHILD; CHILD, PRESCHOOL; CPG ISLANDS; DNA METHYLATION; DNA, NEOPLASM; FEMALE; FOOD, PRESERVED; HOT TEMPERATURE; HUMANS; INDIA; INFANT; INFANT, NEWBORN; MALE; MIDDLE AGED; NEOPLASM PROTEINS; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; PROGNOSIS; PROMOTER REGIONS, GENETIC; STOMACH NEOPLASMS; SUNLIGHT; TEA; YOUNG ADULT;

EID: 84864874630     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2012.13.1.181     Document Type: Article

References (35)

1. Baylin SB, Herman JG, Graff JR, et al (1998). Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res, 72, 141-96 .
2. Cairns P, Polascik TJ, Eby Y, et al (1995). Frequency of homozygous deletion at p16/CDKN2 in primary human tumours. Nat Genet, 11, 210-12 .
3. Carvalho B, Pinto M, Cirnes L, et al (2005). Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas. Eur J Cancer, 39, 1222-27 .
4. Chan AO, Lam SK, Wong BC, et al (2002). Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer. Gut, 52, 502-06.
5. Cloutier JF, Drouin R, Castonguay A, et al(1999). Treatment of human cells with N-Nitroso(acetoxymethyl)methylamine: distribution patterns of piperidine-sensitive DNA damage at the nucleotide level of resolution are related to the sequence context. Chem Res Toxicol, 12, 840-49.
6. El Naggar AK, Lai S, Clayman G, et al (1997). Methylation, a major mechanism of p16/CDKN2 gene inactivation in head and neck squamous carcinoma. Am J Pathol, 151, 1767-74.
7. Fleisher AS, Esteller M, Tamura G, et al (1999). Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Cancer Res, 59, 1090-95 .
8. Heinzel PA, Balaram P, Bernard HU, et al (1996). Mutations and polymorphisms in the p53, p21 and p16 genes in oral carcinomas of Indian betel quid chewers. Int J Cancer, 68, 420-23 .
9. Hirohashi S (1998). Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol, 153, 333-39 .
10. Huang Q, Ai L, Zhang ZY, et al (2004). Promoter hypermethylation and protein expression of the p16 gene: analysis of 43 cases of B-cell primary gastric lymphomas from China. Mod Patho, 17, 416-22 .
11. Kang GH, Shim YH, Yung HY, et al (2001).CpG Island methylation in premalignant stages of gastric carcinoma. Cancer Res, 61, 2847-51.
12. Khuroo MS, Zargar SA, Mahajan R, et al (1992). High incidence of esophageal and gastric cancer in Kashmir in a population with special personal and dietary habits. Gut, 33, 11-15.
13. Ksiaa F, Ziadi S, Amara K, et al (2009). Biological significance of promoter hypermethylation of tumor-related genes in patients with gastric carcinoma. Clinica Chimica Acta, 404, 128-33.
14. Lawson TA, Gingell R (1981). Methylation of hamster DNA by the carcinogen N-nitroso-bis (2-oxopropyl)amine. Cancer Lett, 11, 251-55.
15. Leal MF, Lima EM, et al (2007). Promoter hypermethylation of CDH1, FHIT, MTAP and PLAGL1 in gastric adenocarcinoma in individuals from Northern Brazil. World J Gastroenterol, 13, 2568-74.
16. Leung KH, Archer MC (1985). Mechanism of DNA methylation by N-nitroso(2oxopropyl)propylamine. Carcinogenesis, 6, 189-91 .
17. Leung SY, Yuen ST (1999). hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. Cancer Res, 59, 159-64.
18. Levenberg S, Yarden A, Kam Z, Geiger B (1999). p27 is involved in N-cadherin-mediated contact inhibition of cell growth and S-phase entry. Oncogene, 18, 869-76.
19. Malik GM, Mubarik M, Kadla SA, Durrani HA (2009). Gastric cancer profile in kashmiri population with special dietary habits. Diagn Ther Endosc, 6, 83-6.
20. Milligan JR, Hirani Hojatti S, Catz-Biro L, Archer MC (1989). Methylation of DNA by three N-nitroso compounds: Evidence for sequence specific methylation by a common intermediate. Chem Biol Interact, 72, 175-89.
21. Nan HM, Song YJ, Yun HY, et al (2005). Effect on dietary intake and genetic factors on hypermethylation of the hMLHI1 gene promoter in gastric cancer. World J gasteroenterol, 11, 3834-41.
22. Ngoan LT, Mizoue T, Fujino Y, et al (2002). Dietary factors and stomach cancer mortality. Br J Cancer, 87, 37-42.
23. Pignatelli M, Vessey CJ (1994). Adhesion molecules: novel molecular tools in tumour pathology. Hum Pathol, 25, 849-56 .
24. Rocco JW, Sidransky D(2001). p16 (MTS-1/CDKN2/INK4a) in cancer progression. Exp Cell Res, 264, 42-55 .
25. Sakata K, Tamura G, Endoh Y, et al (2005). Hypermethylation of the hMLH1 gene promoter in solitary and multiple gastric cancers with microsatellite instability. Br J Cancer, 86, 564-67.
26. Salam I, Hussain S, Mir MM, et al (2009). Aberrant promoter methylation and reduced expression of p16 gene in esophageal squamous cell carcinoma from Kashmir valley: a high-risk area. Mol Cell Biochem, 332, 51-8.
27. Sanchez Cespedes M, Esteller M (2000). Gene promoter hypermethylation in tumors and serum of head and neck cancer patients. Cancer Res, 60, 892-95.
28. Santos Reboucas CB, Pimentel MM (2007). Implication of abnormal epigenetic patterns for human diseases. Eur J Hum Genet, 15, 10-17.
29. Siddiqi M, Preussmann R (1989). Esophageal cancer in Kashmir -an assessment. J Cancer Res Clin Oncol, 115, 111-17.
30. Siddiqi M, Tricker AR, et al (1988). Formation of N-nitroso compounds under simulated gastric conditions from Kashmir foodstuffs. Cancer Lett, 39, 259-65.
31. Siddiqi M, Tricker AR, et al (1988). The occurrence of preformed N-nitroso compounds in food samples from a high risk area of esophageal, cancer in Kashmir, India. Cancer Lett, 39, 37-43.
32. Suzuki FH (1999). Distinct methylation pattern and microsatellite instability in sporadic gastric cancer. Int J Cancer, 83, 309-13.
33. Takeichi M (1991). Cadherin cell adhesion receptors as a morphogenetic regulator. Science, 251, 1451-55.
34. Tamura YG, Ajioka Y, et al (2000). Frequent hypermethylation of the hMLH1 gene promoter in differentiated-type tumors of the stomach with the gastric foveolar phenotype. Am J Pathol, 157, 717-22.
35. Wijnhoven BPL, Dinjens WNM (2000). E-cadherin-catenin cell-cell adhesion complex and human cancer. Br J Surg, 87, 992-1005