Mechanisms of antiulcero genie effect of garlic (allium sativum) in albino rats

International Journal of Tropical Medicine

Volumn 8, Issue 5-6, 2013, Pages 119-123

  Tope, Salaudeen Aminat ^a   Sunday, Oluwole Francis ^a   Gabriel, Adedeji Temitope ^a  

^a UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

Allium sativum; Anti ulcer activity; Antioxidant; Gastric mucus cell; Groups

Indexed keywords

CATALASE; GARLIC EXTRACT; MALONALDEHYDE; MISOPROSTOL; NITRIC OXIDE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ANTIULCER ACTIVITY; ARTICLE; CELL COUNT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; LIPID PEROXIDATION; LOW DRUG DOSE; NONHUMAN; OUTCOME ASSESSMENT; RAT; STOMACH MUCOSA; STOMACH PROTECTION; STOMACH ULCER; WISTAR ALBINO GLAXO RAT;

EID: 84896297057     PISSN: 18163319     EISSN: 1818779X     Source Type: Journal    
DOI: 10.3923/ijtmed.2013.119.123     Document Type: Article

References (19)

1. Ademyi, B.A., F.S. Oluwole and F.M. Anyiam, 2006. Antimicrobial and antiulcer activities of methanol extract of Allium sativum on Helicobacter pylori. J. Boil. Sci.,6: 521-526.
2. Akhtar, M.S., A.H. Akhtar and M.A. Khan, 1992. Antiulcerogenic effects of Ocimum basilicum extracts, volatile oils and flavonoid glycosides in albino rats. Int. J. Pharm., 30: 97-104.
3. Borek, C, 2001. Antioxidant health effects of aged garlic extract. J.Nutr., 131: 1010S-1015S.
4. Diab, A.S., G.O. El-Nagar and Y.M. Abd-El-Hady, 2002. Evaluation of NigellasativaL. (Black seeds: Baraka), Allium sativum (garlic) and Biogen as a feed additives on growth performance and immuostimulants of Oreochromis niloticus fmgerlmgs. Suez Canal Vet. Med. J., 2002: 745-775.
5. Freeman, B.A. and J.D. Crapo, 1982. Biology of disease-free radicals and tissue injury. Lab. Invest, 47: 412-426.
6. Gornall, A.G., C.J. Bardawill and M.M. David, 1949. Determination of serum proteins by means of the biuretreaction. J. Biol. Chem., 177: 751-766.
7. Hoogerwerf, W.A. and P.J. Pasricha, 2001. Agents Used for Control of Gastric Acidity and Treatment of Peptic Ulcers and Gastroesophageal Reflux Disease. In: Goodman and Gilamans The Pharmacological Basis of Therapeutics, Hardman, J.G. andL.E. Limbird (Eds.). McGraw-Hill, New York, pp: 1005-1019.
8. Langmead, L. and D.S. Rampton, 2001. Herbal treatment in gastrointestinal and liver disease-benefits and dangers. Aliment Pharmacol. Ther., 15: 1239-1252.
9. Maxwell, S.R., 1995. Prospects for the use of antioxidant therapies. Drugs, 49: 345-361.
10. Metwally, M.A.A., 2009. Effects of garlic (Allium sativum) on some antioxidant activities in Tilapia nilotica (Oreochromis niloticus). World J. Fish Marine Sci., 1: 56-64.
11. Misra, H.P. and I. Fridovich, 1972. Determination of the Level of Superoxide Dismutase in whole Blood. Yale University Press, New Haven, pp: 101-109.
12. Mohamed, A.H., K.E.H. Eltahir, M.B. AH, M. Galal, I.A. Ayeed, S.I. Adam and O.A. Hamid, 1999. Some pharmacological and toxicological studies on Balanites aegyptiaca bark. Phytother. Res., 13: 439-441.
13. Oluwole, F.S., 2001. Effects of Garlic on some haematological and biochemical parameters. Afr. J. Biomed. Res., 4: 139-141.
14. Singh, R., J. Madan and H.S. Rao, 2008. Anti-ulcer activity of black pepper against absolute ethanol induced gastric mucosal damage in mice. Pharmacognosy Magazine, 4: 232-235.
15. Sinha, A.K., 1972. Colorimetric assay of catalase. Anal. Biochem.,47: 389-394.
16. Valle, J.D., 2005. Peptic Ulcer Diseases and Related Disorders. In: Harrisons Principles of Internal Medicine, Braunwald, A.S., D.L. Fauci, S.L. Kasper, D.L. Hauser, Longo and J.L. Jameson (Eds.). 16th Edn, McGraw-Hill, New York, pp: 1746-1762.
17. Wilson, D.E., E. Quadros, T. Rajapaksa, A. Adams and M. Noar, 1986. Effects of misoprostol on gastric acid and mucus secretion in man. Dig. Dis. Sci., 31: 126s-129s.
18. Yaoling, L.C., S. Jiunrong, S.M. Gsyh, Y.L. Mingler, J.R. Chen, M.S. Shien and J.M. Shien, 1998. The effects of garlic powder on the hypolipidemic function and antioxidative status in hamsters. Nutr. Sci. J., 23: 171-187.
19. Yuan, Y., IT. Padol and R.H. Hunt 2006. Peptic ulcer disease today. Nat. Clin. Pract. Gastroenterol. Hepatol, 3: 80-89.