Antiulcer activity of black pepper against absolute ethanol induced gastric mucosal damage in mice

Pharmacognosy Magazine

Volumn 4, Issue 15, 2008, Pages 232-235

  Singh, Ramnik ^a   Madan, Jyotsana ^a   Singh Rao, Harwinder ^a  

^a Sri Sai Institute of Pharmaceutical Education and Research   (India)

Author keywords

Anti oxidant activity; Anti ulcer; Lipid peroxidation; Piper nigrum; TBARS

Indexed keywords

ALCOHOL; ANTIULCER AGENT; BLACK PEPPER EXTRACT; LIPID PEROXIDASE; RANITIDINE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLACK PEPPER; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; LD 50; MALE; MOUSE; NONHUMAN; STOMACH MUCOSA LESION; STOMACH PROTECTION;

EID: 69749117354     PISSN: 09731296     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. MS Akhtar, AH Akhtar and MA Khan. Antiulcerogenic effects of Ocimum basilicum extracts, volatile oils and flavonoid glycosides in albino rats. International Journal of Pharmacognosy. 30: 97-104 (1992).
2. MG Repetto and SF Llesuy. Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Brazilian Journal of Medical and Biological Research. 35: 523-534 (2002).
3. G Pihan, C Regillo, and S Szabo. Free radicals and lipid peroxidation in ethanol-or aspirin-induced gastric mucosal injury. Digestive Diseases Sciences. 32: 1395-1401 (1987).
4. T Mizui, H Sato, F Hirose and M Doteuchi. Effect of anti-peroxidative drugs on gastric damage induced by ethanol in rats. Life Science. 41: 755-763 (1987).
5. H Barry. Antioxidant effects a basis for drug selection. Drugs. 42: 569-605 (1991).
6. IB Koul and A Kapil. Evaluation of the liver protective potential of Piperine, an active principle of black and long peppers. Planta Med. 59: 413-17 (1993).
7. R Singh, N Singh, BS Saini and HS Rao. Hepatoprotective and antioxidant properties of methanolic extract of Piper nigrum Linn. in rats. Phcog Mag. 3 (12): 251-258 (2007).
8. R Singh and HS Rao. In vitro antioxidant activity of Piper nigrum Linn. Phcog Mag. 4(13 suppl): 115-120 (2008). In Press
9. DA Lorke. A new approach to practical acute toxicity testing. Arch. Toxicol. 53: 275-289 (1983).
10. A Robert, JE Nezamis, C Lancaster and AJ Hanchar. Cytoprotection by PGs in rats, Prevention of gastric necrosis produced by alcohol HCI, NaOH, hypotonic and thermal injury. Gastroenterology. 77: 433-443 (1979).
11. XW Yang, ZM Gu, BX Wang, M Hattori and T Namba. Comaparision of anti-lipid peroxidative effects of the underground parts of Notopterygium incisum and N. forbesii in mice. Planta Medica. 57: 399-402 (1991).
12. DW Piper and DD Stiel. Pathogensis of chronic peptic ulcer, current thinking and clinical implications. Medical progress. 2: 7-10 (1986).
13. KH Cheesman. Lipid peroxidation in biological systems. Ellis Horwood, London; 12-17 (1993).