Enantiomeric atropisomers inhibit HCV polymerase and/or HIV matrix: Characterizing hindered bond rotations and target selectivity

Journal of Medicinal Chemistry

Volumn 57, Issue 5, 2014, Pages 1944-1951

  LaPlante, Steven R ^a   Forgione, Pat ^a   Boucher, Colette ^a   Coulombe, René ^a   Gillard, James ^a   Hucke, Oliver ^a   Jakalian, Araz ^a   Joly, Marc André ^a   Kukolj, George ^a   Lemke, Christopher ^a   McCollum, Robert ^a   Titolo, Steve ^a   Beaulieu, Pierre L ^a   Stammers, Timothy ^a  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRANILIC ACID; ANTIVIRUS AGENT; IMIDAZOLE; MATRIX PROTEIN; NONSTRUCTURAL PROTEIN 5B; PROTEINASE INHIBITOR; RNA DIRECTED RNA POLYMERASE INHIBITOR;

ALLOSTERISM; ARTICLE; BINDING SITE; BIOPHYSICS; CHIRALITY; CONTROLLED STUDY; COVALENT BOND; DRUG CONFORMATION; DRUG HALF LIFE; DRUG SELECTIVITY; DRUG TARGETING; ENANTIOMER; HEPATITIS C VIRUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; ISOMER; ISOMERISM; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RACEMIZATION; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; ANTIVIRAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; HEPACIVIRUS; HIV; MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84896283330     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401202a     Document Type: Article

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