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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6879-6885

Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay

(14) Stammers, Timothy A a Coulombe, René a Duplessis, Martin a Fazal, Gulrez a Gagnon, Alexandre a Garneau, Michel a Goulet, Sylvie a Jakalian, Araz a Laplante, Steven a Rancourt, Jean a Thavonekham, Bounkham a Wernic, Dominik a Kukolj, George a Beaulieu, Pierre L a

a BOEHRINGER INGELHEIM CANADA LTD (Canada)

Author keywords

Direct acting antiviral; HCV NS5B polymerase; Non nucleoside inhibitor; Structure based drug design; Thumb Pocket 2

Indexed keywords

AMIDE; ANILINE DERIVATIVE; ANTHRANILIC ACID; ANTHRANILIC ACID METHYL ESTER; DELEOBUVIR; FALDAPREVIR; SULFONAMIDE;

ALKYLATION; ARTICLE; BENZYLATION; CELL CULTURE; CULTURE OPTIMIZATION; DRUG BINDING SITE; DRUG POTENCY; ESTERIFICATION; HYDROGEN BOND; MITSUNOBU REACTION; PHYSICAL CHEMISTRY; REPLICON; SAPONIFICATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

HEPATITIS C VIRUS;

DIRECT-ACTING ANTIVIRAL; HCV NS5B POLYMERASE; NON-NUCLEOSIDE INHIBITOR; STRUCTURE-BASED DRUG DESIGN; THUMB POCKET 2;

ANTIVIRAL AGENTS; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; HEPACIVIRUS; MOLECULAR DOCKING SIMULATION; ORTHO-AMINOBENZOATES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84888861274 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.09.102 Document Type: Article

Times cited : (19)

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