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Volumn 266, Issue , 2014, Pages 255-265

Age-dependent effects of valproic acid in Alzheimer's disease (AD) mice are associated with nerve growth factor (NGF) regulation

Author keywords

AD; Aging; Cognitive improvement; NGF; SAPP; VPA

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CHOLINE ACETYLTRANSFERASE; HISTONE; HISTONE DEACETYLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; NERVE GROWTH FACTOR; PROTEIN TYROSINE KINASE A; TAU PROTEIN; TOLL LIKE RECEPTOR 4; VALPROIC ACID; ENZYME INHIBITOR;

EID: 84896262392     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.02.012     Document Type: Article
Times cited : (36)

References (55)
  • 1
    • 38649124003 scopus 로고    scopus 로고
    • Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
    • Abel T., Zukin R.S. Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders. Curr Opin Pharmacol 2008, 8:57-64.
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 57-64
    • Abel, T.1    Zukin, R.S.2
  • 2
    • 0026743110 scopus 로고
    • Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease
    • Arriagada P.V., Marzloff K., Hyman B.T. Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease. Neurology 1992, 42:1681-1688.
    • (1992) Neurology , vol.42 , pp. 1681-1688
    • Arriagada, P.V.1    Marzloff, K.2    Hyman, B.T.3
  • 4
    • 78650820931 scopus 로고    scopus 로고
    • Amyloid-beta induces cyclooxygenase-2 and PGE2 release in human astrocytes in NF-kappa B dependent manner
    • Blanco A., Alvarez S., Fresno M., Munoz-Fernandez M.A. Amyloid-beta induces cyclooxygenase-2 and PGE2 release in human astrocytes in NF-kappa B dependent manner. J Alzheimers Dis 2010, 22:493-505.
    • (2010) J Alzheimers Dis , vol.22 , pp. 493-505
    • Blanco, A.1    Alvarez, S.2    Fresno, M.3    Munoz-Fernandez, M.A.4
  • 5
    • 77949660874 scopus 로고    scopus 로고
    • Nerve growth factor as a paradigm of neurotrophins related to Alzheimer's disease
    • Calissano P., Matrone C., Amadoro G. Nerve growth factor as a paradigm of neurotrophins related to Alzheimer's disease. Dev Neurobiol 2010, 70:372-383.
    • (2010) Dev Neurobiol , vol.70 , pp. 372-383
    • Calissano, P.1    Matrone, C.2    Amadoro, G.3
  • 6
    • 84876784737 scopus 로고    scopus 로고
    • Administration of MS-275 improves cognitive performance and reduces cell death following traumatic brain injury in rats
    • Cao P., Liang Y., Gao X., Zhao M.G., Liang G.B. Administration of MS-275 improves cognitive performance and reduces cell death following traumatic brain injury in rats. CNS Neurosci Ther 2013, 19:337-345.
    • (2013) CNS Neurosci Ther , vol.19 , pp. 337-345
    • Cao, P.1    Liang, Y.2    Gao, X.3    Zhao, M.G.4    Liang, G.B.5
  • 7
    • 79959985280 scopus 로고    scopus 로고
    • A dual mechanism linking NGF/proNGF imbalance and early inflammation to Alzheimer's disease neurodegeneration in the AD11 anti-NGF mouse model
    • Capsoni S., Brandi R., Arisi I., D'Onofrio M., Cattaneo A. A dual mechanism linking NGF/proNGF imbalance and early inflammation to Alzheimer's disease neurodegeneration in the AD11 anti-NGF mouse model. CNS Neurol Disord Drug Targets 2011, 10:635-647.
    • (2011) CNS Neurol Disord Drug Targets , vol.10 , pp. 635-647
    • Capsoni, S.1    Brandi, R.2    Arisi, I.3    D'Onofrio, M.4    Cattaneo, A.5
  • 8
    • 70350018325 scopus 로고    scopus 로고
    • Multiple roles of HDAC inhibition in neurodegenerative conditions
    • Chuang D.M., Leng Y., Marinova Z., Kim H.J., Chiu C.T. Multiple roles of HDAC inhibition in neurodegenerative conditions. Trends Neurosci 2009, 32:591-601.
    • (2009) Trends Neurosci , vol.32 , pp. 591-601
    • Chuang, D.M.1    Leng, Y.2    Marinova, Z.3    Kim, H.J.4    Chiu, C.T.5
  • 9
    • 0027197191 scopus 로고
    • Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease
    • Crutcher K.A., Scott S.A., Liang S., Everson W.V., Weingartner J. Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease. J Neurosci 1993, 13:2540-2550.
    • (1993) J Neurosci , vol.13 , pp. 2540-2550
    • Crutcher, K.A.1    Scott, S.A.2    Liang, S.3    Everson, W.V.4    Weingartner, J.5
  • 10
    • 84881357704 scopus 로고    scopus 로고
    • Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer s disease-like phenotype of a commonly used mouse model
    • Cuadrado-Tejedor M., Ricobaraza A.L., Torrijo R., Franco R., Garcia-Osta A. Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer s disease-like phenotype of a commonly used mouse model. Curr Pharm Des 2013, 19:5076-5084.
    • (2013) Curr Pharm Des , vol.19 , pp. 5076-5084
    • Cuadrado-Tejedor, M.1    Ricobaraza, A.L.2    Torrijo, R.3    Franco, R.4    Garcia-Osta, A.5
  • 12
    • 62149139389 scopus 로고    scopus 로고
    • Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, diminishes lymphoproliferation in the Fas-deficient MRL/lpr-/- murine model of autoimmune lymphoproliferative syndrome (ALPS)
    • Dowdell K.C., Pesnicak L., Hoffmann V., Steadman K., Remaley A.T., Cohen J.I., Straus S.E., Rao V.K. Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, diminishes lymphoproliferation in the Fas-deficient MRL/lpr-/- murine model of autoimmune lymphoproliferative syndrome (ALPS). Exp Hematol 2009, 37:487-494.
    • (2009) Exp Hematol , vol.37 , pp. 487-494
    • Dowdell, K.C.1    Pesnicak, L.2    Hoffmann, V.3    Steadman, K.4    Remaley, A.T.5    Cohen, J.I.6    Straus, S.E.7    Rao, V.K.8
  • 13
    • 0030297659 scopus 로고    scopus 로고
    • Nerve growth factor mRNA and protein levels measured in the same tissue from normal and Alzheimer's disease parietal cortex
    • Fahnestock M., Scott S.A., Jette N., Weingartner J.A., Crutcher K.A. Nerve growth factor mRNA and protein levels measured in the same tissue from normal and Alzheimer's disease parietal cortex. Brain Res Mol Brain Res 1996, 42:175-178.
    • (1996) Brain Res Mol Brain Res , vol.42 , pp. 175-178
    • Fahnestock, M.1    Scott, S.A.2    Jette, N.3    Weingartner, J.A.4    Crutcher, K.A.5
  • 14
    • 34248523169 scopus 로고    scopus 로고
    • Recovery of learning and memory is associated with chromatin remodelling
    • Fischer A., Sananbenesi F., Wang X., Dobbin M., Tsai L.H. Recovery of learning and memory is associated with chromatin remodelling. Nature 2007, 447:178-182.
    • (2007) Nature , vol.447 , pp. 178-182
    • Fischer, A.1    Sananbenesi, F.2    Wang, X.3    Dobbin, M.4    Tsai, L.H.5
  • 16
    • 33645301867 scopus 로고    scopus 로고
    • Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease
    • Ginsberg S.D., Che S., Wuu J., Counts S.E., Mufson E.J. Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease. J Neurochem 2006, 97:475-487.
    • (2006) J Neurochem , vol.97 , pp. 475-487
    • Ginsberg, S.D.1    Che, S.2    Wuu, J.3    Counts, S.E.4    Mufson, E.J.5
  • 17
    • 80051984937 scopus 로고    scopus 로고
    • Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression
    • Govindarajan N., Agis-Balboa R.C., Walter J., Sananbenesi F., Fischer A. Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression. J Alzheimers Dis 2011, 26:187-197.
    • (2011) J Alzheimers Dis , vol.26 , pp. 187-197
    • Govindarajan, N.1    Agis-Balboa, R.C.2    Walter, J.3    Sananbenesi, F.4    Fischer, A.5
  • 20
    • 58149267462 scopus 로고    scopus 로고
    • Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau
    • Green K.N., Steffan J.S., Martinez-Coria H., Sun X., Schreiber S.S., Thompson L.M., LaFerla F.M. Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci 2008, 28:11500-11510.
    • (2008) J Neurosci , vol.28 , pp. 11500-11510
    • Green, K.N.1    Steffan, J.S.2    Martinez-Coria, H.3    Sun, X.4    Schreiber, S.S.5    Thompson, L.M.6    LaFerla, F.M.7
  • 21
    • 84877903301 scopus 로고    scopus 로고
    • Lysine deacetylases and mitochondrial dynamics in neurodegeneration
    • Guedes-Dias P., Oliveira J.M. Lysine deacetylases and mitochondrial dynamics in neurodegeneration. Biochim Biophys Acta 2013, 1832:1345-1359.
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 1345-1359
    • Guedes-Dias, P.1    Oliveira, J.M.2
  • 22
    • 79957852572 scopus 로고    scopus 로고
    • Valproate reduces tau phosphorylation via cyclin-dependent kinase 5 and glycogen synthase kinase 3 signaling pathways
    • Hu J.P., Xie J.W., Wang C.Y., Wang T., Wang X., Wang S.L., Teng W.P., Wang Z.Y. Valproate reduces tau phosphorylation via cyclin-dependent kinase 5 and glycogen synthase kinase 3 signaling pathways. Brain Res Bull 2011, 85:194-200.
    • (2011) Brain Res Bull , vol.85 , pp. 194-200
    • Hu, J.P.1    Xie, J.W.2    Wang, C.Y.3    Wang, T.4    Wang, X.5    Wang, S.L.6    Teng, W.P.7    Wang, Z.Y.8
  • 23
    • 79956320988 scopus 로고    scopus 로고
    • Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model
    • Jimenez S., Torres M., Vizuete M., Sanchez-Varo R., Sanchez-Mejias E., Trujillo-Estrada L., Carmona-Cuenca I., Caballero C., Ruano D., Gutierrez A., Vitorica J. Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model. J Biol Chem 2011, 286:18414-18425.
    • (2011) J Biol Chem , vol.286 , pp. 18414-18425
    • Jimenez, S.1    Torres, M.2    Vizuete, M.3    Sanchez-Varo, R.4    Sanchez-Mejias, E.5    Trujillo-Estrada, L.6    Carmona-Cuenca, I.7    Caballero, C.8    Ruano, D.9    Gutierrez, A.10    Vitorica, J.11
  • 24
    • 45849105153 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease
    • Jin J.J., Kim H.D., Maxwell J.A., Li L., Fukuchi K. Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease. J Neuroinflamm 2008, 5:23.
    • (2008) J Neuroinflamm , vol.5 , pp. 23
    • Jin, J.J.1    Kim, H.D.2    Maxwell, J.A.3    Li, L.4    Fukuchi, K.5
  • 25
    • 84876554957 scopus 로고    scopus 로고
    • Increasing Tip60 HAT levels rescues axonal transport defects and associated behavioral phenotypes in a Drosophila Alzheimer's disease model
    • Johnson A.A., Sarthi J., Pirooznia S.K., Reube W., Elefant F. Increasing Tip60 HAT levels rescues axonal transport defects and associated behavioral phenotypes in a Drosophila Alzheimer's disease model. J Neurosci 2013, 33:7535-7547.
    • (2013) J Neurosci , vol.33 , pp. 7535-7547
    • Johnson, A.A.1    Sarthi, J.2    Pirooznia, S.K.3    Reube, W.4    Elefant, F.5
  • 26
    • 84877921767 scopus 로고    scopus 로고
    • Potential of chromatin modifying compounds for the treatment of Alzheimer's disease
    • Karagiannis T.C., Ververis K. Potential of chromatin modifying compounds for the treatment of Alzheimer's disease. Pathobiol Aging Age Relat Dis 2012, 2:14980-14987.
    • (2012) Pathobiol Aging Age Relat Dis , vol.2 , pp. 14980-14987
    • Karagiannis, T.C.1    Ververis, K.2
  • 28
    • 66549104205 scopus 로고    scopus 로고
    • Bridging physiology and pathology in AD
    • Kim D., Tsai L.-H. Bridging physiology and pathology in AD. Cell 2009, 137:997-1000.
    • (2009) Cell , vol.137 , pp. 997-1000
    • Kim, D.1    Tsai, L.-H.2
  • 29
    • 84870667053 scopus 로고    scopus 로고
    • Epigenetic histone acetylation and deacetylation mechanisms in experimental models of neurodegenerative disorders
    • Konsoula Z., Barile F.A. Epigenetic histone acetylation and deacetylation mechanisms in experimental models of neurodegenerative disorders. J Pharmacol Toxicol Methods 2012, 66:215-220.
    • (2012) J Pharmacol Toxicol Methods , vol.66 , pp. 215-220
    • Konsoula, Z.1    Barile, F.A.2
  • 30
    • 67749147448 scopus 로고    scopus 로고
    • Searching for disease modifiers-PKC activation and HDAC inhibition - a dual drug approach to Alzheimer's disease that decreases Abeta production while blocking oxidative stress
    • Kozikowski A.P., Chen Y., Subhasish T., Lewin N.E., Blumberg P.M., Zhong Z., D'Annibale M.A., Wang W.L., Shen Y., Langley B. Searching for disease modifiers-PKC activation and HDAC inhibition - a dual drug approach to Alzheimer's disease that decreases Abeta production while blocking oxidative stress. ChemMedChem 2009, 4:1095-1105.
    • (2009) ChemMedChem , vol.4 , pp. 1095-1105
    • Kozikowski, A.P.1    Chen, Y.2    Subhasish, T.3    Lewin, N.E.4    Blumberg, P.M.5    Zhong, Z.6    D'Annibale, M.A.7    Wang, W.L.8    Shen, Y.9    Langley, B.10
  • 31
    • 84858710947 scopus 로고    scopus 로고
    • APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD)
    • Lalonde R., Fukuchi K., Strazielle C. APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD). Neurosci Biobehav Rev 2012, 36:1357-1375.
    • (2012) Neurosci Biobehav Rev , vol.36 , pp. 1357-1375
    • Lalonde, R.1    Fukuchi, K.2    Strazielle, C.3
  • 33
    • 67649379393 scopus 로고    scopus 로고
    • Histone acetyltransferase inhibitors and preclinical studies
    • Manzo F., Tambaro F.P., Mai A., Altucci L. Histone acetyltransferase inhibitors and preclinical studies. Expert Opin Ther Pat 2009, 19:761-774.
    • (2009) Expert Opin Ther Pat , vol.19 , pp. 761-774
    • Manzo, F.1    Tambaro, F.P.2    Mai, A.3    Altucci, L.4
  • 35
    • 77952888035 scopus 로고    scopus 로고
    • Valproic acid stimulates clusterin expression in human astrocytes: implications for Alzheimer's disease
    • Nuutinen T., Suuronen T., Kauppinen A., Salminen A. Valproic acid stimulates clusterin expression in human astrocytes: implications for Alzheimer's disease. Neurosci Lett 2010, 475:64-68.
    • (2010) Neurosci Lett , vol.475 , pp. 64-68
    • Nuutinen, T.1    Suuronen, T.2    Kauppinen, A.3    Salminen, A.4
  • 36
    • 33749521100 scopus 로고    scopus 로고
    • Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation
    • Oakley H., Cole S.L., Logan S., Maus E., Shao P., Craft J., Guillozet-Bongaarts A., Ohno M., Disterhoft J., Van Eldik L., Berry R., Vassar R. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci 2006, 26:10129-10140.
    • (2006) J Neurosci , vol.26 , pp. 10129-10140
    • Oakley, H.1    Cole, S.L.2    Logan, S.3    Maus, E.4    Shao, P.5    Craft, J.6    Guillozet-Bongaarts, A.7    Ohno, M.8    Disterhoft, J.9    Van Eldik, L.10    Berry, R.11    Vassar, R.12
  • 38
    • 69449093036 scopus 로고    scopus 로고
    • Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology
    • Polydoro M., Acker C.M., Duff K., Castillo P.E., Davies P. Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. J Neurosci 2009, 29:10741-10749.
    • (2009) J Neurosci , vol.29 , pp. 10741-10749
    • Polydoro, M.1    Acker, C.M.2    Duff, K.3    Castillo, P.E.4    Davies, P.5
  • 40
    • 80052656815 scopus 로고    scopus 로고
    • The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing
    • Rabe S., Reichwald J., Ammaturo D., de Strooper B., Saftig P., Neumann U., Staufenbiel M. The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing. J Neurochem 2011, 119:231-239.
    • (2011) J Neurochem , vol.119 , pp. 231-239
    • Rabe, S.1    Reichwald, J.2    Ammaturo, D.3    de Strooper, B.4    Saftig, P.5    Neumann, U.6    Staufenbiel, M.7
  • 41
    • 84863757162 scopus 로고    scopus 로고
    • Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients
    • Rao J.S., Keleshian V.L., Klein S., Rapoport S.I. Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients. Transl Psychiatry 2012, 2:e132.
    • (2012) Transl Psychiatry , vol.2
    • Rao, J.S.1    Keleshian, V.L.2    Klein, S.3    Rapoport, S.I.4
  • 42
    • 84859712559 scopus 로고    scopus 로고
    • Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease
    • Ricobaraza A., Cuadrado-Tejedor M., Marco S., Perez-Otano I., Garcia-Osta A. Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease. Hippocampus 2012, 22:1040-1050.
    • (2012) Hippocampus , vol.22 , pp. 1040-1050
    • Ricobaraza, A.1    Cuadrado-Tejedor, M.2    Marco, S.3    Perez-Otano, I.4    Garcia-Osta, A.5
  • 44
    • 66449130960 scopus 로고    scopus 로고
    • Regulation of innate immune responses in the brain
    • Rivest S. Regulation of innate immune responses in the brain. Nat Rev Immunol 2009, 9:429-439.
    • (2009) Nat Rev Immunol , vol.9 , pp. 429-439
    • Rivest, S.1
  • 45
    • 0029022112 scopus 로고
    • Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis
    • Scott S.A., Mufson E.J., Weingartner J.A., Skau K.A., Crutcher K.A. Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis. J Neurosci 1995, 15:6213-6221.
    • (1995) J Neurosci , vol.15 , pp. 6213-6221
    • Scott, S.A.1    Mufson, E.J.2    Weingartner, J.A.3    Skau, K.A.4    Crutcher, K.A.5
  • 46
    • 18244388693 scopus 로고    scopus 로고
    • Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice
    • Seo H., Isacson O. Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice. Exp Neurol 2005, 193:469-480.
    • (2005) Exp Neurol , vol.193 , pp. 469-480
    • Seo, H.1    Isacson, O.2
  • 47
    • 79961134149 scopus 로고    scopus 로고
    • TLR4 mutation reduces microglial activation, increases Abeta deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease
    • Song M., Jin J., Lim J.E., Kou J., Pattanayak A., Rehman J.A., Kim H.D., Tahara K., Lalonde R., Fukuchi K. TLR4 mutation reduces microglial activation, increases Abeta deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease. J Neuroinflamm 2011, 8:92.
    • (2011) J Neuroinflamm , vol.8 , pp. 92
    • Song, M.1    Jin, J.2    Lim, J.E.3    Kou, J.4    Pattanayak, A.5    Rehman, J.A.6    Kim, H.D.7    Tahara, K.8    Lalonde, R.9    Fukuchi, K.10
  • 48
    • 84868549261 scopus 로고    scopus 로고
    • Mercaptoacetamide-based class II HDAC inhibitor lowers Abeta levels and improves learning and memory in a mouse model of Alzheimer's disease
    • Sung Y.M., Lee T., Yoon H., DiBattista A.M., Song J.M., Sohn Y., Moffat E.I., Turner R.S., Jung M., Kim J., Hoe H.S. Mercaptoacetamide-based class II HDAC inhibitor lowers Abeta levels and improves learning and memory in a mouse model of Alzheimer's disease. Exp Neurol 2013, 239:192-201.
    • (2013) Exp Neurol , vol.239 , pp. 192-201
    • Sung, Y.M.1    Lee, T.2    Yoon, H.3    DiBattista, A.M.4    Song, J.M.5    Sohn, Y.6    Moffat, E.I.7    Turner, R.S.8    Jung, M.9    Kim, J.10    Hoe, H.S.11
  • 49
    • 37349069999 scopus 로고    scopus 로고
    • Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell line
    • Udan M.L., Ajit D., Crouse N.R., Nichols M.R. Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell line. J Neurochem 2008, 104:524-533.
    • (2008) J Neurochem , vol.104 , pp. 524-533
    • Udan, M.L.1    Ajit, D.2    Crouse, N.R.3    Nichols, M.R.4
  • 50
    • 84866046667 scopus 로고    scopus 로고
    • Transcriptional signatures mediated by acetylation overlap with early-stage Alzheimer's disease
    • Vadnal J., Houston S., Bhatta S., Freeman E., McDonough J. Transcriptional signatures mediated by acetylation overlap with early-stage Alzheimer's disease. Exp Brain Res 2012, 221:287-297.
    • (2012) Exp Brain Res , vol.221 , pp. 287-297
    • Vadnal, J.1    Houston, S.2    Bhatta, S.3    Freeman, E.4    McDonough, J.5
  • 51
    • 0028286955 scopus 로고
    • Expression of neurotrophin and trk receptor genes in adult rats with fimbria transections: effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administration
    • Venero J.L., Knusel B., Beck K.D., Hefti F. Expression of neurotrophin and trk receptor genes in adult rats with fimbria transections: effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administration. Neuroscience 1994, 59:797-815.
    • (1994) Neuroscience , vol.59 , pp. 797-815
    • Venero, J.L.1    Knusel, B.2    Beck, K.D.3    Hefti, F.4
  • 52
    • 77951247066 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein
    • Venkataramani V., Rossner C., Iffland L., Schweyer S., Tamboli I.Y., Walter J., Wirths O., Bayer T.A. Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein. J Biol Chem 2010, 285:10678-10689.
    • (2010) J Biol Chem , vol.285 , pp. 10678-10689
    • Venkataramani, V.1    Rossner, C.2    Iffland, L.3    Schweyer, S.4    Tamboli, I.Y.5    Walter, J.6    Wirths, O.7    Bayer, T.A.8
  • 53
    • 84858001196 scopus 로고    scopus 로고
    • Increased expressions of TLR2 and TLR4 on peripheral blood mononuclear cells from patients with Alzheimer's disease
    • Zhang W., Wang L.Z., Yu J.T., Chi Z.F., Tan L. Increased expressions of TLR2 and TLR4 on peripheral blood mononuclear cells from patients with Alzheimer's disease. J Neurol Sci 2012, 315:67-71.
    • (2012) J Neurol Sci , vol.315 , pp. 67-71
    • Zhang, W.1    Wang, L.Z.2    Yu, J.T.3    Chi, Z.F.4    Tan, L.5
  • 54
    • 67349092442 scopus 로고    scopus 로고
    • Suppression of nuclear factor kappa B ameliorates astrogliosis but not amyloid burden in APPswe/PS1dE9 mice
    • Zhang X., Luhrs K.J., Ryff K.A., Malik W.T., Driscoll M.J., Culver B. Suppression of nuclear factor kappa B ameliorates astrogliosis but not amyloid burden in APPswe/PS1dE9 mice. Neuroscience 2009, 161:53-58.
    • (2009) Neuroscience , vol.161 , pp. 53-58
    • Zhang, X.1    Luhrs, K.J.2    Ryff, K.A.3    Malik, W.T.4    Driscoll, M.J.5    Culver, B.6
  • 55
    • 84874661821 scopus 로고    scopus 로고
    • Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model
    • Zhang Z.Y., Schluesener H.J. Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model. J Neuropathol Exp Neurol 2013, 72:178-185.
    • (2013) J Neuropathol Exp Neurol , vol.72 , pp. 178-185
    • Zhang, Z.Y.1    Schluesener, H.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.