Pyrroloquinolinone-based dual topoisomerase I/II inhibitor

European Journal of Medicinal Chemistry

Volumn 77, Issue , 2014, Pages 103-109

  Dalla Via, Lisa ^a   Marzaro, Giovanni ^a   Ferrarese, Alessandro ^a   Gia, Ornella ^a   Chilin, Adriana ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Dual activity; Molecular docking; Pyrroloquinolinone; Topoisomerase

Indexed keywords

9 (4' DIMETHYLAMINOBUTOXY) 2,6 DIMETHYLPYRROLO[3,2,1 IJ]QUINOLIN 4 ONE; 9 [2' [2'' (DIMETHYLAMINO)ETHYLAMINO]ETHOXY] 2,6 DIMETHYLPYRROLO[3,2,1 IJ]QUINOLIN 4 ONE; 9 [3' [2'' (DIMETHYLAMINO)ETHYLAMINO]PROPOXY] 2,6 DIMETHYLPYRROLO[3,2,1 IJ]QUINOLIN 4 ONE; 9 [4' [2'' (DIMETHYLAMINO)ETHYLAMINO]BUTOXY] 2,6 DIMETHYLPYRROLO[3,2,1 IJ]QUINOLIN 4 ONE; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE INHIBITOR; GYRASE INHIBITOR; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); PYRROLE DERIVATIVE; QUINOLONE DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; DRUG TARGETING; FEMALE; HUMAN; HUMAN CELL; INTERACTIONS WITH DNA; MOLECULAR INTERACTION; MOLECULAR MODEL; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HELA CELL LINE; HL 60 CELL LINE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HL-60 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRROLES; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS; TOPOISOMERASE II INHIBITORS;

EID: 84896113796     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.02.064     Document Type: Article

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