Synthesis and Antiproliferative Activity of Some Ellipticine-Like 11H-Pyrido[a]carbazole Derivatives

ChemMedChem

Volumn 6, Issue 10, 2011, Pages 1872-1883

  Ferlin, Maria Grazia ^a   Gia, Ornella ^a   DallaVia, Lisa ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Antitumor agents; Carbazoles; Ellipticine; Inhibitors; TopoisomeraseII

Indexed keywords

10 CHLORO 11H PYRIDO[3,4 A]CARBAZOLE; 10 CHLORO 6,11 DIHYDRO 5H PYRIDO[3,4 A]CARBAZOLE; 2 (10 CHLORO 11H PYRIDO[3,4 A]CARBAZOL 11 YL) N,N DIMETHYLETHANAMINE; 2 (10 CHLORO 5,6 DIHYDRO 11H PYRIDO[3,4 A]CARBAZOL 11 YL) N,N DIMETHYLETHANAMINE; 2 (5 CHLORO 11H PYRIDO[3,4 A]CARBAZOL 11 YL) N,N DIETHYLETHANA; 2 (5 CHLORO 7,8,9,10 TETRAHYDRO 11H PYRIDO[3,2 A]CARBAZOL 11 YL)N,N DIETHYLETHANAMINE; 2 (5 CHLORO 7,8,9,10 TETRAHYDROPYRIDO[3,4 A]CARBAZOL 11 YL) N,N DIETHYLETHANAMINE; 2 (5 CHLORO PYRIDO[3,2 A]CARBAZOL 11 YL) N,N DIETHYLETHANAMINE; 2 CYCLOHEXYLIDENE 1 (5 CHLOROISOQUINOLIN 8 YL)HYDRAZINE; 2 CYCLOHEXYLIDENE 1 (8 CHLOROQUINOLIN 5 YL)HYDRAZINE; 5 AMINO 8 CHLOROQUINOLINE; 5 AMINO 8 NITROQUINOLINE; 5 CHLORO 11 METHYL 7,8,9,10 TETRAHYDRO 11H PYRIDO[3,4 A]CARBAZOLE; 5 CHLORO 11H PYRIDO[3,2 A] CARBAZOLE; 5 CHLORO 11H PYRIDO[3,4 A] CARBAZOLE; 5 CHLORO 7,8,9,10 TETRAHYDRO 11H PYRIDO[3,2 A]CARBAZOLE; 5 CHLORO 7,8,9,10, TETRAHYDRO 11H PYRIDO[3,4 A]CARBAZOLE; 5 CHLORO 8 HYDRAZINO ISOQUINOLINE; 5 CHLORO 8N METHYL 7,8,9,10 TETRAHYDRO 11H PYRIDO[3',4',4,5]PYRROLO[2,3F]QUINOLINE; 5 DIMETHYLAMINO 7,8,9,10 TETRAHYDRO 11H PYRIDO[3,2 A]CARBAZOLE; 5 DIMETHYLAMINO 7,8,9,10 TETRAHYDRO 11H PYRIDO[3,2 A]CARBAZOLE N,N DIETHYLETHANAMINE; 5 HYDRAZINO 8 NITROQUINOLINE; 5 HYDRAZINYL N,N DIMETHYLQUINOLIN 8 AMINE; 8 AMINO 5 NITRO ISOQUINOLINE; 8 CHLORO 5 HYDRAZINOQUINOLINE; 9 CHLORO 11H PYRIDO[3,4 A]CARBAZOLE; 9 CHLORO 6,11 DIHYDRO 5H PYRIDO[3,4 A]CARBAZOLE; CARBAZOLE DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING); UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOGEN DNA INTERACTION; CELL DAMAGE; CONTROLLED STUDY; CYTOTOXICITY; DNA REPLICATION; DNA STRAND BREAKAGE; DNA TRANSCRIPTION; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGENATION; IC 50; IN VITRO STUDY; PRIORITY JOURNAL; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CARBAZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; CIRCULAR DICHROISM; DNA; DNA TOPOISOMERASES, TYPE II; ELLIPTICINES; HUMANS; INTERCALATING AGENTS; TOPOISOMERASE II INHIBITORS;

EID: 80053414216     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100233     Document Type: Article

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