Chemistry and pharmacology of Siraitia grosvenorii: A review

Chinese Journal of Natural Medicines

Volumn 12, Issue 2, 2014, Pages 89-102

  Li, Chun ^a   Lin, Li Mei ^b   Sui, Feng ^a   Wang, Zhi Min ^a   Huo, Hai Ru ^a   Dai, Li ^a   Jiang, Ting Liang ^a  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b HUNAN UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Chemical constituents; Cucurbitaceae; Pharmacological effects; Siraitiagrosvenorii

Indexed keywords

AMINO ACID; AMINOTRANSFERASE; CUCURBITACIN GLYCOSIDE; ESSENTIAL OIL; FLAVONOID; GLUCOSE; GLUTATHIONE; PLANT EXTRACT; POLYSACCHARIDE; SIRAITIA GROSVENORII PLANT EXTRACT; SUPEROXIDE DISMUTASE; SWEETENING AGENT; TRITERPENOID; UNCLASSIFIED DRUG; TRITERPENE;

ANTIBACTERIAL ACTIVITY; ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTITUSSIVE ACTIVITY; ARTICLE; BIOCHEMICAL COMPOSITION; BIOLOGICAL ACTIVITY; CHINA; CHINESE HERB; CHINESE MEDICINE; CUCURBITACEAE; DRUG ACTIVITY; DRUG DETERMINATION; DRUG ISOLATION; FRUIT; GLUCOSE BLOOD LEVEL; HUMAN; IMMUNOMODULATION; IMMUNOSTIMULATION; IN VITRO STUDY; INFLORESCENCE; LIVER PROTECTION; MAXIMUM TOLERATED DOSE; NONHUMAN; PHARYNGITIS; PHLEGM EXPELLING ACTIVITY; PHYSIOLOGY; PLANT LEAF; PLANT ROOT; PLANT STEM; REDUCTION; SIRAITIA GROSVENORII; SORE THROAT; TOXICOLOGY; ANIMAL; CHEMISTRY;

AMINO ACIDS; ANIMALS; CUCURBITACEAE; FLAVONOIDS; HUMANS; PLANT EXTRACTS; POLYSACCHARIDES; TRITERPENES;

EID: 84896092928     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.1016/S1875-5364(14)60015-7     Document Type: Article

References (93)

1. Lu AM, Zhang ZY The genus Siraitia Merr. in China [J]. Guihara 1984, 4(1):27-33.
2. Li DP, Zhang HR Studies and usesd of Chinese medicine Luohanguo-a special local product of Guangxi [J]. Guihaia 2000, 20(3):270-276.
3. Chen FX Newly Organized Chinese Patent Drug Manual [M] 1996, 326. China Medicine Science and Technology Press, Beijing.
4. Wang Q, Qin HH, Wang W, et al. The pharmacological research progress of Siraitiagrosvenorii [J]. J Guangxi TraditChin Med Univ 2010, 13(3):75-76.
5. Zhang H, Li XH Research progress on chemical compositions of Fructus Momordicae [J]. J Anhui Agri Sci 2011, 39(8):4555-4556. 4559.
6. Takemoto T, Arihara S, Nakajima T, et al. Studies on the constituents of Fructus Momordicae. I. on the sweet principle [J]. Yakugaku Zasshi 1983, 103(11):1151-1154.
7. Takemoto T, Arihara S, Nakajima T, et al. Studies on the constituents of Fructus Momordicae. II. Structure of sapogenin [J]. Yakugaku Zasshi 1983, 103(11):1155-1166.
8. Takemoto T, Arihara S, Nakajima T, et al. Studies on the constituents of Fructus Momordicae. III. Structure of mogrosides [J]. Yakugaku Zasshi 1983, 103(11):1167-1173.
9. Ukiya M, Akihisa T, Tokuda H, et al. Inhibitory effects of cucurbitane glycosides and other triterpenoids from the fruit of Momordicagrosvenorion on Epstein-Barr virus early antigen induced by tumor promoter 12-O-tetradecanoylphorbol- 13-acetate [J]. J Agric Food Chem 2002, 50(23):6710-6715.
10. Akihisa T, Hayakawa Y, Tokuda H, et al. Cucurbitane glycosides from the fruits of Siraitia grosvenorii and their inhibitory effects on Epstein-Barr virus activation [J]. J Nat Prod 2007, 70(5):783-788.
11. Xu WK, Meng LS, Li ZY Isolation and identification of a bitter constituent from Luohanguo's unripe fruits [J]. Guihaia 1992, 12(2):136-138.
12. Li C, Lin LM, Luo M, et al. A new natural saponin from Siraitia grosvenorii [J]. China J Chin Mater Med 2011, 36(6):721-724.
13. Jia ZH, Yang X A minor, sweet cucurbitane glycoside from Siraitia grosvenorii [J]. Nat Prod Commun 2009, 4(6):769-772.
14. Zheng YB, Yu J, Liu JM. Determination of total saponin content in the fresh fruit of Siraitia grosvenorii [C]. Annual Meeting Proceedings of Sweetener Professional Board, Production and Application of Food Additives Industry Associate, 2007.
15. Li HB, Zhang M, Wang Y, et al. Colorimetric determination of triterpenoid saponin in Luohanguo [J]. Food Sci 2006, 27(6):171-173.
16. Ou Y, Chen JY, Qin RL Content determination of mogroside V in Siraitia grosvenorii fruit by HPLC [J]. J Guangxi Tradit Chin Med Univ 2007, 10(4):85-86.
17. Matsumoto K, Kasai R, Ohtani K, et al. Minor cucurbitane-glycosides from fruits of Siraitia grosvenorii (Cucurbitaceae) [J]. Chem Pharm Bull 1990, 38(7):2030-2032.
18. Si JY, Chen DH, Chang Q, et al. Isolation and determination of cucurbitane-glycosides from fresh fruits of Siraitia grosvenorii [J]. Acta Bot Sin 1996, 38(6):489-494.
19. Li DP, Ikeda T, Matsuoka N, et al. Cucurbitane glycosides from unripe fruits of Lo Han Kuo (Siraitia grosvenorii). [J]. Chem Pharm Bull 2006, 54(10):1426-1428.
20. Yang XW, Zhang JY, Qian ZM Grosmomoside I, a new cucurbitane triterpenoid glycoside from fruits of Momordica grosvenorii[J]. Chin Tradit Herb Drugs 2005, 36(9):1285-1290.
21. Li DP, Ikeda T, Nohara T, et al. Cucurbitane glycosides from unripe fruits of Siraitia grosvenorii [J]. Chem Pharm Bull 2007, 55(7):1082-1086.
22. Zheng Y, Huang W, Yoo JG, et al. Antibacterial compounds from Siraitia grosvenorii leaves [J]. Nat Prod Res 2011, 25(9):890-897.
23. Wang XF, Lu WJ, Chen JY, et al. Studies on the chemical constituents of root of Luohanguo (Siraitia grosvenorii) [J]. Chin Tradit Herb Drugs 1996, 27(9):515-518.
24. Si JY, Chen DH, Shen LG, et al. Studies on the chemical constituents from the root of Siraitia grosvenorii [J]. Acta Pharm Sin 1999, 34(12):918-920.
25. Wang XF, Lu WJ, Chen JY, et al. Studies on the chemical constituents of root of Luohanguo (Siraitia grosvenorii). [J]. Chin TraditHerb Drugs 1998, 29(5):293-295.
26. Si JY, Chen DH, Tu GZ, Siraiticacid F a new nor-cucurbitacin with novel skeleton, from the roots of Siraitia grosvenorii [J]. J Asian Nat Prod Res 2005, 1(7):37-41.
27. Wang YP, Chen JY Study on the chemical constituents of Siraitia grosvenorii fruits [J]. Chin Tradit Herb Drugs 1992, 23(2):61-62.
28. Liao RQ, Li J, Huang XS, Huang Y, et al. Chemical constituents of Siraitia grosvenorii (Swingle) C. Jeffrey [J]. Acta BotBoreal-Occident Sin 2008, 28(6):1250-1254.
29. Li DP, EI-Aasr M, Ikeda T, et al. Two new cucurbitane-type glycosides obtained from roots of Siraitia grosvenorii [J]. Chem Pharm Bull 2009, 57(8):870-872.
30. Kaiser R, Matsumoto K, Nie RL, et al. Glycosides from Chinese medicinal plant, Hemsleyapanacis-scandens and structure-taste relationship of cucurbitane-glycosides [J]. Chem Pharm Bull 1988, 36(1):234-243.
31. Kaiser R Studies on the constituents of cucurbitaceous plant [J]. Yakugaku Zasshi 2008, 128(10):1369-1382.
32. Li DP, Chen YY, Pan ZH, et al. Study on variation of mogrol glycosides from fruits of Siraitia grosvenorii in different growing ages [J]. Guihaia 2004, 24(6):546-549.
33. Chen QB, Yi XH, Yu LJ, et al. Study on the variation of mogroside V and flavones glycosides in Siraitia grosvenorii fresh fruits in different growth periods [J]. Guihaia 2005, 25(3):274-277.
34. Xiang Q, Lei X, Huang LZ, et al. Study of metabolic conversion of mogrol glycosides in fruit of Siraitia grosvenorii [J]. Biotechnol 2009, 19(4):49-51.
35. Yang XW, Zhang JY, Qian ZM New natural saponins form fruits of Momordica grosvenorii [J]. Chin Tradit Herb Drugs 2008, 39(6):810-813.
36. Si JY, Chen DH, Chang Q, et al. Isolation and structure determination of flavonol glycosides from the fresh fruits of Siraitiagrosvenorii [J]. Acta Pharma Sin 1994, 29(2):158-160.
37. Mo LL, Li DP Antioxidant activity of flavonol glycosides of Siraitia grosvenorii flower [J]. Mod Food Sci Technol 2009, 25(5):484-486.
38. Chen QB, Yang JX, Chen ZQ, et al. Separation, purification and identification of flavonol glycoside from Momordica grosvenorii leafs [J]. Guangxi Sci 2006, 13(1):35-42.
39. Chen QB, Yang RY, Yi XH, et al. The determination of total falvonoids in Momordica grosvenorii fresh fruit and mogrosides by RP-HPLC [J]. Food Sci 2003, 24(5):133-135.
40. Chen QB, Yang JX, Chen ZQ, et al. The determination of total flavonoids in Momordica grosvenrii leaf by RP-HPLC [J]. Guangxi Sci 2005, 12(1):43-45.
41. Chen QB, Luo XY, Liang GQ, et al. Content determination of flavonol glycosides in the different parts of Siraitia grosvenorii plant. [J]. Guangxi J Light Ind 2007, 10:1-2.
42. Zhong MC, Xiao C. Content determination of kaempferol in the fruit of Siraitia grosvenorii by HPLC [C]. The Memoir of the Ninth Conference for Chinese Medicine Authentication of China Associate of Chinese Medicine, 2008.
43. Zhou L, Wu HZ, Zhao X, et al. Determination of total flavone in Siraitia grosvenorii (Swingle) vine, leaf and extract [J]. Guide China Med 2010, 8(17):65-66.
44. Zhou L, Wu HZ, Liu YW The content determination of kaempferitrin in the leaf, stem and extracts of Siraitia grosvenorii by RP-HPLC [J]. Mod Chin Med 2010, 12(11):24-26. 31.
45. Li J, Huang XS, Zhang YJ Chemical constituents of Siraitia grosvenorii (Swingle) C. Jeffrey [J]. China J Chin Mater Med 2007, 32(6):548-549.
46. Li Q, Xiao C. The content determination of carbohydrate components of Siraitia grosvenorii fruits[C]. The Symposium of the Ninth Conference of TCM Identification of China Association of Chinese Medicine, 2008.
47. Chen QB, Chen HY, Li J, et al. The determination of the molecular weight of Siraitia grosvenoriipoly saccharides by HPLC [J]. Chin Tradit Herb Med 2003, 34(12):1075-1076.
48. Li J, Chen HY, Deng SP, et al. Study on the extracting technology of polysaccharides from Siraitia grosvenorii [J]. Chem World 2005, 5:277-280.
49. Li J, Huang XS, Zhang YJ, et al. Extracting polysaccharides from Siraitia grosvenorii (Swingle) C. Jeffrey and constituents analysis [J]. J Guangxi Normal Univ (Nat Sci Edit) 2007, 25(1):70-73.
50. 13C NMR spectroscopy [J]. Chem World 2007, 2:81-85.
51. Li J, Huang Y, He XC, et al. Study on the structure of polysaccharide from the fruits of Siraitia grosvenorii [J]. Sci Technol Food Ind 2008, 29(8):169-172.
52. Yan XJ, Lu FL, Chen HY, et al. Studies on isolation, purification, structural identification and its antitumor activity of polysaccharides from Momordica grosvenorii Swingle root [J]. Guihaia 2012, 32(1):138-142.
53. Xu WK, Meng LS The determination of the nutritional compositions from Siraitiagrosvenorii fruits [J]. Guihaia 1981, 1(2):50-51.
54. Xu WK, Meng LS The content determination of the proteins from Siraitia grosvenorii fruits [J]. Guihaia 1986, 6(4):295-296.
55. Li F, Zhang BY, Qin L, et al. A study on the variation of vitamin C content in fruits of Luohanguo [J]. Guihaia 1985, 5(3):307-310.
56. Li S, Wang HS, Zhang GY The analysis of seed oil from Siraitia grosvenorii[J]. Guangxi Med J 2003, 25(5):850-852.
57. Chen QB, Cheng ZQ, Xu ZJ, et al. Study on the extraction and properties of oil from seeds of Siraitia grosvenorii (Swingle) C. Jeffery [J]. Sci Technol Food Oil 2004, 12(2):25-27.
58. Chen QB, Cheng ZQ, Yang JX, et al. Extraction and structure identification of Siraitia grosvenorii squalene [J]. Guihaia 2006, 26(6):687-689.
59. Zhou XX Study on the essential oil of Siraitia grosvenorii fruits [J]. World Phytomed 2007, 22(4):164-165.
60. Huang LJ, Su XJ, Ye XB, et al. Analysis of volatile oil components from Siraitia grosvenorii and Siraitia grosvenorii wine quality [J]. Res Develop Food 2009, 30(10):106-109.
61. Meng XL, Zhou Q, Rong XY The determination of inorganic elements in the fruit and root of Siraitia grosvenorii. [J]. Guangxi J Tradit Chin Med 1989, 12(6):42.
62. Mo LS, Pan XZ, Wang YL, et al. High pressure microwave digestion and determination of microelements Siraitia grosvenoriiby ICP-AES [J]. Guangxi Sci 2008, 15(4):408-410.
63. Wang Q, Li AY, Li XP, et al. Pharmacological effects of S. grosvenorii fruit [J]. China J Chin Mater Med 1999, 24(7):425-428.
64. Wang T, Huang ZJ, Jiang YM, et al. Studies on the pharmacological profile of mogrosides [J]. Chin Tradit Herb Drugs 1999, 30(12):914-916.
65. Liu T, Wang XH, Li C, et al. Study on the antitussive, expectorant and antispasmodic effects of saponin V from Momordicagrosvenorii [J]. Chin Pharma J 2007, 42(20):1534-1536.
66. Wang M, Song ZJ, Ke MZ, et al. Effects of different doses of Momordica grosvenorii Swingle on the immune function of rats [J]. Acta Acad Med Guangxi 1994, 11(4):408-410.
67. Wang Q, Wang K, Dai SM, et al. Regulation on the immunological effect of mogromides in the mice [J]. J Chin Med Mat 2001, 24(11):811-812.
68. Li J, Huang Y, Liao RQ, et al. Effect of Siraitia grosvenorii polysaccharide on immunity of mice [J]. Chin Pharmacol Bull 2008, 24(9):1237-1240.
69. Qi XY, Chen WJ, Zhang LQ, et al. Study on the inhibitory effects of natural sweetener mogrosides on radical and lipid peroxidation [J]. Sci Agric Sin 2006, 39(2):382-388.
70. Wang K, Zhu ZR, Pan YM, et al. Study on antioxidant activity of different solvents extracts of the stem of Siraitia grosvenorii[J]. Sci Technol Food Ind 2008, 29(3):57-62.
71. Chen QB, Su XJ, Shen ZS Antioxidant activities of the total flavones in Siraitia grosvenorii extracts [J]. Food Res Develop 2006, 27(10):189-190.
72. Mo LL, Li DP Antioxidant activity of flavonol glycosides of Siraitia grosvenorii flower [J]. Mod Food Sci Technol 2009, 25(5):484-486.
73. Yao JW, Tang H, Zhou L, et al. Effect of Siraitia grosvenorii extract on the movement endurance and liver tissue injury of mice. [J]. Chin J Sports Med 2008, 27(2):221-223.
74. Wang Q, Xiao G Experimental study of protective effect of Mog on chronic injury of rats [J]. Guangxi J Tradit Chin Med 2007, 30(5):54-56.
75. Xiao G, Wang Q Protective effect of mogrosides on experimental liver injury in mice [J]. China Pharm 2008, 19(3):163-165.
76. Chen WJ, Song FF, Liu LG Effects of mogroside extract on cellular immune functions in alloxan-induced rats [J]. Acta Nutr Sin 2006, 28(3):221-225.
77. Qi XY, Chen WJ, Song YF, et al. Efficacy Study on Siraitia grosvenorii powder and its extracts on reducing blood glucose in diabetic mice [J]. Food Sci 2003, 24(12):124-127.
78. Qi XY, Chen WJ, Zhang LQ, et al. Mogrosides extract from Siraitia grosvenorii scavenges free radicals in vitro and lowers oxidative stress, serum glucose, and lipid levels in alloxan-induced diabetic mice [J]. Nutr Res 2008, 28:278-284.
79. Suzuki YA, Tomoda M, Murata Y, et al. Antidiabetic effect of long-term supplementation with Siraitia grosvenorii on the spontaneously diabetic Goto-Kakizaki rat [J]. Br J Nutr 2007, 97(4):770-775.
80. Takasaki M, Konoshima T, Murata Y, et al. Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides from Momordica grosvenorii [J]. Cancer Lett 2003, 198(1):37-42.
81. Matsumoto S, Jin M, Dewa Y, et al. Suppressive effect of Siraitiagrosvenorii extract on dicyclanil-promoted hepatocellular proliferative lesions in male mice [J]. J Toxicol Sci 2009, 34(1):109-118.
82. Ye M, Zhou Y Preliminary research on antibacterial activity of the ethanol extracts from Momordica grosvenorii leaf and stem [J]. J Mount Agric Biol 2008, 27(1):42-46.
83. Pan MH, Yang JR, Tasi ML, et al. Anti-inflammatory effect of Momordica grosvenorii Swingle extract through suppressed LPS-induced upregulation of INOS and COX-2 in murine macrophages [J]. J Funct Foods 2009, 1(2):145-152.
84. Zhou Y, Huang CF Identification of the antibacterial activity from leaf, vine and root of Lo Han Kuo (Momordica grosvenorii) [J]. Lishizhen Med Mater Med Res 2008, 19(7):1797-1799.
85. Yao JW, Tang H, Shen WH, et al. The observation on impacts of the different dosage of Luo Han Guo on physiological function in mice by training of increasing intensity [J]. Liaoning Sports Sci Technol 2007, 29(3):24-26.
86. Chen M. The experimental study of protective effects of anti-oxidation damage on some tissues of the flavones in Siraitiagrosvenorii leaf on exhaustive swimming in rat [D]. Master's degree thesis of Guangxi Normal University, 2008.
87. Maria AH, Yoshifumi S Effect of Lo Han Kuo (Siraitia grosvenorii Swingle) on nasal rubbing and scratching behavior in ICR mice [J]. Biol Pharm Bull 2005, 28(2):238-241.
88. Lin YW, Chen XY Influence of Siraitia grosvenorii on the growth and conservation of lactic acid bacteria [J]. Food Sci Technol 2008, 4:150-153.
89. Wang CQ, Hu SL Study on the protection effect and mechanism of total flavones from Siraitia grosvenorii leaf on the endothelial cell injury induced by metal ion [J]. J Yangtze Univ 2012, 9(3):1-2. 9.
90. Jin M, Muguruma M, Moto M, et al. Thirteen-week repeated dose toxicity of Siraitia grosvenorii extract in Wistar Hannover (GALAS) rats [J]. Food Chem Toxicol 2007, 45:1231-1237.
91. Su XJ, Xu Q, Liang RG, et al. Experiments study on the non-toxicity action of mogrosides [J]. Food Sci 2005, 26(3):221-224.
92. Marone PA, Borzelleca JF, Merkel BD, et al. Twenty eight-day dietary toxicity study of Luo Han fruit concentrate in Hsd: SD rats [J]. Food Chem Toxicol 2008, 46:910-919.
93. Xu Q, Su XJ, Liang RG, et al. Subchronic 90-days oral (Gavage) toxicity study of a Luo Han Guo mogroside extract in dogs [J]. Food Chem Toxicol 2006, 44:2106-2109.