Subchronic 90-day oral (Gavage) toxicity study of a Luo Han Guo mogroside extract in dogs

Food and Chemical Toxicology

Volumn 44, Issue 12, 2006, Pages 2106-2109

  Qin, X ^a   Xiaojian, S ^b   Ronggan, L ^a   Yuxian, W ^a   Zhunian, T ^a   Shouji, G ^b   Heimbach, J ^c  

^a GUILIN MEDICAL UNIVERSITY   (China)

^b GUANGXI NORMAL UNIVERSITY   (China)

^c JHeimbach LLC   (United States)

Author keywords

Luo han; Mogroside; Subacute; Subchronic; Sweetener; Toxicity

Indexed keywords

GLYCOSIDE; MOGROSIDE; SWEETENING AGENT; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; AUTOPSY; BLOOD CHEMISTRY; BODY WEIGHT; CONTROLLED STUDY; DOG; FEMALE; FOOD INTAKE; FRUIT; HEMATOLOGY; HISTOPATHOLOGY; MALE; NONHUMAN; ORGAN WEIGHT; URINALYSIS;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; CLINICAL CHEMISTRY TESTS; DOGS; DRUGS, CHINESE HERBAL; FEMALE; FRUIT; HEMATOLOGIC TESTS; LONGEVITY; MALE; MOMORDICA; NO-OBSERVED-ADVERSE-EFFECT LEVEL; SWEETENING AGENTS; TIME FACTORS; TRITERPENES;

CANIS FAMILIARIS; SIRAITIA GROSVENORII;

EID: 33749580805     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.07.023     Document Type: Article

References (11)

1. ™ brand of Luo Han Guo. Unpublished report, February.
2. Centers for Disease Control and Prevention (CDC), 2005. Overweight and obesity: obesity trends 1991-2001; prevalence of obesity among US adults by state. Available from: .
3. Chang Q. Isolation and determination of cucurbitane glycosides from fresh fruits of Siraitia grosvenorii. Acta Bot. Sin. 38 (1996) 489-494
4. Croom, E.M., 1999. Lo han guo: a literature review. Unpublished manuscript. Available from: .
5. Deis, R.C., 2005. How sweet it is-using polyols and high-potency sweeteners. Food Product Design, October.
6. Fry, J., 2001. The future for high-potency sweeteners of natural origin. Food Ingredients First, November. Available from: .
7. Haley, S., Reed, J., Biing-Hwan, L., Cook, A., 2005. Sweetener consumption in the United States: distribution by demographic and product characteristics. Electronic Outlook Report SSS-243-01 from the Economic Research Service. Available from: .
8. Hussain R.A., Lin Y.M., Poveda L.J., Bordas E., Chung B.S., Pezzuto J.M., Soejarto D.D., and Kinghorn A.D. Plant-derived sweetening agents: saccharide and polyol constituents of some sweet-tasting plants. J. Ethnopharmacol. 28 (1990) 103-115
9. Jifu, Z. et al., 1993. A corpus of the research, development and the utilization of Chinese medicine: Lo Han Guo. Beijing.
10. Kinghorn A.D., and Soejarto D.D. Discovery of terpenoid and phenolic sweeteners from plants. Pure Appl. Chem. 74 (2002) 1169-1179
11. Suzuki Y.A., Murata Y., Inui H., Sugiura M., and Nakano Y. Triterpene glycosides of Siraitia grosvenori inhibit rat intestinal maltase and suppress the rise in blood glucose level after a single oral administration of maltose in rats. Agric. Food. Chem. 53 (2005) 2941-2946