Thymosin beta 4 and thymosin beta 10 expression in hepatocellular carcinoma

European Journal of Histochemistry

Volumn 58, Issue 1, 2014, Pages 27-32

  Theunissen, W ^a,b   Fanni, D ^b   Nemolato, S ^b   Di Felice, E ^b   Cabras, T ^b   Gerosa, C ^b   Van Eyken, P ^c   Messana, I ^b   Castagnola, M ^d   Faa, G ^b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d CATHOLIC UNIVERSITY   (Italy)

Author keywords

Hepatocellular carcinoma; Stromal invasion; T 10; T 4; thymosins

Indexed keywords

EID: 84896088735     PISSN: 1121760X     EISSN: None     Source Type: Journal    
DOI: 10.4081/ejh.2014.2242     Document Type: Article

References (28)

1. Goldstein AL, Slater FD, White A. Preparation assay and partial purification of a thymic lymphocytopoietic factor. Proc Natl Acad Sci USA 1966;56:1010-7.
2. Hannappel E. βThymosins. Ann NY Acad Sci 2007;1112:21-37.
3. Goldstein AL, Hannappel E, Kleinman HK. Thymosin β4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med 2005;11:421-9.
4. Jo JO, Kang YJ, Ock MS, Kleinman HK, Chang HK, Cha HJ. Thymosin? 4 expression in human tissues and in tumors using tissue microarrays. Appl Immunohistochem Mol Morphol 2011;19: 160-7.
5. Sosne G, Qiu P, Goldstein AL, Wheater M. Biological activities of thymosin beta 4defined by active sites in short peptide sequences. Faseb J 2010;24:2144-51.
6. Yu FX, Lin SC, Morrison-Bogorad M, Atkinson MA, Yin HL. Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins. J Biol Chem 1993;268:502-9.
7. Sribenja S, Li M, Wongkham S, Wongkham C, Yao Q, Chen C. Advances in thymosin β10 research: Differential expression, molecular mechanisms and clinical implications in cancer and other conditions. Canc Invest. 2009;2:1016-1022.
8. Lee SH, Son MJ, Oh SH, Rho SB, Park K, Kim YJ et al. Thymosin β10 inhibits angiogenesisand tumor growth by interfering with Ras function. Cancer Res 2005;65: 137-48.
9. Hall AK. Thymosin β10 accelerates apoptosis. Cell Mol Biol Res 1995;41:167-80.
10. Nemolato S, Cabras T, Fanari MU, Cau F, Fanni D, Gerosa C. Immunoreactivity of thymosin beta 4 in human foetal and adult genitourinary tract. Eur J Histochem 2010;54:e43.
11. Nemolato S, Cabras T, Fanari MU, Cau F, Fraschini M, Manconi B, et al. Thymosin beta 4 expression in normal skin, colon mucosa and in tumor infiltrating mast cells. Eur J Histochem 2010;54:e3.
12. Nemolato S, Ekstrom J, Cabras T, Gerosa C, Fanni D, Di Felice E, et al. Immunoreactivity for thymosin beta 4 and thymosin beta 10 in the adult rat oro-gastro- intestinal tract. Eur J Histochem 2013;57:e17.
13. Faa G, Nemolato S, Cabras T, Fanni F, Gerosa C, Fanari M, et al. Thymosin beta-4 expression reveals intriguing similarities between fetal and cancer cells. Ann NY Acad Sci 2012;1269:53-60.
14. Nemolato S, Restivo A, Cabras T, Coni PP, Zorcolo, L Orrù G, et al. Thymosin β4 in colorectal cancer is localized predominantly at the invasion front in tumor cells undergoing epithelial mesenchymal transition. Canc Biol Ther 2012;13:191-7.
15. Verghese-Nikolakaki S, Apostolikas N, Livaniou E, Ithakissios DS, Evangelatos GP. Preliminary findings on the expression of thymosin β10 in human breast cancer. Br J Cancer 1996;74:1441-4.
16. Gu Y, Wang C, Wang Y, Qiu X, Wang E. Expression of thymosin β10 and its role in non-small cell lung cancer. Hum Pathol. 2009;40:117-24.
17. Santelli G, Cannada Bartoli P, Giuliano A, Porcellini A, Mineo A, Barone MV, et al. Thymosin β-10 protein synthesis suppression reduces the growth of human thyroid carcinoma cells in semisolid medium. Thyroid 2002;12:765-72.
18. Burt AD, Portman BC, Ferrell LD. Tumours and tumour-like lesions of the liver. In: MacSween's pathology of the liver. Elsevier; 2012, pp 792-3.
19. Ricci-Vitiani L, Mollinari C, Di Martino S, Biffoni M, Pilozzi E, Pagliuca A. Thymosin β4 targeting impairs tumorigenic activity of colon cancer stem cells. Faseb J 2010;24:4291-301.
20. Wei-Shu W, Po-Min C, Hung-Liang H, Sy-Yeuan J, Yeu S. Overexpression of the thymosin β4 gene is associated with malignant progression of SW480 colon cancer cells. Oncogene 2003;22:3297-306.
21. Mei-Chuan T, Li-Chaun C, Yi-Chen Y, Cheng-Yu C, Teh-Ying C, Wei-Shu W. Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway. Cancer Lett 2011;308:162-71.
22. Wei-Shu W, Hung-Liang H, Mei-Chuan T, Su Y. Thymosin beta-4 from a G-actin binding protein to a malignancy promoter for human colon cancer. Third Annual Symposium on Thymosins in health and disease, Washington, DC, USA, March 14-16, 2012, pp 31.
23. Li M, Zhang Y. Thymosin beta 10 is Aberrantly Expressed in Pancreatic Cancer and Induces JNK Activation. Cancer Invest 2009;27:251-6.
24. Weterman MAJ, Van Muijen GNP, Ruiter DJ, Bloemers HPJ. Thymosin β10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma. Int J Cancer 1993;53:278-84.
25. Santelli G, Califano D, Chiapatta G, Vento MT, Bartoli PC, Zullo F. Thymosin beta-10 gene overexpression is a general event in human carcinogenesis. Am J Pathol 1999; 155:799-804.
26. Chiappetta G, Pentimalli F, Monaco M, Fedele M, Pasquinelli, R Pierantoni GM. Thymosin beta-10 gene expression as a possible tool in diagnosis of thyroid neoplasias. Oncol Rep. 2004;12:239-43.
27. Nemolato S, Van Eyken P, Cabras T, Cau F, Fanari MU, Fanni D. Expression pattern of thymosin beta 4 in adult human liver. Eur J Histochem 2011;55:e25.
28. Senes G, Fanni D, Faa G, Cois A, Uccheddu A. Intratumoral sampling variability in hepatocellular carcinoma: a case report. World J Gastroenterol 2007;13:4019-21.