Heat shock protein 70 gene polymorphisms are associated with paranoid schizophrenia in the Polish population

Cell Stress and Chaperones

Volumn 19, Issue 2, 2014, Pages 205-215

  Kowalczyk, Malgorzata ^a   Owczarek, Aleksander ^a   Suchanek, Renata ^a   Paul Samojedny, Monika ^a   Fila Danilow, Anna ^a   Borkowska, Paulina ^a   Kucia, Krzysztof ^a   Kowalski, Jan ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

Association study; Haplotype; HSP70 gene; Paranoid schizophrenia; Single nucleotide polymorphism

Indexed keywords

HEAT SHOCK PROTEIN 70;

ADULT; ARTICLE; CAUCASIAN; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; PARANOID SCHIZOPHRENIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; AGED; ALLELES; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; POLAND; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA, PARANOID; YOUNG ADULT;

EID: 84896088733     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-013-0446-7     Document Type: Article

References (60)

1. Bates PR, Hawkins A, Mahadik SP, McGrath JJ (1996) Heat stress lipids and schizophrenia. Prostaglandins Leukot Essent Fatty Acids 55:101-107. doi:10.1016/S0952-3278(96)90153-2 DOI:10.1016/S0952-3278%2896%2990153-2#doilink
2. Bechtold DA, Rush SJ, Brown IR (2000) Localization of the heat-shock protein Hsp70 to the synapse following hyperthermic stress in the brain. J Neurochem 74:641-646. doi:10.1046/j.1471-4159.2000.740641.x (Pubitemid 30053736)
3. Benarroch EE (2011) Heat shock proteins: multiple neuroprotective functions and implications for neurologic disease. Neurology 76:660-667. doi:10.1212/WNL.0b013e31820c3119
4. Bergen SE, O'Dushlaine CT, Ripke S (2012) Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. Mol Psychiatry 17:880-886. doi:10.1038/mp.2012.73
5. Brocchieri L, Conway de Macario E, Macario AJ (2008) hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions. BMC Evol Biol 8:19. doi:10.1186/1471- 2148-8-19
6. Brown IR (2007) Heat shock proteins and protection of the nervous system. Ann N Y Acad Sci 1113:147-158. doi:10.1196/annals.1391.032
7. Carsillo T, Carsillo M, Traylor Z, Rajala-Schultz P, Popovich P, Niewiesk S, Oglesbee M (2009) Major histocompatibility complex haplotype determines hsp70-dependent protection against measles virus neurovirulence. J Virol 83:5544-5555. doi:10.1128/JVI.02673-08
8. Cascino I, Sorrentino R, Tosi R (1993) Strong genetic association between HLA-DR3 and a polymorphic variation in the regulatory region of the HSP70-1 gene. Immunogenetics 37:177-182. doi:10.1007/BF00191882 (Pubitemid 23011430)
9. Clarimon J, Bertranpetit J, Boada M, Tàrraga L, Comas D (2003) HSP70-2 (HSPA1B) is associated with noncognitive symptoms in late-onset Alzheimer's disease. J Geriatr Psychiatry Neurol 16:146-150. doi:10.1177/0891988703256051 (Pubitemid 37409023)
10. Csernansky JG (2007) Neurodegeneration in schizophrenia: evidence from in vivo neuroimaging studies. Sci World J 7:135-143. doi:10.1100/tsw.2007.47
11. De Jong S, van Eijk KR, Zeegers DW et al (2012) Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes. Eur J Hum Genet 20:1004-1008. doi:10.1038/ejhg.2012.38
12. Dulin E, García-Barreno P, Guisasola MC (2012) Genetic variations of HSPA1A, the heat shock protein levels and risk of atherosclerosis. Cell Stress Chaperones 17:507-516. doi:10.1007/s12192-012-0328-4
13. Fatemi SH, Folsom TD (2009) The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophr Bull 35:528-548. doi:10.1093/schbul/sbn187
14. Feng Y, Wang XD, Guo CM, Yang Y, Li JT, Su YA, Si TM (2010) Expressions of neuregulin 1beta and ErbB4 in prefrontal cortex and hippocampus of a rat schizophrenia model induced by chronic MK-801 administration. J Biomed Biotechnol 2010:859516. doi:10.1155/2010/859516
15. First MB, Spitzer RL, Gibbon M, Williams J (1997) Structured clinical interview for DSM-IVaxis I disorders, clinician version (SCID-CV). American Psychiatric Press, Washington
16. Grossman LS, Harrow M, Rosen C, Faull R (2006) Sex differences in outcome and recovery for schizophrenia and other psychotic and nonpsychotic disorders. Psychiatr Serv 57:844-850. doi:10.1176/appi.ps.57.6.844 (Pubitemid 43846297)
17. Hayes E, Gavrilidis E, Kulkarni J (2012) The role of oestrogen and other hormones in the pathophysiology and treatment of schizophrenia. Schizophr Res Treatment. doi:10.1155/2012/54027
18. He M, Guo H, Yang X, Zhang X, Zhou L, Cheng L, Zeng H, Hu FB, Tanguay RM, Wu T (2009) Functional SNPs in HSPA1A gene predict risk of coronary heart disease. PLoS One 4:e4851. doi:10.1371/journal.pone.0004851
19. Himeda T, Tounai H, Hayakawa N, Araki T (2007) Postischemic alterations of BDNF, NGF, HSP 70 and ubiquitin immunoreactivity in the gerbil hippocampus: pharmacological approach. Cell Mol Neurobiol 27:229-250. doi:10.1007/s10571-006- 9104-2
20. Hoehn B, Ringer TM, Xu L, Giffard RG, Sapolsky RM, Steinberg GK, Yenari MA (2001) Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damage. J Cereb Blood Flow Metab 21:1303-1309. doi:10.1097/00004647-200111000-00006 (Pubitemid 33130942)
21. Howes OD, Kapur S (2009) The dopamine hypothesis of schizophrenia: version III-the final common pathway. Schizophr Bull 35:549-562. doi:10.1093/schbul/sbp006
22. Jia P, Wang L, Fanous AH, Chen X, Kendler KS, International Schizophrenia Consortium, Zhao Z (2012) A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia. J Med Genet 49:96-103. doi:10.1136/jmedgenet-2011-100397
23. Jun TY, Pae CU, Chae JH, Bahk WM, Kim KS, Han H, Serretti A (2003) TNFB polymorphism may be associated with schizophrenia in the Korean population. Schizophr Res 61:39-45. doi:10.1016/S0920-9964(02)00303-1
24. Karunanithi S, Barclay JW, Brown IR, Robertson RM, Atwood HL (2002) Enhancement of presynaptic performance in transgenic Drosophila over-expressing heat shock protein Hsp70. Synapse 44:8-14. doi:10.1002/syn.10048 (Pubitemid 34174373)
25. Kay SR, Opler LA, Lindenmayer JP (1988) Reliability and validity of the positive and negative syndrome scale for schizophrenics. Psychiatry Res 23:99-110. doi:10.1016/0165-1781(88)90038-8
26. Kim JJ, Lee SJ, Toh KY, Lee CU, Lee C, Paik IH (2001) Identification of antibodies to heat shock proteins 90 kDa and 70 kDa in patients with schizophrenia. Schizophr Res 52:127-135. doi:10.1016/S0920-9964(00)00091-8 (Pubitemid 32947056)
27. Kim JJ, Mandelli L, Lim S, Lim HK, Kwon OJ, Pae CU, Serretti A, Nimgaonkar VL, Paik IH, Jun TY (2008) Association analysis of heat shock protein 70 gene polymorphisms in schizophrenia. Eur Arch Psychiatry Clin Neurosci 258:239-244. doi:10.1007/s00406-007-0791-6 (Pubitemid 351624363)
28. Leonard BE (2005) Is there an immunologic basis for schizophrenia? Expert Rev Clin Immunol 1:103-112. doi:10.1586/1744666X.1.1.103
29. Li W, Wang X, Zhao J, Lin J, Song XQ, Yang Y, Jiang C, Xiao B, Yang G, Zhang HX, Lv LX (2012) Association study of myelin transcription factor 1-like polymorphisms with schizophrenia in Han Chinese population. Genes Brain Behav 11:87-93. doi:10.1111/j.1601-183X.2011.00734.x
30. Lu A, Ran RQ, Clark J, Reilly M, Nee A, Sharp FR (2002) 17-betaestradiol induces heat shock proteins in brain arteries and potentiates ischemic heat shock protein induction in glia and neurons. J Cereb Blood Flow Metab 22:183-195. doi:10.1097/00004647-200202000-00006 (Pubitemid 34135649)
31. Milner CM, Campbell RD (1990) Structure and expression of the three MHC-linked HSP70 genes. Immunogenetics 32:242-251. doi:10.1007/BF00187095 (Pubitemid 20370377)
32. Milner CM, Campbell RD (1992) Polymorphic analysis of the three MHC-linked HSP70 genes. Immunogenetics 36:357-362. doi:10.1007/BF00218042
33. Moskvina V, Smith M, Ivanov D, Blackwood D, Stclair D, Hultman C, Toncheva D, Gill M, Corvin A, O'Dushlaine C, Morris DW, Wray NR, Sullivan P, Pato C, Pato MT, Sklar P, Purcell S, Holmans P, O'Donovan MC, Owen MJ, Kirov G (2010) Genetic differences between five European populations. Hum Hered 70:141-149. doi:10.1159/000313854
34. Otnaess MK, Djurovic S, Rimol LM, Kulle B, Kähler AK, Jönsson EG, Agartz I, Sundet K, Hall H, Timm S, Hansen T, Callicott JH, Melle I, Werge T, Andreassen OA (2009) Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia. Neurobiol Dis 34:518-524. doi:10.1016/j.nbd.2009.03.011
35. Pae CU, Kim TS, Kwon OJ, Artioli P, Serretti A, Lee CU, Lee SJ, Lee C, Paik IH, Kim JJ (2005) Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia. Neurosci Res 53:8-13. doi:10.1016/j. neures.2005.05.004 (Pubitemid 41073722)
36. Pae CU, Drago A, Kim JJ, Mandelli L, De Ronchi D, Serretti A (2009) The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients. Neuropsychobiology 59:135-141. doi:10.1159/000218075
37. Paul-Samojedny M, Owczarek A, Suchanek R, Kowalczyk M, Fila-Danilow A, Borkowska P, Kucia K, Kowalski J (2011) Association study of interferon gamma (IFN-gamma) +874T/A gene polymorphism in patients with paranoid schizophrenia. J Mol Neurosci 43:309-315. doi:10.1007/s12031-010-9442-x
38. Pociot F, Ronningen KS, Nerup J (1993) Polymorphic analysis of the human MHC-linked heat shock protein 70 (HSP 70-2) and HSP 70-HOM genes in insulin dependent diabetes mellitus (IDDM). Scand J Immunol 38:491-495 (Pubitemid 23327292)
39. Purcell SM, Wray NR, Stone JL et al (2009) Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460:748-752. doi:10.1038/nature08185
40. Reed-Herbert K, Samali A, Gorman AM (2006) The role of heat shock proteins in neuronal differentiation and development. In: Richter-Landsberg C (ed) Heat Shock Proteins in Neural Cells, Landes Bioscience and Springer Science+Business Media, pp. 25-37.
41. Sacchetti E, Bocchio-Chiavetto L, Valsecchi P, Scassellati C, Pasqualetti P, Bonvicini C, Corsini P, Rossi G, Cesana BM, Barlati S, Gennarelli M (2007) G308A tumor necrosis factor alpha functional polymorphism and schizophrenia risk: meta-analysis plus association study. Brain Behav Immun 21:450-457. doi:10.1016/j.bbi.2006.11.009 (Pubitemid 46546518)
42. Sato K, Matsuki N (2002) A 72 kDa heat shock protein is protective against the selective vulnerability of CA1 neurons and is essential for the tolerance exhibited by CA3 neurons in the hippocampus. Neuroscience 109:745-756. doi:10.1016/S0306-4522(01)00494-8 (Pubitemid 34260858)
43. Schroeder S, Reck M, Hoeft A, Stuber F (1999) Analysis of two human leukocyte antigen-linked polymorphic heat shock protein 70 genes in patients with severe sepsis. Crit Care Med 27:1265-1270 (Pubitemid 29379362)
44. Schwab SG, Hallmayer J, Freimann J, Lerer B, Albus M, Borrmann-Hassenbach M, Segman RH, Trixler M, Rietschel M, Maier W, Wildenauer DB (2002) Investigation of linkage and association/linkage disequilibrium of HLA A-, DQA1-, DQB1- and DRB1- alleles in 69 sib-pair- and 89 trio-families with schizophrenia. Am J Med Genet 114:315-320. doi:10.1002/ajmg.10307 (Pubitemid 34258858)
45. Schwarz MJ, Riedel M, Gruber R, Ackenheil M, Müller N (1999) Antibodies to heat shock proteins in schizophrenic patients: implications for the mechanism of the disease. Am J Psychiatry 156:1103-1104 (Pubitemid 29302810)
46. Schumacher J, Laje G, Abou Jamra R, Becker T, Mühleisen TW, Vasilescu C, Mattheisen M, Herms S, Hoffmann P, Hillmer AM, Georgi A, Herold C, Schulze TG, Propping P, Rietschel M, McMahon FJ, Nöthen MM, Cichon S (2009) The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations. Hum Mol Genet 18:2719-2727. doi:10.1093/hmg/ddp204
47. Shifman S, Johannesson M, Bronstein M, Chen SX, Collier DA, Craddock NJ, Kendler KS, Li T, O'Donovan M, O'Neill FA, Owen MJ, Walsh D, Weinberger DR, Sun C, Flint J, Darvasi A (2008) Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genet 4:e28. doi:10.1371/journal.pgen.0040028
48. Strkalj Iveziæ S, John N (2009) Gender and schizophrenia. Psychiatr Danub 21(Suppl.1):106-110.
49. Terao Y, Miyamoto S, Hirai K, Kamiguchi H, Ohta H, Shimojo M, Kiyota Y, Asahi S, Sakura Y, Shintani Y (2009) Hypothermia enhances heat-shock protein 70 production in ischemic brains. NeuroReport 20:745-749. doi:10.1097/WNR. 0b013e32832a2f32
50. Traherne JA (2008) Human MHC architecture and evolution: implications for disease association studies. Int J Immunogenet 35:179-192. doi:10.1111/j.1744- 313X.2008.00765.x
51. Tsuchiya D, Hong S, Matsumori Y, Kayama T, Swanson RA, Dillman WH, Liu J, Panter SS, Weinstein PR (2003) Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia and kainic acidinduced seizures. Neurosurgery 53:1179-1187. doi:10.1227/01.NEU.0000090341.38659.CF
52. Uezato A, Kimura-Sato J, Yamamoto N, Iijima Y, Kunugi H, Nishikawa T (2012) Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia. Behav Brain Funct 8:2. doi:10.1186/1744-9081-8-2
53. Van der Weerd L, Lythgoe MF, Badin RA, Valentim LM, Akbar MT, de Belleroche JS, Latchman DS, Gadian DG (2005) Neuroprotective effects ofHSP70 overexpression after cerebral ischaemia-anMRI study. Exp Neurol 195:257-266. doi:10.1016/j.expneurol.2005.05.002 (Pubitemid 41116830)
54. Vinasco J, Beraun Y, Nieto A, Fraile A, Pareja E, Mataran L, Martín J (1997) Heat shock protein 70 gene polymorphisms in rheumatoid arthritis. Tissue Antigens 50:71-73 (Pubitemid 27273717)
55. Wright P, Nimgaonkar VL, Donaldson PT, Murray RM (2001) Schizophrenia and HLA: a review. Schizophr Res 47:1-12. doi:10.1016/S0920-9964(00)00022-0 (Pubitemid 32121766)
56. Wu YR, Wang CK, Chen CM, Hsu Y, Lin SJ, Lin YY, Fung HC, Chang KH, Lee-Chen GJ (2004) Analysis of heat-shock protein 70 gene polymorphisms and the risk of Parkinson's disease. Hum Genet 114:236-241. doi:10.1007/s00439-003-1050- 1 (Pubitemid 38208300)
57. Zhang F, Chen Q, Ye T, Lipska BK, Straub RE, Vakkalanka R, Rujescu D, St Clair D, Hyde TM, Bigelow L, Kleinman JE, Weinberger DR (2011a) Evidence of sex-modulated association of ZNF804A with schizophrenia. Biol Psychiatry 69:914-947. doi:10.1016/j.biopsych.2011.01.003
58. Zhang Y, Champagne N, Beitel LK, Goodyer CG, Trifiro M, LeBlanc A (2004) Estrogen and androgen protection of human neurons against intracellular amyloid beta1-42 toxicity through heat shock protein 70. J Neurosci 24:5315-5321. doi:10.1523/JNEUROSCI.0913-04.2004 (Pubitemid 38747672)
59. Zhang X, Tanguay RM, He M, Deng Q, Miao X, Zhou L,Wu T (2011b) Variants of HSPA1A in combination with plasma Hsp70 and anti- Hsp70 antibody levels associated with higher risk of acute coronary syndrome. Cardiology 119:57-64. doi:10.1159/000329917
60. Ziegler A, Van Steen K, Wellek S (2011) Investigating Hardy-Weinberg equilibrium in case-control or cohort studies or meta-analysis. Breast Cancer Res Treat 128:197-201. doi:10.1007/s10549-010-1295-z