Hepatoprotective effect of polyphenols rich methanolic extract of Amorphophallus commutatus var. wayanadensis against CCl4 induced hepatic injury in swiss albino mice

Food and Chemical Toxicology

Volumn 67, Issue , 2014, Pages 105-112

  Raj, Sreena ^a   Gothandam, K M ^a  

^a VIT UNIVERSITY   (India)

Author keywords

Amorphophallus commutatus var. wayanadensis; Antioxidants; Free radicals; Hepatotoxicity; Polyphenols

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; AMORPHOPHALLUS WAYANADENSIS EXTRACT; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LIVER PROTECTIVE AGENT; METHANOL; PLANT EXTRACT; POLYPHENOL; SILYMARIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; CARBON TETRACHLORIDE;

AMORPHOPHALLUS; AMORPHOPHALLUS WAYANADENSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; CORRELATIONAL STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; HISTOPATHOLOGY; IN VIVO STUDY; INFRARED SPECTROSCOPY; LIPID PEROXIDATION; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PHYTOCHEMISTRY; ULTRAVIOLET SPECTROSCOPY; ANIMAL; CHEMISTRY; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; LIVER; LIVER FUNCTION TEST; PATHOPHYSIOLOGY; TOXICITY;

AMORPHOPHALLUS; ANIMALS; CARBON TETRACHLORIDE; DRUG-INDUCED LIVER INJURY; LIVER; LIVER FUNCTION TESTS; METHANOL; MICE; PLANT EXTRACTS; POLYPHENOLS;

EID: 84896074337     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.02.028     Document Type: Article

References (49)

1. Angayarkanni J., Ramkumar K.M., Priyadharshini U., Ravendran P. Antioxidant activity of Amorphophallus paeoniifolius in relation to their phenolic content. Pharm. Biol. 2010, 48:659-665.
2. Anita J., Katewa S.S., Galav P.K., Pallavi S. Medicinal plant diversity of Sitamata wildlife sanctuary, Rajasthan, India. J. Ethnopharmacol. 2005, 102:143-157.
3. Anusuya N., Raju K., Manian S. Hepatoprotective and toxicological assessment of an ethnomedicinal plant Euphorbia fusiformis Buch.-Ham.ex D.Don. J. Ethnopharmacol. 2010, 127:463-467.
4. Arjun R.K., Asis S., Abdul J.V., Raj Sreena, Karthikeyan S., Gothandam K.M. Morphological, phytochemical, and anti-bacterial properties of wild and indigenous plant Amorphophallus commutatus. J. Med. Plants Res. 2013, 7(13):744-748.
5. Avijeet J., Manish S., Lokesh D., Anurekha J., Rout S.P., Gupta V.B., Krishna K.L. Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb. leaves. J. Ethnopharmacol. 2008, 115:61-66.
6. Beers R.F., Sizer I.W. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J. Biol. Chem. 1952, 195:133-140.
7. Boll M., Weber L.W., Becker E., Stampfl A. Mechanism of carbon tetrachloride-induced hepatotoxicity. Hepatocellular damage by reactive carbon tetrachloride metabolites. Z. Naturforsch. C 2001, 56:649-659.
8. Burton G.W., Ingold K.U. Vitamin E as an in vitro and in vivo antioxidant. Ann. NY Acad. Sci. 1989, 570:7-22.
9. Cantin A.M., White T.B., Cross C.E., Forman H.J., Sokol R.J., Borowitz D. Antioxidants in cystic fibrosis conclusions from the CF Antioxidant Workshop, Bethesda, MD, November 11-12, 2003. Free Radic. Biol. Med. 2007, 42:15-31.
10. Coballase U.E., Pedraza C.J., Cardenas R.N., et al. Hepatoprotective effect of acetonic and methanolic extracts of Heterothecainuloides against CCl4-induced toxicity in rat. Exp. Toxicol. Pathol. 2011, 63:363-370.
11. Djeridane A., Yousfi M., Nadjemi B., Boutassouna D., Stocker P., Vidal N. Antioxidant activity of some Algerian medicinal plants extracts containing phenolic compounds. Food Chem. 2006, 97:654-660.
12. Girish C., Koner B.C., Jayanthi S., Ramachandra R.K., Rajesh B., Pradhan S.C. Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. Fundam. Clin. Pharmacol. 2009, 23:735-745.
13. Gowri S.N.L., Manavalan R., Venkappayya D., David R.C. Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl4- induced oxidative damage in rats. Food Chem. Toxicol. 2008, 46:3182-3185.
14. Gurpreet K., Zoobi J., Mohammed A., Sarwar M.A. Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice. Food Chem. Toxicol. 2006, 44:984-993.
15. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione-S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 1974, 249:7130-7139.
16. Hsu Y.W., Tsai C.F., Chang W.H., Ho Y.C., Chen W.K., Lu F.J. Protective effects of Dunaliella salina - a carotenoids-rich alga, against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem. Toxicol. 2008, 46:3311-3317.
17. Ishwer K., Mohd A.K., Yusufuddin I., Veerana G.A. Hepatoprotective potential of ethanolic and aqueous extract of flowers of Sesbania grandiflora (Linn) induced by CCl4. Asian Pac. J. Trop. Biomed. 2012, S670-S679.
18. Jadhav V.D., Mahadkar S.D., Valvi S.R. Documentation and ethnobotanical survey of wild edible plants from Kolhapur district. Recent Res. Sci. Technol. 2011, 3:58-63.
19. Jagtap S.D., Deokule S.S., Pawar P.K., Harsulkar A.M. Traditional ethnomedicinal knowledge confined to the Pawra Tribe of Satpura Hills, Maharashtra, India. Ethnobota. Leaflets 2009, 13:98-115.
20. Jain S., Dixit V.K., Malviya N., Ambawatia V. Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Amorphophallus campanulatus Roxb. tubers. Acta Pol. Pharm. 2009, 66:423-428.
21. Jayakumar T., Ramesh E., Geraldine P. Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl4-induced liver injury in rats. Food Chem. Toxicol. 2006, 44:1989-1996.
22. Jiang W., Gao M., Sun S., Bi A., Xin Y., Han X., Wang L., Yin Z., Luo L. Protective effect of l-theanine on carbon tetrachloride-induced acute liver injury in mice. Biochem. Biophys. Res. Commun. 2012, 422:344-350.
23. Karp S.J. Clinical implications of advances in the basic science of liver repair and regeneration. Am. J. Transplan. 2009, 9:1973-1980.
24. Kasote D.M., Hegde M.V., Deshmukh K.K. Antioxidant activity of phenolic components from n-butanol fraction (PC-BF) of defatted flaxseed meal. Am. J. Food Technol. 2011, 6:604-612.
25. Marklund S., Marklund G. Involvement of superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 1974, 47:469-474.
26. Martinez C.M. Oxygen free radicals and human disease. Biochimie 1995, 77:147-161.
27. Meenakshi V.K., Shanmugapriya D. HPLC and FTIR spectral studies of the simple ascidian Phallusia nigra. Arch. Appl. Sci. Res. 2012, 4:2145-2148.
28. Moron M.S., Depierre J.W., Mannervik B. Levels of glutathione. Glutathione reductase and glutsathione-S-transferase activities in rat lung and liver. Biochem. Biophys. Acta 1979, 582:67-78.
29. 4-induced acute liver damage in mice. Food Chem. Toxicol. 2013, 55:234-240.
30. Nishida K., Ohta Y., Kongo M., Ishiquro I. Response of endogenous reduced glutathione through hepatic glutathione redox cycle to enhancement of hepatic lipid peroxidation with the development of acute liver injury in mice intoxicated with carbon tetrachloride. Res. Commun. Mol. Pathol. Pharmacol. 1996, 93:198-218.
31. Ohkawa H., Ohishi N., Yagi K. Assay of lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal. Biochem. 1979, 95:351-358.
32. Poli G. Liver damage due to free radicals. Br. Med. Bull. 1993, 49:604-620.
33. Reiter R.J., Tan D., Osuna C., Gitto E. Actions of melatonin in the reduction of oxidative stress. J. Biomed. Sci. 2000, 7:444-458.
34. Rotruck J.T., Pope A.L., Ganther H.E., Swanson A.B., Hafeman D.G., Hoekstra W.G. Selenium, biochemical role as a component of glutathione peroxidase purification and assay. Science 1973, 179:588-590.
35. Sabir S.M., Ahmed S.D., Hamid A., Khan M.Q., Athayde M.L., Santos D.B., Boligon A.A., Roch J.B.T. Antioxidant and hepatoprotective activity of ethanolic extract of leaves of Solidago microglossa containing polyphenolic compounds. Food Chem. 2012, 131:741-747.
36. Sivadasan M., Jaleel V.A. Two new varieties of Amorphophallus commutatus (Schott) Engl. (Araceae) from India. Rheedea 2002, 12:155-157.
37. Sreelatha S., Padma P.R., Umadevi M. Protective effect of Coriandrum sativum extract on carbon tetrachloride-induced hepatotoxicity in rats. Food Chem. Toxicol. 2008, 47:702-708.
38. Sreena R., Karthikeyan S., Gothandam K.M. Ayurveda - a glance. Res. Plant Biol. 2011, 1:1-14.
39. Swati N.D., Dipak K.P., Ranjitsinh V.D., Prabhudas V.P., Ramachandran A.V. Hepatoprotective potential of polyphenol rich extract of Murraya Koenigii L.: an in vivo study. Food Chem. Toxicol. 2012, 50:310-314.
40. Timmerman K.P. Molecular characterization of corn glutathione-S-transferase isozymes involved in herbicide detoxification. Physiol. Plant. 1989, 77:465-471.
41. Valchos N., Akopelitia Y., Psaroudaki M., Konstantinidou V., Chatzilazarou A., Tegou E. Applications of Fourier transform-infrared (FTIR) spectroscopy to edible oils. Anal. Chem. Acta 2006, 573-574:459-465.
42. Valko M.L.D., Moncol J., Cronin M.T., Mazur M., Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 2007, 39:44-84.
43. Ved D.K., Goraya G.S. Diversity of herbal raw drugs and plant species in trade. ENVIS Newslett. Med. Plants. 2008, 2:4-6.
44. Vuda M., D'Souza R., Upadhya S., Kumar V., Rao N., Kuma V., Boillat C., Mungli P. Hepatoprotective and antioxidant activity of aqueous extract of Hybanthus enneaspermus against CCl4-induced liver injury in rats. Exp. Toxicol. Pathol. 2011, 64:855-859.
45. 4-induced liver damage. Food Chem. Toxicol. 2004, 42:609-617.
46. Wolf P. Biochemical diagnosis of liver disease. Indian J. Clin. Biochem. 1999, 14:59-65.
47. Yang J.Y., Li Y., Wang F., Wu C. Hepatoprotective effects of apple polyphenols on CCl4-induced acute liver damage in mice. J. Agric. Food Chem. 2010, 58:6525-6531.
48. Zeashan H., Amresha G., Singh S., Rao C.V. Hepatoprotective and antioxidant activity of Amaranthus spinosus against CCl4 induced toxicity. J. Ethnopharmacol. 2009, 125:364-366.
49. Zheng X., Pan C., Diao Y., You Y., Yang C., Hu Z. Development of microsatellite markers by transcriptome sequencing in two species of Amorphophallus (Araceae). BMC Genom. 2013, 14:490.