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Volumn 6, Issue 3, 2014, Pages 107-113

Canagliflozin: A novel SGLT2 inhibitor for type 2 diabetes mellitus

Author keywords

Canaglifl ozin; Diabetes mellitus; H0062A1C; Inhibitors; SGLT2

Indexed keywords

CANAGLIFLOZIN; HEMOGLOBIN A1C;

EID: 84896038446     PISSN: 22501541     EISSN: 19472714     Source Type: Journal    
DOI: 10.4103/1947-2714.128471     Document Type: Review
Times cited : (41)

References (62)
  • 1
    • 82955247909 scopus 로고    scopus 로고
    • Diabetes Atlas: Global estimates of the prevalence of diabetes for 2011 and 2030
    • Whiting DR, Guariguata L, Weil C, Shaw J. IDF Diabetes Atlas: Global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011;94:311-21.
    • (2011) Diabetes Res Clin Pract , vol.94 , pp. 311-321
    • Whiting, D.R.1    Guariguata, L.2    Weil, C.3    Shaw, J.I.D.F.4
  • 2
    • 73749083481 scopus 로고    scopus 로고
    • Global estimates of the prevalence of diabetes for 2010 and 2030
    • Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010;87:4-14.
    • (2010) Diabetes Res Clin Pract , vol.87 , pp. 4-14
    • Shaw, J.E.1    Sicree, R.A.2    Zimmet, P.Z.3
  • 3
    • 84896043729 scopus 로고    scopus 로고
    • IDF Diabetes Atlas Update 2012. (Accessed October 3, 2013, at
    • IDF Diabetes Atlas Update 2012. (Accessed October 3, 2013, at http://www.idf.org/diabetesatlas/5e/Update2012).
  • 4
    • 79960262492 scopus 로고    scopus 로고
    • Management of type 2 diabetes: New and future developments in treatment
    • Tahrani A, Bailey C, Del Prato S, Barnett AH. Management of type 2 diabetes: New and future developments in treatment. Lancet 2011;378:182-97.
    • (2011) Lancet , vol.378 , pp. 182-197
    • Tahrani, A.1    Bailey, C.2    del Prato, S.3    Barnett, A.H.4
  • 5
    • 0033533596 scopus 로고    scopus 로고
    • Diabetes and cardiovascular disease: A statement for healthcare professionals from the American Heart Association
    • Grundy SM, Benjamin IJ, Burke GL, Chait A, Eckel RH, Howard BV, et al. Diabetes and cardiovascular disease: A statement for healthcare professionals from the American Heart Association. Circulation 1999;100:1134-46.
    • (1999) Circulation , vol.100 , pp. 1134-4446
    • Grundy, S.M.1    Benjamin, I.J.2    Burke, G.L.3    Chait, A.4    Eckel, R.H.5    Howard, B.V.6
  • 6
    • 80051962202 scopus 로고    scopus 로고
    • Trends in the risk for coronary heart disease among adults with diagnosed diabetes in the U.S.: Findings from the National Health and Nutrition Examination Survey, 1999-2008
    • Ford ES. Trends in the risk for coronary heart disease among adults with diagnosed diabetes in the U.S.: Findings from the National Health and Nutrition Examination Survey, 1999-2008. Diabetes Care 2011;34:1337-43.
    • (2011) Diabetes Care , vol.34 , pp. 1337-1343
    • Ford, E.S.1
  • 7
    • 84855185039 scopus 로고    scopus 로고
    • Standards of medical care in diabetes-2012
    • American Diabetes Association
    • American Diabetes Association. Standards of medical care in diabetes-2012. Diabetes Care 2012;35:S11-63.
    • (2012) Diabetes Care , vol.35 , pp. 11-63
  • 8
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998;352:854-65.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 9
    • 60449089649 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, et al. Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009;32:193-203.
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3    Ferrannini, E.4    Holman, R.R.5    Sherwin, R.6
  • 10
    • 53749096863 scopus 로고    scopus 로고
    • 10-year follow-up of intensive glucose control in type 2 diabetes (UKPDS 80)
    • Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA. 10-year follow-up of intensive glucose control in type 2 diabetes (UKPDS 80). N Engl J Med 2008;359:1577-89.
    • (2008) N Engl J Med , vol.359 , pp. 1577-1589
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3    Matthews, D.R.4    Neil, H.A.5
  • 11
    • 0035031042 scopus 로고    scopus 로고
    • Current therapies and emerging targets for the treatment of diabetes
    • Wagman AS, Nuss JM. Current therapies and emerging targets for the treatment of diabetes. Curr Pharm Des 2001;7:417-50.
    • (2001) Curr Pharm Des , vol.7 , pp. 417-450
    • Wagman, A.S.1    Nuss, J.M.2
  • 12
    • 77957128949 scopus 로고    scopus 로고
    • SGLT2 inhibitors: Glucuretic treatment for type 2 diabetes
    • Bailey CJ, Day C. SGLT2 inhibitors: Glucuretic treatment for type 2 diabetes. Br J Diabetes Vasc Dis 2010;10:193.
    • (2010) Br J Diabetes Vasc Dis , vol.10 , pp. 193
    • Bailey, C.J.1    Day, C.2
  • 13
    • 33748547195 scopus 로고    scopus 로고
    • Insulin resistance and obesity: Finding a balance
    • Wilding J. Thiazolidinediones, insulin resistance and obesity: Finding a balance. Int J Clin Pract 2006;60:1272-80.
    • (2006) Int J Clin Pract , vol.60 , pp. 1272-1280
    • Thiazolidinediones, W.J.1
  • 14
    • 68949186346 scopus 로고    scopus 로고
    • Long-term treatment with serglifl ozin etabonate improves disturbed glucose metabolism in KK-A(y) mice
    • Katsuno K, Fujimori Y, Ishikawa-Takemura Y, Isaji M. Long-term treatment with serglifl ozin etabonate improves disturbed glucose metabolism in KK-A(y) mice. Eur J Pharmacol 2009;618:98-104.
    • (2009) Eur J Pharmacol , vol.618 , pp. 98-104
    • Katsuno, K.1    Fujimori, Y.2    Ishikawa-Takemura, Y.3    Isaji, M.4
  • 15
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007;356:2457-71.
    • (2007) N Engl J Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 16
    • 79958197888 scopus 로고    scopus 로고
    • Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type 2 diabetes, with or without a previous myocardial infarction: A nationwide study
    • Schramm TK, Gislason GH, Vaag A, Rasmussen JN, Folke F, Hansen ML, et al. Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type 2 diabetes, with or without a previous myocardial infarction: A nationwide study. Eur Heart J 2011;32:1900-8.
    • (2011) Eur Heart J , vol.32 , pp. 1900-1908
    • Schramm, T.K.1    Gislason, G.H.2    Vaag, A.3    Rasmussen, J.N.4    Folke, F.5    Hansen, M.L.6
  • 17
    • 80051499525 scopus 로고    scopus 로고
    • Resolving drug effects from class effects among drugs for type 2 diabetes mellitus: More support for cardiovascular outcome assessments
    • Gore MO, McGuire DK. Resolving drug effects from class effects among drugs for type 2 diabetes mellitus: More support for cardiovascular outcome assessments. Eur Heart J 2011;32:1832-4.
    • (2011) Eur Heart J , vol.32 , pp. 1832-1834
    • Gore, M.O.1    McGuire, D.K.2
  • 18
    • 80052731231 scopus 로고    scopus 로고
    • Encapsulation of exenatide in poly-(d,l-lactide-co-glycolide) microspheres produced an investigational long-acting onceweekly formulation for type-2 diabetes
    • DeYoung MB, MacConell L, Sarin V, Trautmann M, Herbert P. Encapsulation of exenatide in poly-(d,l-lactide-co-glycolide) microspheres produced an investigational long-acting onceweekly formulation for type-2 diabetes. Diabetes Technol Ther 2011;13:1145-54.
    • (2011) Diabetes Technol Ther , vol.13 , pp. 1145-1154
    • Deyoung, M.B.1    Macconell, L.2    Sarin, V.3    Trautmann, M.4    Herbert, P.5
  • 19
    • 83655184782 scopus 로고    scopus 로고
    • Achieving a clinically relevant composite outcome of an HbA1C of <7% without weight gain or hypoglycemia in type 2 diabetes: A meta-analysis of the liraglutide clinical trial program
    • Zinman B, Schmidt WE, Moses A, Lund N, Gough S. Achieving a clinically relevant composite outcome of an HbA1C of <7% without weight gain or hypoglycemia in type 2 diabetes: A meta-analysis of the liraglutide clinical trial program. Diabetes Obes Metab 2012;14:77-82.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 77-82
    • Zinman, B.1    Schmidt, W.E.2    Moses, A.3    Lund, N.4    Gough, S.5
  • 20
    • 84896046597 scopus 로고    scopus 로고
    • Byetta (exenatide injection) prescribing information. (Accessed October 4, 2013, at
    • Byetta (exenatide injection) prescribing information. (Accessed October 4, 2013, at http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=751747da-7c1f-41ad-b1a6-a6d920f70599
  • 21
    • 84896053209 scopus 로고    scopus 로고
    • Januvia (sitagliptin). (Accessed October 4, 2013, at
    • Januvia (sitagliptin). (Accessed October 4, 2013, at http://www.drugs.com/monograph/januvia.html).
  • 22
  • 23
    • 84896045259 scopus 로고    scopus 로고
    • New and Future Medications for the Treatment of Type 2 Diabetes Mellitus
    • [Published online before print]
    • Mathers MC, Zarbock SD, Sutton EE. New and Future Medications for the Treatment of Type 2 Diabetes Mellitus. Am J Lifestyle Med 2013. [Published online before print]
    • (2013) Am J Lifestyle Med
    • Mathers, M.C.1    Zarbock, S.D.2    Sutton, E.E.3
  • 24
    • 1242272759 scopus 로고    scopus 로고
    • The sodium/glucose cotransport family SLC5
    • Wright EM, Turk E. The sodium/glucose cotransport family SLC5. Pfl ugers Arch 2004;447:510-8.
    • (2004) Pfl Ugers Arch , vol.447 , pp. 510-518
  • 25
    • 77953614344 scopus 로고    scopus 로고
    • Turning glucosuria into a therapy: Effi cacy and safety with SGLT2 inhibitors
    • Patel AK, Fonseca V. Turning glucosuria into a therapy: Effi cacy and safety with SGLT2 inhibitors. Curr Diab Rep 2010;10:101-7.
    • (2010) Curr Diab Rep , vol.10 , pp. 101-107
    • Patel, A.K.1    Fonseca, V.2
  • 26
    • 0035146344 scopus 로고    scopus 로고
    • Renal gluconeogenesis: Its importance in human glucose homeostasis
    • Gerich JE, Meyer C, Woerle HJ, Stumvoll M. Renal gluconeogenesis: Its importance in human glucose homeostasis. Diabetes Care 2001;24:382-91.
    • (2001) Diabetes Care , vol.24 , pp. 382-391
    • Gerich, J.E.1    Meyer, C.2    Woerle, H.J.3    Stumvoll, M.4
  • 27
    • 33846023326 scopus 로고    scopus 로고
    • Active sugar transport in health and disease
    • Wright EM, Hirayama BA, Loo DF. Active sugar transport in health and disease. J Intern Med 2007;261:32-43.
    • (2007) J Intern Med , vol.261 , pp. 32-43
    • Wright, E.M.1    Hirayama, B.A.2    Loo, D.F.3
  • 28
    • 84863169443 scopus 로고    scopus 로고
    • Dapagliflozin: An emerging treatment option for type 2 diabetes mellitus
    • Song J. Dapagliflozin: An emerging treatment option for type 2 diabetes mellitus. Formulary 2011;46:412-31.
    • (2011) Formulary , vol.46 , pp. 412-431
    • Song, J.1
  • 29
    • 83655193529 scopus 로고    scopus 로고
    • The role of the kidneys in glucose homeostasis: A new path towards normalizing glycaemia
    • DeFronzo RA, Davidson JA, Del Prato S. The role of the kidneys in glucose homeostasis: A new path towards normalizing glycaemia. Diabetes Obes Metab 2012;14:5-14.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 5-14
    • Defronzo, R.A.1    Davidson, J.A.2    del Prato, S.3
  • 30
    • 0015122757 scopus 로고
    • Maximum tubular reabsorption capacity for glucose and renal hemodynamcis during rapid hypertonic glucose infusion in normal and diabetic subjects
    • Mogensen CE. Maximum tubular reabsorption capacity for glucose and renal hemodynamcis during rapid hypertonic glucose infusion in normal and diabetic subjects. Scand J Clin Lab Invest 1971;28:101-9.
    • (1971) Scand J Clin Lab Invest , vol.28 , pp. 101-109
    • Mogensen, C.E.1
  • 31
    • 67349189212 scopus 로고    scopus 로고
    • Renal sodiumglucose transport: Role in diabetes mellitus and potential clinical implications
    • Bakris GL, Fonseca VA, Sharma K, Wright EM. Renal sodiumglucose transport: Role in diabetes mellitus and potential clinical implications. Kidney Int 2009;75:1272-7.
    • (2009) Kidney Int , vol.75 , pp. 1272-1277
    • Bakris, G.L.1    Fonseca, V.A.2    Sharma, K.3    Wright, E.M.4
  • 33
    • 79956331954 scopus 로고    scopus 로고
    • Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects
    • Sha S, Devineni D, Ghosh A, Polidori D, Chien S, Wexler D, et al. Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects. Diabetes Obes Metab 2011;13:669-72.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 669-672
    • Sha, S.1    Devineni, D.2    Ghosh, A.3    Polidori, D.4    Chien, S.5    Wexler, D.6
  • 35
    • 12744250420 scopus 로고
    • On the action of phlorizin
    • Stiles PG, Lusk G. On the action of phlorizin. Am J Physiol 1903;10:61-79.
    • (1903) Am J Physiol , vol.10 , pp. 61-79
    • Stiles, P.G.1    Lusk, G.2
  • 36
    • 0023275573 scopus 로고
    • Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats
    • Rossetti L, Smith D, Shulman GI, Papachristou D, DeFronzo RA. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest 1987;79:1510-5.
    • (1987) J Clin Invest , vol.79 , pp. 1510-1515
    • Rossetti, L.1    Smith, D.2    Shulman, G.I.3    Papachristou, D.4    Defronzo, R.A.5
  • 37
    • 64549093267 scopus 로고    scopus 로고
    • Serglifl ozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocininduced diabetic rats and Zucker fatty rats
    • Fujimori Y, Katsuno K, Ojima K, Nakashima I, Nakano S, Ishikawa-Takemura Y, et al. Serglifl ozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocininduced diabetic rats and Zucker fatty rats. Eur J Pharmacol 2009;609:148-54.
    • (2009) Eur J Pharmacol , vol.609 , pp. 148-154
    • Fujimori, Y.1    Katsuno, K.2    Ojima, K.3    Nakashima, I.4    Nakano, S.5    Ishikawa-Takemura, Y.6
  • 38
    • 77956319973 scopus 로고    scopus 로고
    • Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus
    • Nomura S, Sakamaki S, Hongu M, Kawanishi E, Koga Y, Sakamoto T, et al. Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus. J Med Chem 2010;53:6355-60.
    • (2010) J Med Chem , vol.53 , pp. 6355-6360
    • Nomura, S.1    Sakamaki, S.2    Hongu, M.3    Kawanishi, E.4    Koga, Y.5    Sakamoto, T.6
  • 39
    • 84857099986 scopus 로고    scopus 로고
    • Effect of canaglifl ozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models
    • Liang Y, Arakawa K, Ueta K, Matsushita Y, Kuriyama C, Martin T, et al. Effect of canaglifl ozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. Plos One 2012;7:e30555.
    • (2012) Plos One , vol.7
    • Liang, Y.1    Arakawa, K.2    Ueta, K.3    Matsushita, Y.4    Kuriyama, C.5    Martin, T.6
  • 40
    • 84896031572 scopus 로고    scopus 로고
    • New Drugs at FDA. (Accessed October 4, 2013, at
    • New Drugs at FDA. (Accessed October 4, 2013, at http://www.fda.gov/drugs/developmentapprovalprocess/druginnovation/default.htm).
  • 41
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin sompared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin sompared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;353:837-53.
    • (1998) Lancet , vol.353 , pp. 837-853
  • 42
    • 84861088227 scopus 로고    scopus 로고
    • Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2 (SGLT2) improves glycemic control and reduces body weight in Japanese type 2 diabetes mellitus (T2DM)
    • abstract
    • Inagaki N, Kondo K, Iwasaki T. Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2 (SGLT2) improves glycemic control and reduces body weight in Japanese type 2 diabetes mellitus (T2DM). Diabetes 2011;60:abstract 0999-P.
    • (2011) Diabetes , vol.60 , pp. 999
    • Inagaki, N.1    Kondo, K.2    Iwasaki, T.3
  • 43
    • 77957593008 scopus 로고    scopus 로고
    • Canagliflozin, an inhibitor of sodium glucose co-transporter 2 (SGLT2), improves glycemic control and lowers body weight in subjects with type 2 diabetes (T2D) on metformin
    • abstract
    • Rosenstock J, Arbit D, Usiskin K, Capuano G, Canovatchel W. Canagliflozin, an inhibitor of sodium glucose co-transporter 2 (SGLT2), improves glycemic control and lowers body weight in subjects with type 2 diabetes (T2D) on metformin. Orlando: American Diabetes Association; 2010, abstract 77.
    • (2010) Orlando: American Diabetes Association , pp. 77
    • Rosenstock, J.1    Arbit, D.2    Usiskin, K.3    Capuano, G.4    Canovatchel, W.5
  • 44
    • 84861079902 scopus 로고    scopus 로고
    • Canagliflozin, an inhibitor of sodium glucose cotransporter 2 (SGLT2), improves glycemic control, lowers body weight and improves beta cell function in subjects with type 2 diabetes on back- ground metformin (T2D) on metformin
    • Rosenstock J, Polidori D, Zhao Y, Sha S, Arbit D, Usiskin K, et al. Canagliflozin, an inhibitor of sodium glucose cotransporter 2 (SGLT2), improves glycemic control, lowers body weight and improves beta cell function in subjects with type 2 diabetes on back- ground metformin (T2D) on metformin. Diabetologia 2010;53:S1-556.
    • (2010) Diabetologia , vol.53 , pp. 1-556
    • Rosenstock, J.1    Polidori, D.2    Zhao, Y.3    Sha, S.4    Arbit, D.5    Usiskin, K.6
  • 45
    • 84896029918 scopus 로고    scopus 로고
    • Canaglifl ozin, a SGLT2 inhibitor, improves glycemia and is well tolerated in type 2 diabetes mellitus subjects with moderate renal impairment
    • Yale JF, Bakris G, Xi L, Figueroa K, Wajs E, Usiskin K, et al. Canaglifl ozin, a SGLT2 inhibitor, improves glycemia and is well tolerated in type 2 diabetes mellitus subjects with moderate renal impairment. Abstracts. Can J Diabetes 2012;36:S24-76.
    • (2012) Abstracts. Can J Diabetes , vol.36 , pp. 24-76
    • Yale, J.F.1    Bakris, G.2    Xi, L.3    Figueroa, K.4    Wajs, E.5    Usiskin, K.6
  • 46
    • 79952221451 scopus 로고    scopus 로고
    • Glucose dynamics and mechanistic implications of SGLT2 inhibitors in animals and humans
    • List JF, Whaley JM. Glucose dynamics and mechanistic implications of SGLT2 inhibitors in animals and humans. Kidney Int Suppl 2011:120:S20-7.
    • (2011) Kidney Int Suppl , vol.120 , pp. 20-70
    • List, J.F.1    Whaley, J.M.2
  • 47
    • 84876311251 scopus 로고    scopus 로고
    • Effi cacy and safety of canaglifl ozin in subjects with type 2 diabetes and chronic kidney disease
    • Yale JF, Bakris G, Cariou B, Yue D, David-Neto E, Xi L, et al. Effi cacy and safety of canaglifl ozin in subjects with type 2 diabetes and chronic kidney disease. Diabetes Obes Metab 2013;15:463-73.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 463-473
    • Yale, J.F.1    Bakris, G.2    Cariou, B.3    Yue, D.4    David-Neto, E.5    Xi, L.6
  • 48
    • 53749091595 scopus 로고    scopus 로고
    • Longterm follow-up after tight control of blood pressure in type 2 diabetes
    • Holman RR, Paul SK, Bethel A, Neil HA, Matthews DR. Longterm follow-up after tight control of blood pressure in type 2 diabetes. N Engl J Med 2008;359:1565-76.
    • (2008) N Engl J Med , vol.359 , pp. 1565-1576
    • Holman, R.R.1    Paul, S.K.2    Bethel, A.3    Neil, H.A.4    Matthews, D.R.5
  • 50
    • 67650082354 scopus 로고    scopus 로고
    • Use of blood pressure lowering drugs in the prevention of cardiovascular disease: Metaanalysis of 147 randomised trials in the context of expectations from prospective epidemiological studies
    • Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: Metaanalysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ 2009;338:b1665.
    • (2009) BMJ , vol.338
    • Law, M.R.1    Morris, J.K.2    Wald, N.J.3
  • 51
    • 84896041591 scopus 로고    scopus 로고
    • CANVAS. Canaglifl ozin Cardiovascula Assessment Study. (Accessed October 4, 2013, at
    • CANVAS. Canaglifl ozin Cardiovascula Assessment Study. (Accessed October 4, 2013, at http://clinicaltrials.gov/show/NCT01032629).
  • 52
    • 84874291673 scopus 로고    scopus 로고
    • Effi cacy and safety of canaglifl ozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
    • Stenlof K, Cefalu WT, Kim KA, Alba M, Usiskin K, Tong C, et al. Effi cacy and safety of canaglifl ozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise. Diabetes Obes Metab 2013;15:372-82.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 372-382
    • Stenlof, K.1    Cefalu, W.T.2    Kim, K.A.3    Alba, M.4    Usiskin, K.5    Tong, C.6
  • 53
    • 84887825367 scopus 로고    scopus 로고
    • Canaglifl ozin, a sodium glucose co-transporter 2 inhibitor, improves glycaemic control in subjects with type 2 diabetes inadequately controlled with diet and exercise (Abstract 760)
    • Stenlof K, Cefalu WT, Tong C. Canaglifl ozin, a sodium glucose co-transporter 2 inhibitor, improves glycaemic control in subjects with type 2 diabetes inadequately controlled with diet and exercise (Abstract 760). Diabetologia 2012;55 Suppl 1:S312-3.
    • (2012) Diabetologia , Issue.55 SUPPL. 1 , pp. 312-313
    • Stenlof, K.1    Cefalu, W.T.2    Tong, C.3
  • 54
    • 84884167643 scopus 로고    scopus 로고
    • Ecacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial
    • Cefalu WT, Leiter LA, Yoon KH, Arias P, Niskanen L, Xie J, et al. Ecacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial. Lancet 2013;382:941-50.
    • (2013) Lancet , vol.382 , pp. 941-950
    • Cefalu, W.T.1    Leiter, L.A.2    Yoon, K.H.3    Arias, P.4    Niskanen, L.5    Xie, J.6
  • 55
    • 84896035405 scopus 로고    scopus 로고
    • Invokana (canaglifl ozin). Prescribing information. (Accessed October 4, 2013, at
    • Invokana (canaglifl ozin). Prescribing information. (Accessed October 4, 2013, at http: //www.invokanahcp.com/prescribing-information.pdf).
  • 56
    • 84896028748 scopus 로고    scopus 로고
    • Invokana. (Accessed October 5, 2013, at
    • Invokana. (Accessed October 5, 2013, at http://www.drugs.com/invokana.html).
  • 57
    • 84880320337 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of canaglifl ozin, a sodium glucose co-transporter 2 inhibitor, in subjects with type 2 diabetes mellitus
    • Devineni D, Curtin CR, Polidori D, Gutierrez MJ, Murphy J, Rusch S, et al. Pharmacokinetics and pharmacodynamics of canaglifl ozin, a sodium glucose co-transporter 2 inhibitor, in subjects with type 2 diabetes mellitus. J Clin Pharmacol 2013;53:601-10.
    • (2013) J Clin Pharmacol , vol.53 , pp. 601-610
    • Devineni, D.1    Curtin, C.R.2    Polidori, D.3    Gutierrez, M.J.4    Murphy, J.5    Rusch, S.6
  • 58
    • 84860252876 scopus 로고    scopus 로고
    • Canagliflozin improves glycemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin
    • Devineni D, Morrow L, Hompesch M, Skee D, Vandebosch A, Murphy J, et al. Canagliflozin improves glycemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin. Diabetes Obes Metab 2012;14:539-45.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 539-545
    • Devineni, D.1    Morrow, L.2    Hompesch, M.3    Skee, D.4    Vandebosch, A.5    Murphy, J.6
  • 59
    • 84861781220 scopus 로고    scopus 로고
    • Dose-ranging effects of Canagliflozin, a Sodium-Glucose Cotransporter 2 Inhibitor, as add- on to metformin in subjects with type 2 diabetes
    • Rosenstock J, Aggarwal N, Polidori D, Alba M, Usiskin K, Tong C, et al. Dose-ranging effects of Canagliflozin, a Sodium-Glucose Cotransporter 2 Inhibitor, as add- on to metformin in subjects with type 2 diabetes. Diabetes Care 2012;35:1232-8.
    • (2012) Diabetes Care , vol.35 , pp. 1232-1238
    • Rosenstock, J.1    Aggarwal, N.2    Polidori, D.3    Alba, M.4    Usiskin, K.5    Tong, C.6
  • 60
    • 84883641414 scopus 로고    scopus 로고
    • Janssen Research and Development to Present Results from Five Phase 3 Studies Evaluating Investigational Canagliflozin for the Treatment of Type 2 Diabetes
    • LLC, June 5, (Accessed October 4, 2013, at
    • Janssen Research and Development to Present Results from Five Phase 3 Studies Evaluating Investigational Canagliflozin for the Treatment of Type 2 Diabetes. Janssen Research and Development, LLC, June 5, 2012. (Accessed October 4, 2013, at http://www.prnewswire.com/news-releases/janssenresearch).
    • (2012) Janssen Research and Development
  • 61
    • 84891784200 scopus 로고    scopus 로고
    • Canagliflozin compared with sitagliptin for patients with type 2 Diabetes who do not have adequate glycemic control with metformin plus sulfonylurea- a 52-week randomized trial
    • Schernthaner G, Gross JL, Rosenstock J, Guarisco M, Fu M, Yee J, et al. Canagliflozin compared with sitagliptin for patients with type 2 Diabetes who do not have adequate glycemic control with metformin plus sulfonylurea- a 52-week randomized trial. Diabetes Care 2013;36:2508-15.
    • (2013) Diabetes Care , vol.36 , pp. 2508-2515
    • Schernthaner, G.1    Gross, J.L.2    Rosenstock, J.3    Guarisco, M.4    Fu, M.5    Yee, J.6
  • 62
    • 56749160374 scopus 로고    scopus 로고
    • Twenty-one additional cases of familial renal glucosuria: Absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion
    • Calado J, Sznajer Y, Metzger D, Rita A, Hogan MC, Kattamis A, et al. Twenty-one additional cases of familial renal glucosuria: Absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion. Nephrol Dial Transplant 2008;23:3874-9.
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 3874-3879
    • Calado, J.1    Sznajer, Y.2    Metzger, D.3    Rita, A.4    Hogan, M.C.5    Kattamis, A.6


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