Possible involvement of cathepsin B/D and caspase-3 in deferoxamine-related neuroprotection of early brain injury after subarachnoid haemorrhage in rats

Neuropathology and Applied Neurobiology

Volumn 40, Issue 3, 2014, Pages 270-283

  Yu, Z Q ^a   Jia, Y ^a   Chen, G ^b  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

Apoptosis; Cathepsin; Deferoxamine; Subarachnoid haemorrhage

Indexed keywords

BRAIN PROTEIN; CASPASE 3; CATHEPSIN B; CATHEPSIN D; DEFEROXAMINE; DNA NUCLEOTIDYLEXOTRANSFERASE; IMMUNOGLOBULIN G;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BLOOD BRAIN BARRIER IMPAIRMENT; BRAIN CORTEX; BRAIN DISEASE; BRAIN EDEMA; BRAIN INJURY; BRAIN LEVEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORTICAL APOPTOSIS; DOWN REGULATION; ENZYME REGULATION; EXTRAVASATION; IMMUNOHISTOCHEMISTRY; INVESTIGATIVE PROCEDURES; MALE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SUBARACHNOID HEMORRHAGE; UPREGULATION; WESTERN BLOTTING; WET AND DRY METHOD;

APOPTOSIS; CATHEPSIN; DEFEROXAMINE; SUBARACHNOID HAEMORRHAGE;

ANIMALS; APOPTOSIS; BLOOD-BRAIN BARRIER; BRAIN INJURIES; CASPASE 3; CATHEPSIN B; CATHEPSIN D; DEFEROXAMINE; MALE; NEUROPROTECTIVE AGENTS; PERMEABILITY; RATS; SUBARACHNOID HEMORRHAGE;

EID: 84896035602     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/nan.12091     Document Type: Article

References (24)

1. Broderick JP, Brott TG, Duldner JE, Tomsick T, Leach A. Initial and recurrent bleeding are the major causes of death following subarachnoid hemorrhage. Stroke 1994; 25: 1342-1347
2. Cahill J, Calvert JW, Zhang JH. Mechanisms of early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab 2006; 26: 1341-1353
3. Ayer RE, Zhang JH. Oxidative stress in subarachnoid haemorrhage: significance in acute brain injury and vasospasm. Acta Neurochir Suppl 2008; 104: 33-41
4. Persson HL, Yu Z, Tirosh O, Eaton JW, Brunk UT. Prevention of oxidant-induced cell death by lysosomotropic iron chelators. Free Radic Biol Med 2003; 34: 1295-12305
5. Yu Z, Persson HL, Eaton JW, Brunk UT. Intralysosomal iron: a major determinant of oxidant-induced cell death. Free Radic Biol Med 2003; 34: 1243-1252
6. Fosburg M, Nathan D, Wayne A. Treatment of Cooley's anemia: deferoxamine provocation test. Blood 1990; 76: 1897
7. Lee JY, Keep RF, He Y, Sagher O, Hua Y, Xi G. Hemoglobin and iron handling in brain after subarachnoid hemorrhage and the effect of deferoxamine on early brain injury. J Cereb Blood Flow Metab 2010; 30: 1793-17803
8. Loftspring MC. Iron and early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab 2010; 30: 1791-1792
9. Wang Z, Ma C, Meng CJ. Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model. J Pineal Res 2012; 53: 129-137
10. Chen G, Fang Q, Zhang J, Zhou D, Wang Z. Role of Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage. J Neurosci Res 2011; 89: 515-523
11. Yamaguchi M, Zhou C, Nanda A, Zhang JH. Ras protein contributes to cerebral vasospasm in a canine double-hemorrhage model. Stroke 2004; 35: 1750-1755
12. Yang D, Han Y, Zhang J, Ding C, Anagli J, Seyfried DM. Improvement in recovery after experimental intracerebral hemorrhage using a selective cathepsin B and L inhibitor. J Neurosurg 2011; 114: 1110-1116
13. Ozden H, Durmaz R, Kanbak G, Uzuner K, Aral E, Kartkaya K, Kabay SC, Atasoy MA. Erythropoietin prevents nitric oxide and cathepsin-mediated neuronal death in focal brain ischemia. Brain Res 2011; 1370: 185-193
14. Matz PG, Fujimura M, Chan PH. Subarachnoid hemolysate produces DNA fragmentation in a pattern similar to apoptosis in mouse brain. Brain Res 2000; 858: 312-319
15. Hasegawa Y, Suzuki H, Sozen T, Altay O, Zhang JH. Apoptotic mechanisms for neuronal cells in early brain injury after subarachnoid hemorrhage. Acta Neurochir Suppl 2011; 110: 43-48
16. Kidd VJ. Proteolytic activities that mediate apoptosis. Annu Rev Physiol 1998; 60: 533-573
17. Yuksel S, Tosun YB, Cahill J, Solaroglu I. Early brain injury following aneurysmal subarachnoid hemorrhage: emphasis on cellular apoptosis. Turk Neurosurg 2012; 22: 529-533
18. Graf E, Mahoney JR, Bryant RG, Eaton JW. Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site. J Biol Chem 1984; 25: 3620-3624
19. Ollinger K, Brunk UT. Cellular injury induced by oxidative stress is mediated through lysosomal damage. Free Radic Biol Med 1995; 19: 565-574
20. Laub R, Schneider YJ, Octave JN, Trouet A, Crichton RR. Cellular pharmacology of deferrioxamine B and derivatives in cultured rat hepatocytes in relation to iron mobilization. Biochem Pharmacol 1985; 34: 1175-1183
21. Lloyd JB, Cable H, Rice-Evans C. Evidence that desferrioxamine cannot enter cells by passive diffusion. Biochem Pharmacol 1991; 41: 1361-1363
22. Cable H, Lloyd JB. Cellular uptake and release of two contrasting iron chelators. J Pharmacol 1999; 51: 131-134
23. Fang Q, Chen G, Zhu W, Dong W, Wang Z. Influence of melatonin on cerebrovascular proinflammatory mediators expression and oxidative stress following subarachnoid hemorrhage in rabbits. Mediators Inflamm 2009; 2009: 426346
24. Lee JY, Keep RF, Hua Y, Ernestus RI, Xi G. Deferoxamine reduces early brain injury following subarachnoid hemorrhage. Acta Neurochir Suppl 2011; 112: 101-106