Expression of GRP78 predicts taxane-based therapeutic resistance and recurrence of human gastric cancer

Experimental and Molecular Pathology

Volumn 96, Issue 2, 2014, Pages 235-241

  Yang, Lei ^a,b   Yang, Shuyun ^b   Liu, Jibin ^b   Wang, Xiaolin ^b   Ji, Jianmei ^b   Cao, Yongfeng ^b   Lu, Kun ^c   Wang, Jianhong ^b   Gao, Yong ^a  

^a Key Laboratory of Arrhythmias of Ministry of Education   (China)

^b NANTONG UNIVERSITY   (China)

^c TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Gastric cancer; Glucose regulated protein 78; Prognosis; Proliferation

Indexed keywords

GLUCOSE REGULATED PROTEIN 78; TAXANE DERIVATIVE; BRIDGED COMPOUND; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; TAXANE; TAXOID; TUMOR MARKER;

ADULT; AGE DISTRIBUTION; ARTICLE; CANCER ADJUVANT THERAPY; CANCER CELL CULTURE; CANCER INFILTRATION; CANCER INHIBITION; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER RESISTANCE; CANCER STAGING; CANCER TISSUE; CELL CYCLE PROGRESSION; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GASTRECTOMY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MEDICAL PARAMETERS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; SEX DIFFERENCE; STOMACH CANCER; TIME TO RECURRENCE; TUMOR DIFFERENTIATION; TUMOR INVASION; AGED; ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PATHOLOGY; PROGNOSIS; STOMACH NEOPLASMS;

AGED; ANIMALS; BRIDGED COMPOUNDS; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAT-SHOCK PROTEINS; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROGNOSIS; STOMACH NEOPLASMS; TAXOIDS; TUMOR MARKERS, BIOLOGICAL;

EID: 84896030993     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2014.02.011     Document Type: Article

References (25)

1. Daneshmand S., Quek M.L., Lin E., Lee C., Cote R.J., Hawes D., Cai J., Groshen S., Lieskovsky G., Skinner D.G., Lee A.S., Pinski J. Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival. Hum. Pathol. 2007, 38:1547-1552.
2. Denoyelle C., Abou-Rjaily G., Bezrookove V., Verhaegen M., Johnson T.M., Fullen D.R., Pointe,r J.N., Gruber S.B., Su L.D., Nikiforov M.A., Kaufman R.J., Bastian B.C., Soengas M.S. Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. Nat. Cell Biol. 2006, 8:1053-1063.
3. Fasano E., Serini S., Piccioni E., Toesca A., Monego G., Cittadini A.R., Ranelletti F.O., Calviello G. DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. Biochim. Biophys. Acta 2012, 1822:1762-1772.
4. Fisher D.E. Apoptosis in cancer therapy: crossing the threshold. Cell 1994, 78:539-542.
5. Fu Y., Lee A.S. Glucose regulated proteins in cancer progression, drug resistance and immunotherapy. Cancer Biol. Ther. 2006, 5:741-744.
6. Hersey P., Zhang X.D. Adaptation to ER stress as a driver of malignancy and resistance to therapy in human melanoma. Pigment Cell Melanoma Res. 2008, 21:358-367.
7. Jiang C.C., Mao Z.G., Avery-Kiejda K.A., Wade M., Hersey P., Zhang X.D. Glucose-regulated protein 78 antagonizes cisplatin and adriamycin in human melanoma cells. Carcinogenesis 2009, 30(2):197-204.
8. Jin H.R., Zhao J., Zhang Z., Liao Y., Wang C.Z., Huang W.H., Li S.P., He T.C., Yuan C.S., Du W. The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress. Cell Death Dis 2012, 3:e376.
9. Kandala P.K., Srivastava S.K. Regulation of macroautophagy in ovarian cancer cells in vitro and in vivo by controlling glucose regulatory protein 78 and AMPK. Oncotarget 2012, 3:435-449.
10. Lee A.S. GRP78 induction in cancer: therapeutic and prognostic implications. Cancer Res. 2007, 67:3496-3499.
11. Lee E., Nichols P., Groshen S., Spicer D., Lee A.S. GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy. Int. J. Cancer 2011, 128(3):726-731.
12. Li J., Lee A.S. Stress induction of GRP78/BiP and its role in cancer. Curr. Mol. Med. 2006, 6:45-54.
13. Ma Y., Hendershot L.M. The role of the unfolded protein response in tumour development: friend or foe?. Nat. Rev. Cancer 2004, 4:966-977.
14. Malhi H., Kaufman R.J. Endoplasmic reticulum stress in liver disease. J. Hepatol. 2011, 54:795-809.
15. Mao C., Dong D., Little E., Luo S., Lee A.S. Transgenic mouse models for monitoring endoplasmic reticulum stress in vivo. Nat. Med. 2004, 10:1013-1014.
16. Meyer H.J., Wilke H.L. Treatment strategies in gastric cancer. Dtsch. Arztebl. Int. 2011, 108:698-705.
17. Miao Y.R., Eckhardt B.L., Cao Y., Pasqualini R., Argani P., Arap W., Ramsay R.G., Anderson R.L. Inhibition of established micrometastases by targeted drug delivery via cell surface-associated GRP78. Clin Cancer Res. 2013, 19:2107-2116.
18. Misra U.K., Payne S., Pizzo S.V. Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen. J. Biol. Chem. 2011, 286(2):1248-1259.
19. Nagini S. Carcinoma of the stomach: a review of epidemiology, pathogenesis, molecular genetics and chemoprevention. World J. Gastrointest. Oncol. 2012, 4:156-169.
20. Navin N., Hicks J. Future medical applications of single-cell sequencing in cancer. Genome Med 2011, 3:31-38.
21. Pyrko P., Schönthal A.H., Hofman F.M., Chen T.C., Lee A.S. The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer Res. 2007, 67:9809-9816.
22. Rutkowski D.T., Kang S.W., Goodman A.G., Garrison J.L., Taunton J., Katze M.G., Kaufman R.J., Hegde R.S. The role of p58IPK in protecting the stressed endoplasmic reticulum. Mol Biol Cell. 2007, 18:3681-3691.
23. Terasaki M., Reese T.S. Interactions among endoplasmic reticulum, microtubules, and retrograde movements of the cell surface. Cell Motil. Cytoskeleton 1994, 29:291-300.
24. Ye R., Mareninova O.A., Barron E., Wang M., Hinton D.R., Pandol S.J., Lee A.S. Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis. Am. J. Pathol. 2010, 177:2827-2836.
25. Zhang J., Jiang Y., Jia Z., Li Q., Gong W., Wang L., Wei D., Yao J., Fang S., Xie K. Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer. Clin. Exp. Metastasis 2006, 23:401-410.