Diagnosing skin rejection in vascularized composite allotransplantation: Advances and challenges

Clinical Transplantation

Volumn 28, Issue 3, 2014, Pages 277-285

  Sarhane, Karim A ^a   Khalifian, Saami ^a   Ibrahim, Zuhaib ^a   Cooney, Damon S ^a   Hautz, Theresa ^b   Lee, Wei Ping Andrew ^a   Schneeberger, Stefan ^a,b   Brandacher, Gerald ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Banff classification; Face transplantation; Hand transplantation; Molecular markers; Skin rejection; Transplantation; Vascularized composite allotransplantation

Indexed keywords

CD68 ANTIGEN; COMPLEMENT COMPONENT C4D; CUTANEOUS LYMPHOCYTE ASSOCIATED ANTIGEN; HLA DR ANTIGEN; MONOCYTE CHEMOTACTIC PROTEIN 1;

ACUTE GRAFT REJECTION; ANTIBODY MEDIATED REJECTION; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CHRONIC GRAFT REJECTION; COMPLEMENT DEPOSITION; GRAFT REJECTION; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; LYMPHOCYTIC INFILTRATION; PRACTICE GUIDELINE; PRIORITY JOURNAL; REVIEW; SKIN ALLOGRAFT; SKIN BIOPSY; SKIN GRAFT; VASCULARIZED COMPOSITE ALLOTRANSPLANTATION;

BANFF CLASSIFICATION; FACE TRANSPLANTATION; HAND TRANSPLANTATION; MOLECULAR MARKERS; SKIN REJECTION; TRANSPLANTATION; VASCULARIZED COMPOSITE ALLOTRANSPLANTATION;

GRAFT REJECTION; HUMANS; SKIN; VASCULARIZED COMPOSITE ALLOTRANSPLANTATION;

EID: 84895924256     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/ctr.12316     Document Type: Review

References (52)

1. Petruzzo P, Dubernard JM. The International Registry on Hand and Composite Tissue Allotransplantation. Clin Transplant 2011: 247: 53.
2. Kaufman CL, Ouseph R, Blair B et al. Graft vasculopathy in clinical hand transplantation. Am J Transplant 2012: 12: 1004.
3. Cendales LC, Kanitakis J, Schneeberger S et al. The Banff 2007 working classification of skin-containing composite tissue allograft pathology. Am J Transplant 2008: 8: 1396.
4. Lakkis FG, Billiar TR. Molecular analysis of transplant rejection: marching onward. J Exp Med 2013: 210: 2147.
5. Jordan SC, Reinsmoen N, Peng A et al. Advances in diagnosing and managing antibody-mediated rejection. Pediatr Nephrol 2010: 25: 2035.
6. Starzl R, Brandacher G, Lee WPA et al. Review of the early diagnoses and assessment of rejection in vascularized composite allotransplantation. Clin Dev Immunol 2013: 2013: 402980.
7. Afzali B, Lombardi G, Lechler RI. Pathways of major histocompatibility complex allorecognition. Curr Opin Organ Transplant 2008: 13: 438.
8. Khalifian S, Broyles JM, Tuffaha SH, Alrakan M, Ibrahim Z, Sarhane KA. Immune mechanisms of ischemia-reperfusion injury in transplantation. Open J Immunol 2013: 3: 158.
9. Hautz T, Zelger B, Brandacher G et al. Histopathologic characterization of mild rejection (grade I) in skin biopsies of human hand allografts. Transpl Int 2012: 25: 56.
10. Kanitakis J, Badet L, Petruzzo P et al. Clinicopathologic monitoring of the skin and oral mucosa of the first human face allograft: report on the first eight months. Transplantation 2006: 82: 1610.
11. Mengel M, Sis B, Haas M et al. Banff 2011 Meeting report: new concepts in antibody-mediated rejection. Am J Transplant 2012: 12: 563.
12. Hautz T, Zelger BG, Weissenbacher A et al. Standardizing skin biopsy sampling to assess rejection in vascularized composite allotransplantation. Clin Transplant 2013: 27: E81.
13. Perez-Abadia G, Laurentin-Perez L, Gorantla VS et al. Low-dose immunosuppression in a rat hind-limb transplantation model. Transpl Int 2003: 16: 835.
14. Unadkat JV, Schneeberger S, Horibe EH et al. Composite tissue vasculopathy and degeneration following multiple episodes of acute rejection in reconstructive transplantation. Am J Transplant 2010: 10: 251.
15. Kanitakis J. The challenge of dermatopathological diagnosis of composite tissue allograft rejection: a review. J Cutan Pathol 2008: 35: 738.
16. Dvorak HF, Mihm MC, Dvorak AM, Barnes BA, Galli SJ. The microvasculature is the critical target of the immune response in vascularized skin allograft rejection. J Invest Dermatol 1980: 74: 280.
17. Kanitakis J, Petruzzo P, Jullien D et al. Pathological score for the evaluation of allograft rejection in human hand (composite tissue) allotransplantation. Eur J Dermatol 2005: 15: 235.
18. Hautz T, Zelger B, Grahammer J et al. Molecular markers and targeted therapy of skin rejection in composite tissue allotransplantation. Am J Transplant 2010: 10: 1200.
19. Maeshima AM, Taniguchi H, Fukuhara S et al. Follow-up data of 10 patients with B-cell non-Hodgkin lymphoma with a CD20-negative phenotypic change after rituximab-containing therapy. Am J Surg Pathol 2013: 37: 563.
20. Zarkhin V, Li L, Sarwal M. To B or not to B? B-cells and graft rejection Transplantation 2008: 85: 1705.
21. Beranek JT, Cavarocchi NC. Smooth muscle cells and macrophages in rabbit cardiac allograft atherosclerosis. J Heart Transplant 1990: 9: 732.
22. Andreeva ER, Pugach IM, Orekhov AN. Subendothelial smooth muscle cells of human aorta express macrophage antigen in situ and in vitro. Atherosclerosis 1997: 135: 19.
23. Beranek JT, Kunisch E, Anderson R et al. CD68 is not a macrophage-specific antigen. Authors' reply. Ann Rheum Dis 2005: 64: 342.
24. Nikkels AF, Arrese Estrada J, Piérard-Franchimont C, Piérard GE. CD68 and factor XIIIa expressions in granular-cell tumor of the skin. Dermatology 1993: 186: 106.
25. Nikolic T, Leenen P. Histiocyte function and development in the normal immune system. In: Weitzamn S, Egeler R, eds. Histiocytic Disorders of Children and Adults. Weitzman, Cambridge: Cambridge University Press, 2005: 40.
26. Robbins CS, Swirski FK. The multiple roles of monocyte subsets in steady state and inflammation. Cell Mol Life Sci 2010: 67: 2685.
27. Nakamura K, Yasaka N, Asahina A et al. Increased numbers of CD68 antigen positive dendritic epidermal cells and upregulation of CLA (cutaneous lymphocyte-associated antigen) expression on these cells in various skin diseases. J Dermatol Sci 1998: 18: 170.
28. Obhrai JS, Oberbarnscheidt M, Zhang N et al. Langerhans cells are not required for efficient skin graft rejection. J Invest Dermatol 2008: 128: 1950.
29. Zell D, Hu S, Kirsner RS. A paradigm shift in the mechanisms of graft rejection. J Invest Dermatol 1874: 2008: 128.
30. Racusen LC, Colvin RB, Solez K et al. Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection. Am J Transplant 2003: 3: 708.
31. Landin L, Cavadas PC, Ibañez J, Roger I, Vera-Sempere F. CD3+-mediated rejection and C4d deposition in two composite tissue (bilateral hand) allograft recipients after induction with alemtuzumab. Transplantation 2009: 87: 776.
32. Kanitakis J, McGregor B, Badet L et al. Absence of C4d deposition in human composite tissue (hands and face) allograft biopsies: an immunoperoxidase study. Transplantation 2007: 84: 265.
33. Wiebe C, Gibson IW, Blydt-Hansen TD et al. Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant. Am J Transplant 2012: 12: 1157.
34. Sellarés J, de Freitas DG, Mengel M et al. Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence. Am J Transplant 2012: 12: 388.
35. Wu S, Xu H, Chen B et al. Sensitized recipients exhibit accelerated but not hyperacute rejection of vascularized composite tissue allografts. Transplantation 2011: 92: 627.
36. Brandacher G, Lee WA, Schneeberger S. Minimizing immunosuppression in hand transplantation. Expert Rev Clin Immunol 2012: 8: 673.
37. Sarhane K, Ibrahim Z, Leto Barone AA, Cooney DS, Lee WPA, Brandacher G. Minimization of immunosuppression and tolerance induction in reconstructive transplantation. Curr Surg Reports 2012: 1: 40.
38. Prabhune KA, Gorantla VS, Maldonado C, Perez-Abadia G, Barker JH, Ildstad ST. Mixed allogeneic chimerism and tolerance to composite tissue allografts. Microsurgery 2000: 20: 441.
39. Petruzzo P, Kanitakis J, Badet L et al. Long-term follow-up in composite tissue allotransplantation: in-depth study of five (hand and face) recipients. Am J Transplant 2011: 11: 808.
40. Weissenbacher A, Pierer G, Gabl M et al. The Innsbruck Hand Transplant Program: an update more than a decade after the first transplant. Transplant J 2012: 94: 394.
41. Petruzzo P, Lanzetta M, Dubernard J-M et al. The International Registry on Hand and Composite Tissue Transplantation. Transplantation 2010: 90: 1590.
42. Mundinger GS, Munivenkatappa R, Drachenberg CB et al. Histopathology of chronic rejection in a nonhuman primate model of vascularized composite allotransplantation. Transplantation 2013: 95: 1204.
43. Mengel M, Sis B, Halloran PF. SWOT analysis of Banff: strengths, weaknesses, opportunities and threats of the international Banff consensus process and classification system for renal allograft pathology. Am J Transplant 2007: 7: 2221.
44. Beimler J, Zeier M. Borderline rejection after renal transplantation-to treat or not to treat. Clin Transplant 2009: 23: 19.
45. Moulavi D, Hajiloo M, Sander J, Halloran PF, Greiner R. Combining gene expression and interaction network data to improve kidney lesion score prediction. Int J Bioinform Res Appl 2012: 8: 54.
46. Sarhane K. Tissue CLN3: A potential biomarker for breast cancer? Department of Biochemistry and Molecular Genetics, Faculty of Medicine, A.U.B. 2012: MSc Dissertation. Available from: http://scholarworks.aub.edu.lb/handle/10938/9318
47. Mueller TF, Reeve J, Jhangri GS et al. The transcriptome of the implant biopsy identifies donor kidneys at increased risk of delayed graft function. Am J Transplant 2008: 8: 78.
48. Sarwal M, Chua M-S, Kambham N et al. Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. N Engl J Med 2003: 349: 125.
49. Reeve J, Einecke G, Mengel M et al. Diagnosing rejection in renal transplants: a comparison of molecular- and histopathology-based approaches. Am J Transplant 2009: 9: 1802.
50. Mueller TF, Einecke G, Reeve J et al. Microarray analysis of rejection in human kidney transplants using pathogenesis-based transcript sets. Am J Transplant 2007: 7: 2712.
51. O'Leary JG, Kaneku H, Susskind BM et al. High mean fluorescence intensity donor-specific anti-HLA antibodies associated with chronic rejection postliver transplant. Am J Transplant 2011: 11: 1868.
52. Mengel M. Transplantation pathology 2013: current diagnostic challenges. Curr Opin Organ Transplant 2013: 18: 304.